synthesis of thienyl appended porphyrins for cancer treatment by edith amuhaya

Synthesis of Thienyl-appended Porphyrins for

Cancer TreatmentDr. Edith K. Amuhaya

Technical University of Kenya28/11/2014

Cancer StatisticsGlobal

Cancers among the leading causes of morbidity and mortality worldwide.

14 million new cases and 8.2 million cancer related deaths in 2012.

New cases expected to rise by about 70% by 2030.

Kenya

Third leading cause of death.

39,000 new cases annually

28,000 deaths annually

WHO, 2014 http://www.who.int/mediacentre/factsheets/fs297/en/Githanga, 2013

Cancer Treatment

http://www.jerryryanphd.com/biopage.html

http://www.tirgan.com/vp16.htm

http://medgadget.com/archives/2008/07/varians_rapidarc_radiation_delivery_system_goes_clinical.html

SURGERY

CHEMOTHERAPY

RADIATION THERAPY

3

Photodynamic Therapy (pdt)

PDT is a relatively new mode of treatment.

Components of PDT•Light of appropriate wavelength

•Oxygen

•Light sensitive drug (Photosensitizer)

Jablonski Diagram

http://www.discoverymedicine.com/Diana-M-Tacelosky/files/2012/04/discovery_medicine_no_71_brian_m_barth_figure_1.png

Drug Administration

• Administration of drug

• Incubation period

• Irradiation of tumor by light of desired wavelength.

http://belfield.cos.ucf.edu/pdt.html

Porphyrin-Based Photosensitizers

Synthesis of Dipyrromethane

Synthesis of thienyl-appended porphyrins

Synthesis of thienyl-appended porphyrins

Photophysical Studies

Biological Studies

Biological Studies

Future Work

Acknowledgements

• Technical University of Kenya

• Prof. M.G.H. Vicente (LSU, USA)

• Prof. Kevin M. Smith (LSU, USA)

• Dist. Prof. Tebello Nyokong’ (Rhodes University, SA)

• KESHO- Kenya