nucleotide metabolism. nucleotide nucleoside
Post on 15-Jan-2016
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Nucleotide Metabolism
nucleotide
nucleoside
a key molecule in purine and pyrimidine biosynthesis
fig 22-32
purines: where does all them darn atoms come from??
fig 22-33
fig 22-33
ETC.
fig 22-33, sorta
fig 22-33, still
inosine, built“on the ribose”to make IMP
fig 22-34
and inosinate begat adenylate and xanthylate, and xanthylatebegat guanylate…
fig 22-35
regulationof the early stepsof purinesynthesis
pyrimidinebiosynthesis
orotate, built“off the ribose”
fig 22-36
fig 22-36
pyrimidinebiosynthesis
OTP thenmodified toCTP, etc
fig 22-38
Two ways for mammals to make and/or use purines and pyrimidines
1) de novo synthesis (see above)
2) salvage pathways
Ad + PRPP AMP + PP
Two ways for mammals to make and/or use purines and pyrimidines
1) de novo synthesis (see above)
2) salvage pathways
hypoxanthine + PRPP IMP + PP
Lesch-Nyhan disease
Two ways for mammals to make and/or use purines and pyrimidines
1) de novo synthesis (see above)
2) salvage pathways
pyrimidine salvage is similar but not wellunderstood in mammals…
fig 22-48
inhibitors of glutamineamindo-transferases
chemo-therapeutics
fig 22-39
rememberthe “D” inDNA???
either or
what’s thedifference between T and U??
fig 22-44
where theTHF getsits methy...
fig 22-44
more chemotherapeutics
fig 22-49
inhibitors of dihydrofolate reductase cycle
catabolism ofpurines…
fig 22-45
xanthineoxidase
fig 22-45
out with gout!!!
1735
fig 22-47
out with gout!!!
xanthine oxidase too active
fig 22-47
out with gout!!!
xanthine oxidase inhibitor
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