malaysian healthy ageing society...e. laconi, s. doratiotto, p. vineis, the microenvironments of...
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Organised by:
Malaysian Healthy Ageing Society
Co-Sponsored:
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Nutritional Therapy for
Cancer
Dato’ Steve Yap
Fellowship, Integrative Cancer Therapies
(USA)
Fellowship, Anti-Aging Regenerative
Medicine (USA)
DSY Wellness & Longevity Center
&
Mohamad Roji Sarmidi
Living Active, Wellness Centre
Universiti Teknologi Malaysia
22 March 2012 ■ FIRST WORLD CONGRESS ON HEALTY AGEING ■ Kualal Lumpur
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Presentation
Introduction: Halmarks of Cancer
Hypoxia, Mitochondria & Metabolism
Nutrients
Figure 1
Source: Cell , Volume 144, Issue 5, Pages 646-674 (DOI:10.1016/j.cell.2011.02.013)
Copyright © 2011 Elsevier Inc. Terms and Conditions
Hallmarks of Cancer
Hanahan, D, & Weinberg RA (2011). Hallmarks of cancer:the next generation
.
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Hallmarks of cancer
Increased glucose consumption and high rates of glycolysis
Resistance to the toxicity of local acidification
Evasion of anoikis
Cancer-associated inflammation
Hallmarks of Cancer
R.A. Gatenby, R.J. Gillies, A microenvironmental model of carcinogenesis, Nat Rev Cancer 8 (2008) 56-61. F. Colotta, P. Allavena, A. Sica, C. Garlanda, A. Mantovani, Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability, Carcinogenesis (2009).
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Why cancer cells do what they do
Hostile cellular environment
Adaptation & survival
Switch to default primitive state
J.S. Fang, R.D. Gillies, R.A. Gatenby, Adaptation to hypoxia and acidosis in carcinogenesis and tumor progression, Semin Cancer Biol 18 (2008) 330-337. E. Laconi, S. Doratiotto, P. Vineis, The microenvironments of multistage carcinogenesis, Semin Cancer Biol 18 (2008) 322-329.
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Cellular Hypoxia
Vladimir Gogvadze, Sten Orrenius and Boris Zhivotovsky, Mitochondria in cancer cells: what is so special about them?Trends in Cell Biology Vol.18 No.4 [J.F. De Los Santos, G.M. Thomas, Anemia correction in malignancy management: threat or opportunity?, Gynecol Oncol 105 (2007) 517-529.
O2 O2 O2
Microcapillar
y
Expression of HIF-1 in human cancer: causes and consequences.
Vaupel P The Oncologist 2004;9:10-17
©2004 by AlphaMed Press
HIF-1-mediated switch from aerobic to anaerobic metabolism in hypoxic tumors for energy
preservation.
Vaupel P The Oncologist 2004;9:10-17
©2004 by AlphaMed Press
Schematic displaying the vicious circle of tumor hypoxia and malignant progression [6].
Vaupel P The Oncologist 2004;9:10-17
©2004 by AlphaMed Press
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Nutritional Therapy Strategy
Nutritional Therapy Strategy
Enhance overall health
Restore homeostasis
Optimize metabolism
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Raising Metabolism
Reduce Oxidation &
Inflammation
Optimize Basal Body
Temperature 97.8-98.3 oF
Normalize Thyroid
Function
Nutrient Dense & Low
GI Foods
Raising Metabolism
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Cell Membranes nutrients
Linoleic Acid (LA)
Alpha-Linolenic Acid (ALA)
Eicosapentanoic Acid (EPA; 20:5)
Docosahexanoic Acid (DHA; 22:6)
Phosphatidylcholine (PC)
Phosphatidylserine (PS)
Cell Membranes Nutrients
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Mitochondrial Nutrients
Mitochodrial Nutrients
Acetyl-L-Carnitine
Coenzyme-Q10
Alpha-Lipoic acid
Linoleic acid
Biotin
Nicotinamide
Riboflavin
Pyridoxine Pyrroloquinoline Quinone (PQQ)
Jiankang Liu a,f,⁎, Weili Shen b, Baolu Zhao c, Ying Wang d, Karin Wertz d, Peter Weber d, Peifang Zhang e, Targeting mitochondrial biogenesis for preventing and treating insulin resistance in diabetes and obesity : Hope from natural mitochondrial nutrients, Advanced Drug Delivery Reviews 61 (2009) 1343–1352
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Mitochondrial Toxin
Mitochondrial Toxins
Arsenite
Cynide
Fluoride
Oligomycin
Carbon monoxide
Sodium benzoate
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Sodium-Potassium Pumps
Magnesium
Potassium
SCFA enhances the absorption of Mg, K and Na in colon
Na+/K+ - ATPase
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Liver Nutrients
Vit C
Mg
Arginine
Tumeric
Silybum marianum
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Collagen Synthesis
Vit C
Lysine
Proline
Glycine
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Anti-inflammatory Nutrients
EPA
Papain
Quercetin
Anthocyanins
Curcumin
Methylsulphonylmethane (MSM)
Gamma-linolenic acid, VCO
Bromelain
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EGCG
Green tea (-)-epigallocatechin-3-gallate (EGCG)
Inhibit hypoxia-induced HIF-1a
Reduce vascular endothelial growth factor (VEGF)
Limit angiogenesis
Qunzhou Zhang, Xudong Tang, QingYi Lu, et al. Green tea extract and (−)-epigallocatechin-3-gallate inhibit hypoxia- and serum-induced HIF-1 α protein accumulation and VEGF expression in human cervical carcinoma and hepatoma cells
Mol Cancer Ther 2006;5:1227-1238. Published online May 26, 2006.
THANK YOU P r o v i d i n g w e l l n e s s s o l u t i o n fo r h e a l t h i e r b o d y …
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