the czech republic: genetic counseling in high- risk...

Disease Markers 15 (1999) 50IOS Press

0278-0240/99/$8.00 © 1999 – IOS Press. All rights reserved

50

L. Foretova1, E. Machackova2,D. Valik1 and L. Messiaen2

1Masaryk Memorial Cancer Institute Brno,Czech Republic2Center of Medical Genetics, UniversityHospital Gent, Belgium

Genetic counseling of high-risk cancerfamilies was started one and a half years ago inMasaryk Memorial Cancer Institute in Brno, thesecond largest city in the Czech Republic locatedin South Moravia. Since that time more than 120families, mostly with breast/ovarian or colorectalcancers were seen. The inheritance and the pos-sibilities of cancer prevention and surveillancewere discussed.

Genetic testing in high-risk breast/ovariancancer families was offered to 9 families.

Families are currently analyzed at the Center ofMedical Genetics, University Hospital, Gent,Belgium. By protein truncation analysis ofBRCA1 exon 11 and BRCA2 exon 10 and 11 andheteroduplex analysis of selected exons,truncating mutations were found in 4 out of 9families. One of these mutations (3875del4 inBRCA1) is frequently seen in the Europeanpopulation and the family would be eligible forhaplotype study directed by IARC. Analysis ofthe remaining exons of BRCA1 and BRCA2 is inprogress in the other families.

The genetic surveillance was supported bygrants from the agency League Against CancerPrague, Czech Republic and Terry FoxFoundation. The genetic counseling, and genetictesting in the Czech families will be supported bya grant from the Internal Grant Agency ofMinistry of Health of the Czech Republic.

Abstract

The Czech Republic: Genetic Counseling in High-Risk Breast/Ovarian Cancer Families

Submit your manuscripts athttp://www.hindawi.com

Stem CellsInternational

Hindawi Publishing Corporationhttp://www.hindawi.com Volume 2014

Hindawi Publishing Corporationhttp://www.hindawi.com Volume 2014

MEDIATORSINFLAMMATION

of

Hindawi Publishing Corporationhttp://www.hindawi.com Volume 2014

Behavioural Neurology

EndocrinologyInternational Journal of

Hindawi Publishing Corporationhttp://www.hindawi.com Volume 2014

Hindawi Publishing Corporationhttp://www.hindawi.com Volume 2014

Disease Markers

Hindawi Publishing Corporationhttp://www.hindawi.com Volume 2014

BioMed Research International

OncologyJournal of

Hindawi Publishing Corporationhttp://www.hindawi.com Volume 2014

Hindawi Publishing Corporationhttp://www.hindawi.com Volume 2014

Oxidative Medicine and Cellular Longevity

Hindawi Publishing Corporationhttp://www.hindawi.com Volume 2014

PPAR Research

The Scientific World JournalHindawi Publishing Corporation http://www.hindawi.com Volume 2014

Immunology ResearchHindawi Publishing Corporationhttp://www.hindawi.com Volume 2014

Journal of

ObesityJournal of

Hindawi Publishing Corporationhttp://www.hindawi.com Volume 2014

Hindawi Publishing Corporationhttp://www.hindawi.com Volume 2014

Computational and Mathematical Methods in Medicine

OphthalmologyJournal of

Hindawi Publishing Corporationhttp://www.hindawi.com Volume 2014

Diabetes ResearchJournal of

Hindawi Publishing Corporationhttp://www.hindawi.com Volume 2014

Hindawi Publishing Corporationhttp://www.hindawi.com Volume 2014

Research and TreatmentAIDS

Hindawi Publishing Corporationhttp://www.hindawi.com Volume 2014

Gastroenterology Research and Practice

Hindawi Publishing Corporationhttp://www.hindawi.com Volume 2014

Parkinson’s Disease

Evidence-Based Complementary and Alternative Medicine

Volume 2014Hindawi Publishing Corporationhttp://www.hindawi.com