nursing research seminar series using ctsa resources for big data research, scholarship, and...
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NURSING RESEARCH SEMINAR SERIES
Using CTSA Resources for Big Data Research, Scholarship, and Teaching
Presented byConnie White Delaney, PhD, RN, FAAN, FACMI
Bonnie L. Westra, PhD, RN, FAAN, FACMI
Monday, February 2, 2015Noon to 1:00 pm ♦ 4-130 WDH (Benson Center)
Objectives•Connect Clinical and Translational Science Award (CTSA) resources to facilitate your teaching and scholarship
•Explore a powerful emerging nursing and other health data set for research and teaching
Clinical and Translational Science Institutehttp://www.ctsi.umn.edu/
Rank order the top 3 wordsEstimate how many times were words repeated in
the CTSA RFA?• Stakeholder• Innovation• Collaboration• Engage/Engagement• Enterprise• Integrate/Integration
… Answer …
• Stakeholder - 10• Innovation - 40• Collaboration - 14• Engage/Engagement - 43• Enterprise - 9• Integrate/Integration - 35
The CTSI Research Supported Pipeline
Intro/Exposureto Research
Foundational Training
in Research
Training AwardPreparedness
Career Development in Research
Pathways to Independence
SUC
CES
S
Career Establishment
URPARP
ARPTRDP
K to R01Pre-KKL2TL1
Researchers & Users
Data Education
ServicesTools Community
• AHC IE Clinical Data Repository• i2b2 cohort-discovery tool• MN Death IndexIn process:• Dental EHR• Imaging; Center for Magnetic
Resonance Research (CMRR); clinical images
• UMN Biospecimen Enterprise Storage initiative & data: Enterprise storage initiative, BioMedical Genomics Center
• Generalist • Specialist \Informaticians
• IHI – MHI, MS and PhD• SON – DNP-NI, PhD-NI• SPH – MPH-Informatics• UMII Biomedical Informatics
& Computational Biology Graduate degrees
Informatics meeting your needs for data, resources, and collaborators
• Informatics Consulting Service
• AHC IS• CTSI Portal• Front Door
• Greater Plains Collaborative (PCORI)
• Hennepin County Medical Center (NSF grant)
• CTSA Collaborations
• CTMS• Experts@Minnesota• ResearchMatch• Redcap• Analytical tools• Natural Language Processing
MN Supercomputer Institute (MSI) Tunnel
In process:• Genotype/phenotype mapping
Researchers & Users
Data Education
ServicesTools Community
• AHC IE Clinical Data Repository• i2b2 cohort-discovery tool• MN Death IndexIn process:• Dental EHR• Imaging; Center for Magnetic
Resonance Research (CMRR); clinical images
• UMN Biospecimen Enterprise Storage initiative & data: Enterprise storage initiative, BioMedical Genomics Center
• Generalist • Specialist \Informaticians
• IHI – MHI, MS and PhD• SON – DNP-NI, PhD-NI• SPH – MPH-Informatics• UMII Biomedical Informatics
& Computational Biology Graduate degrees
Informatics meeting your needs for data, resources, and collaborators
• Informatics Consulting Service
• AHC IS• CTSI Portal• Front Door
• Greater Plains Collaborative (PCORI)
• Hennepin County Medical Center (NSF grant)
• CTSA Collaborations
• CTMS• Experts@Minnesota• ResearchMatch• Redcap• Analytical tools• Natural Language Processing
MN Supercomputer Institute (MSI) Tunnel
In process:• Genotype/phenotype mapping
Our Infrastructure capacity for big data
• Minnesota Super Computer Institute (MSI)• Access to supercomputers that meet high-performance computing needs for
advanced computation and scientific visualization
• Minnesota Population Center• Access to U.S. census data back to 1790 for the U.S., as well as data from 75
other countries• Technical expertise to support strong empirical orientation for large-scale data
analysis, geospatial analysis, and policy-relevant research
• Optum Labs partnership
Inter-CTSA collaborations
• Greater Plains Collaborative (10 sites) for the Patient-Centered Outcomes Research Institute (PCORI) award
– Leader in applying and sharing LOINC mappings for Labs
– Developed a common data model for demographic data
– First site to get PopMedNet client installed and functioning; the tool allows multiple sites to submit and receive queries
• NCATS Accrual to Clinical Trials – NCATS ACT leverages i2b2 across 13 CTSA sites– Our governance model is driving the ACT model
Inter-CTSA collaborations
• Midwest Area Research Consortium for Health (MARCH)
– Established multi-site IRB agreement– MARCH leverages i2b2
• UMN/Mayo CTSA– UMN is a national leader on extended clinical data
space– Sharing experience and expertise in SHRINE and i2b2
with Mayo
Our partnerships
• Minnesota Department of Health• E-Health: Public-private collaborative that aims to accelerate the adoption and
use of health information technology• Death Index: Key researcher resource that offers improved data quality, and is
updated weekly
• National Center for Interprofessional Practice and Education• Data from the nation’s only coordinating center is part of the Academic Health
Center Information Exchange
Providing support throughout the research tools & process
Define question
Participants & logistics Collect data Findings Share and
output Translate
Front Door
Experts@ Minnesota
i2b2 cohort-discovery tool
Research-Match
REDcap
Clinical Data Repository
Biospecimen repository
OnCore Clinical Trials Management System
Informatics Consulting Service
Analytical Tools (JMP, R, SAS, SPSS)
NLP
Standards Knowledge
representationData cleaning
Researchers & Users
Data Education
ServicesTools Community
• AHC IE Clinical Data Repository• i2b2 cohort-discovery tool• MN Death IndexIn process:• Dental EHR• Imaging; Center for Magnetic
Resonance Research (CMRR); clinical images
• UMN Biospecimen Enterprise Storage initiative & data: Enterprise storage initiative, BioMedical Genomics Center
• Generalist • Specialist \Informaticians
• IHI – MHI, MS and PhD• SON – DNP-NI, PhD-NI• SPH – MPH-Informatics• UMII Biomedical Informatics
& Computational Biology Graduate degrees
How BMI adds value and meets researchers needs for data, resources, and collaborators
• Informatics Consulting Service
• AHC IS• CTSI Portal• Front Door
• Greater Plains Collaborative (PCORI)
• Hennepin County Medical Center (NSF grant)
• CTSA Collaborations
• CTMS• Experts@Minnesota• ResearchMatch• Redcap• Analytical tools• Natural Language Processing
MN Supercomputer Institute (MSI) Tunnel
In process:• Genotype/phenotype mapping
IMPORTANCE AND AVAILABILITY OF DATA FOR RESEARCH AND TEACHING
Bonnie L. Westra, PhD, RN, FAAN, FACMI
Use of Clinical Data Sets
• Facilitate cross-study comparison of results• Enable aggregation of data from multiple
studies / sources – greater statistical power, detect weaker signals
• Speed study start up by selecting from existing data
• Improve replication and reproducibility• Find patients for recruitment into studies
cwd 2012
U of Minnesota AHC Information Exchange (AHC IE)
University of Minnesota AHC IE Platform2.3 M Patients5.6 Billion lines of data8 hospitals and 40+ clinical settings
65,597,327 18,478,842
785,879,618
1,939,232,775
59,924,418
1,402,423,830
88,364,370
397,546,666
368,473,93
4
46,367,516
439,081,234
2,263,847 26,068,675
UMN CDR - Rows of data
Reference
Accounts / Coverage
Medications
Procedures and Labs
Diagnosis
Flowsheets
Encounter
Encounter Chart
Patient Chart
Episodes
Notes
Patient
Interventions
Flowsheets
Flowsheet Example - Falls
Flowsheet Data
• Nursing and interprofessional– OT, PT, ST, Nutrition, SW
• Collected across settings – varies in use– ED, Clinic, Hospital, Rehab– Hospital – ICU, Peds, NICU, OB, Adult (generic)
Initial Framework Flowsheet Data
Example Respiratory Data
Example Skin/ Pressure Ulcers
EXAMPLES RESEARCH QUESTIONSTEACHING STRATEGIES
AHC-IE Services/ Resources
• Access to data – identified/ deidentified• Linking AHC-IE data to other data sets• De-identification of data• Data storage• Access to data analytic tools
• SAS, SPSS, Stata, R and Rstudio, MatLab, Microsoft Office, JMP Pro, EpiInfo
Sepsis & Diabetes• Evaluate whether use of EBP guidelines make a difference in
development of complications• Discover new interventions which lead to improvement in outcomes
and add to EBP guidelines• Determine if there are differences in use of EBP guidelines and
outcomes for health disparities• HCMC Epic data – mapping data based on FHS data in AHC-IE• Data storage/ analytic tools• Interprofessional team – Faculty & Students
• Computer Science - Michael Steinbach, Vipin Kumar, Pranjul Yadav, Andrew Hangsleben, Sanjoy Dey, Katherine Hauwiller, Kevin Schiroo
– School of Nursing - Bonnie L. Westra, Connie W. Delaney, Lisiane Pruinelli– Institute for Health Informatics - György J. Simon
Predictive Models for CAUTI
• Jung In Park, PhD-C• Requesting AHC-IE services
– EHR data from the UMN-TIDE and add in UMMC’s NDNQI Data
– De-identify MRN after matching CAUTI to hospitalizations
– Link unit level nurse staff characteristics to patients with CAUTI i.e. education, experience
– Data storage and use analytic tools
Predictors Liver Transplant Survival
• Lisiane Pruinelli, PhD Student• Transplant Information System• Requesting AHC-IE services
– Use of secure workbench - assures data remain secure
– Potentially de-identify dates (date shifting)– Access to analytic tools
Unanticipated ICU Admissions After Surgery
• Jessica Peterson, PhD Student• Examine anesthesia variables and patient
characteristics that predict unanticipated admission to ICUs
• AHC-IE Services– Exploring availability of data from UMN TIDE– Data storage– Use of analytic tools in secure workbench
Teaching Preparation of EHR Data for Research
• Participating in a CTSA pilot project (Lisa Pulkrabek, DNP Student)
• Assisting with mapping flowsheets to concepts in a clinical data model
• Learning how to apply national data standards for comparing data across CTSA sites
Discussion – Your Use of CTSI Resources
• Potential courses– Evidence-based practice– Quality improvement– Research– Specialty courses – data projects i.e. gero, psych, etc.
• Your research topic and potential use of data and other CTSI resources
Find Information on Data Access
z.umn.edu/clinicaldata
Data Set Access
NURSING RESEARCH SEMINAR SERIES
Using CTSA Resources for Big Data Research, Scholarship, and Teaching
Presented byConnie White Delaney, PhD, RN, FAAN, FACMI
Bonnie L. Westra, PhD, RN, FAAN, FACMI
Thank you
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