using the cdd vault for mm4tb
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Using the CDD Vault for MM4TB Sean Ekins PhD, DSc.
CSO, Collaborative Drug Discovery, IncBurlingame, CA
The Exploitation pathway…
Research Information system (RIS)
Technology transfer Entrepreneurship Networking
Torbjörn IngemanssonEuropean Commission
Sean EkinsCollaborative Drug Discovery, Inc.
Claire SkentelberyEuropean Biotechnology Network
Bonny HarbingerNational Institutes of Health
“by provisioning the right amount of storage and compute resources, cost can be significantly reduced with no significant impact on application performance”
Cloud
CDD- a decade of drug discovery collaborations
2004 - presentSaaS
Easy to use
Used by AcademiaIndustry, Biotech
Private
Selective collaboration
100’s of published datasets
NIH funded STTR collaboration
Some collaborations outside also
1R41AI088893-012R42AI088893-02
Developing molecules for TBUsing computational data miningNew technologies for TB drug discovery
From Desktop to Mobile apps – making data accessible
Clark et al., submitted 2014
Predict targets
http://goo.gl/vPOKS
http://goo.gl/iDJFR
Drug discovery is repetitive and there are 1000s of diseases
Drug discovery is high risk
Do we need robots or just smarter programs that discover the ideas we test?
24 groups in this project use a single
Participants from India, Russia, South Africa, Europe, USA
TB Drug AcceleratorAnother example of a big TB collaboration7 Big Pharma and 4 academic institutes will open up targeted sections of their compound libraries and share data with each other.
• Abbott• AstraZeneca• Bayer • Eli Lilly• GlaxoSmithKline• Merck • Sanofi • Infectious Disease Research Institute (IDRI)• NIH National Institute of Allergy and Infectious
Diseases• Texas A&M University • Weill Cornell Medical College
The Big Picture• This did not happen overnight – 10 years to get here!• Collaboration and selective secure sharing is key – move
ideas and data – to clinical compounds• Domain expertise in drug discovery• Bring scientists together globally• Grants can accelerate / catalyze collaboration• Grants can fund further technology development• Impact how we develop therapies
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