quantum immunlogics
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Fighting Cancer With Leading Edge Immunotherapy
November 2009
Mission Statement Putting Cancer Into Context Immunotherapy Overview & QI’s Approach QI’s Immunotherapy Video FDA Authorized Phase I/II Trials Economic Perspective QI’s Ongoing Research & Development About QI
An investment in QI is speculative, involves a high degree of risk and is suitable for persons of substantial means who have no need for liquidity with respect to their investment and can bear such risks, including the risk of losing their entire investment. Any investor considering making a potential investment in QI needs to read and review the “Private Placement Memorandum for Quantum Immunologics, Inc.,” particularly the “Risk Factors” section.
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Quantum Immunologics (QI):Agenda
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Quantum Immunologics (QI) is dedicated to the research, development and production of products and services that will promote immunologic cancer treatments and cancer detection technologies that are:
All at greatly reduced and highly competitive costs.
Mission Statement
Individualized Targeted Safe Highly efficacious
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Putting Cancer Into Context: Recent News Articles
New York Times Article, April 24, 2009 entitled “Forty Years’ War: Advances Elusive in Drive to Cure Cancer”
• “Cancer has always been an expensive priority. Since the war on cancer began, the National Cancer Institute…has alone spent $105 billion. And other government agencies, universities, drug companies and philanthropies have chipped in uncounted billions more.”
• “Yet the death rate for cancer, adjusted for size and age of the population dropped only 5% from 1950 to 2005. In contrast, the death rate for heart disease dropped 64% in that time.”
• “With breast cancer…only 20% with metastatic disease – cancer that has spread outside the breast, like to bones, lungs, or liver – live five years or more, barely changed since the war on cancer began.”
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May 31, 2009 Associated Press Article “Immune Therapies Finally Working Against Cancer”
• “First there was surgery, then chemotherapy and radiation. Now doctors have overcome 30 years of false starts and found success with a fourth way of fighting cancer: using the body’s natural defender, the immune system.”
• Positive late stage clinical results have been obtained for: Prostate cancer Brian cancer Small cell lung cancer
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Putting Cancer Into Context: Recent News Articles (cont.)
Time Magazine Article, September 14, 2009: “A Shot at Cancer”
• “It’s been a slow evolution, but we are seeing the first inklings that cancer vaccines can work,” says Dr. Steven Rosenberg, chief of the surgery branch at the National Cancer Institute.
• “Understanding how the immune system works is going to play a significant role in our treatment of cancer going forward” says Dr. Len Lichtenfeld of the American Cancer Society.
Putting Cancer Into Context: Recent News Articles Putting Cancer Into Context: Recent News Articles (cont.)(cont.)
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Two general approaches to immunotherapy
• Directed against a structure vital in the replication/growth process of the cancer cell
• Directed against a foreign protein on the cancer cell leading to cell destruction
Immunotherapy allows patients to have a better quality of life
• Fewer side effects because immunotherapy targets only cancer cells, avoiding healthy tissue
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Immunotherapy Overview
OFA - immature form is not found on normal tissue The OFA protein is found on many cancer lines
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QI’s Immunotherapy Approach: Oncofetal Antigen - Immature Laminin Receptor (OFA)
Sensitizes cells known as antigen presenting cells (dendritic cells) to OFA
Dendritic cells then present OFA to T-lymphocytes
T-lymphocytes are directed to combat cells that have OFA
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QI’s Immunotherapy Approach Focuses on OFA
QI is the exclusive licensee of various patent rights in the U.S., Europe and other countries for the use of OFA to
diagnose, monitor and treat cancer diseases
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QI’s Process: Video of OFA / Dendritic Cell Immunotherapy
Multi center, open label, non-randomized
Metastatic Stage IV Breast Cancer Patients, who have undergone and failed radiation and/or chemotherapy
27 Total Phase I - 3 patients (safety) Phase II - 24 patients (safety and efficacy)
3 OFA loaded activated dendritic cell injections, with monthly intervals between each injection
Determine safety and toxicity Determine immunological response and induction of OFA
specific T-lymphocytes
Evaluate objective clinical responses Evaluate time to disease progression Evaluate survival
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Design
Target Population
Number of Patients
Treatment
Primary Objectives
Secondary Objectives
QI’s FDA Authorized Phase I/II Trial Is Underway
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4 – 20+IV - Year long, every week or every 3 weeks
3 injections, monthly intervals
$10,000 - $200,000 $70,000 - $100,000 $60,000
Can Be Multiple and Severe
Some, and likely to be Moderate
Minimal, and likely to be Mild
Chemotherapy Herceptin QI ImmunoTx
Micro Economic Perspective of Treatment Options for Metastatic Breast Cancer
Total Cost
Patient Side Effects
Number of Treatments
The market niche for Stage IV breast cancer only is Huge• The estimated number of deaths of American patients with breast cancer
in 2009 is 40,610 (Source: American Cancer Society)
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Penetration Rate 10% 20% 30% 40%
Number of Patients(US Only)
4,061 8,122 12,183 16,244
Annual QI Rev at $60,000/Patient
$243,660,000 $487,320,000 $730,980,000 $974,640,000
Macro Economic Perspective of Stage IV Breast Cancer Market
Number of estimated deaths from breast cancer in 2007 worldwide is 464,854 (Source: American Cancer Society)
The market niche for ALL stages of breast cancer is Beyond Huge• The estimated number of new breast cancer cases in America in 2009 is
194,280 (Source: American Cancer Society)
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Penetration Rate 10% 20% 30% 40%
Number of Patients
(US Only)19,428 38,856 58,284 77,712
Annual QI Rev at $60,000/Patient
$1,165,680,000 $2,331,360,000 $3,497,040,000 $4,662,720,000
Macro Economic Perspective of All Stages of Breast Cancer
Number of estimated new breast cancer cases worldwide in 2007 is 1,301,867 (Source: American Cancer Society)
Looking Ahead:
QI’s Ongoing Research & QI’s Ongoing Research & DevelopmentDevelopment
• Provisional Patent 1: OFA peptides
• Specific protein sequences found within OFA
• More easily recognized and processed by dendritic cells
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QI’s Ongoing Research & Development: QI’s Ongoing Research & Development: Two Provisional Patents Have Been FiledTwo Provisional Patents Have Been Filed
It may be possible to directly administer these peptides to the patient without the need for ex vivo sensitization by
dendritic cells
This could lead to a diagnostic test for the presenceof cancer in the body
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• Provisional Patent 2: QI has discovered antibodies against specific OFA peptides
• Antibodies are proteins made by the body’s immune system that aid in the recognition and destruction of foreign substances, including cancer cells
QI’s Ongoing Research & Development: QI’s Ongoing Research & Development: Two Provisional Patents Have Been Filed (cont.)Two Provisional Patents Have Been Filed (cont.)
Historical Milestone Dates
Management & Science Team
Funding Needs
Capitalization - Past and Present
Looking Out Through 2010
Summary
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About QI
JulOct Jan SepDec Mar Apr AugNov Feb
2008 2009
Opened TN Lab to conduct further cancer research and immunotherapy product development
Filed two provisional patent applications involving cutting-edge cancer immunotherapies and diagnostics
Took control of management and operations of the AL Lab to oversee and conduct Phase I/II Trial
Secured Exclusive Worldwide License Agreement for all products/patents developed by SAMSF related to OFA
Begin Phase I/II Trials of immunotherapy for Stage IV Breast Cancer Patients
QI’s Historical Milestone Dates
May Jun
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QI receives FDA authorization for Phase I/II Clinical Trial for Stage IV Breast Cancer Patients
Oct
QI presented at the Rodman & Renshaw Global Investor Conference
The scientists behind the science• Martin Eason, MD – Chief of Industry Relations, Director• Kent Johnson, MD – Chief Scientific Adviser• Eric Olle, PhD – Director of Research
Chuck Broes – Chief Executive Officer & Chairman of the Board• Taina Broes – Chief Operating Officer• Josh Coughlin – Chief Investment Officer, Director• Barry Rooth – Chief of Corporate Affairs, Director• Tim Schwiers – Director of Investor Relations• Don Wright – Chief Financial Officer
Because of their belief in QI, all of QI’s management/science team is working for stock, or at reduced salaries plus stock.
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QI’s Management & Science Team
Round 1 Capital Raise - $5,000,000 Private Placement Memorandum• Used to substantially complete Phase I / II Trial• Used to track/monitor Phase I / II Trial results• Continue the R&D efforts on other cancer products• Plan and prepare FDA submission of Phase II b / III Trial
Round 2 Capital Raise / IPO / JV or Acquisition by Pharmaceutical Company - $TBD• To execute Phase II b / III Trial• Continue R&D
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QI’s Funding Needs
QI’s Capitalization: Past Capital Raising InitiativesQI’s Capitalization: Past Capital Raising Initiatives
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Capital Raising
Tranche
$ per share
#
Warrants
$
Amount Invested
# Shares Issued
#
Warrants
Issued
Imputed Price per
Share
Tranche 1 $10 3 $ 924,100 92,410 277,230 $ 3.57
Tranche 2 $10 2 $ 2,169,712 216,971 433,942 $ 4.55
Tranche 3 $10 1 $ 1,104,720 110,472 110,472 $ 6.25
Mentor Capital *
*note receivable
$12 na $ 2,244,000 187,000 na $ 12.00
TOTAL: $ 6,442,532 606,853 821,644
Non-cash Shares
Founders/Directors/CEO 237,757
VRI / Venturific 82,172
Total Shares Outstanding
926,782
QI Summary Capitalization Table (as of 9-30-09)
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Current Shares Current Warrants
Total # Outstanding 926,782 821,644
QI Equity Capitalization $ 11,121,384
Round 1 Shares
Total $ Amount $ 5,000,000
Share Price $ 12
# Shares 416,666
% of QI Outstanding 31.0%
Post Round 1 Shares
Total # Outstanding 1,343,448
QI Equity Capitalization $ 16,121,376
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Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov DecDecNovOct
Phase I/II Trial
Phase II b/ III Trial
R&D
Corp.
2009 2010
QI: Estimated Timeline Through 2010
Financing
Take on FTEs
Round 1 - $5mm
Continue to Follow Up
FDA Application/Planning Process
Round 2 –IPO/Rev Merge Shell + SPO/JV/Acquisition
QI is the exclusive licensee of various patent rights in the U.S., Europe and other countries for the use of OFA to diagnose, monitor and treat cancer diseases
In addition to breast cancer, OFA is present in multiple cancer lines
Market niche for a successful immunotherapy treatment approach for breast cancer is several billion dollars
QI’s management team has accomplished much in a short amount of time with scarce resources and minimal capital
QI seeks additional capital to:- validate QI’s immunotherapy approach in the Phase I / II trial - plan and execute subsequent Phase II b / III trials
Significant ROI potential, with numerous avenues to a liquidity event
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QI Summary: Business Perspective
1 in 8 women will be diagnosed with breast cancer
Despite vast amounts of research time, billions of dollars in research, and trillions of dollars in treatment, mortality rates for breast cancer are essentially unchanged
QI’s FDA-Authorized Phase I / II Trial for Stage IV Breast Cancer Patients is underway
Preliminary Phase I / II results will be known by year end 2009
An investment in QI is speculative, involves a high degree of risk and is suitable for persons of substantial means who have no need for liquidity with respect to their investment and can bear such risks, including the risk of losing their entire investment. Any investor considering making a potential investment in QI needs to read and review the “Private Placement Memorandum for Quantum Immunologics, Inc.,” particularly the “Risk Factors” section.
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QI Summary: Clinical Perspective
Fighting Cancer With Leading Edge Immunotherapy
November 2009
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