micman final symposium 2006 microbes and man research programme 2003-2005
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MICMAN Final Symposium 2006
MICROBES AND MANMICROBES AND MANResearch Programme 2003-2005
MICMAN Final Symposium 2006
• Implemented jointly by the Academy of Finland (AF) and the Swedish Foundation for Strategic Research (SSF)
• Budget: 5,4 million €
• 15 projects (26 research groups)
MICMANMICMAN
2
Finland: 4.1 M€
Sweden: 1.3 M€
Finland: 21
groups
Sweden: 5
groups
MICMAN Final Symposium 2006
OBJECTIVESOBJECTIVES
• to increase our knowledge of the interaction between host and microbes• to apply this knowledge to the maintenance of health and the prevention and treatment of diseases
• to generate multidisciplinary networks • to promote researcher training and exchange• to promote international contacts • to strengthen cooperation between universities and research institutes
MICMAN Final Symposium 2006
BEFORE
Pre-MICMAN planning 2001-2002
MICMAN
MICMAN Final Symposium 2006
• Exploratory workshop Microbes and Man - Health, Nutrition and Environment August 2001 in Gustavelund (near Helsinki)
– 140 researchers,
– Chair: Res.prof. Pentti Huovinen, KTL
– Topics for the programme
INITIATIVE FOR MICMANINITIATIVE FOR MICMAN
MICMAN Final Symposium 2006
Milestones of preparation
Aug 2001 Exploratory workshop
Nov 2001 Decision on the programme by the Academy
Dec 2001 Negotiations between funding organisations
Feb-Mar 2002 Programme memorandum
April 2002 Launch of the programme
May 2002 Deadline: Plans of intent
June 2002 Decisions: Plans of intent
Sep 2002 Deadline: Applications proper
Nov 2002 Evaluation
Dec 2002 Decisions on accepted projects
Jan 2003 The projects start
MICMAN Final Symposium 2006
MICMAN proposalsMICMAN proposals
PLAN OF INTENT
FULL APPLICATION
S
FUNDED PROJECTS
96
28
15
21 Finnish groups
5 Swedish groups
MICMAN Final Symposium 2006
The steering programme The steering programme committee committee
2002-2003Academy of Finland:Prof Marja Makarow, (UH) (chair) Prof Timo Vesikari, (UTa) Prof Annele Hatakka, (UH) Prof Juha Sihvola, (UJy)
Swedish Foundation for Strategic Research:Dr. Henryk Wos Prof Olle Stendahl, Lindköping University Prof Hans Wolf-Watz, Umeå University Dr. Olle Edqvist
An additional expert: Academician, prof Pirjo Mäkelä, KTL
Also participating from the Academy of Finland: Dr. Soile Juuti Dr. Sirpa Nuotio Dr. Tuula Aarnio
2004-2006
Prof Marja-Liisa Hänninen, (UH) Res.Prof Tiina Mattila-Sandholm (Valio)
MICMAN Final Symposium 2006
DURING THE PROGRAMME
MICMAN projects 2003-2005
MICMAN
MICMAN Final Symposium 2006
MICMAN THEMESMICMAN THEMES
Resident microbiota
- influence of internal and external factors (host itself, pathogenic and
probiotic bacteria)
Host-microbe interactionsin the development and course of diseases
4
Other - bioinformatics; environmental microbes
2
15 PROJECTS:
5 Finnish-Swedish consortia2 Finnish consortia8 Finnish individual projects
9
MICMAN Final Symposium 2006
15 MICMAN PROJECTS15 MICMAN PROJECTSConsortium: Bacterial-epithelial cross-talk and the establishment of the mucosal immune system
Consortium: Microbial factors and host responses discriminating commensals from pathogens
Pathogenesis of reactive arthritis: Research of abnormal host-microbe interaction
Consortium: A paradox of a microbe and man - what makes Staphylococcus aureus a pathogen?
Consortium: Host-microbe interaction in acute and persistent Chlamydia pneumoniae infection
Microbes and allergy: From population observations to animal models and prevention products
Consortium: Microbial ecology ofman in health and disease: Emer-gence, spread and persistence ofAntibiotic resistance in the normalMicroflora (ESPAR)
Microbial pathogenesis of cardiovascular disease
Host-microbe crosstalk in infancy: creating a balance between the internal and external environments
Consortium: Genetic susceptibility to streptococcal infections
DNA microarrays for studying interactions of probiotic, pathogenic and normal gut microbiota bacteria with human intestinal epithelial cells
Cyanobacteria and adjacent microbes: causes of acute human intoxications and indicators of water quality
Consortium: Reactivation and immune evasion of Borrelia infection
Microbial resistance to innate immunity
Infectious origins of the human genome. Human endogenous retroviruses in health and disease
MICMAN Final Symposium 2006
MICMAN CoordinationMICMAN Coordination
To advance the objectives of the programme
• Communication– www-pages, MICMAN News, seminars/symposia/meetings, publicity
relations
• Administrative tasks – Planning, lauching, proposal evaluations, annual reports,
final evaluation
• Researcher training– Graduate school proposals (InfBio) (under evaluation)
• International contacts to other programmes– ERA-NET PathoGenoMics (2004-2009)
• Programme manager: Soile Juuti, National Public Health Institute
Contact person at the SSF: Scientific secretary Henryk Wos
MICMAN Final Symposium 2006
Talks Particip. (n)
30.1.2003 MICMAN Opening Symposium 13 58
11-12.2.2004 MICMAN Annual Symposium 2004
16 92
16-17.2.2005 MICMAN Annual Symposium 2005
15 83
14-15.3.2006 MICMAN Final Symposium 2006
14 97
MICMAN EVENTSMICMAN EVENTS
Prof. Volkmar Braun and prof. Pirjo Mäkelä
MICMAN Final Symposium 2006
2005
Prof. Seppo Meri
MICMAN Final Symposium 2006
Talks Particip. (n)
18.9.2003 1st Finnish Microbial Pathogenesis Day
20 125
7.10.2004 2nd Finnish Microbial Pathogenesis Day
10 74
5.10.2005 3rd Finnish Microbial Pathogenesis Day
8 84
Sept. 2006 4th Finnish Microbial Pathogenesis Day
MICMAN EVENTSMICMAN EVENTS
With prof. Mikael Skurnik, Univ. Helsinki
“The aim of these seminars is to invite researchers on microbial pathogenesis together and advance scientific discussion between the research groups.”
MICMAN Final Symposium 2006
MICMAN Consortia MICMAN Consortia eventsevents
Open seminars: Talks Particip. (n)
3.6.2004 Chlamydia pneumoniae research in Finland: Update and future plans
17 47
20.10.2005 Infection, Inflammation and Atherosclerosis
13 70
With prof. Pekka Saikku, Univ. Oulures.prof. Maija Leinonen, KTLdoc. Mirja Puolakkainen, KTL
MICMAN Final Symposium 2006
Closed seminars: Talks Particip. (n)
19-21.4.2004 Reactivation and immune evasion of Borrelia infection
15 18
20-22.5.2005 12 27
MICMAN Consortia MICMAN Consortia eventsevents
With prof. Sven Bergström, Univ.Umeå prof. Matti Viljanen, Univ.Turku+ prof. Seppo Meri, Univ. Helsinki
MICMAN Final Symposium 2006
2005
MICMAN Final Symposium 2006
CLOSED SEMINARS: Talks
Particip. (n)
22-23.8.2003 Bacterial-epithelial cross-talk and the establishment of the mucosal immune system
10 10
31.8.-1.9.2005 13 13
MICMAN Consortia MICMAN Consortia eventsevents
With prof. William Agace, Univ.Lundprof. Mikael Skurnik, Univ.Helsinkiprof. Sirpa Jalkanen, Univ. Turku
MICMAN Final Symposium 2006
MICMAN Consortia MICMAN Consortia eventsevents
- Regular meetings of the consortium
Microbial ecology of man in health and disease: Emergence, spread and persistence of antibiotic resistance in the normal microflora (ESPAR)
Prof. Charlotta EdlundKarolinska Inst. andRes.prof. Pentti HuovinenKTL
- Meetings of otherconsortia
MICMAN Final Symposium 2006
MICMAN travel supportMICMAN travel support
Support to doctoral students for short-term visits, 6800 €
MICMAN
Finland Sweden
MICMAN Final Symposium 2006
OtherOther
• Graduate School in Infection Biology (2007-2011)– Proposal submitted Dec. 2005
– 32 groups from the Universities of Helsinki, Turku and Oulu and the National Public Health Institute
– Decision ~May 2006
• ERA-NET PathoGenoMics – EU 6thFP project between funding agencies
– MICMAN/Academy of Finland as a partner
– European research programme on Pathogenomics 2007-2009: Deadline of proposals to the call by 31.3.2006
– Funding allocated by the Academy ~1,5 Million €
MICMAN Final Symposium 2006
www.aka.fi/micman
MICMAN Final Symposium 2006
AFTER
MICMAN evaluation 2006
MICMAN
MICMAN Final Symposium 2006
REPORTINGREPORTING
• Final report AF: The final report of the AF using electronic services
SSF: The final report form used by the SSF at www.aka.fi/micman <results
• Self-Evaluation report
An abstract, facts and thoughts of the programme
Deadline 31.3.2006
MICMAN Final Symposium 2006
EVALUATION EVALUATION
• International evaluation panel:Prof. Guy Cornelis, University of Basel, Swizerland (chair)Prof. Robert Sim, MRC Immunochemistry Unit, Oxford, UKProf. Ann-Mari Svennerholm, University of Gothenburg, SwedenProf. Gunna Christiansen, Aarhus University, Denmark
• Based on– E.g. Self-evaluations, final reports, interviews,
additional summary material
• Panel meeting 17-18.10.2006 in Helsinki
• Evaluation report written by the panel
• Concerns all project groups and coordination
MICMAN Final Symposium 2006
EXPERIENCESEXPERIENCES
• Commitment of the researchers to the programme
• Active participation of the graduate students!• Strengthning the Finnish-Swedish collaboration
in research • Collaboration between the FIN-SWE funding
agencies was successful
Heritage of MICMAN:• Graduate school in Infection Biology ???• ERA-NET PathoGenoMics (?)
MICMAN Final Symposium 2006
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