presented by andrew cinderella - university of delaware · 2013-02-12 · presented by andrew...
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Presented by Andrew Cinderella
Samuel Danishefsky� Born 1936 in Bayonne, NJ� B.S. from Yeshiva University 1956� PhD from Harvard 1962� NIH post-doc fellow at Columbia, Stork Lab� 1963-1980 University of Pittsburg� 1963-1980 University of Pittsburg� 1980-1993 Yale University� 1993-present Columbia UniversityAwards� Wolf Prize in Chemistry with Stork� Arthur C. Cope Award� Benjamin Franklin Medal in Chemistry� National Academy of Science’s Award in Chemistry� >480 publications
Dynemicin A� Possible anti-tumor agent
� Binds to the minor-groove of the DNA double helix
� Most effective in rapid growth cells
Retrosynthesis
Approach
Early Synthetic Steps
Approach
Attempted Routes
Approach
Path II Synthetic Steps
Path II Synthetic Steps Cont.
Approach
Final Synthetic Steps
Conclusion� Dynemicin A was successfully synthesized in 33 steps.
� Overall yield of 0.13%
Questions???Thank you!!!
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