sepsis & septic shock management
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By Duangruethai Tunprom, MD. (Emergency physician), Phrae hospital
Incidence
Definition
Definition
Definition
MODS =Multiorgan dysfunction syndrome
Pathophysiology
Clinical
Early Hypodynamic state Peripheral
vasodilatation
Hypovolemia Global tissue
hypoxia Reversible tissue Anaerobic
metabolism Latate
Late Hyperdynamic state Perpheral
vasoconstrction Cardiac output
Global tissue hypoxia
Irreversible tissue then tissue necrosis
Organ failure
ScVO2 SvO2
ScVO2 SvO2
Warm shock Cold shock
Diagnosis
Bone’s criteria
Bone’s criteria
Diagnosis
Bone’s criteria Source of infection
H/C Sputum C/S ± G/S Pus C/S + G/S Urine C/S + G/S Synovial fluid CSF Imaging investigation
Biomarkers for diagnosis
Severity scoring system & prognostic models
CURP 65 , PSI score BISAP score, Ranson’s score Revised Atlanta Classification
APACHE II score (Acute Physiologic and Chronic Heath Evaluation II score)
SOFA score (Sepsis-related Organ Failure)
Bone’s criteria
Treatment
Get rid of source infection Intensive life support Innovative therapy
Get rid of source infection Source control Antibiotic
Source control
Antibiotics1. Intravenous antibiotic therapy should be started within the first hour of recognition of severe sepsis and septic shock
AntibioticsAntibiotics2. Broad-spectrum: one or more agents active against likely bacterial/fungal pathogens and withgood penetration into presumed source
3. The antimicrobial regimen should always be reassessed daily - The aim of using a narrow spectrum antibiotic - to prevent the development of resistance - to avoid toxicity - to reduce costs
AntibioticsAntibiotics
•suggest combination therapy for patients with known or suspected Pseudomonas infections as a cause of severe sepsis
AntibioticsAntibiotics
4. The duration should typically be 7–10 days
AntibioticsAntibiotics
5. The presenting clinical syndrome is determined to be due to a noninfectious cause
Intensive life support
Fluid Vasopressor
Fluid Therapy
1.Fluid-resuscitate using crystalloids or colloids
SAFE Study
• Indicated that albumin administration was safe andequally as effective as crystalloid .
• There was an insignificant decrease in mortalityrates with the use of colloid in a subset analysis of septic patients
SAFE Study
NEJM 2004; 350:2247
The SAFE Study Investigators, N Engl J Med 2004;350:2247-2256
Kaplan-Meier Estimates of the Probability of Survival
Primary Endpoint was 28 day mortality
Fluid TherapyFluid Therapy2. Target a CVP of 8 mm Hg (12 mm Hg if mechanically ventilated)
3. Use a fluid challenge technique while associated with a hemodynamic improvement
Give fluid challenges of 1000 mL of crystalloids or 300–500 mL of colloids over 30 mins. More
rapid and larger volumes may be required in sepsis-induced tissue hypoperfusion
VasopressorVasopressor
VasopressorVasopressor
Norepinephrine vs Dopamine+/_ Epinephrine in Septic Shock
Results of a prospective observational study
Claude, Critical Care Med 2000;28:2758
VasopressorVasopressor
VasopressorVasopressor
Inotropic therapyInotropic therapy
•.
New innovative therapy
Early goal-directed therapy Tight control of blood sugar Activated protein C
Early Goal Directed Therapy (EGDT)
Finish within 6 hr Process
Fluid resuscitation Vassopressor and inotrophic drug
Early Goal-Directed Therapy
NEJM 2001;345:1368-77.
Early goal directed therapy N=130
Standard therapy N=133
CVP > 8-12 mm HgMAP > 65 mm Hg
Urine Output > 0.5 ml/kg/hr
CVP > 8-12 mm HgMAP > 65 mm HgUrine Output > 0.5 ml/kg/hrScvO2 > 70%SaO2 > 93%Hct > 30%
Antibiotics given at discretion of
treating clinicians
As soon as possible Mean 6.2hrs
ICU MDs blinded to study treatment
NEJM 2001;345:1368-77.
At least 6 hoursof EGDTMean 8hrs
Transfer to ICU
49.2%
33.3%
0
10
20
30
40
50
60
Standard Therapy N=133
EGDTN=130
P = 0.01*
*Key difference was in sudden CV collapse, not MODS
Early Goal-Directed Therapy Results:28 Day Mortality
Sudden CV Collapse
MODS
21% vs 10%
p=0.02
22% vs 16%
P=0.27
NEJM 2001;345:1368-77.
Mo
rta
lity
Mortality 50 %30%
Glucose Control
Tight Glucose Control
Van den Berghe, NEJM 2001; 345: 1359
Intensive
>215 mg/dL
180 to 200 mg/dL (10.0 and 11.1
mmol/L)
>110 mg/dL
80 to 110 mg/dL (4.4 to 6.1 mmol/L)
Blood glucose level when insulin infusion
was started
Infusion adjusted to maintain blood
glucose
van den Berghe G, et al. NEJM 2001;345:1359-1367.
Intensive Insulin Therapy in Critically Ill Patients
39 % Received insulin 99% Received Insulin
Tight Glucose Control Improved Survival
Intensive Insulin Therapy in Critically Ill Patients: Mortality
8.0%
4.6%
0%
5%
10%
15%
10.9%
7.2%
0%
5%
10%
15%
ICU Mortality was reduced by 42%
In-Hospital Mortality was reduced by 34%
Mo
rtal
ity
(%)
p = 0.01p < 0.04 (adjusted)
N=783 N=765
Conventional IntensiveN=783 N=765
NEJM 2001;345:1359-1367.
Glucose Control
NICE-SUGAR=Normoglycemia in Intensive Care Evaluation and Survival Using Glucose Algorithm Regulation
Recombinant HumanActivated Protein C
(rhAPC)
Recombinant HumanRecombinant HumanActivated Protein C Activated Protein C
(rhAPC)(rhAPC)
Thank youFor your attention
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