per2
Post on 03-Jan-2016
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Supplemental Figure 3. Cross-correlation analyses of clock gene expression in human peripheral blood leukocytes challenged with endotoxin or saline at 09:00 h or 21:00 h. The gene expression data for each subject was cross-correlated across all studied genes within a subject. The cross-correlation data were normalized to one, where one represents a perfect correlation between gene responses. The correlation matrices for (A) placebo day and night subjects (09:00 h plus 21:00 h saline infusion time; n=3), (B) endotoxin day subjects (09:00 h infusion; n=4), (C) endotoxin night subjects (21:00 h infusion; n=3), (D) endotoxin day and night subjects (09:00 h plus 21:00 h endotoxin infusion time; n=7), were clustered into a tree form.
Per2
Bmal1
Per3
Cry2
Cry1
Clock
Ror
CSNK1
Per1
Rev-erb
0
0.05 0.
1
0.15 0.
2
0.25 0.
3
0.350
0.05 0.
1
0.15 0.
2
0.25 0.
3
0.35
Per2
Bmal1
Per3
Cry2
Cry1
Clock
Ror
CSNK1
Per1
Rev-erb
Per2
Bmal1
Per3
Cry2
Cry1
Clock
Ror
CSNK1
Per1
Rev-erb
A B
D
Per2
Bmal1
Per3
Cry2
Cry1
Clock
Ror
CSNK1
Per1
Rev-erb
0
0.05 0.
1
0.15 0.
2
0.25 0.
3
0.35
C
0
0.05 0.
1
0.15 0.
2
0.25 0.
3
0.35
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