perennial success with vivo: sustained engagement with stakeholders and the community

Perennial Success with VIVOSustained engagement with stakeholders and the community

Paul Albertpaa2013@med.cornell.eduWeill Cornell Medical College

Annual or Perennial?

AnnualsEasy to grow, but their lifecycle is just

one growing season.

Perennials

Take longer to fruit andharder to grow...

...but have longer roots and live longer

Perennial success with VIVO

1. Aggressively pursue the most important data.

2. Strive for automated ingest.3. Focus on ingesting from sources maintained by third parties.4. If you really must manually enter data...

5. Use VIVO data to create something useful.6. Cultivate champions.

Perennial success with VIVO

1. Aggressively pursue the most important data. 2. Strive for automated ingest.3. Focus on ingesting from sources maintained by third parties.4. If you really must manually enter data...

5. Use VIVO data to create something useful.6. Cultivate champions.

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BIOGRAPHICAL SKETCH

NAME Jian Zhong

POSITION TITLE Assistant Professor of Neuroscience

BIRTHDATE (Mo., Day, Yr.) 03/07/1964

EDUCATION (Begin with baccalaureate or other initial education and include postdoctoral training.)

INSTITUTION AND LOCATION DEGREE YEAR CONFERRED FIELD OF STUDY

Ruhr University Bochum, Germany Ruhr University Bochum, Germany California Institute of Technology, Pasadena UNC Neuroscience Center, School of Medicine, University of North Carolina at Chapel Hill

Dipl.-Chem. Ph.D. Postdoc postdoc

1992 1997 1998-2001 2001-2008

Neurochemistry Neurochemistry Biology Neuroscience

RESEARCH AND PROFESSIONAL EXPERIENCE: Concluding with current position, list, in chronological order, previous employment, experience, and honors. List, in chronological order, the titles and COMPLETE references to all publications during the past five years and to representative earlier publications pertinent to this application. DO NOT EXCEED TWO PAGES. Positions and Employment 1993-1997 Research Assistant, Department of Molecular Neurobiochemistry, Ruhr University Bochum,

Germany. 1997-1998 Research Associate, Department of Molecular Neurobiochemistry, Ruhr University Bochum,

Germany. 1998-2001 Postdoctoral fellow, Division of Biology, California Institute of Technology, Pasadena, CA. 2001-2008 Research Scientist, Neuroscience Center, School of Medicine, University of North Carolina,

Chapel Hill, NC. Present Assistant Professor (tenure track), Department of Neurology and Neuroscience, Weill

Medical College of Cornell University, New York, NY, and Director of Molecular Regeneration and Neuroimaging Laboratory, Burke Medical Research Institute, White Plains, NY.

Ad hoc Reviewer Nature Neuroscience Neuron Journal of Neuroscience European Journal of Neuroscience

Honors 1987-1994 Max-Buchner Scholarship, Germany. 2003 Abcam travel award. 2007 Prize for the best “Short Talk”, Neurotrophic Factors, Gordon Research Conference. RI

Selected Peer-reviewed Publications

1. O’Donovan K, Ma K, Guo H, Sun F, Pritchard CA, Marais R, Charron J, He Z, Zhong�J. B-RAF kinase signaling drives axon growth of both embryonic and adult neurons in the PNS and CNS (under revision)

2. Newbern JM, Li X, Shoemaker SE, Zhou J, Zhong J, Wu Y, Bonder D, Hollenback S, Coppola G, Geschwind DH, Landreth GE, Snider WD (2011) Specific functions for ERK/MAPK signaling during PNS development. Neuron 69:91-105.

3. Newbern J, Zhong J, Wickramasinghe S, Li X, Wu Y, Samuels I, Cherosky N, Karlo J, O'Loughlin B, Wikenheiser J, Gargesha M, Doughman Y, Charron J, Ginty DD, Watanabe M, Saitta S, Snider WD, Landreth G (2008) Mouse and human phenotypes indicate a critical conserved role for the ERK2 signaling pathway in neural crest development. Proc Natl Acad Sci USA 105:17115-20.

4. Zhong J, Li X, McNamee C, Chen A, Baccarini M, Snider WD (2007) Raf kinase signaling functions in sensory neuron differentiation and axon growth in vivo. Nat Neurosci 10:598-607.

(Selected as a Featured Article by “Signaling Gateway” http://www.signaling-gateway.org/update/updates/-200704/su-0704-2.html)

5. Zhong J, Pevny L, Snider WD (2006) "Runx"ing towards sensory differentiation. Neuron 49(3), 325-7.

6. Markus A, Zhong J, Snider WD (2002) Raf and Akt mediate distinct aspects of sensory axon growth. Neuron 35:65-76.

Research Support 2008- Institutional startup funds (Role: PI) Burke-Cornell Medical Research Institute

2010-2013 Three year research grant 2010-08-61 (Role: PI) Whitehall Foundation RAF signaling in sensory-motor circuit formation

2011-2013 Two years scholarship for Dr. Kevin O’Donovan (Role: Mentor) Goldsmith Foundation

2012-2017 R01EY022409 (Role: PI) NIH B-RAF dives regenerative axon growth in the optic nerve in vivo

What is important?

ņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņņ

BIOGRAPHICAL SKETCH

NAME Jian Zhong

POSITION TITLE Assistant Professor of Neuroscience

BIRTHDATE (Mo., Day, Yr.) 03/07/1964

EDUCATION (Begin with baccalaureate or other initial education and include postdoctoral training.)

INSTITUTION AND LOCATION DEGREE YEAR CONFERRED FIELD OF STUDY

Ruhr University Bochum, Germany Ruhr University Bochum, Germany California Institute of Technology, Pasadena UNC Neuroscience Center, School of Medicine, University of North Carolina at Chapel Hill

Dipl.-Chem. Ph.D. Postdoc postdoc

1992 1997 1998-2001 2001-2008

Neurochemistry Neurochemistry Biology Neuroscience

RESEARCH AND PROFESSIONAL EXPERIENCE: Concluding with current position, list, in chronological order, previous employment, experience, and honors. List, in chronological order, the titles and COMPLETE references to all publications during the past five years and to representative earlier publications pertinent to this application. DO NOT EXCEED TWO PAGES. Positions and Employment 1993-1997 Research Assistant, Department of Molecular Neurobiochemistry, Ruhr University Bochum,

Germany. 1997-1998 Research Associate, Department of Molecular Neurobiochemistry, Ruhr University Bochum,

Germany. 1998-2001 Postdoctoral fellow, Division of Biology, California Institute of Technology, Pasadena, CA. 2001-2008 Research Scientist, Neuroscience Center, School of Medicine, University of North Carolina,

Chapel Hill, NC. Present Assistant Professor (tenure track), Department of Neurology and Neuroscience, Weill

Medical College of Cornell University, New York, NY, and Director of Molecular Regeneration and Neuroimaging Laboratory, Burke Medical Research Institute, White Plains, NY.

Ad hoc Reviewer Nature Neuroscience Neuron Journal of Neuroscience European Journal of Neuroscience

Honors 1987-1994 Max-Buchner Scholarship, Germany. 2003 Abcam travel award. 2007 Prize for the best “Short Talk”, Neurotrophic Factors, Gordon Research Conference. RI

Selected Peer-reviewed Publications

1. O’Donovan K, Ma K, Guo H, Sun F, Pritchard CA, Marais R, Charron J, He Z, Zhong�J. B-RAF kinase signaling drives axon growth of both embryonic and adult neurons in the PNS and CNS (under revision)

2. Newbern JM, Li X, Shoemaker SE, Zhou J, Zhong J, Wu Y, Bonder D, Hollenback S, Coppola G, Geschwind DH, Landreth GE, Snider WD (2011) Specific functions for ERK/MAPK signaling during PNS development. Neuron 69:91-105.

3. Newbern J, Zhong J, Wickramasinghe S, Li X, Wu Y, Samuels I, Cherosky N, Karlo J, O'Loughlin B, Wikenheiser J, Gargesha M, Doughman Y, Charron J, Ginty DD, Watanabe M, Saitta S, Snider WD, Landreth G (2008) Mouse and human phenotypes indicate a critical conserved role for the ERK2 signaling pathway in neural crest development. Proc Natl Acad Sci USA 105:17115-20.

4. Zhong J, Li X, McNamee C, Chen A, Baccarini M, Snider WD (2007) Raf kinase signaling functions in sensory neuron differentiation and axon growth in vivo. Nat Neurosci 10:598-607.

(Selected as a Featured Article by “Signaling Gateway” http://www.signaling-gateway.org/update/updates/-200704/su-0704-2.html)

5. Zhong J, Pevny L, Snider WD (2006) "Runx"ing towards sensory differentiation. Neuron 49(3), 325-7.

6. Markus A, Zhong J, Snider WD (2002) Raf and Akt mediate distinct aspects of sensory axon growth. Neuron 35:65-76.

Research Support 2008- Institutional startup funds (Role: PI) Burke-Cornell Medical Research Institute

2010-2013 Three year research grant 2010-08-61 (Role: PI) Whitehall Foundation RAF signaling in sensory-motor circuit formation

2011-2013 Two years scholarship for Dr. Kevin O’Donovan (Role: Mentor) Goldsmith Foundation

2012-2017 R01EY022409 (Role: PI) NIH B-RAF dives regenerative axon growth in the optic nerve in vivo

Publications

GrantsAppointments/positions

Honors/awards

Service/committees

Education

What is important?

Completely objective list of most important data sources

1. Appointments and positions

2. Journal articles

3. Educational history

4. Headshot

5. Email

6. Courses

7. Grants and agreements

8. Honorable mention: professional service, honors and awards, postal address, geographic location, bio, events, patents, research expertise, board certifications, other publications

Sizing up a new data source

Direct ingest

CoursesGrantsFaculty A!airsHuman ResourcesPhysicians Profile

relevantauthoritative

well-structured

Yes

Yes

Yes

No

Partially

Perennial success with VIVO

1. Aggressively pursue the most important data.

2. Strive for automated ingest.3. Focus on ingesting from sources maintained by third parties.4. If you really must manually enter data...

5. Use VIVO data to create something useful.6. Cultivate champions.

Perennial success with VIVO

1. Aggressively pursue the most important data.

2. Strive for automated ingest.3. Focus on ingesting from sources maintained by third parties.4. If you really must manually enter data...

5. Use VIVO data to create something useful.6. Cultivate champions.Manual entry: Day #1

Manual entry: Day #500

Manual entry is not the answer

Reason #1. If you're lucky, researchers will enter their metadata... but often they will do so incorrectly.

Reason #2. Most researchers will not enter any data. At all.

Manual entry is not the answer

Most recent publication: 2006

Here is the latest: one month ago.

Reason #3. It costs money, year after year.

Manual entry is not the answer

This is not you.

Reason #4. No mechanism for removing expired content.

Manual entry is not the answer

All the extra work required to set up workflows for ingesting data from an authoritative source is definitely worth the trouble.

Automated ingested is way worth it

Never mind xkcd’s mockery.

You will save time in the long run.

Set it and forget it

VIVO

Perennial success with VIVO

1. Aggressively pursue the most important data.

2. Strive for automated ingest.3. Focus on ingesting from sources maintained by third parties.4. If you really must manually enter data...

5. Use VIVO data to create something useful.6. Cultivate champions.

Do we really need authoritative data, Sarge?

Missing title: Provost for Medical A!airs

Once you look for it, missing or incomplete data is everywhere.

Encourage others’ efforts to create authoritative systems.

Libraries have a key role, but I.T. needs to be a driving force.

Good Data Bad Data

Perennial success with VIVO

1. Aggressively pursue the most important data.

2. Strive for automated ingest.3. Focus on ingesting from sources maintained by third parties.4. If you really must manually enter data... 5. Use VIVO data to create something useful.6. Cultivate champions.

Strive to limit manually entered data to things that don't change.

Lock down the fields where you would not want end users to touch data.

Train administrative support.

• Department chief or other administrator mandates compliance

• Grants o"ce won't approve grant unless VIVO profile is up to date

• Others?

Incentive users to keep data current.

• Administration uses VIVO to measure (and reward) performance.

• Part of giving an institutional honor is representing it in the winner’s VIVO profile.

• VIVO is reused to create a biosketch, a CV in institutional formatting

• Others?

Incentive users to keep data current.

Perennial success with VIVO

1. Aggressively pursue the most important data.

2. Strive for automated ingest.3. Focus on ingesting from sources maintained by third parties.4. If you really must manually enter data...

5. Use VIVO data to create something useful.6. Cultivate champions.

Step #1Get good data.

Step #2Create something useful.

Step #1Get good data.

Step #2Create something useful.

exceptional

1. Automatic CV/biosketch generation 2. Grant opportunity recommendation

What meets a researcher’s definition of exceptional?

1. Ability to easily manipulate, visualize, and get alerts about institutional data.

What meets an administrators definition of exceptional?

WarningEsoteric metaphor ahead

Your boss’s bossYour boss’s boss’s boss

Administrators are avid consumers of data.

Data

Administrators want a more usable version of this

What about groups of researchers?

What is a research group?• Most granular and maybe the most important organizational unit of the research endeavor

• Often led by one (or sometimes two) senior faculty members.

• Contains a diverse group of people:

- principal investigator(s)

- postdoctoral fellows

- postdoctoral associates

- research fellows

-graduate students

Research groups have shared interests, requiring a polished

and current public face

• attract high quality talent

• showcase their lab's publications

• show o! images of their work (image galleries)

• keep track of and promoting journal club and speakers

• links to commonly used resources

Are researchers good

web designers?

Researchers’ web presence need not tittilate design snobs, but... they shouldn’t be an homage to MySpace either.

???

Tool for groups to easily maintain great web presences

Perennial success with VIVO

1. Aggressively pursue the most important data.

2. Strive for automated ingest.3. Focus on ingesting from sources maintained by third parties.4. If you really must manually enter data...

5. Use VIVO data to create something useful.6. Cultivate champions.

Champions...

• Allocate time and resources for your team, especially developers

• Endorse key choices• Appreciate and articulate the need for

analyses/tools using VIVO data which add value

Perennial success with VIVO

1. Aggressively pursue the most important data.

2. Strive for automated ingest.3. Focus on ingesting from sources maintained by third parties.4. If you really must manually enter data...

5. Use VIVO data to create something useful.6. Cultivate champions.

library.weill.cornell.edu

Is VIVO Facebook for Researchers?

• No Mendeley is… (Ha)

Questions?