organic converstions: an aid in perspective

Lewis Whitehead

Senior Investigator & Computational Medicinal Chemist

Global Discovery Chemistry Novartis Institutes for Biomedical Research

Cambridge, Massachusetts

I knew Rae Lawrence & David Bardsley were listening, but I didn’t expect there to be ANY constructive follow up. I was wrong....

Organic Conversions: An Aid in Perspective

The importance & value of common sense reagent selection & procurement protocols, to me.

2 of 9

PI 3-kinase, Novartis Horsham Research Centre, 2001.

NH

ON

HH

$111.36/g from Aldrich

Moiety contained or referenced in 45 patents (2004-2014)

The importance & value of common sense reagent selection & procurement protocols, to me.

3 of 9

Elongation Factor Tu, NIBR Cambridge, 2006.

OO

OH

H$0/g from NIBR-Basel

A Common FieldStere / Spark experience

4

I perform the detective work of where an EXCITING fragment came from.....

....only to discover that the disconnection isn’t the same... ...or the reagent my team needs is P.O.A...

Organic Conversions: An Aid in Perspective

5

Fond memories of ‘learn-by-rote’ undergraduate & A-level chemistry

Organic Conversions: An Aid in Perspective

6 of 9

Rae, David & I had an hour in my office to talk about Cresset

7 Tiers of selection in my own protocol - Laboratory bench storage - Local Stockrooms - Compound Handling Centre - Intermediates Archive - Global Stockrooms (USEM, GBHO, CHBS, CNIBR, NITD) - Preferred vendors - Everything

Reduces wait time & increases feedback

Sometimes 2-4 weeks is too long...

Organic Conversions: An Aid in Perspective

7 of 9. Is he finishing soon?

12 months later I learn that a new module had been developed!!

I knew Rae Lawrence & David Bardsley were listening, but I didn’t expect there to be ANY constructive follow up. I was wrong....

Thank you.

Organic Conversions: An Aid in Perspective

8 of 9, yes, I’m nearly finished.

Where do I see this going?

What I would like to see..... - Sigma-Aldrich, Thermo-Fisher, Acros, Nagase.... - Reactions?

What I intend to do.... - Accessible to my colleagues

in medicinal chemistry - Avoiding me,

for simplistic tasks....

What would you like to see.....?

Lewis Whitehead

Computational Medicinal Chemist Global Discovery Chemistry

Novartis Institutes for Biomedical Research Cambridge, Massachusetts

Rae Lawrence David Bardsley Tim Cheeseright Sue Peffer

Organic Conversions: An Aid in Perspective

Ololomutiek, Maasai-Mara, Kenya.