venue: university of los andes, bogotá, colombia sd ... · camilo aponte ulrich schwarz 10:30 –...
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VENUE: University of Los Andes, Bogotá, ColombiaSD Building (Cll. 21 # 1-20, Entrance 9 in the map). Room SD-803
PROGRAM OVERVIEW
Monday (30.09)
Tuesday (01.10)
Wed. (02.10)
8:00 – 9:00 Registration
9:00 – 9:30 Welcome
9:30 – 10:30 Helmut Grubmüller Frauke Gräter Camilo Aponte
Ulrich Schwarz
10:30 – 11:00 Coffee break
11:00 – 12:00 Frauke Gräter Helmut Grubmüller Alfredo Alexander-
Katz (VC)12:00 – 14:00 Lunch
14:00 – 15:00 Ulrich Schwarz Ulrich Schwarz CT: Helman Amaya
CT: Sergio Cruz-León
15:00 – 15:30 CT: A. Sandoval CT: Alberto CastilloJosé D. Muñoz
15:30 – 16:00 PhotoPoster session
Coffee break
16:00 – 17:00 Pilar Cossio Departure
PRESENTATION
Mechanical forces are ubiquitous in biology. At the macroscopic level, mechanical stress influences key aspects such as the morphology or the growth of tissues and organs. In addition, specific organs, like the ear, have evolved to work as highly sensitive detectors of mechanical signals. Moreover, biological frameworks, such as silk fibers, are fabulous materials, designed to withstand large mechanical stresses while staying very flexible. At the cellular level, mechanics define vital processes such as stability, division, proliferation, or migration of cells. At the molecular level, mechanical forces stimulate ion channels, molecular motors, or adhesive proteins to trigger their function. Mechanical forces are also manifested in diseases. For instance, bacteria and parasites use the shear-stress of flows to adhere more firmly to host cells.Theoretical and simulation approaches have greatly contributed to our understanding of how biological systems cope with mechanical forces. The goal of the workshop is thus to bring a selected group of renown scientist, to provide the basis and the state of the art of mechanical forces in biology, over a wide resolution range, from biomolecules to organs, from a theoretical and a simulation perspective.The workshop is addressed to students, researchers, and professors interested in this area. The participants will have the opportunity to interact with the invited speakers and to present their own work in contributed talks and poster presentations.
Topics include:
• Biomaterials: spider silk • Mechanics of focal adhesions • Mechanics of collagen fibers • Blood clotting • Biophysics of malaria • Cells in shear flow • Collective cell migration • Molecular motors • Ribosomal translation • Force-probe simulations • Modeling of the cochlea • ...
PROGRAM IN DETAIL
Monday, September 30
8:00 – 9:00 Registration
9:00 – 9:30 Welcome
9:30 – 10:30 Helmut Grubmüller MPIBPC, Göttingen
Force-probe molecular dynamics simulations
10:30 – 11:00 Coffee break
11:00 – 12:00 Frauke Gräter HITS, Heidelberg
Mechanics of focal adhesions and collagen fibers
12:00 – 14:00 Lunch
14:00 – 15:00 Ulrich SchwarzU. Heidelberg
Introduction to modeling cell mechanics and adhesion
15:00 – 15:30 Contributed talk: Angélica Sandoval. UNIANDES, Bogotá
The interaction of blood proteins with extracellular DNA
15:30 – 15:40 Photo
15:40 – 17:00 Poster session
19:00 – Invited speakers dinner
Tuesday, October 1
9:30 – 10:30 Frauke Gräter HITS, Heidelberg
Spider silk and other biomaterials with exceptional mechanical properties
10:30 – 11:00 Coffee break
11:00 – 12:00 Helmut Grubmüller MPIBPC, Göttingen
Molecular motors & Ribosomal translation
12:00 – 14:00 Lunch
14:00 – 15:00 Ulrich SchwarzU. Heidelberg
Biophysics of malaria-infected red blood cells
15:00 – 15:30 Contributed talk: Alberto Castillo, UJTL, Bogotá
A parasite's thoughts: What is like to swim inside you?
15:30 – 16:00 Coffee break
16:00 – 17:00 Pilar CossioUDEA, Medellín
Rates and transition paths in atomic force spectroscopy
Wednesday, October 2
9:30 – 10:00 Camilo AponteUNIANDES, Bogotá
Mechanosensation in biological membranes
10:00 – 10:30 Ulrich SchwarzU. Heidelberg
Biophysics of malaria-infected red blood cells (continued)
10:30 – 11:00 Coffee break
11:00 – 12:00 Alfredo Alexander-Katz. MIT, Cambridge
biological or bio-inspired biopolymers under flows: blood clotting (video conf.)
12:00 – 14:00 Lunch
14:00 – 14:30 Contributed talk: Helman AmayaUNIANDES, Bogotá
Dynamics of self-interacting bio-inspired polymers in shear flows
14:30 – 15:00 Contributed talk: Sergio Cruz-LeónMPI-Biophysics, Frankfurt
Specific effects of metal cations in RNA: the interplay of binding affinity and kinetics
15:00 – 16:00 José D. Muñoz UNAL, Bogotá
Modeling of the propagation of sound through the cochlea
16:00 – 17:00 Closing remarks and departure
POSTERS
1Leonel ArdilaUNAL, Bogotá
Heat exchange fluctuation relation in the transition between a micro-canonical and a canonical ensemble
2 Iván PulidoUNIANDES, Bogotá
Structural modeling and charge-distribution of the shear-sensitive Plasmodium falciparum adhesin VAR2CSA
3Sebastian Ortiz UDEA, Medellín
The similarity between the probability distributions of cryo-EM reconstructions can control overfitting
4
Valeria MejíaUNIANDES, Bogotá
The effect of G1324A and G1324S mutations on the complex formed by the von Willebrand factor A1 domain and the glycoprotein Iba-platelet receptor, studied through molecular dynamics simulations and free energy calculations.
5 Juan OrjuelaUNIANDES, Bogotá
Effect of lipid-protein interactions on the hemostatic function of the mechanoactivated platelet glycoprotein IB membrane receptor
6Gilles Pieffet UAN, Bogotá
Determination of the Binding Free Energy of a peptide inhibitor of the N-Methyl-D-Aspartate (NMDA) Receptor using Umbrella Sampling
7 Santiago Agudelo UDEA,
Steered molecular dynamics simulations for studying ZIKV E protein- Glycosaminoglycan interaction.
Medellín
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