structural evidence for evolution of the β / α barrel scaffold by gene duplication and fusion
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Structural Evidence for Evolution of the β/α Barrel Scaffold by Gene Duplication and Fusion
Horng –uei Lii
Background
What is β/α Barrel ?
β/α Barrel (I)
Are found in many proteins(enzymes) The eight-stranded β/α Barrel structure
are one of the largest and most regular of all domain structure
β/α Barrel(II)
Different structure and function
Loops---varies, functional domain
Evolution material
TIM barrel
Triosephosphate isomerase
Introduction Evolution Material Computational Tool Genome Protein Dtata
Materials
Thermotoga maritimaHisA & HisF
HisAConverts (ProFAR)
to (PRFAR)
HisFCatalyze condensation of PRFAR and ammonia,
AICAR and ImGPHisF:HisH cowork
Methods X-ray analysis Multi-sequence alignment Superimpose Mutual residual activities
Conclusion
Half-barrel Ancestor Duplication and Fusion Model
ApplicationSubdomain structures:
Genome searchFunctionally and
structurally related proteins
Thank you!
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