neuroinflamação e neurodegeneração€¦ · contributions of the d-serine pathway to...

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Neuroinflamação e neurodegeneração

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Altern Med Rev 1998;3(6):432-447

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Vascular risk factor detection and control may prevent Alzheimer’s disease

Ageing Research Reviews 9 (2010) 218–225

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Glycine and N-Methyl-D-Aspartate Receptors: Physiological Significance and Possible TherapeuticApplications

PHARMACOLOGICAL REVIEWS Vol. 50, No. 4

NMDA receptors

Neurology 76 May 17, 2011

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Hipótese glutamatérgica da esquizofrenia

Rev Bras Psiquiatr 2003;25(3):177-83

Contributions of the D-serine pathway to schizophrenia

Neuropharmacology 62 (2012) 1484e1503

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Glycine and its synaptic interactions

Neurology 77 August 16, 2011

Glutamate signaling in the pathophysiology and therapy of schizophrenia

Pharmacology, Biochemistry and Behavior 100 (2012) 665–677

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Adenosine, energy metabolism and sleep homeostasis

Sleep Medicine Reviews 15 (2011) 123e135

Overview of glutamatergic neurotransmission in the nervous system

Pharmacology, Biochemistry and Behavior 100 (2012) 656–664

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Glutamate abnormalities in obsessive compulsive disorder: Neurobiology,pathophysiology, and treatment

Pharmacology & Therapeutics 132 (2011) 314–332

Glutamate abnormalities in obsessive compulsive disorder: Neurobiology,pathophysiology, and treatment

Pharmacology & Therapeutics 132 (2011) 314–332

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From pancreatic islets to central nervous system, the importance of glutamatedehydrogenase for the control of energy homeostasis

Neurochemistry International 59 (2011) 510–517

Trycats

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Inflammatory Biomarkers and Depression

Neurotox Res

The new ‘5-HT’ hypothesis of depression: Cell-mediated immune activation inducesindoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased

synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression

Progress in Neuro-Psychopharmacology & Biological Psychiatry 35 (2011) 702–721

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A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness

Progress in Neuro-Psychopharmacology & Biological Psychiatry 35 (2011) 676–692

Schizophrenia is primed for an increased expression of depression through activation of immuno-inflammatory, oxidative and nitrosative stress, and tryptophan catabolite pathways

Progress in Neuro-Psychopharmacology & Biological Psychiatry 42 (2013) 101–114

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Schizophrenia is primed for an increased expression of depression through activation of immuno-inflammatory, oxidative and nitrosative stress, and tryptophan catabolite pathways

Progress in Neuro-Psychopharmacology & Biological Psychiatry 42 (2013) 101–114

Excitotoxicidade

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The role of glutamate in neuronal ischemic injury: the role of spark in fire

Neurol Sci

Anedonia

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The possible role of the kynurenine pathway in anhedonia in adolescents

J Neural Transm

Stress

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Metabotropic and ionotropic glutamate receptors as neurobiological targets inanxiety and stress-related disorders: Focus on pharmacology and preclinical

translational models

Pharmacology, Biochemistry and Behavior 100 (2012) 775–800

Parkinson

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Novel anti-inflammatory therapy for Parkinson’s disease

TRENDS in Pharmacological Sciences Vol.24 No.8 August 2003

Pathogenesis of Parkinson’s Disease

Movement Disorders, Vol. 28, No. 1, 2013

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Does cellular iron dysregulation play a causative role in Parkinson’s disease?

Ageing Research Reviews 3 (2004) 327–343

Alzheimer

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Mechanisms Underlying Inflammation in Neurodegeneration

Cell 140, 918–934, March 19, 2010

New therapeutic targets in Alzheimer’s disease: brain deregulation of calcium and zinc

Cell Death and Disease (2011) 2, e176;

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Neuroprotective Effect of Natural Products Against Alzheimer’s Disease

Neurochem Res

Molecular mechanisms for Alzheimer’s disease: implications for neuroimaging and therapeutics

Journal of Neurochemistry, 2006, 97, 1700–1725

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Antioxidant properties of natural polyphenols and their therapeutic potentials for Alzheimer’s disease

Brain Research Bulletin 87 (2012) 144– 153

The failure of mitochondria leads to neurodegeneration: Do mitochondria need ajump start?

Advanced Drug Delivery Reviews 61 (2009) 1316–1323

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Glutamate-Based Antidepressants: Preclinical Psychopharmacology

BIOL PSYCHIATRY 2013;]:]]]–]]]

Modulando glutamato

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The promise of N-acetylcysteine in neuropsychiatry

Trends in Pharmacological Sciences xx (2013) 1–11

The promise of N-acetylcysteine in neuropsychiatry

Trends in Pharmacological Sciences xx (2013) 1–11

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N-Acetyl Cysteine for Depressive Symptoms in Bipolar Disorder—A Double-Blind RandomizedPlacebo-Controlled Trial

BIOL PSYCHIATRY 2008;64:468–475 1g

N-Acetyl Cysteine as a Glutathione Precursor for Schizophrenia—A Double-Blind, Randomized,Placebo-Controlled Trial

BIOL PSYCHIATRY 2008;64:361–368 1g

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N-Acetylcysteine, a Glutamate Modulator, in the Treatment of Trichotillomania

Arch Gen Psychiatry. 2009;66(7):756-763

Chronic N-Acetylcysteine during Abstinence or Extinction after Cocaine Self-Administration Produces Enduring Reductions in Drug Seeking

THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS vol. 337, no. 2

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N-acetyl cysteine add-on treatment for bipolar II disorder: a subgroupanalysis of a randomized placebo-controlled trial

Journal of Affective Disorders 129 (2011) 317–320

Hipótese glutamatérgica da esquizofrenia

Rev Bras Psiquiatr 2003;25(3):177-83

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Depressão

Depression and treatment response: dynamic interplay of signaling pathways and altered neural processes

Cell. Mol. Life Sci. (2013) 70:39–53

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An intriguing and hitherto unexplained co-occurrence: Depression and chronic fatigue syndrome are manifestations of shared inflammatory, oxidative and nitrosative (IO&NS) pathways

Progress in Neuro-Psychopharmacology & Biological Psychiatry 35 (2011) 784–794

Oxidative/nitrosative stress and antidepressants: Targets for novel antidepressants

Progress in Neuro-Psychopharmacology & Biological Psychiatry xxx (2012) xxx–xxx

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Nitric oxide and major depression

Nitric Oxide 24 (2011) 125–131

Signaling pathways underlying the rapid antidepressant actions of ketamine

Neuropharmacology 62 (2012) 35e41

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Safety and Efficacy of Repeated-Dose Intravenous Ketamine for Treatment-Resistant Depression

BIOL PSYCHIATRY 2010;67:139–145

Safety and Efficacy of Repeated-Dose Intravenous Ketamine for Treatment-Resistant Depression

BIOL PSYCHIATRY 2010;67:139–145

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Ketamine for Depression: Where Do We Go from Here?

BIOL PSYCHIATRY 2012;72:537–547

Novel therapeutic targets in depression: Minocycline as a candidate treatment

Behavioural Brain Research 235 (2012) 302– 317

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Minocycline as adjunctive therapy for patients with unipolar psychotic depression: An open-label study

Progress in Neuro-Psychopharmacology & Biological Psychiatry 37 (2012) 222–226

Minocycline as adjunctive therapy for patients with unipolar psychotic depression: An open-label study

Progress in Neuro-Psychopharmacology & Biological Psychiatry 37 (2012) 222–226

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Multiple antidepressant potential modes of action of curcumin: a review of its anti-inflammatory, monoaminergic, antioxidant, immune-modulating and neuroprotective effects

Journal of Psychopharmacology 26(12) 1512–1524

Multiple antidepressant potential modes of action of curcumin: a review of its anti-inflammatory, monoaminergic, antioxidant, immune-modulating and neuroprotective effects

Journal of Psychopharmacology 26(12) 1512–1524

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The role of zinc in neurodegenerative inflammatory pathways in depression

Progress in Neuro-Psychopharmacology & Biological Psychiatry 35 (2011) 693–701

The role of zinc in neurodegenerative inflammatory pathways in depression

Progress in Neuro-Psychopharmacology & Biological Psychiatry 35 (2011) 693–701

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Plasma magnesium levels and treatment outcome in depressed patients

Nutritional Neuroscience 2012 VOL. 15 NO. 2

Serum zinc level in depressed patients during zinc supplementation of imipraminetreatment

Journal of Affective Disorders 126 (2010) 447–452

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Serum zinc level in depressed patients during zinc supplementation of imipraminetreatment

Journal of Affective Disorders 126 (2010) 447–452

Eicosapentaenoic acid versus docosahexaenoic acid in mild-to-moderate depression:A randomized, double-blind, placebo-controlled trial (1g_

European Neuropsychopharmacology(]]]]) ], ]]]–]]]

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Neuroinflamação

• Omega-3 e GLA.

• Polifenóis ou antiinflamatórios.

• Magnésio.

• Antioxidantes.

• Sinergia.

• Drogas