tolstoy target,mult obj,evolving enzymes

Tolstoy Targets for Evaluating Multiple Objectives

in Arrays of Candidates

Dennis E Sweitzer, Ph.D.

Tolstoy?

Failure in a few ways Failure of the whole⇒

Happy families are all alike; Every unhappy family is unhappy in its own way.

--Leo Tolstoy, Anna Karenina

Successful projects are all alike; Every unsuccessful project fails in its own way.

--Someone else…….

BasicsEach Axis: An AttributeEach target:• Green: Go (acceptable)

Red: (STOP) (unacceptable)• Yellow: (SLOW) (marginal/uncertain)

The Waterline Convention:• Below: Any Red Sinks the Candidate• Above: Need >1 Green

36 Candidates at a glance:

Subsequent GenerationsWeed: Pick the BestSeed: Base next on Best

Array of Tolstoy Targets allow rapid identification of best

Dominate Candidates(1) Superior to ≥1 other in all

attributes (2) No other candidate dominates it

Focus on Dominant Candidates

• Below the waterline: Must have ALL Green (Any Red Sinks the Candidate)• Above the waterline: Must have ONE Green