spectroscopy & predictive analytics - euraxessprocess analytical technology end-product quality...

Gledson Emidio

Spectroscopy &

Predictive Analytics

Process Analytical Technology

End-product

qualityPatient

safetyManufacturing

process

Raw

Mat

Quality should be built

not just tested

Quality by design

Raman VIS

NIR FLUORESCENCE

CALORIMETRY DIELETRIC

NMR IMPEDANCE

VIDEO MICROSCOPY

ACCOUSTICS

SENSORS

PAT Tools

Multivariate

Data

Analysis

PAT Tools

denoising

Variable selectionScatter correction

Sample selection Predictive models

Classification models

Design of experiments

Tc

particle concentration

Particle position correlation

Td

Tc

particle concentration

Particle position correlation

TdRd

Tc

Light Scattering

ITN-initial training Networks

- equipping young researchers with the

knowledge and skills required for

Europe's knowledge-based economy

- offering decisive training and transfer of

knowledge opportunities.

- SusChem report ‘Vision for 2025 and

Beyond’ as ‘the urgent need to train the

next generation of individuals able to

work across the boundaries of

chemistry, biology, chemical and

biochemical engineering’.

University of Strathclyde campus

Suspension polymerisation reactions

Spatially and angularly resolved

diffuse reflectance spectroscopy

Vis and NIR

Suspension polymerisation reactions

Spatially and angularly resolved

diffuse reflectance spectroscopy

Vis and NIR

Vis and NIR spectra

Suspension polymerisation reactions

Predictive models for conversion

MODEL-BASED OPTIMIZATION &

CONTROL FOR PROCESS-

INTENSIFICATION IN CHEMICAL AND

BIOPHARMACEUTICAL SYSTEMS

Suspension polymerisation reactions

Suspension polymerisation reactions

contain information on

particle size provided

repeatable measurements

can be made

RAMAN VIS NIR+ +techniques

providing information

at low concentrations

of residual monomer

and of styrene conversion

providing information

of styrene conversion

VIS NIR

Suspension polymerisation reactions

Vis and NIR spectra

Thank you