the bio directorate microbial biology emphasis bio advisory committee april, 2005
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The BIO Directorate The BIO Directorate Microbial Biology EmphasisMicrobial Biology Emphasis
BIO Advisory CommitteeBIO Advisory CommitteeApril, 2005April, 2005
BIO’s Microbial Biology EmphasisBIO’s Microbial Biology Emphasis
• BIO is proposing an increased effort to advance microbial biology beginning in FY 2006.
• A new working group has been charged to consider:
What programs or activities will best serve
the microbial science of the future? How should they be structured?
BackgroundBackground and Contextand Context
• Microbes are vastly understudied, given their importance on Earth.
• NSF has supported research on microbes in a number of contexts over many years.
• Interest and opportunities are growing.
BackgroundBackground and Contextand Context
• Genomics has provided the key to understanding the microbial world.
• Complementary approaches have been enhanced and revitalized.
• Microbes and their interactions can now be placed in the context of their natural environments.
The BIO Microbial Biology The BIO Microbial Biology Working Group Working Group
Approach
Identify the leading edge biological questions and research needs in microbial biology.
Match the questions and research needs to current programs and opportunities.
Identify intersections and complementarity of programs and gaps.
Develop a plan for the BIO Microbial Emphasis in 2006
Community Input
A Number of Workshops, Including
• 1999. Microbial Genomes: Blueprints for Life
• 2000. The Microbe Project – The NSF Role (a BIO/NSF Advisory Committee Workshop)
• 2002. Microbial Ecology and Genomics: A Crossroads of Opportunity
• 2004. Facilitating Microbial Research through Advanced Data Management Infrastructure (A workshop sponsored by the Microbe Project Interagency Working Group)
Community Input
Recommendations from PI Meetings
Microbial Genome Sequencing Program• 2005 Genome sequencing is still needed.
Microbial Observatories• 2002: Add an opportunity for research on
Microbial Interactions and Processes
• 2004 White paper from meeting of Microbial Observatories PIs with USDA grantees and staff recommends a joint effort.
Interagency Coordination: The Microbe Project
Member Agencies
Department of Agriculture
Department of Commerce
Department of Defense
Department of Energy
Department of Health and Human Services
National Aeronautics and Space Administration
National Science Foundation
The Microbe Project Interagency Working Group
• 1999. Interagency Report on the Federal Investment in Microbial Genomics
• 2001. Interagency Working Group on Microbial Genomics of the NSTC Committee on Science, Subcommittee on Biotechnology, The Microbe Project Report
• 2005. Updated strategic planning document in preparation.
The Microbe Project Interagency Working Group
2005 Topics under Consideration
Infrastructure needs (including more genome sequencing) Assigning Functions
• Mechanisms of Microbe-Microbe and Microbe-other organism interactions
• Comparative Genomics
• Databases and Bioinformatics Infrastructure
• Environmental Genomics (aka Metagenomics)
• Proteomics
• Microbial Epidemiology and Forensics
Recommendations from All Sources
• Advance genome-enabled research at all levels of biological organization
• Education and outreach programs
• Resource needs: Genome sequence and quality annotation Cyberinfrastructure Accessible technologies
Research Frontiers
Explore and elucidate microbial:
• Metabolic diversity and function
• Communication, signaling, and behavior• Interactions with other organisms• Diversity
• Evolution and how groups maintain cohesion
• Ecology
Understand the fundamental processes of life from molecular to ecological levels
Infrastructure and Infrastructure and Resource NeedsResource Needs
• Build the genome sequence knowledge base.
• Determine the functions of open reading frames to improve annotation.
• Develop ontologies, databases, and informatics tools for: Analysis of microbial genomes. Analysis of DNA from environmental samples. Linking genomic data with other data types.
• Develop and make accessible new research tools and techniques.
Education and OutreachEducation and Outreach
• Educate at the interfaces of microbial biology with:
Genomics Math, physical sciences, computer science Environmental Science
• Broaden Participation
• Increase public awareness
NSF/BIO Current Opportunities in NSF/BIO Current Opportunities in Microbial BiologyMicrobial Biology
• Microbial Genome Sequencing (Joint with USDA)
• Microbial Observatories & Microbial Interactions and Processes
• Microbial Research in: Core Programs FIBR Plant Genome Research Program Ecology of Infectious Disease (Joint with NIH)
Instrumentation & Instrumentation & Instrument Instrument
DevelopmentDevelopment
PEETPEET
IGERTIGERT
Dissertation Dissertation ImprovemeImprovementnt
Post Post DocsDocs
Databases and Databases and InformaticsInformatics
Living Living StocksStocks
Genome Genome SequencingSequencing
Ecological & Evolutionary Ecological & Evolutionary PhysiologyPhysiology
Ecology & Ecology & EcosystemsEcosystems
Plant Genome Plant Genome ResearchResearch
SystematiSystematicscs
Metabolic Metabolic BiochemistBiochemist
ryry
Plant BiologyPlant Biology
DevelopmentaDevelopmentall
SystemsSystems
Biodiversity Biodiversity SurveysSurveys
& Inventories& Inventories
Microbial Microbial Observatories & Observatories & Interactions & Interactions &
ProcessesProcesses
RCNRCN
MicrobialMicrobialGeneticsGenetics
[Education ][Education ]
[Research [Research Frontiers]Frontiers]
[Infrastructure[Infrastructure]]
REUREUUMEUMEBB
NSF/BIO Planning for Future NSF/BIO Planning for Future Opportunities in Microbial BiologyOpportunities in Microbial Biology
• The Microbial Biology Working Group is charged to consider:
What activities and programs will best serve the microbial science of the future?
How should they be structured?
Cyb
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fras
tru
ctu
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Databases
PEET
IGERT
Postdoc
Living Stocks
REUUBM
Instrumentation
Ecology
Ecosystem
s
Physiology
FIBR
Systematics
Evolution
Microbial Observatories
Biochemistry
Genetics
GenomeSequencing
Ecology of Infectious
Disease
Cell biology
Plant genome
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