vasculogenesis and angiogenesis integrins in vasculature and ko phenotypes growth factor receptors...
Post on 21-Jan-2016
217 Views
Preview:
TRANSCRIPT
Vasculogenesis and angiogenesis
Integrins in vasculature and KO phenotypes
Growth Factor Receptors signaling and vasculature phenotypesVEGFRTip cells VEGF, Notch
Vasculogesis and angiogenesis in vertebrates
Models Intussuseptive angiogenesis
(tissues as muscle, often blood flow dependent etc.)
Angiogenesis is a dynamic and context determined process
Examples of vascular defects
Integrins in the vasculature
L1CAM
A7 Lm 68% embryonic lethal hemorrgaged E10-14.5 SM cells
Integrin inhibitors and RTK agonistic interactions (Kaan)
Angiopoitins, Tie1 and Tie2 receptor
PDGF RTK signaling
VEGF RTK signaling
VEGFR3 at tips cells
Signaling in sprouting tip cells
Delta-Notch signaling
Sema3 inhibits integrin function. Normal angiogenesis…
semaphorins
Mouse models affecting TGFbeta signaling
Haemodynamics affect vascular remodelling
example
Pixt2 KO phenotypes in 6th BAAOcclusion of right BAAs results in Persistence of left 6 BAA
top related