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PRE- READING COURSE MATERIAL
FOUNDATION BOTOX® AND DERMAL FILLERS
Module 2
2
Dear Acquisition Aesthetics delegate,
These pre-reading documents form the lectures you will attend on the day of training.
As a CPD certified course based on theoretical knowledge, we ask that you review all
the material prior to the course date.
Please feel free to print the pre-reading modules to annotate on the day.
You will be provided with an abbreviated practical guide for your review on the
training day.
We look forward to seeing you soon and happy reading!
Yours sincerely,
Acquisition Aesthetics
3
Botulinum Toxin
Treatment: Foundation Techniques
4
Overview
• Pharmacology
• Indications
• Foundation techniques
• Advanced techniques (introduction)
• Cautions and contra-indications
• Reconstitution
• The treatment process
• Technique
Treatment of the glabella
Treatment of the frontalis
Treatment of crows feet
• Aftercare instructions
• Adverse effects
• The market – key manufacturers and products
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Botulinum Toxin
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Botulinum Toxin
http://www.statista.com/statistics/307411/revenue-of-the-global-cosmetics-industry/
Botulinum Toxin is a neurotoxin
Produced by clostridium botulinum
Used to treat a wide variety of medical and surgical conditions
FDA approval granted in 2002
Over 11 million cosmetic clients treated since
The most popular non-invasive cosmetic procedure worldwide
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Botulinum Toxin - Core principles
http://www.allergan.com/assets/pdf/botox_cosmetic_pi.pdf
Botulinum
Toxin inhibits
cholinergic
transmission
Cleaves the SNAP-
25 protein (needed
for the exocytosis
of Acetylcholine)
The resulting effect
is a temporary
paralysis of the
target muscles
Cholinergic
reinnervation at
the NMJ takes 3-4
months to occur
The pharmacology of botulinum Toxin
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Botulinum Toxin - Core principles
Indications for use in the Aesthetic client:
• Eliminate or reduce dynamic facial wrinkles
• Soften static wrinkles
• Create a ‘lift’
Glabella Complex/
Frown lines
Frontalis/
Forehead lines
Crow’s Feet / lateral canthal lines
The 3 most common treatment zones for Botulinum Toxin
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Learning outcomes
Indications for use / treatment zones
• Glabellar complex (frown lines)
• Frontalis (forehead)
• Lateral canthal lines (crow’s feet)• Neck lift (Nefertiti technique)
• ‘Smoker’s lines’• Gummy smile
• Masseteric hypertrophy
• Chin dimpling
• Hyperhidrosis
• Bunny lines
• Chemical brow lift
• Downturned mouth corners
• Management of complications
Today’s foundation course Advanced course in toxin and
dermal fillers
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Indications for use
• Glabellar complex (frown lines)
• Frontalis (forehead)
• Crows feet
• Bunny lines
• Neck lift (nefertiti technique)
• Smokers lines
• Gummy smiles
• Chin dimpling
• Hyperhidrosis
• Management of complications
Indications for use / treatment zones
11
Indications for use
• Glabellar complex (frown lines)
• Frontalis (forehead)
• Crows feet
• Bunny lines
• Neck lift (nefertiti technique)
• Smokers lines
• Gummy smiles
• Chin dimpling
• Hyperhidrosis
• Management of complications
Indications for use / treatment zones
12
Indications for use
• Glabellar complex (frown lines)
• Frontalis (forehead)
• Lateral canthal lines
• Bunny lines
• Neck lift (nefertiti technique)
• Smokers lines
• Gummy smiles
• Chin dimpling
• Hyperhidrosis
• Management of complications
Indications for use / treatment zones
13
Advanced toxin and dermal fillers course
• Foundation refresher
• Advanced techniques in toxin and dermal fillers
• Supervised hands-on training
• Live models
• Development of the ‘aesthetic eye’• Complications management protocols
• Interactive lecture on the latest developments in the cosmetic
industry (new products, novel techniques and changing
guidelines)
• Business and marketing seminar
• Q+A session with the experts of facial rejuvenation
• CPD certification ceremony
• Post-certification support package with discount on further
courses
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Advanced applications
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Indications for use
• Glabellar complex (frown lines)
• Frontalis (forehead)
• Crows feet
• Bunny lines
• Neck lift (nefertiti technique)
• Smokers lines
• Gummy smiles
• Chin dimpling
• Hyperhidrosis
• Management of complications
Indications for use / treatment zones
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Botulinum Toxin - Core principles
• Aged under 18 years
• Known hypersensitivity to
Botulinum Toxin or any
components within the chosen
formulation
• Neuromuscular disorders
• Soft tissue infection
• Pregnancy
• Breast-feeding
• Contra-indicating medications
• Skin disorders
• Bleeding disorders
• Anti-coagulant / anti-platelet
medication
• Excessive weakness or atrophy
of the target muscles
• Unrealistic expectations
• Concomitant Botulinum Toxin
treatment
• Severe lactose intolerance
(Azzalure)
Contra-indications Cautions
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AbobotulinumtoxinA - Core principles
Product development
• Azzalure contains a purified
botulinum toxin A
• Widely used for over 25 years
• Over 2600 patients involved in
the clinical trails behind
development of the toxin
• High levels of evidence
demonstrating safety and
efficacy profile
Randomised controlled trial
Prospective cohort study
Retrospective cohort study
Case series
Case report / expert opinion / anecdotal evidence
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AbobotulinumtoxinA - Core principles
Product characteristics
✓ Solid clinical evidence
✓ Extensively evaluated safety profile
✓ Predictable results
✓ Fast onset of action
✓ Desirable longevity
✓ High rates of patient satisfaction
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AbobotulinumtoxinA - Core principles
• Unopened vials of Azzalure®
must be stored in a refrigerator
at 2-8°C
• Reconstituted Azzalure® is kept
refrigerated at 2-8°C
• Should be used within 24 hours
• Should not be frozen
• Unused reconstituted toxin
should be deactivated in Dakin
solution (1% hypochlorite)
Storage and shelf life
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Botulinum Toxin - Core principles
Reconstitution
• Azzalure ® should be reconstituted with 0.9% Sodium Chloride (normal saline)
• Reconstituting a 125 U vial of Azzalure ® with 0.63ml NaCl results in a solution
of 10U/0.05ml concentration
• Cleanse the rubber stopper of the vial with alcohol
• Introduce the diluent (NaCl) slowly into the vial. Do not shake or invert the
vial
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Botulinum Toxin - Core principles
Injection technique / hand positioning
tips are in your practical guide!
The treatment process
• Positioning and lighting
• (Pretreatment photographs)
• Cleanse the target areas
• (Apply topical anaesthetic)
• Mark out the injection sites as guided by the client’s activity lines• Deliver the product into the target
areas
• Treat any bleeding points with moist
gauze / cotton pads and light pressure
• Remain receptive and aware of the
client at all times
• Provide all aftercare instructions as
detailed below, including contact
details to arrange follow-up
appointments
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Botulinum Toxin - Core principles
Glabellar zone - Standard injection sites and dosing regimen
1010
10
10 10
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Botulinum Toxin - Technique
1. Procerus (deep, central)
2. Medial aspect of corrugators (deep)
3. Lateral aspect of corrugators
(superficial)
Glabella zone - Injection sites
• Be mindful of avoiding injections near
levator palpebrae superioris
• Use your thumb to prevent spread of
toxin inferior to the supraorbital rim
• Position lateral corrugator injections at
least 1cm above the supraorbital ridge
• Keep the needle bevel upward facing
Glabella zone - Treatment tips:
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Botulinum toxin - technique
4cm5 5 5 5
Forehead region – Standard injection sites and dosing regimen
NOTE: Off-label application of Azzalure
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Botulinum Toxin - Technique
Forehead - Treatment tips
• Tailor the pattern of administration
to suit your client
• Inject into the peaks of the wrinkles
and not the troughs
• Inject superficially
• Angle the needle at 45 degrees to
facilitate superficial administration
• Avoid injecting the aponeurosis
• Ensure you manage to create a ‘bleb’ of product
Pattern A Pattern B
Over-treating frontalis can result in a
brow ptosis (esp. in the older client)
Stay well above >4cm supraorbital rim
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Botulinum Toxin - Technique
Lateral canthal lines - Standard injection sites and dosing regimen
55
10
5 5
10
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Botulinum Toxin - Technique
Lateral canthal lines - Injection sites and
treatment tips
• Central site at least 1.5cm temporal
to the lateral canthus
• Ensure the site is temporal to the
orbital rim
• Mark out the upper and lower sites
1.5cm above and below the central
site. Remain lateral to the orbital rim
• Keep all injections lateral to the
lateral canthus
• Keep the needle bevel tip up and the
syringe orientated away from the
eye to avoid injury
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Botulinum Toxin – Technique Summary
4cm
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Botulinum Toxin – Documentation
Sample treatment record forms
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Botulinum Toxin - Aftercare
Aftercare instructions
• Reiterate the potential for slight bruising and discomfort
• Seek medical attention in the event of any major concerns
• Do not lie down, fall asleep or rub / massage the treated areas for at
least 4 hours after treatment
• Gently exercising the muscles that have been treated (i.e. frowning /
smiling) can help to activate the Toxin and expedite results
• Clients should avoid consuming alcohol for 24 hours after treatment
or wearing makeup
• Advise the patient that the effects can take up to a week to become
apparent
• Remember the effects are temporary and treatment is recommended
every 3-6 months
• Contact details for follow up assessment / further treatment provided
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Botulinum Toxin - Complications
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Botulinum Toxin – ComplicationsPlease refer to your starter packs...
Adverse effects
• Haematoma
• Pain at the injection sites
• Headache
• Ptosis (3%)
• Eyelid oedema (1%)
• Diplopia
• Hyperactivity of local antagonist
muscles
Serious risks
• Systemic spread of product
(breathing / swallowing
difficulties)
• Potentially (theoretically) life
threatening
• No reports of death following
cosmetic administration of
Botulinum toxin yet
J Cutan Aesthet Surg. 2008 Jul-Dec; 1(2): 95–97. doi: 10.4103/0974-2077.44169
Rzany B, Zielke H. Mauricio de Maio and Berthold Rzany, Botulinum Toxin in Aesthetic Medicine. Berlin Heidelberg:
Springer-Verlag; 2007. Safety of botulinum Toxin in aesthetic medicine; pp. 119–25
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Botulinum Toxin – Complications
Bruising Headache
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Botulinum Toxin – Complications
Ptosis
Spock eyebrow
Asymmetrical smile
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Botulinum Toxin - The market
Key manufacturers and products
Many products on the market. Read instruction manual and consider
dosing and storage of product
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Botulinum Toxin - The market
A comparison of key products
Product Manufacturer U/Vial Excipients
Storage /
shelf life
Stability of
reconstituted
product Supplier
Azzalure® Galderma 125
(Speywood
units)
HSA, Lactose 2 years at 2-8℃ 24 hours 2-8℃ MedFX
Dysport® Galderma 300 / 500 HSA, Lactose 2 years at 2-8℃ 8 hours 2-8℃ MedFX /
Wigmore
Bocouture® Merz 50 HSA, Sucrose 3 years <25℃ 24 hours 2-8℃ Wigmore
Botox® Allergan 50 / 100 HSA, NaCl 3 years at 2-8℃ 24 hours 2-8℃ Health
Xchange
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Summary
Learning outcomes
• Pharmacology
• Indications for use
• Foundation and advanced techniques applications:
– Glabellar
– Frontalis
– Crow’s feet– Advanced techniques
• Cautions and contra-indications
• Reconstitution
• The treatment process
• Technical tips
• Treatment of the glabella, frontalis and crow’s feet• Aftercare instructions
• Adverse effects
• The market – key manufacturers and products
38
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