perception of a sensory experience can change even though the input remains the same

Perception of a sensory experience can change even though the input remains the same.

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Agnosia - failure of perception

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W. W. Norton

Pohl, W., Dissociation of spatial discrimination deficits following frontal and parietal lesions in monkeys, Journal of Comparative and

Physiological Psychology 82 (1973): 227–239. Copyright © 1973 by the American Psychological Association. Adapted with permission.

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W. W. NortonSingle neuron inferior temporal cortex

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Mapping the Auditory System in Rhesus

Monkeys

NIMH, July 2002

University of Iowa

NeuroscienceProgram

The University of IowaDepartment of Psychology

Behavioral and Cognitive Neuroscience

Auditory cortexUnfolded view of

supratemporal plane and adjoining STG.

BeltParabelt

Core

Kaas and Hackett, PNAS 2000

Auditory Projection System

Lower Brainstem

Lower Brainstem

IC

MGB

IC

Early Auditory

Areas

MGB

Early Auditory

Areas

Auditory Projection System

Lower Brainstem

Lower Brainstem

IC

MGB

IC

Early Auditory

Areas

MGB

Early Auditory

Areas

Corpus Callosum,Anterior & Posterior

Commissures

Tectal Commissures

Lower Brainstem

Lower Brainstem

MGB

Early Auditory

Areas

MGB

Early Auditory

AreasForebrain Comm.

Tectal Comm. ICIC

Intact side 'Deaf' side

Methods

Speakers 2-DG injected intravenously

Monkey listens passively for 45 min

Wide variety of acoustic stimuli

Brain prepared for autoradiography

LCGU measured in ROIs throughout brain

ROIs compared for hemispheric asymmetries

Three surgically prepared monkeys

2 DG in Intact (left) and Deafferented (right) Hemisphere

Early auditory areas

MGB

IC

Columns of 2-DG activation in rSTG

Metabolic Mapping of Visual Cortex

Metabolic Mapping of Auditory Cortex

Overlap of Auditory and Visual Maps

Auditory and Visual Processing Streams

Parabelt projections to prefrontal cortex

Romanski et al., Nature Neuroscience, 1999

Left Hemisphere Right Hemisphere

Superior Temporal Gyrus (STG)(n=7 monkeys)

12

34 5

% o

f Who

le B

rain

Act

ivity

Monkey Vocalizations

Complex Sounds and Vocalizations

Complex Sounds No Vocalizations

Ambient Background Sound

70

80

90

100

110

120

130

Human Vocalizations

High

Low

High

Low

Monkey Vocalizations

p<0.001

*

Complex Sounds and

Vocalizations

p<0.01

*

FDG Activity in the Dorsal Temporal Pole

70

80

90

100

Ambient Background

Noise

% o

f Who

le B

rain

Act

ivity

Left Hemisphere Right Hemisphere

Monkey Vocalizations

p<0.001

*

Complex Sounds and

Vocalizations

p<0.01

*

FDG Activity in the Dorsal Temporal Pole

70

80

90

100

Ambient Background

Noise

Left Hemisphere Right Hemisphere

Complex Sounds No Vocalizations

% o

f Who

le B

rain

Act

ivity