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MutagensandReproductiveToxinsChemicalClassStandardOperatingProcedure

Rev.Date:2017-03-28

MutagensandReproductiveToxinsH340H341H360H361H362

ThisSOPisnotasubstituteforhands-ontraining.PrintacopyandinsertintoyourlaboratorySOPbinder.

Department: Chemistry

DateSOPwaswritten: Thursday,March23,2017

DateSOPwasapprovedbyPI/labsupervisor: Friday,March24,2017

PrincipalInvestigator:Name:F.Fischer

Signature:______________________________

InternalLabSafetyCoordinatororLabManager:Name:StephenvonKugelgen

LabPhone:510.301.1058

OfficePhone:510.642.8252

EmergencyContact:Name:StephenvonKugelgen

PhoneNumber:510.301.1058

Location(s)coveredbythisSOP: TanHall674,675,676,679,680,683,684

1.Purpose

ThisSOPcoverstheprecautionsandsafehandlingproceduresfortheuseofMutagensandReproductiveToxins.ForalistofMutagensandReproductiveToxinscoveredbythisSOPandtheiruse(s),seethe“ListofChemicals”.ProceduresdescribedinSection12applytoallmaterialscoveredinthisSOP.Achangetothe“ListofChemicals”doesnotconstituteachangeintheSOPrequiringrevieworretraining.Ifyouhavequestionsconcerningtheapplicabilityofanyrecommendationorrequirementlistedinthisprocedure,contactthePrincipalInvestigator/LaboratorySupervisororthecampusChemicalHygieneOfficeratucbcho@berkeley.edu.

2.Physical&ChemicalProperties/DefinitionofChemicalGroupGermCellMutagenicityisahazardclassthatisprimarilyconcernedwithchemicalsthatmaycausemutationsinthegermcellofhumansthatcanbetransmittedtotheprogeny.Amutationisdefinedasapermanentchangeintheamountorstructureofgeneticmaterialinacell.

MutagensandReproductiveToxinsChemicalClassStandardOperatingProcedure

Rev.Date:2017-03-28

Mutagensareagentsgivingrisetoanincreasedoccurrenceofmutationsinpopulationsofcellsand/ororganisms.Reproductivetoxicityincludesadverseeffectsonsexualfunctionandfertilityinadultmalesandfemales,aswellasdevelopmentaltoxicityintheoffspring.Thesechemicalsmaypresentextremeriskpotentialtolaboratoryworkersifnothandledappropriately;therefore,thesesubstancesmayrequireadditionalcontrolmeasureswhenused.

3.PotentialHazards/Toxicity

MutagensandReproductiveToxinsarechemicalsthataffectthereproductivecapabilitiesincludingcausingchromosomaldamage(mutations)andadverseeffectsonfetaldevelopment(teratogenesis).AsdefinedbytheGloballyHarmonizedSystemofClassificationandLabelingofChemicals(GHS),reproductivetoxinsaredesignatedbyoneormoreofthefollowingHcodes:

H340MaycausegeneticdefectsH341SuspectedofcausinggeneticdefectsH360MaydamagefertilityortheunbornchildH361SuspectedofdamagingfertilityortheunbornchildH362Maycauseharmtobreast-fedchildren

Additionalrequirementsmayapply,dependingonthespecificchemical.Examplesincludeparticularlyhazardoussubstancesthatarealsohighlyflammableand/orreactive.Safeuserequiresassessingallpotentialhazards.ItisthePrincipal Investigator’s responsibility toensureactivity-specific laboratoryproceduresand/orprocessesaretakenintoaccountwhenusingthisChemicalClassSOP.Please,reviewtheSDSofanychemicalbeforeuse(seeSection11–SDSLocation).

4.EngineeringControlsUsetheengineeringcontrolslistedbelowunlessotherlab-specificinformationisincludedinSection12-Protocol/Procedure.

• Workwithmutagensandreproductivetoxins–theworkmustbeconductedinafumehoodunlessothercontrolsaredesignatedinthelab-specificProtocol/Proceduresection.Sashheightmustbekeptaslowaspossibletoavoidescapingfumesandprovideaphysicalbarrier.

• LaboratoriesandroomswhereMutagensandReproductiveToxinsareusedmusthavegeneralroomventilationthatisnegativepressurewithrespecttothecorridorsandexternalenvironment.Thelaboratory/roomdoormustbekeptclosedatalltimes.

5.PersonalProtectiveEquipmentAtaminimum,thefollowingPPEmustbewornatalltimes.EyeandFaceProtection

A. ANSIZ87.1-compliantsafetyglasseswithsideshields,orchemicalsplashgoggles.

• Ordinary prescription glasses will NOT provide adequate protection unless they alsomeetANSIstandardandhavecompliantsideshields.

MutagensandReproductiveToxinsChemicalClassStandardOperatingProcedure

Rev.Date:2017-03-28

B. Ifthepotentialforexplosion/splashingexists,andadequatecoverageisnotprovidedbythehoodsash,afaceshieldmustbeworn.

SkinandBodyProtection

A. Glovesarerequiredwhenhandlinghazardouschemicals.• RefertospecificchemicalSDSforinformationongloveselection.• Foradditionalinformationongloveselection,goto:

http://ehs.berkeley.edu/hs/63-laboratory-safety/94-glove-selection-and-usage.htmlB. Labcoatsarerequiredwhenhandlinghazardouschemicalsinthelab.Selectthetypeoflabcoat

accordingtothehazardsatthespecificworkplace.C. Longpants,closed-toe/closed-heelshoes,coveredlegs,andankles.

RespiratoryProtectionRespiratoryprotectionisnormallynotrequiredforUCBerkeleylaboratoryactivities.Anylabpersonnelconsideringtheuseofarespirator(e.g.N-95respirator,dustmask)mustcontactEH&Sforaworkplaceassessment.

6.FirstAidProceduresandMedicalEmergenciesIntheeventofaninjury,notifyyoursupervisorimmediatelyandEH&Swithin8hours.

GototheOccupationalHealthFacility(TangHealthCenter,oncampus); ifafterhours,gotothenearestemergencyroom(AltaBates,2450AshbyAveinBerkeley);or

Call911(fromacellphone:510-642-3333)if:

• itisalifethreateningemergency;or

• younotareconfidentinyourabilitytofullyassesstheconditionsoftheenvironmentand/orthe condition of the contaminated/injured person, or you cannot be assured of your ownsafety;or

• thecontaminated/injuredpersonisnotbreathingorisunconscious.

Please remember to provide a copy of the appropriate manufacturer SDS (if available) to theemergency responders or physician. At a minimum, be ready to provide the identity/name of anyhazardousmaterialsinvolved.

Incaseofskincontact

Ifskincontactoccurs,and/orskinorclothingareonfire,immediatelydrenchinthesafetyshowerwithcopious amounts of water for no less than 15 minutes to remove any remaining contaminants. Ifpossibletodosowithoutfurtherinjury,removeanyremainingjewelryorclothing.

Incaseofeyecontact

Rinse thoroughlywith plenty ofwater using an eyewash station for at least 15minutes, occasionallyliftingtheupperandlowereyelids.Removecontactlensesifpossible.

Ifswallowed

MutagensandReproductiveToxinsChemicalClassStandardOperatingProcedure

Rev.Date:2017-03-28

DoNOT induce vomiting unless directed otherwise by the SDS. Never give anything bymouth to anunconsciousperson.Rinsemouthwithwater.

Ifinhaled

Moveintofreshair.

Needlestick/punctureexposure

Washtheaffectedareawithantisepticsoapandwarmwaterfor15minutes.

7.SpecialHandling,StorageandDisposalRequirementsLab-specificinformationonhandlingandstoragemaybeincludedinSection12-Protocol/Procedure.

PrecautionsforSafeHandling:• Eliminateorsubstituteforalesshazardousmaterialwhenpossible.• Designyourexperimenttousetheleastamountofmaterialpossibletoachievethedesired

result.• DonotexceedthescaleofproceduresspecifiedinProtocol/Proceduresectionwithoutapproval

ofthePI.• Verifyyourexperimentalset-upandprocedurepriortouse.• Knowthelocationofthenearesteyewash,safetyshowerandfireextinguisherbeforebeginning

work.• Uponleavingtheworkarea,removeanypersonalprotectiveequipmentwornandwashhands.• Attheendofeachproject,thoroughlydecontaminatetheworkareaaccordingtothematerial

beinghandled.

ConditionsforSafeStorage• Storenon-flammablemutagensandreproductivetoxinswithinsecondarycontainment.• Chemicalsthatrequirerefrigerationmustbestoredappropriately.• Storeflammablemutagensandreproductivetoxinswithinflammablestoragecabinet.

Disposal

● Wastematerialsgeneratedmustbetreatedasahazardouswaste.● TheemptycontainermustberinsedthreetimeswithaCOMPATIBLEsolvent;leaveitopen

inthebackofthehoodovernight.Solventrinsesandwaterrinsemustbedisposedofashazardouswaste.

● Asanalternative,unrinsedemptycontainerscanbedisposedofthroughEH&Sashazardouswaste.Theunrinsedemptycontainersmustbecapped.

● Donotmixwithincompatiblewastestreams.

8.ChemicalSpillSpill–Assesstheextentofdanger;ifnecessaryrequesthelpbycalling911(fromacellphone:510-642-3333)foremergencyassistanceor510-642-3073fornon-lifethreateningsituations.Ifyoucannotassesstheconditionsoftheenvironmentwellenoughtobesureofyourownsafety,donotenterthearea.Ifpossiblehelpcontaminatedorinjuredpersons.Evacuatethespillarea.Avoidbreathingvaporsfromspill.Ifpossible,confinethespilltoasmallareausingaspillkitorabsorbentmaterial.Keepothersfromenteringcontaminatedarea.

MutagensandReproductiveToxinsChemicalClassStandardOperatingProcedure

Rev.Date:2017-03-28

• MinorSpill–Intheeventofaminorspill,ifthereisnopotentialforhazardouschemicalexposure,reportthespillto510-642-3073andproceedtocleanit,ifyouaretrained.Useappropriatepersonalprotectiveequipmentandclean-upmaterialforchemicalspilled.Doublebagspillwasteinclearplasticbags,labelandrequestpick-up.

• MajorSpill–Anyhazardouschemicalspillthatinvolveschemicalexposure,anychemicalspillthatduetosizeand/orhazardrequirescapabilitiesbeyondyourtraining,oranychemicalspillthatgivestheperception(becauseofodor,forexample)thattherehasbeenahazardousrelease.Call911or510-642-3073forassistance.

9.CleaningandDecontaminationLab-specificinformationondecontaminationmaybeincludedinSection12-Protocol/Procedure.

• WearingproperPPE,laboratoryworksurfacesmustbecleanedattheconclusionofeachprocedureandattheendofeachworkday.

• Decontaminateallequipmentbeforeremovingfromadesignatedarea.

10.HazardousWasteDisposalLabelWaste

• Labelallwastecontainers.SeetheEH&SFactSheet,“HazardousWasteManagement”forgeneralinstructionsonproceduresfordisposingofhazardouswaste.

DisposeofWaste

• Disposeofregularlygeneratedchemicalwastewithin6months.

• ContactEH&Sat642-3073ifyouneedassistance.

11.SafetyDataSheet(SDS)LocationSDScanbeaccessedonlineathttp://ucsds.com

MutagensandReproductiveToxinsChemicalClassStandardOperatingProcedure

Rev.Date:2017-03-28

MutagensandReproductiveToxinsChemicalClassStandardOperatingProcedure

Rev.Date:2017-03-28

12.Protocol/Procedure–MutagensandReproductiveToxins

Procedure/Use Scale EngineeringControls/Equipment

PPE(eye,face,gloves,clothing) ProcedureStepsandPrecautions

1.UsingMutagensorReproductiveToxinsasreagents.

Upto100gassuppliedinthereagentbottle.RemembertoobtainPIapprovalifhigherscaleisnecessary.Documentthisapprovalinyournotebook

Allreactionsusingthesematerialsmustbeperformedinaproperlyoperatingfumehoodwiththesashaslowaspossibleorinaninertatmosphereglovebox.

Eyeprotection:WearANSIApprovedtight-fittingsafetygogglesorsafetyglasseswithsideshields.FaceProtection:Faceshieldsaretobeusedwhenthereisnoprotectionfromthehoodsash.HandProtection:Confirmcompatibilityofglovematerialwithchemicalbeingused.Generalguidance(unlessotherwisespecifiedinthespecificSDS):Nitrileglovesmustbeusedtopreventincidentalcontact.Forspillhandlingorforpotentialcontactwithlargerquantities,usedoublenitrileorheaviergaugenitrileorneoprenegloves.Glovesmustbeinspectedpriortouse.Washanddryhandsafteruse.Clothing:Wearlabcoat;fulllengthpantsorequivalent;andclose-toed,close-heeledshoes.

Avoidinhalationandskinexposuretothesematerials.Avoidtheformationofdustswithsolids.Ifthereagentisvolatileorposesanacuteinhalationhazard,carefullyweighreagentsinanenclosedorventedareasuchasaglovebox.Ifthisisnotpossibleusethetaredvesselmethodandcapthevesselduringtransporttoandfromthebalance.Inaproperlyfunctioningfumehood,addreagenttothereactionvessel.Ifthereagentposesanacuteskincontacthazard,usedoublegloves,washhandsandchangeglovesimmediatelyaftermanipulationsandcleanupofthereagentarecomplete.Ifthereagentisaliquid,dispensevolumetricallyandtransfertothereactionvesselusingagraduatedcylinder,syringe,cannula,orpipettorinaproperlyfunctioningfumehood.

Notes AnydeviationfromthisSOPrequiresapprovalfromPI.

MutagensandReproductiveToxinsChemicalClassStandardOperatingProcedure

Rev.Date:2017-03-28

Procedure/Use Scale EngineeringControls/Equipment

PPE(eye,face,gloves,clothing) ProcedureStepsandPrecautions

2.UsingMutagensorReproductiveToxinsassolventsinreactionsorforextractions

Upto2Lassuppliedinthereagentbottle.RemembertoobtainPIapprovalifhigherscaleisnecessary.Documentthisapprovalinyournotebook

Allreactionsusingthesematerialsmustbeperformedinaproperlyoperatingfumehoodwiththesashaslowaspossibleorinaninertatmosphereglovebox.

Eyeprotection:WearANSIApprovedtight-fittingsafetygogglesorsafetyglasseswithsideshields.FaceProtection:Faceshieldsaretobeusedwhenthereisnoprotectionfromthehoodsash.HandProtection:Confirmcompatibilityofglovematerialwithchemicalbeingused.Generalguidance(unlessotherwisespecifiedinthespecificSDS):Nitrileglovesmustbeusedtopreventincidentalcontact.Forspillhandlingorforpotentialcontactwithlargerquantities,usedoublenitrileorheaviergaugenitrileorneoprenegloves.Glovesmustbeinspectedpriortouse.Washanddryhandsafteruse.Clothing:Wearlabcoat;fulllengthpantsorequivalent;andclose-toed,close-heeledshoes.

Avoidinhalationandskinexposuretothesematerials.Ifthereagentposesanacuteskincontacthazard,usedoubleglovesandwashhandsandchangeglovesimmediatelyaftermanipulationsandcleanupofthereagentarecomplete.Ifarotaryevaporatorisused,useanopencoldtrapsystemtocondensethesolventvaporandventtheexhaustintothefumehood.Pressurecanbebuiltupwhenthesesolventsareusedinclosedreactionvessels.Adequateventilation(e.g.pressurebubbleronSchlenkmanifold,oranequilibratingballoon)mustbeusedtopreventdangerousoverpressurization.Pressuremaybebuiltupwhenperformingextractions.Adequateventilation(openthevalvefrequentlyduringtheextraction)hastobeusedtopreventdangerousoverpressurization.Thevaporinsuchaprocessmustbereleasedinafumehood.Ifheated,thereactionapparatushastobefittedwithanadequatelysizedcondenserwithadequatecoolingtopreventevaporation.Coolanthoseshavetobesecuredwithhoseclampstothecondenserandtheoutlet.

MutagensandReproductiveToxinsChemicalClassStandardOperatingProcedure

Rev.Date:2017-03-28

Notes AnydeviationfromthisSOPrequiresapprovalfromPI.

Procedure/Use Scale EngineeringControls/Equipment

PPE(eye,face,gloves,clothing) ProcedureStepsandPrecautions

3.UsingMutagensorReproductiveToxinsassolventsincolumnchromatography(CC)orthinlayerchromatography(TLC).

Upto2Lassuppliedinthereagentbottle.RemembertoobtainPIapprovalifhigherscaleisnecessary.Documentthisapprovalinyournotebook

Allchromatographyoperationsusingthesematerialsmustbeperformedinaproperlyoperatingfumehoodwiththesashaslowaspossible.

Eyeprotection:WearANSIApprovedtight-fittingsafetygogglesorsafetyglasseswithsideshields.FaceProtection:Faceshieldsaretobeusedwhenthereisnoprotectionfromthehoodsash.HandProtection:Confirmcompatibilityofglovematerialwithchemicalbeingused.Generalguidance(unlessotherwisespecifiedinthespecificSDS):Nitrileglovesmustbeusedtopreventincidentalcontact.Forspillhandlingorforpotentialcontactwithlargerquantities,usedoublenitrileorheaviergaugenitrileorneoprenegloves.Glovesmustbeinspectedpriortouse.Washanddryhandsafteruse.Clothing:Wearlabcoat;fulllengthpantsorequivalent;andclose-toed,close-heeledshoes.

Avoidinhalationandskinexposuretothesematerials.Ifthereagentposesanacuteskincontacthazard,usedoubleglovesandwashhandsandchangeglovesimmediatelyaftermanipulationsandcleanupofthereagentarecomplete.ThinLayerChromatography:ifthesolventposesanacuteinhalationhazard,developandallowtheplatetodryinthefumehoodafterremovalfromthedevelopmentbath.ColumnChromatography:collectfractionsofinterestandconcentrateasneeded.Ifmorethan2Loftotalsolventisrequiredfortheoperation,dispense,collect,andconcentratenomorethan2Latatime.Ifarotaryevaporatorisused,useanopencoldtrapsystemtocondensethesolventvaporandventtheexhaustintothefumehood.Afteruseinthecolumn,allowthesolventtoevaporatefromthepackingmaterialpriortoproperdisposalofthepackingmaterial.

Notes AnydeviationfromthisSOPrequiresapprovalfromPI.

MutagensandReproductiveToxinsChemicalClassStandardOperatingProcedure

Rev.Date:2017-03-28

10

13.DocumentationofTraining(signatureofallusersisrequired)

• PriortoconductinganyworkwithMutagensandReproductiveToxins,designatedpersonnelmust

providetrainingtohis/herlaboratorypersonnelspecifictothehazardsinvolvedinworkingwiththis

substance,workareadecontamination,andemergencyprocedures.

• ThePrincipalInvestigatormustprovidehis/herlaboratorypersonnelwithacopyofthisSOPanda

copyoftheParticularlyHazardousSubstancesSDSsprovidedbythemanufacturer.

IhavereadandunderstandthecontentofthisSOP:

Name Signature Identifier Date

MutagensandReproductiveToxinsChemicalClassStandardOperatingProcedure

Rev.Date:2017-03-28

11

ListofChemicals

Chemical(s) Chemical(s) Chemical(s)

(-)-Delta9-THC-D3solution (-)-Deoxyephedrine (-)-Thalidomide

(+)-Thalidomide (+/-)-11-Hydroxy-Delta9-THC

solution

(+/-)-11-nor-9-Carboxy-Delta9-THC-

D3solution

(+/-)-11-nor-9-Carboxy-Delta9-THC-

D9solution

(+/-)-3-Chloro-1,2-propane-

1,1,2,3,3-d5-diol

(+/-)-3-Chloro-1,2-propanediol

(+/-)-alpha-

Hexabromocyclododecane

(+/-)-Baclofen (+/-)-Cloprostenolsodiumsalt

hydrate

(+/-)-gamma-

Hexabromocyclododecane

(+/-)-Glycidol (+/-)-Lorazepam

(+/-)-Propyleneoxide (±)Amethopterinhydrate (11bR,11'bR)-4,4'-(Oxydi-2,1-

phenylene)bis-dinaph

(11bS,11'bS)-4,4'-(Oxydi-2,1-

phenylene)bis-dinaph

(17R)-4'-Chloro-5'-ethyl-9-fluoro-

11beta-hydroxy-1

(1R,3S,4S)-N-Boc-2-

azabicyclo[2.2.1]heptane-3-carb

(2S)-(+)-Glycidyltosylate (3-Bromo-1-propynyl)benzene

solution

(Acetylacetonato)dicarbonyliridium(I

)

(Chloromethylene)dimethyliminium

chloride

(R)-(+)-Glycidol (R)-(+)-Indoline-2-carboxylicacid

(R)-(+)-o-Tolyl-CBS-oxazaborolidine

solution

(R)-(+)-Warfarin (S)-(-)-Glycidol

(S)-(-)-Indoline-2-carboxylicacid (S)-(-)-o-Tolyl-CBS-oxazaborolidine

solution

(S)-(-)-Warfarin

(Z)-4-Hydroxytamoxifen [1-

(Diphenylphosphino)ethyl]ferrocene

[1,1':4',1"]Terphenyl-3,3",5,5"-

tetracarboxylica

[D-Ala6,N-Me-Leu7]-LH-RH [des-Gly10,D-His(Bzl)6]-LH-RH

ethylamide

[des-Gly10,D-Phe6]-LH-RH

ethylamide

[des-Gly10,D-Trp6]-LH-RH

ethylamide

[des-pGlu1]-LH-RH [D-Lys6]-LH-RH

[D-pGlu1,D-Phe2,D-Trp3,6]-LH-RH [D-Trp6]-LH-RH [Hyp9]-LH-RH

{2-[(alpha-

Methyl)diphenylphosphinomethyl]fe

rrocen

1-(cis-3-Chloroallyl)-3,5,7-triaza-1-

azoniaadamant

1,1,1,3,3,3-Hexafluoro-2-propanol

1,1,1,3,3,3-

Hexakis(dimethylamino)diphosphaze

nium

1,1,1-Trimethylhydraziniumiodide 1,1-Bis(tert-butylperoxy)cyclohexane

solution

1,1'-Carbonyl-di-(1,2,4-triazole) 1,2,3-Trichloropropane 1,2,4-Triazole

1,2,4-Triazole-15N3 1,2,5,6,9,10-

Hexabromocyclododecane

1,2,7,8-Diepoxyoctane

1,2-Dibromo-3-chloropropane 1,2-Dimethoxyethane 1,2-Epoxy-3-phenoxypropane

1,2-Epoxy-5-hexene 1,3,5-Trioxane 1,3-Butadiene

1,3-Butadienediepoxide 1,3-Butadiene-1,3-13C2 1,3-Butadiene-d6

MutagensandReproductiveToxinsChemicalClassStandardOperatingProcedure

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1,3-Diaminopropane-N,N,N',N'-

tetraaceticacid

1,3-Dichloroacetone 1,3-Dimethyl-2-imidazolidinone

1,3-Dimethyl-3,4,5,6-tetrahydro-

2(1H)-pyrimidinone

1,3-Diphenylguanidine 1,5-Dinitronaphthalene

11-Hydroxy-Δ9-

tetrahydrocannabinol

11β-Hydroxytestosterone 13-cis-4-Oxoretinoicacid

13-cis-Retinoicacid 15α-Hydroxytestosterone 16alpha-Hydroxytestosterone

16beta-Hydroxytestosterone 17alpha-Ethynylestradiol3-

cyclopentylether

17alpha-Hydroxyprogesterone

17alpha-Hydroxyprogesterone

hexanoate

17alpha-Hydroxyprogesterone-

2,3,4-13C3

17alpha-Methyltestosterone

17beta-Estradiol-16,16,17-d3 19-Hydroxy-4-androsten-3,17-dione 19-Hydroxytestosterone

19-Nortestosterone 1-Bromopropane 1-Bromopropane-2,3-13C2

1-Bromopropane-3,3,3-d3 1-Butyl-3-(2-pyridinylmethyl)-1H-

imidazoliumhexaf

1-Chloro-4-nitrobenzene

1-Ethyl-1-methylpyrrolidinium

bromide

1-Ethyl-2-pyrrolidone 1-Iodo-2-(trimethylsilyl)acetylene

1-Methyl-2-pyrrolidinone 1-PHENYL-2-

(TRIPHENYLPLUMBYL)ACETYLENE

2-(4-Morpholino)ethyl2-

bromoisobutyrate

2-(4-tert-

Butylbenzyl)propionaldehyde

2-(Propyl-2,3-13C2)pentanoic-4,5-

13C2acidsodium

2-(TERT-BUTYL)-4,6-DINITROPHENOL

2,2,6,6-

Tetramethylpiperidinylmagnesium

chloridel

2,3,7,8-Tetrachlorodibenzo-p-dioxin

solution

2,3-Dibromo-1-propanol

2,3-Dichloro-1-propene 2',3'-Dideoxy-3'-fluorouridine 2,3-Dinitrotoluene

2,4,6,8-Tetramethyl-2,4,6,8-

tetrakis(propylglycid

2,4-Diaminoanisole 2,4-Diaminoanisolesulfatesalt

hydrate

2,4-Diaminotoluene 2,4-Dinitroaniline 2,4-Dinitrotoluene

2,6-Diaminotoluene 2,6-Dinitrotoluene 2,6-Dinitrotoluene-

alpha,alpha,alpha-d3

2-[(2-Amino-6-oxo-1,6-dihydro-9H-

purin-9-yl)methox

2-[4-(Dimethylamino)styryl]-1-

methylquinoliniumio

21-Chloro-9-fluoro-11beta-hydroxy-

16-methylpregna-

2aHydroxytestosterone 2-Aminoacetamidine

dihydrobromide

2-Aminophenol

2-Azido-beta-D-glucosetetraacetate 2-Azido-D-galactosetetraacetate 2beta-Hydroxytestosterone

2-Bromo-2-chloro-1,1,1-

trifluoroethane-d

2-Bromopropane 2-Bromopropane-1,1,1,3,3,3-d6

2-Bromopropane-2-d1 2-Bromopropane-d7 2-Chloroacetamide

2-Chloroethylaminehydrochloride 2-Chlorotoluene 2-Ethoxyethanol

2-Ethoxyethylacetate 2-Ethylhexanal 2-Ethylhexanoicacid

2-Ethylhexanoic-d15acid 2-Hexanone 2-Hydroxy-3-{3-[2,4,6,8-tetramethyl-

4,6,8-tris(pro

2-Imidazolidinethione 2-Imidazolidinethione-4,4,5,5-d4 2-Methoxy-13C,d3-estradiol

MutagensandReproductiveToxinsChemicalClassStandardOperatingProcedure

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2-Methoxyestradiol 2-Methoxyethanol 2-Methoxyethanol-13C3

2-Methoxyethylacetate 2-Methyl-1,5-hexadiene 2-Methyl-2-butene

2-Methyl-4'-(methylthio)-2-

morpholinopropiophenone

2-Methylimidazole 2-Nitropropane

2-Nitrotoluene 3-(4-Methylbenzylidene)camphor 3-(Methylthio)butanal

3,3',5-Triiodothyronine-(tyrosine

phenyl-13C6)hyd

3,3ʹ-Dipentyloxacarbocyanineiodide 3,3'-Diaminobenzidine

3,3'-Diaminobenzidine(DAB)Liquid

SubstrateDropp

3,3'-Diaminobenzidine

tetrahydrochloridehydrate

3,3'-Dichlorobenzidine-(diphenyl-d6)

3,3'-Diheptyloxacarbocyanineiodide 3,4-

(Methylenedioxy)phenylmagnesium

bromidesoluti

3,4,5-Trifluorobenzaldehyde

3,4-Dinitrotoluene 3,5,5,-Trimethyloxazolidine-2,4-

dione

3,7-Dimethyl-2,6-octadienenitrile

3-Amino-1,2,4-triazole 3-Aminopropionitrilefumaratesalt 3-Bromo-7-nitroindazole

3-Chlorothiophene 3-Ethyl-2-methyl-2-(3-

methylbutyl)oxazolidine

3-Iodobenzylamine

3-Iodobenzylaminehydrochloride 3-Methylpyrazole 4-(1-Ethyl-1-methylhexyl)phenol

4-(2,6-Dimethyl-2-heptyl)phenol 4-(2-Ethyl-1-methylhexyl)phenol 4-(2-Oxiranylmethoxy)-9H-carbazole

4-(3,5-Dimethyl-3-heptyl)phenol 4,4'-(1,3-

DIMETHYLBUTYLIDENE)DIPHENOL

4,4'-Carbonylbis[(2-

ethoxycarbonyl)benzoicacid],

4,4'-Carbonylbis[2-

(ethoxycarbonyl)benzoicacid],

4,4'-Diaminodiphenylmethane 4,4'-Methylene-13C-dianiline

4,4'-Methylene-bis(2-chloroaniline) 4,4'-Oxydianiline 4-Acetylmorpholine

4-Allylanisole 4-Aminophenol 4-Aminophenol-d7

4-Androstene-3,17-dione 4-Chloro-2-methylaniline 4-Chlorobenzotrichloride

4-Hydroxytamoxifen 4-Methylanisole 4-Nitrophenylbeta-D-

lactopyranoside

4-Nitrosophenol 4-Nonylphenol 4-Nonylphenol-2,3,5,6-d4

4-Oxoretinoicacid 4-tert-Butylphenol 4-Vinyl-1-cyclohexene

5-(p-Methylphenyl)-5-

phenylhydantoin

5,5-Diphenylhydantoin 5,5-Diphenylhydantoinsodiumsalt

5,5-Diphenylhydantoin-d5 5alpha-Androstan-17beta-ol-3-one 5-Aza-2'-deoxycytidine

5-Bromo-2'-deoxyuridine 5-Bromoisatoicanhydride 5-Chloro-2-oxindole

5-Ethynyl-2'-deoxyuridine,(EdU) 5-Fluorocytosine 5-Iodo-1,3-dimethyluracil

5-Iodo-2'-deoxyuridine 5β-Pregnane-3β,11β,17α,21-tetrol-

20-one

6,7-BIS-BENZYLOXY-1-(3-

BENZYLOXY-4-MEO-BZL)-8-MEO-

6alpha-Hydroxytestosterone 6alpha-Methylprednisolone21-

hemisuccinatesodium

6-Aminonicotinamide

6-Azido-6-deoxy-1,2:3,4-di-O-

isopropylidene-alpha-

6-Methyluracil 6-Nitrochrysene

6β-Hydroxytestosterone 7-Nitroindazole 9,9-Di(2-ethylhexyl)fluorene-2,7-

diboronicacidbi

MutagensandReproductiveToxinsChemicalClassStandardOperatingProcedure

Rev.Date:2017-03-28

14

9-Borabicyclo[3.3.1]nonanesolution 9-cis-Retinoicacid 9-Vinylcarbazole

Abacavirsulfate Abirateroneacetate Acethydrazide

Acetohydroxamicacid Acetoxytrimethyllead(IV) Acitretin

AcridineOrangehemi(zincchloride)

salt

Acrylamide-1-13C Acrylamide-13C3

Acrylamide-2,3,3-d3 Acrylicacid-d4 Acrylonitrile-1-13C

Acrylonitrile-13C3 Acrylonitrile-15N Acrylonitrile-2-13C

Acrylonitrile-2-d Acrylonitrile-3-13C Acrylonitrile-d3

ActinomycinI,fromStreptomyces

antibioticus

ActinomycinV,fromStreptomyces

antibioticus

Adenine9-beta-D-arabinofuranoside

AflatoxicolInaturalisomer AflatoxicolIIunnaturalisomer Albendazole

Albendazolesulfone Alclometasonedipropionate Aldimorph

Allylchloride Allylglycidylether alpha-Hydroxytriazolam

alpha-Zearalanol Alprostadil Altenuene,fromAlternariasp.

Aluminumacetate,dibasic Aminopterin Amitriptyline-d3hydrochloride

solution

Ammoniumdichromate Ammoniumnickel(II)sulfate

hexahydrate

Anastrozole

Androstanolone17-benzoate Aniline Anilinehydrochloride

Anilinephthalatesolution Anilinesulfate Aniline-1-13C

Aniline-13C6 Aniline-13C6hydrochloride Aniline-15N

Aniline-2,3,4,5,6-d5 Aniline-4-13C Aniline-d7

Aniliniumhypophosphite Antide Antimony(III)butoxidesolution

Apramycinsulfatesalt Aramite Aroclor1260solution

AsparaginasefromEscherichiacoli Austdiol Azobenzene

BDENo99 Beclomethasonedipropionate Benfuracarb

Benomyl Benzamide Benzamide-alpha-13C

Benzene Benzene-1,2,3,5-d4 Benzene-1,3,5-d3

Benzene-13C Benzene-13C6 Benzene-13C6,d6

Benzene-d Benzene-d5 Benzene-d6

Benzenethiol Benzo[a]pyrene Benzo[a]pyrene-7-d

Benzo[a]pyrene-8-d Benzo[a]pyrene-d12 Benzphetaminehydrochloride

Benzylbutylphthalate Benzylbutylphthalate-3,4,5,6-d4 Benzyldiazoacetatesolution

Bergapten beta-CFTnaphthalenedisulfonate

monohydrate

beta-Estradiol

beta-Estradiol17-acetate beta-Estradiol17-cypionate beta-Estradiol17-valerate

beta-Estradiol3-benzoate beta-Estradiolhemihydrate beta-Estradiol-d2

Betamethasone beta-Zearalanol Binapacryl

Biotin3-sulfo-N-hydroxysuccinimide

estersodiums

BiotindisulfideN-

hydroxysuccinimideester

Bis(2,2,6,6-tetramethyl-3,5-

heptanedionato)lead(II

Bis(2,4,6-trimethylpyridine)iodine(I) Bis(2,6-diphenylphenoxy)niobium(V) Bis(2-ethylhexyl)isophthalate

MutagensandReproductiveToxinsChemicalClassStandardOperatingProcedure

Rev.Date:2017-03-28

15

hexafluoroph chloride,benze

Bis(2-ethylhexyl)phthalate-3,4,5,6-d4 Bis(2-methoxy­ethyl)

carbonate

Bis(3-aminopropyl)amine

Bis(4-aminophenyl)ether-15N2 Bis(4-aminophenyl)ether-d12 Bis(4-methylpentyl)phthalate

Bis(8-hydroxy-2-methylquinoline)-(4-

phenylphenoxy)

Bis(cyclopentadienyl)cobalt(II) Bis(methylglycol)phthalate

Bis[2-(2-benzothiazolyl-

N3)phenolato-O]zinc

bisBenzimideH33342

trihydrochloride

BisphenolA

BisphenolApropoxylatediglycidyl

ether

BisphenolAsulfatesodiumsalt BisphenolA-(dimethyl-d6)

BisphenolA-d16 BisphenolPH Bisphenol-A-(diphenyl-13C12)

Bleomycinsulfatefrom

Streptomycesverticillus

Boc-4-phenyl-Phe-OH BoraxAnhydrous

Boricacid Boricacid-10B Boricacid-11B

Boricacid-d3 Boricanhydride Bromomethane

BROMOMETHANE-(13)C Bromomethane-d1 Bromomethane-d2

Bromomethane-d3 BROMOTRIETHYLLEAD Bromotrimethyllead(IV)

Bromoxynil Bromoxynilmethylether Bromoxynil-octanoate

Bropirimine BudesonideRelatedCompoundE Buprenorphinehydrochloride

Buserelinacetatesalt Butane-1,1,1-d3 Butane-d10

ButirosinA,fromBacillusvitellinus Butorphanol(+)-tartratesalt Butralin

Butylglycidylether Butylglycolate Cadmium

Cadmiumcarbonate Cadmiumchloride Cadmiumchloride

hemi(pentahydrate)

Cadmiumchloridehydrate Cadmiumchloridemonohydrate Cadmiumfluoride

Cadmiumhydroxide Cadmiumnitratetetrahydrate Cadmiumoxide

Cadmiumstandardsolution Cadmiumsulfate Cadmiumsulfate8/3-hydrate

Cadmiumsulfatehydrate Cadmiumsulfide Cadmium(II)acetate

Caffeicacid Caffeicacid-13C9 Calciumacetylacetonate

Calciumacetylacetonatehydrate Cambendazole Cambendazole-d7

CanamycinAdisulfatesalthydrate Candesartancilexetil Capecitabine

Capreomycinsulfatefrom

Streptomycescapreolus

Captopril Carbendazim

Carbendazim-(ring-4,5,6,7-d4) Carbendazim-d3 Carbondisulfide

Carbonmonoxide Carbon-13Cdisulfide Carbon-13Cmonoxide

Carboplatin Carmofur Carmustine

Celecoxib Cerium(III)acetylacetonatehydrate Cesiumchloride

Cesiumchloride/sodiumchloride

(2:1)eutectic

Cetrorelixacetate Chinomethionate

ChlorazolBlack Chlorden Chlormadinoneacetate

Chloroform-d Chlorotriphenyllead(IV) Chlortoluron

MutagensandReproductiveToxinsChemicalClassStandardOperatingProcedure

Rev.Date:2017-03-28

16

Chorionicgonadotropinhuman ChorionicgonadotropinHumanβ-

SubunitFragment10

ChorismicacidfromEnterobacter

aerogenes

Chromium(III)bromidehexahydrate Chromium(III)

trifluoroacetylacetonate

Chromium(VI)oxide

ChromomycinA3fromStreptomyces

griseus

Chromylchloride Chrysene

Chrysene-d12 ChrysoidineG Cimetidine

CitreoviridinA ClavulanateLithium Clobetasol

Clobetasolpropionate Clomiphenecitratesalt Clorazepatedipotassiumsalt

Clozapine Cobaltatomicspectroscopy

standardconcentrate10

CobaltstandardforICP

Cobalt(II)2-ethylhexanoatesolution Cobalt(II)acetate Cobalt(II)acetylacetonate

Cobalt(II)carbonate Cobalt(II)chloride Cobalt(II)chloridehexahydrate

Cobalt(II)chloridehydrate Cobalt(II)sulfateheptahydrate Cobalt(II)sulfatehydrate

Cobalt(II)thiocyanate Cocainehydrochloride Colchicine

Compound52 ConcanavalinAfromCanavalia

ensiformis(Jackbea

CongoRed

Copperhydride(CuH)solution CP-395,267-15tosylate Creosotefrombeechwoodtar

Cresolmixtureofisomers Cresolredtetraoctylammoniumsalt

solution

Crizotinib

Crotonaldehyde,mixtureofcisand

trans

Crotonaldehyde,predominantly

trans

Cyanamide

Cyclohexanoneperoxidesolution CYCLOHEXIMIDE Cyclohexylamine

Cyclopentadienylhafnium(IV)

trichloride

Cyclopropylboronicacid CyclosporinA

CyclosporinH Cymoxanil Cyproconazol

CytochalasinAfromDrechslera

dematioidea

CytochalasinBfromDrechslera

dematioidea

CytochalasinD

CytochalasinEfromAspergillus

clavatus

Cytosinebeta-D-arabinofuranoside Cytosinebeta-D-arabinofuranoside

hydrochloride

D(-)-Norgestrel Dacarbazine D-Amphetamine-d3sulfatesalt

Danazol Delta9-Tetrahydrocannabinol

solution

Dexamethasone21-phosphate

disodiumsalt

Dexamethasone–biotinlabeled Dibekacinsulfatesalt Dibutylphthalate

Dibutylphthalate-3,4,5,6-d4 Dibutylborontriflatesolution Dibutyltinbis(acetylacetonate)

Dibutyltindiacetate Dibutyltindichloride Dibutyltindilaurate

Dibutyltinmaleate Dibutyltin(IV)oxide Dicarbonylcyclopentadienylcobalt(I)

Dienestrol Dienestrol-3',3",5',5"-d4 Dienogest

Diethylsulfate Diethylaluminumcyanidesolution DIETHYLDITHIOCARBAMICACID,

LEADSALT,MOIST

Diethyleneglycoldimethylether Diethyleneglycolmethylether Diethylenetriamine-pentaaceticacid

pentasodiumsa

DIETHYLLEADDIBROMIDE Diethylstilbestrol Diethylstilbestroldipropionate

MutagensandReproductiveToxinsChemicalClassStandardOperatingProcedure

Rev.Date:2017-03-28

17

Diethylstilbestrol,mixtureofcisand

trans

Diflunisal Diheptylphthalate

Dihexylphthalate Diisobutylphthalate Diisobutylphthalate-3,4,5,6-d4

Diisoheptylphthalate Diisononylphthalate Diisononylphthalate-d4

Diisopentylphthalate Diisopropylzincsolution D-Ile-Pro-Argp-nitroanilide

dihydrochloride

Dilithiumphthalocyanine Dimethylmethylphosphonate Dimethylphosphite

Dimethylsulfate Dimethylsulfate-13C2 Dimethylsulfate-13C2,d6

Dimethylsulfate-d6 Dinocap Dinoseb

Dinosebacetate Dinoterbacetate Dioctylphthalate

Dipentylphthalate Dipentylphthalate-3,4,5,6-d4 Diphenyl(2,4,6-

trimethylbenzoyl)phosphineoxide

Diphenylzinc Dipropylphthalate Dipyronmonohydrate

Disopyramide DL-Amethopterinhydrate DNOC

Dobutaminehydrochloride Dofetilide Domperidone

Dothiepinsolution D-Phe2,D-Ala6-luteinizing

hormonereleasinghormon

D-Phe-L-pipecolyl-Arg-p-nitroanilide

dihydrochlori

Drospirenone D-Val-Leu-Argp-nitroanilide

diacetatesalt

D-Val-Leu-Lys4-nitroanilide

dihydrochloride

D-Val-Phe-Lysp-Nitroanilide

dihydrochloride

Dysprosium(III)acetylacetonate

hydrate

Dysprosium(III)iodide

Efinaconazole Enalapril Epirubicinhydrochloride

Epitetracyclinehydrochloride Epoxiconazole Eprinomectin

Equilin Equilin-2,4,16,16-d4 Erbium(III)acetylacetonatehydrate

Erbium(III)iodide ErgotamineD-tartrate Estriol

Estriol-2,3,4-13C3 Estrone Estrone3-sulfatepotassiumsalt

Estroneacetate Estrone-2,3,4-13C3 Estrone-2,4,16,16-d4

Estrone-2,4,16,16-d43-sulfate

sodiumsalt

Ethambutoldihydrochloride Ethenesulfonylfluoride

Ethidiumbromide Ethionamide Ethisterone

Ethylmethanesulfonate ETHYLTETRAHYDROFURFURYL

ETHER

Ethyleneoxide

Ethylene-13Coxide Ethylene-d4oxide Ethyllithiumsolution

Etiocholan-17β-ol-3-one Etofenprox Etofenprox-(ethoxy-d5)

Etonogestrel Europium(II)iodide Exemestane

ExemestaneRelatedCompoundA Fadrozolehydrochloride FastGreenFCF

Fenarimol Fenpropimorph Fenthion

Ferrocene Flecainideacetate Fluazifop

Fluazifop-butyl Fluazifop-P-butyl Fluazinam

Fludrocortisoneacetate Flumioxazin Fluocinoloneacetonide21-acetate

Fluoxymesterone Fluphenazinedihydrochloride Flusilazole

MutagensandReproductiveToxinsChemicalClassStandardOperatingProcedure

Rev.Date:2017-03-28

18

Flutamide Formaldehydesolution Formaldehyde-13Csolution

Formamide Formamide-13C Formamide-13C,15N

Formamide-15N Formamide-18O Formamide-1-d

Formamide-d3 Formestane Fosphenytoindisodiumsalthydrate

Furan Furan-d4 Furazolidone

Furazolidone-d4 Furosemide Gabapentin

Gadolinium(III)iodide Gallium(III)iodide Ganciclovir

Gemcitabinehydrochloride Gestodene Glufosinate-ammonium

Glycidamide-13C3 Glycidyl2-methylphenylether Glycidylmethacrylate

Glycidyltrimethylammonium

chloride

Glyoxalsolution Goserelinacetate

Griseofulvin Guanabenz Hafnium(IV)iodide

Halcinonide Haloperidol HCH

Heptadecafluorooctanesulfonicacid Heptadecafluorooctanesulfonicacid

tetraethylammon

Hexafluoroacetone

Hexafluoroacetonedeuterate Hexafluoroacetonetrihydrate Hexamethylphosphoramide

Hexane-1-13C Hexane-d14 Holmium(III)iodide

Hydrocortisone Hydrocortisone21-acetate Hydrocortisone-9,11,12,12-d4

Hydroquinone Hydroquinone-d4-(ring-d4) Hydroquinone-d6

Hydroxymethanesulfinicacid

monosodiumsaltdihydr

Hydroxypropylmethacrylate Hydroxyurea

Idarubicinhydrochloride Imidazole-15N2 Indium(III)iodide

Indium(III)phosphide Indoline-2-carboxylicacid Inhibinalpha-SubunitFragment1-32

porcine

Inhibinbeta-SubunitFragment67-94

human

Inhibinfromporcineovary Inhibinα-SubunitFragment1-32

human

Inhibin-LikePeptide,human Ioxynil Ioxynil-octanoate

IR-676iodide IR-786iodide Iron(II)iodide

Isobutylnitrite Isopropylbeta-D-

thioglucopyranoside

Isopropylchloroformatesolution

Isopropylmethanesulfonate Isopyrazam Isoxaflutole

Jone'sreagent Kaempferol Kaempferol3-O-alpha-L-

arabinopyranoside

Kanamycindisulfatesaltfrom

Streptomyceskanamyc

Kanamycinsulfate Kanamycinsulfate,from

Streptomyceskanamyceticus

Ketoconazole Lamivudine Lanreotideacetate

Lead Leadbis(2-ethylhexanoate) Leadcompounds

Leaddiethyldithiocarbamate Leadhydrogenphosphate Leadoxide

Leadsubacetate Lead(II)acetatetrihydrate Lead(II)acetylacetonate

Lead(II)bromide Lead(II)carbonate Lead(II)chloride

Lead(II)chromate Lead(II)fluoride Lead(II)iodate

MutagensandReproductiveToxinsChemicalClassStandardOperatingProcedure

Rev.Date:2017-03-28

19

Lead(II)iodide Lead(II)metavanadate Lead(II)molybdate

Lead(II)niobate Lead(II)nitrate Lead(II)oxide

Lead(II)perchloratehydrate Lead(II)perchloratetrihydrate Lead(II)phthalocyanine

Lead(II)salicylate Lead(II)selenide Lead(II)selenite

Lead(II)sulfate Lead(II)sulfide Lead(II)tantalate

Lead(II)tartrate Lead(II)telluride Lead(II)tetrakis(4-

cumylphenoxy)phthalocyanine

Lead(II)thiocyanate Lead(II)titanate Lead(II)trifluoroacetate

Lead(II)tungstate Lead(II)zirconate Lead(IV)acetate

LeucomalachiteGreen LeukotrieneA3methylester Leuprorelin

Levofloxacin Levofloxacin-(N-methyl-13C,d3) Levorphanol(+)-tartratesalt

dihydrate

Ligroin Lindane Lindane-13C6(gamma-BHC)

Linuron Linuron-(methyl-d3,methoxy-d3) Lithiumacetylacetonate

Lithiumaluminumhydride

bis(tetrahydrofuran)solu

Lithiumdichromatehydrate Lithiumdiisopropylamide

mono(tetrahydrofuran)sol

Lithiumiodate Lithiumiron(III)oxide Lithium

pentamethylcyclopentadienide

Lithiumpotassiumacetylphosphate Lithium-6Lifluoride Lonidamine

Luperox(R)224,2,4-Pentanedione

peroxidesolution

Luperox(R)DI,tert-Butylperoxide LuteinizingHormonefromequine

pituitary

Luteinizinghormonereleasing

hormone

Luteinizinghormonereleasing

hormoneFragment4-1

Luteinizinghormonereleasing

hormoneFragment7-1

Luteinizinghormonereleasing

hormonehumanacetat

Luteinizinghormonereleasing

hormonesalmon

Luteinizinghormonereleasing

hormonefragment3-1

LuteinizingHormone,beta-subunit

fromhumanpitui

Lutetium(III)acetylacetonate

hydrate

Magnesiumbis(diisopropyl)amide

solution

Magnesiummethylcarbonate

solution

MalachiteGreenCarbinol

hydrochloride

MalachiteGreenchloride

MalachiteGreenoxalatesalt Maleichydrazide Mancozeb

Maneb Manganese(II)iodide Mechlorethaminehydrochloride

Meclozinedihydrochloride Medroxyprogesterone Melengestrolacetate

Melphalan Mercury Mercury(II)chloride

Methimazole Methotrexatehydrate Methoxyaceticacid

Methyl2-acrylamido-2-

methoxyacetate

Methylisocyanate Methyl-d3salicylate-OD

Methylergonovinemaleatesalt Methylglycolchitosan Methylprednisoloneacetate

Methyltrioctylammoniumiodide Metoclopramide Mibolerone

Michler'sketone Mifepristone Miloxacin-d3

Mirex Misoprostol Misoprostolfreeacid

Mitoxantronedihydrochloride Mizoribine MMAO-12

Molinate mono-Butylphthalate Monocrotophos

MutagensandReproductiveToxinsChemicalClassStandardOperatingProcedure

Rev.Date:2017-03-28

20

Morphinesulfatesaltsolution m-Phenylenediamine m-Phenylenediamine

dihydrochloride

MS-275 m-Xylene-(dimethyl-13C2) Myclobutanil

Mycophenolicacid N-(Hydroxymethyl)acrylamide

solution

N,N-Dimethyl-13C2-formamide

N,N-Dimethylacetamide N,N-Dimethylacetamide-1,2-13C2 N,N-Dimethylacetamide-d9

N,N-Dimethyl-d6-formamide N,N-Dimethylformamide N,N-Dimethylformamidediethyl

sulfateadduct

N,N-Dimethylformamide-(carbonyl-

13C)

N,N-Dimethylformamide-15N N,N-Dimethylformamide-d

N,N-Dimethylformamide-d7 N-[3-(Trimethoxysilyl)propyl]aniline N4-Benzoyl-5'-O-(4,4'-

dimethoxytrityl)-2'-deoxycyt

Naphtha Naproxensodium Narciclasine

N-DesmethyltamoxifenHCl Neodymium(III)iodide Netilmicinsulfatesalt

NickelstandardforIC Nickelsulfide Nickel(II)bromide

Nickel(II)bromidetrihydrate Nickel(II)carbonatebasichydrate Nickel(II)chloride

Nickel(II)chloridehexahydrate Nickel(II)chloridehydrate Nickel(II)fluoride

Nickel(II)fluoridetetrahydrate Nickel(II)hexafluorosilicate

hexahydrate

Nickel(II)hydroxide

Nickel(II)iodide Nickel(II)molybdate Nickel(II)nitratehexahydrate

Nickel(II)octanoatehydrate Nickel(II)perchloratehexahydrate Nickel(II)stearate

Nickel(II)sulfamatetetrahydrate Nickel(II)sulfate Nickel(II)sulfateheptahydrate

Nickel(II)sulfatehexa-/

heptahydrate

Nickel(II)sulfatehexahydrate Nilutamide

Nitrobenzene Nitrobenzene-13C6 Nitrobenzene-15N

Nitrobenzene-d5 Nitrofen N-Methylacetamide-d7

N-Methyl-d3-2-pyrrolidinone-d6 N-Methylformamide N-Methylformamide-18O

N-Nitroso-N-ethylurea N-Nitroso-N-methylurea n-Nonylphenol

Nocodazole Nogalamycin Nomegestrolacetate

Nonylphenol Norcocaine Norcocainehydrochloridesolution

Norethandrolonesolution Norethynodrel N-Succinyl-Ala-Ala-Pro-Asp-p-

nitroanilide

N-Vinylformamide o-Anisidine Octamethylcyclotetrasiloxane

o-Phenylenediamine o-Phenylenediamine

dihydrochloride

Oxadiargyl

Oxalicacid-13C2dihydrate Oxandrolone Oxibendazole-d7

Paclitaxel Parbendazole Parbendazole-(methyl-d3)

Pentadecafluorooctanoicacid

ammoniumsalt

Pentobarbital Perfluorooctanoicacid

Petroleum Petroleumether pGlu-Gly-Argp-nitroanilide

hydrochloride

Phenazepam Phenobarbital Phenobarbital-D5(ring)solution

MutagensandReproductiveToxinsChemicalClassStandardOperatingProcedure

Rev.Date:2017-03-28

21

Phenol Phenol-chloroform-isoamyl

alcoholmixture

Phenol-13C6

Phenol-2,3,4,5,6-d5 Phenol-2,4,6-d3 Phenol-2,4,6-d3,OD

Phenol-3,5-d2 Phenol-4-d1 Phenol-d6

Phenolphthalein Phenol-UL-14C Phenylammoniumiodide

Phenylhydrazine Phenylhydrazinehydrochloride Phosphamidon

PhosphazenebaseP1-t-Bu Phoxim Phthalazine

PigmentOrange5 Piperazinedihydrochloride Piperazinehexahydrate

Pizotifen Platinum(II)acetylacetonate PodophyllinfromPodophyllum

emodii

Poly(2-ethylhexylacrylate)solution Poly(2-ethylhexylmethacrylate)

solution

Poly(3,3',4,4'-

biphenyltetracarboxylicdianhydride

Poly(butylacrylate)solution Poly(hexadecylmethacrylate)

solution

Poly(hexylmethacrylate)solution

Poly(laurylmethacrylate)solution Poly(melamine-co-formaldehyde)

isobutylated,solut

Poly(methylacrylate)solution

Poly(methylvinylether-alt-maleic

anhydride)

Poly(octadecylmethacrylate)

solution

Poly(propyleneglycol)4-

nonylphenyletheracrylat

Poly(vinylN-octadecylcarbamate) Potassiumacetylacetonate

hemihydrate

Potassiumchromate

Potassium

cyclopropyltrifluoroborate

Potassiumdichromate Potassiumdichromatesolutionin

sulfuricacid,re

Potassiumtert-pentoxidesolution Praseodymium(III)acetylacetonate

hydrate

Praseodymium(III)iodide

Prazosinhydrochloride Prednisone Pregabalin

Prinomastathydrochloride Procarbazinehydrochloride Progesterone-2,3,4-13C3

Prolactinfromsheeppituitary Propargylbromidesolution Propidiumiodide

Propyleneoxide-d6 Propylenethiourea Propylphosphonicanhydride

solution

ProstaglandinD2 ProstaglandinE2 ProstaglandinF2alphatrissalt

Prunasin PseudolaricAcidB p-Toluenesulfonylazidesolution

Pyrene Pyrocatechol Pyrogallol

Pyronaridinetetraphosphate Quinoline R(-)-Denopamine

RadicicolfromDiheterospora

chlamydosporia

Red-Al(R)sodiumbis(2-

methoxyethoxy)aluminumhydr

Resorcinoldiglycidylether

Retinoicacidp-hydroxyanilide Retinol Retinylacetate

RetinylPropionate Rhodium(III)acetylacetonate Ribavirin

Ribostamycinsulfatesalt Risedronatesodium Rizatriptanbenzoatesalt

Rutheniumiodide Ruthenium(III)iodidehydrate S(−)-Terguridehydrogenmaleate

Safrole SAHA Samarium(III)acetylacetonate

hydrate

Sassafrasoil Scandium(III)iodide Secobarbitalsodiumsalt

MutagensandReproductiveToxinsChemicalClassStandardOperatingProcedure

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22

Semustine Seratrodast Serotonin

Serotonincreatininesulfate

monohydrate

Silafluofen Silicontetraiodide

Sisomicinsulfatesalt sn-Glycero-3-phosphocholine1:1

cadmiumchloridea

Sodiumbutyrate

Sodiumchromate Sodiumchromatetetrahydrate Sodiumdichromate

Sodiumdichromatedihydrate Sodiumdiethyldihydroaluminate

solution

Sodiumhexafluoroaluminate

Sodiumhydroxymethanesulfinate

hydrate

Sodiummercuryamalgam Sodiumperboratemonohydrate

Sodiumtetraboratedecahydrate Sodiumtriethylborohydridesolution Sodium-leadalloy

Spiperone Spironolactone Stanozolol

Stanozolol-D3solution Streptomycinsulfatesalt S-Trioxane-13C3

Styreneoxide Styrene-(phenyl-13C6) Styrene-2,3,4,5,6-d5

Styrene-alpha,beta,beta-d3 Styrene-alpha,2,3,4,5,6-d6 Styrene-alpha-d1

Styrene-beta,beta-d2 Styrene-d8 Sulcotrione

Sulindac Sulindacsulfide Sulprostone

Sunitinibmalate Tamoxifen Tamoxifencitratesalt

Tebbereagentsolution Tebuconazole Tebuconazole-(tert-butyl-d9)

Tebuconazole-(trimethyl-13C3) Tellurium Temozolomide

Tenivastatinammoniumsalt Tepraloxydim Terbium(III)iodide

Terbutalinehemisulfatesalt tert-Butyldiazoacetate tert-Butylhydroperoxidesolution

Testosterone Testosterone17beta-cypionate Testosteroneacetate

Testosteroneenanthate Testosteronepropionate Testosteroneβ-D-glucuronide

Tetraethyllead Tetraisobutyldialuminoxanesolution Tetrakis[tris(dimethylamino)phosph

oranylidenamino]

ThiazolylBlueTetrazoliumBromide Thiocolchicine Thiophanate-methyl

Thiourea Thiourea-13C,15N2 Thiourea-15N2

Thiourea-d4 ThromboxaneB2 Thulium(III)iodide

Tigecycline Tigecyclinehydrate Timololmaleatesalt

Tin(II)2-ethylhexanoate Tin(II)chloride Tin(II)chloridedihydrate

Tin(II)iodide Tin(II)sulfate Tinidazole

TolterodineL-tartrate Tolterodinetartrate Toluene

Toluene-(phenyl-13C6) Toluene-13C7 Toluene-4-13C

Toluene-alpha,alpha,alpha-d3 Toluene-d8 Topotecanhydrochloridehydrate

Topramezone Trenbolone Trenboloneacetate

Triamcinoloneacetonide Tributylmethylphosphoniummethyl

sulfate

Trichloroethylene

Trichloroethylene-13C2 Trichloroethylene-d Tridemorph

Triethyleneglycoldimethylether Trifluoroiodomethane Trilostane

Trimethylphosphate TRIMETHYL-(5-METHYL-FURAN-2- Trimethylgermaniumiodide

MutagensandReproductiveToxinsChemicalClassStandardOperatingProcedure

Rev.Date:2017-03-28

23

YLMETHYL)-AMMONIUM,IO

Trimethylphenylphosphoniumiodide Trimipraminemaleatesalt Trioctylaluminumsolution

Triphenylphosphinediiodide Triphenyltinhydroxide TRIPROPYLPLUMBYLACETATE

Tris(2,3-epoxypropyl)isocyanurate Tris(2-chloroethyl)phosphate Tris(2-chloroethyl)phosphite

Tris(2-methoxyethoxy)(vinyl)silane Tris(nonylphenyl)phosphite Tris(triphenylsilyloxy)molybdenum

nitridepyridine

Tritolylphosphate Trovafloxacinmesylate TTNPB

Ulipristalacetate Vanadium(V)oxide Veratridine

Vinclozolin Vincristinesulfate Vindoline

Vinyl2-ethylhexanoate Voriconazole WarfarinSodium

Warfarin(TM) Woodsmetal Yttrium(III)acetylacetonatehydrate

Yttrium(III)butoxidesolution Zearalenone Ziprasidonesolution

Z-Leu-OH Zopiclone α-Chaconine

α-Ergocryptine

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