urticaria- a presentation for patients provided courtesy of unev
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Urticaria-A presentation for patients
Provided courtesy of UNEV
Urticaria
Hives or angioedema
Hives and angioedema
Men and women
Young and elderly
Urticaria is common
Gesamtbevölkerung UrtikariaTotal population Urticaria
Urticaria is common
Akute Urtikaria Chronische UrtikariaAcute Urticaria Chronic Urticaria
Urticaria
http://www.arianapagerussell.com/work/skin/
http://www.facebook.com
People and animals
What happens in the skin?
What happens in the skin?
What happens in the skin?
What happens in the skin?
What happens in the skin?
What happens in the skin?
Triggers
http://www.kkr.it/de/referenzen.htm?menID=2433,0&grp=1&p=2 © Rolf Neeser http://vitagate.ch/de/schoenheit/hautpflege/juckreiz
Triggers
http://wallpaperstock.net
http://www.pc-modding.biz
…. without triggers
Chronic Spontaneous Urticaria
Causes
Infection26%
Intolerance38%
Auto-reactivity20%
No known cause30%
Other2%
Infection
Auto-reactivityZirkulierende MZ Sekeretagoga = Circulating MZ secretagogues
Auto-reactivity
Intolerance
MZ MZ
Intolerance
Intolerance
?Infection
26%
Intolerance38%
Auto-reactivity20%
No known cause30%
Other2%
Treatment
aus: http://memo-an-mich.de/
complete symptomcontrol
Treatment
2nd-generation H1-antihistamine
Increase dose (up to 4-fold)
If after 2 weeks of continued symptoms
Syst
emic
ster
oids
in e
xace
rbati
ons,
po
ssib
ly a
s a
brie
f the
rapy
Symptoms persist after two weeks
Symptoms persist after 2 weeks
What doesn‘t help ....
• Cortisone ointments are rarely effective in urticaria and have long-term side effects.
• Anti-allergic creams and gels penetrate too slowly into the skin to be effective
Summary
• Urticaria is often incredibly annoying and often disfiguring
• The most common form is chronic spontaneous urticaria
• Possible causes are infections, food intolerances or autoimmune processes
• The treatment of choice is:1. Antihistamines2. More antihistamines3. Mast cell inhibition
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