palladium-catalyzed alkylation of aryl c—h bonds with sp3 organotin reagents using benzoquinone as...
Post on 06-Jun-2016
214 Views
Preview:
TRANSCRIPT
2006
Oxazole derivativesR 0220 Palladium-Catalyzed Alkylation of Aryl C—H Bonds with sp3 Organotin Re-
agents Using Benzoquinone as a Crucial Promoter. — By the combination of direct C—H activation, batch-wise addition of tetraalkyltin reagents (20 batches every 3h), and rate enhancement by benzoquinone, the alkylated products are obtained in good yields. Microwave irradiation reduces the overall reaction time to 10h and the reaction can be carried out by adding the organotin every 0.5h. — (CHEN, X.; LI, J.-J.; HAO, X.-S.; GOODHUE, C. E.; YU*, J.-Q.; J. Am. Chem. Soc. 128 (2006) 1, 78-79; Dep. Chem., Brandeis Univ., Waltham, MA 02454, USA; Eng.) — Bartels
19- 109
top related