personal system biology
Post on 05-Dec-2014
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Empowering data driven health.
Discovering & Optimizing Your Personal System Biology
E(exposures)N(nutrition)L(lifestyle)
RESPONSEM(metabolic response)
SYSTEMG(genetics)
fG(E,N,L)= M
INPUTS
21st Century = System Biology
Rectangularize Your Aging Curve
age
heal
th
0 60 120
Shifting LanesWhich lane are you in? The earlier you start, the more choice of lanes you have.Age and health are different measurements!
*CrossFit Training Guide, pg19
• Blood pressure• Body Fat• Bone Density• Triglycerides
“Fitness”
“Wellness”
“Sickness”
• Good & Bad Cholesterol• Flexibility• Muscle Mass• Etc.
Based on measurements of
Our assumption is that if everything we can measure about health will conform to this continuum then it seems that sickness, wellness, and fitness are different measurements of a single quality: health.
The Health Continuum*
As time goes by…The quantity of diagnostic data increases exponentially, while the cost to deliver diagnostics decreases
Cost of Diagnostic Testing
Volume of Inform
ation
The Golden Age of Measurement
1990 2000 2010
Total CholesterolA single number
HDL / LDLMeasurements of both good
and bad cholesterol levels
Advanced FractionsDetailed numbers on types of fat, proteins and forms
of cholesterol
of data needed for accurate diagnosis and health management is contained in blood chemistry 70%
Due to huge scientific advances in diagnostics over the past 25 years, we now have unprecedented abilities to predict and manage an individual’s risk of a wide range of lifestyle and other diseases
Deeply Predictive Diagnostics
Blood ChemistryIncredible Information, Currently Inaccessible
Blood chemistry data is extremely valuable for wellness and prevention, not just treating disease.
Over 75% of US adults have low levels of Vitamin D, associated with increased risk of cardiovascular disease, cancer and infectionArch Intern Med. 2009;169(6):626-632
50% of heart attack patients admitted to the hospital have normal HDL and LDL levelsAm Heart J. 2009 Jan;157(1):111-11
More than 1 in 10 Americans have undiagnosed thyroid disease, commonly causing fatigue and weight gainMurdoc Khaleghi, MD
30-45% of female endurance athletes are iron deficient, which can negatively affect performanceMed Sci Sports Exerc 1998, 20:116-121 and 1998, 30:S70
However, it is extremely difficult for consumers to access and act upon this valuable information
Dynamically Changing EnvironmentOver the next 24 months, 10’s of Millions people will participate in the
individual health services marketplace
Carriers must insure by law
and people must be insured
by law Prevention oriented services a key
component of ACA
Mandated federally or at state level
like in MA, depending on political
landscape
Organizations adapting the
way they provide health
services, defined
contributionsPrivate and Government sponsored
exchanges
More and more people
buying health services
directly
Affordable Care Act and Consumer Health Landscape
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