radiology of brain diseases - docs.neu.edu.tr

18/11/2015

1

Nail Bulakbaşı, M.D.Professor of Radiology

Near East University Faculty of MedicineDepartment of Radiology

• A major cause of death & fatal morbidity in young adults (15-24 ages)

• M/F: 2-3/1

• Imaging• Severity of trauma

• Treatment options

• Fast & effective

• CT is first choice of modality• Acute hematoma

• Fractures

• MRI• DAI, SAH, temporal

• Vascular injury

• DSA• Dissection

• Pseudoaneurysm, AVF

FracturesA. meningea media

Between tabula & duraWithin sutures

Ruptrure of briding veins due to trauma

Between dura & arachnoidBeyond sutures

Petechial hemorrhage Frontal & temporal lobes

BAD PROGNOSIS

18/11/2015

2

Aneurysmal rupture Between arachnoid & pia Subendothelial hemorhage Carotid-vertebral arteries

Functional impairment due to corruption of blood flow

Emboli, thrombosis, hemorrhage

• Increased T1/T2 time• Axonal degeneration

• Inflammation

• Edema

• Gliozis

• DDx is not possible

• Dysmyelinatingdiseases• Oligodendrocyte

dysfunction

• Congenital/hereditary

• Demyelinatingdiseases• Myelin breakdown

• Autoimmunity ?

• Acquired

18/11/2015

3

SLE

14

Behçet

Moya-moya

Sjogren

Sarcoidosis

Infection of leptomeninx Bacteria, TB, Prion, Virus

Bacterial abscess

RCC metastasis

18/11/2015

4

18/11/2015

5

25

Grade II Astrositom

18/11/2015

6

18/11/2015

7

• Trauma

• Degenerative disease

• Tumors and other masses

• Inflammation and infection

• Vascular disorders

• Congenital anomalies

Acquire images axially…

…reconstruct sagittal / coronal

18/11/2015

8

Axial Coronal Sagittal

Lumbar Spinal Stenosis

18/11/2015

9

Lumbar Spinal Stenosis

• 85-95% at L4-L5, L5-S1

• 5-8% at L3-L4

• 2% at L2-L3

• 1% at L1-L2, T12-L1

• Cervical: most common C4-C7

• Thoracic: 15% in asymptomatic pts. at multiple levels, not often symptomatic

Protrusion Extrusion Extrusion

Adapted from: “Nomenclature and Classification of Lumbar Disc Pathology: Recommendations of the Combined Task Forces of the

North American Spine Society, American Society of Spine Radiology, and American Society of Neuroradiology,” 2001.

Protrusion Protrusion w/

migration

Protrusion w/

migration +

sequestration

Adapted from: “Nomenclature and Classification of Lumbar Disc Pathology: Recommendations of the Combined Task Forces of the

North American Spine Society, American Society of Spine Radiology, and American Society of Neuroradiology,” 2001.

18/11/2015

10

L-S1DiscR-S1

Schmorl’s Nodes

Spondylolysis / Spondylolisthesis

• Spondylosis = “spondylosis deformans” = degenerative spine

• Spondylitis = inflamed spine (e.g. ankylosing, pyogenic, etc.)

• Spondylolysis = chronic fracture of pars interarticulariswith nonunion (“pars defect”)

• Spondylolisthesis = anterior slippage of vertebra typically resulting from bilateral pars defects

• Pseudospondylolisthesis = “degenerative spondylolisthesis” (spondylolisthesis resulting from degenerative disease rather than pars defects)

• Extradural = outside the thecal sac (including vertebral bone lesions)

• Intradural / extramedullary = within thecal sac but outside cord

• Intramedullary = within cord

Extradural IntramedullaryIntraduralExtramedullaryDuraCord

18/11/2015

11

Extradural: Vertebral Body Tumor Intradural Extramedullary: Meningioma

Intramedullary: Astrocytoma Intramedullary: Cavernoma

Intramedullary: Syringohydromyelia

• Hydromyelia: Fluid accumulation/dilatation within central canal, therefore lined by ependyma

• Syringomyelia: Cavitary lesion within cord parenchyma, of any cause (there are many). Located adjacent to central canal, therefore not lined by ependyma

• Syringohydromyelia: Term used for either of the above, since the two may overlap and cannot be discriminated on imaging

• Hydrosyringomyelia: Same as syringohydromyelia

• Syrinx: Common term for the cavity in all of the above

18/11/2015

12

• Common chain of events (bacterial spondylitis): • Hematogenous seeding of subchondral VB

• Spread to disc and adjacent VB

• Spread into epidural space epidural abscess

• Spread into paraspinal tissues psoas abscess

• May lead to cord abscess

T2 T1 T1+C T1+C

• Inflamed cord of uncertain cause

• Viral infections

• Immune reactions

• Idiopathic

• Myelopathy progressing over hours to weeks

• DDX: MS, glioma, infarction