morning report august 7, 2012 good morning. chorea **show video**
Post on 01-Jan-2016
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Symptoms
Acute /subacute Chronic
Localized Diffuse
Single Multiple
Static Progressive
Constant Intermittent
Single Episode Recurrent
Abrupt Gradual
Severe Mild
Painful Nonpainful
Bilious Nonbilious
Sharp/Stabbing Dull/Vague
Problem Characteristics
Ill-appearing/Toxic
Well-appearing/Non-toxic
Localized problem
Systemic problem
Acquired Congenital
New problem Recurrence of old problem
Semantic Qualifiers
Illness Scripts
Predisposing Conditions Age, gender, preceding events
(trauma, viral illness, etc), medication use, past medical history (diagnoses, surgeries, etc)
Pathophysiological Insult What is physically happening in
the body, organisms involved, etc.
Clinical Manifestations Signs and symptoms Labs and imaging
Predisposing Conditions
Bimodal age distribution First decade: 5-7 years old Fifth decade
Females > Males (2:1)Asian (especially Japanese)Associations
Down’s Syndrome Neurofibromatosis Type 1 Sickle Cell Disease Prior intracranial irradiation Autoimmune/collagen vascular disorders
Pathophysiology
Chronic progressive cerebrovascular disorder Progressive stenosis of the terminal portion of
bilateral internal carotid arteries Also stenosis of the main branches of the internal
carotids (esp. middle and anterior cerebral arteries)
This leads to abnormally dilated collateral vessels at the base of the brain
Exact cause unknown General vascular dysplasia Genetic involvement? Autoimmune, environmental, infectious?
Clinical Manifestations
Results from poor cerebral perfusion and infarction
Cause of 6% of pediatric strokes Fixed, unilateral neurologic
deficit Often hemiplegia
SeizuresInvoluntary movement
disordersHeadacheTransient Ischemic Attacks
Precipitated by crying, coughing, blowing
Other
Treatment Neurosurgical revascularization…has been shown to
decrease the risk of stroke Aspirin: prevents micro-thrombi formation at the sites of stenosis Anti-epileptic medications Calcium channel blockers Steroids (as in our patient with chorea)
Early diagnosis and surgical management are important
Long-term outcome is most closely related to patient’s neurologic status at diagnosis and treatment
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