superficial fungal infection dermatophytosis three genera known to cause disease -tricophyton -...
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SUPERFICIAL FUNGAL SUPERFICIAL FUNGAL INFECTION INFECTION
DERMATOPHYTOSISDERMATOPHYTOSIS
SUPERFICIAL FUNGAL SUPERFICIAL FUNGAL INFECTION INFECTION
DERMATOPHYTOSISDERMATOPHYTOSIS
THREE GENERA KNOWN TO CAUSE DISEASETHREE GENERA KNOWN TO CAUSE DISEASE-TRICOPHYTON-TRICOPHYTON- MICROSPORUM - MICROSPORUM - EPIDERMOPHYTON- EPIDERMOPHYTON
EPIDEMIOLOGY• GEOPHILIC - GEOPHILIC -
– M.GYPSEUM – M.GYPSEUM – M. FERRUGINEUM – M. FERRUGINEUM - T. TERRESTRE - T. TERRESTRE - T.VIOLACEUM - T.VIOLACEUM
• ZOOPHILIC -ZOOPHILIC - - M. CANIS – CAT, DOGS,SHEEPS - M. CANIS – CAT, DOGS,SHEEPS - T. EQUINUM – CATS, DOGS,CATTLES - T. EQUINUM – CATS, DOGS,CATTLES - T. VERRUCOSUM – CATS , DOGS, - T. VERRUCOSUM – CATS , DOGS, CATTLES,SHEEPSCATTLES,SHEEPS
• ANTHROPOPHILIC - ANTHROPOPHILIC - - -E. FLOCCOSUM E. FLOCCOSUM –M. AUDOUINII –M. AUDOUINII –T. MENTAGROPHYTES –T. MENTAGROPHYTES –T. RUBRUM –T. RUBRUM – T. – T. TONSURANS – TONSURANS –
PATHOGENESIS• FUNGI MUST OVER COME
- EFFECT OF UV LIGHT –TEMPERATURE VARIATION – COMPITION WITH NORMAL FLORA -FUNGISTATIC AGENTS –
• FATTY ACIDS,SPHINGOSINES • - EPIDERMAL GROWTH
• DTH IMMUNE RESPONSE
TINEA CAPITIS
ECTOTHRIX ENDOTHRIXYELLOW- GREEN FLUORESCENCE DULL GRAY-GREEN FLUORESCENCE
M.AUDOUINIIM.CANISM.FERRUGINEUM
T.SCHOENLEINII
NO FLUORESCENCE NO FLUORESCENCE
M.GYPSEUMT.MENTAGROPHYTEST. RUBRUM
T.TONSRANST. VIOLACEUM
ORGANISMS ASSOCIATED WITH ORGANISMS ASSOCIATED WITH CLINICAL TYPES OF TINEA CAPITISCLINICAL TYPES OF TINEA CAPITIS
INFLAMMATORYZOOPHILICGEOPHILIC
NONINFLAMMATORYANTHROPOPHLICECTOTHRIC
BLAK DOTANTHROPOPHILICENDOTHRIX
FAVUS
M.AUDOUINIIM. CANISM. GYPSEUMT.MENTAGROPHYTET.TONSURANST. VERRUCOSUM
M.AUDOUINIIM. CANISM.FERRUGINEUMT.TONSURANS
T.TONSURANST.VIOLACEUM
M.GYPSEUMT. SCHOENLEINIIT.VIOLACEUM
TINEA BARBAE
• INFAMATORY TYPE- T. MENTAGROPHTE, T. VERRUCOSUM
• SUPERFICIAL TYPE - ANTHROPOPHILIC –T. VIOLACEUM,T.RUBRUM
• CIRCINATE TYPE
TINEA PEDIS• CHRONIC INTERTRIGINOUS TYPE• CHRONIC HYPERKERATOTIC TYPE• VESICULOBULLOUS TYPE• ACUTE ULCERATIVE TYPE
SYSTEMIC ANTIFUNGALS
• ALLYLAMINS –
• INHIBITS SQUALENE EPOXIDASE BLOCKING BIOSYNTHESIS OF ERGOSTEROL
• FUNGICIDAL• 3 TO 6 mg/kg OD• CONTRAINDICATED IN PREGNANCY & LACTATION
• TRIAZOLES – ITRACONAZOLE, FLUCONAZOLE INHIBIT 14 alfa DEMETHYLASE ENZYME IN CELL
MEMBRANE USEFUL FOR CONVERSION OF SQUALENE TO ERGOSTEROL
.
IMIDAZOLE – KETOCONAZOLE
GRISEOFULVIN – DISRUPS MICROTUBULE MITOTIC SPINDLE FORMATON THUS ARREST MITOTIC AT METAPHASE STAGE
TREATMENT
TOPICAL -ALLYLAMINES – TERBINAFINE,NAFTIFINE -BENZYLAMINE - BUTENAFINE -IMIDAZOLES CLOTRIMAZOLE,
MICONAZOLE,KETOCONAZOLE
-TOLNAFTAE
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