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Volume 4Supplement 2September 2010
BMCProceedings
Abstracts of the 16th International Charles Heidelberger Symposium on Cancer Research
Coimbra, Portugal26-28 September 2010
BMC-Proceedings-ICHSCR-ofc.indd 1BMC-Proceedings-ICHSCR-ofc.indd 1 14/09/2010 15:23:0514/09/2010 15:23:05
Volume 4 Supplement 2September 2010
BMCProceedings
Abstracts of the 16th International Charles Heidelberger
Symposium on Cancer Research
Coimbra, Portugal26-28 September 2010
Committees
The Organization of the 16th International Charles Heidelberger Symposium on Cancer Research acknowledges the support of:• FCTUC (Faculdade de Ciências e Tecnologia da Universidade de Coimbra)• CIUC (Centro de Informática da Universidade de Coimbra)• DIIC-UC (Divisão de Identidade, Imagem e Comunicação da Universidade de Coimbra)• Turismo de Coimbra• Turismo Centro de Portugal• Bentham Science Publishers
International Advisory Committee
Eli Huberman (USA)Johan Lillehaug (Norway)Joseph Landolph (USA)Karl Heinrich Link (Germany)Robert Langenbach (USA)Toshio Kuroki (Japan)
Symposium Executive Committee
Eli Huberman (USA)Johan Lillehaug (Norway)Joseph Landolph (USA)Karl Heinrich Link (Germany)
Secretariat
Ana Paula Parreira
Symposium Chairs
Carlos Freire de Oliveira (Portugal) Joseph Landolph (USA)Eli Huberman (USA) Maria Carmen Alpoim (Portugal)
Local Organizing Committee
Ana Castro Jardim (FMUC) Joana Felício Cerveira (FCTUC)Ana Daniela Sampaio (FCTUC) Leonardo Manuel Ferreira (FCTUC)Ana Margarida Urbano (FCTUC) Luís Miguel Pires (FMUC)António Jorge Guiomar (FCTUC) Maria Carmen Alpoim (FCTUC)Armando Cristovão (FCTUC) Maria Filomena Botelho (FMUC)Carlos Freire de Oliveira (FMUC) Marta Pinto Coelho (FMUC)Isabel Maria Abrantes (FCTUC) Paula Vasconcelos Morais (FCTUC)Isabel Marques Carreira (FMUC)
Local Programme Committee
Ana Margarida Urbano (FCTUC) Maria Carmen Alpoim (FCTUC)Carlos Freire de Oliveira (FMUC) Maria Filomena Botelho (FMUC)Isabel Marques Carreira (FMUC) Paula Vasconcelos Morais (FCTUC)
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Volume 4 Supplement 2September 2010
BMCProceedings
Contents
Opening Lecture
O1 Inflammation, senescence and cancer: interweaving microRNA, inflammatory cytokines and p53 networksCurtis C. Harris
Session 1 - Cancer Etiology and Epidemiology
O2 Gene-environment in the induction of cancerHerman Autrup
O3 Gene variants and lung cancer riskNina E Landvik, Shanbeh Zienolddiny, Vidar Skaug, Aage Haugen
O4 Polychlorinated biphenyls (PCB), UV radiation, and cutaneous malignant melanomaRichard P Gallagher, Tim K Lee, Jean-Philippe Weber, Alain Leblanc, Marilyn Borugian, J Mark Elwood, Amy C MacArthur, Zenaida Abanto, John J Spinelli
P1 Abstract not submitted for publishing
P2 Association between night shift work, melatonin and estradiol in nursesBeata Peplonska, Agnieszka Bukowska, Jolanta Gromadzinska, Wojciech Sobala, Edyta Reszka, Jenny A S Lie
P3 Mastermind-like 1 (MAML-1) as a new metastatic marker in esophageal squamous cell carcinomaMohammad M Forghanifard, Moein Farshchian, Reza Raeisossadati, Mohammad N Forghani, Meysam Moghbeli, Hussein Naseh, Mohammad R Abbaszadegan
P4 Polymorphisms of GSTM1, GSTT1, GSTP1 and CYP1A1 genes and susceptibility to lung cancerPaula Mota, Michelle Horta, Luis Mesquita, Henriqueta Silva
P5 Obesity and breast cancer: inflammatory and adipocytokine correlations
Paulo C Matafome, Ana L Gomes, Manuel Gomes, Lélita C Santos, Ana B Sarmento, Raquel F Seiça
P6 Polymorphisms of estrogen receptors, ERα and GPR30: association with breast cancer susceptibility and prognosisSusana M Alves, Luís Mesquita, Rita Sousa, Fátima Peralta, Henriqueta C Silva
P7 Breast cancer and environmental factorsJ Vicente Paulo, Lélita Santos, Graça Fernandes
P8 Primary bone lymphomaC Pissarro C Azevedo, P José A F F Tavares, M Isabel P Portela, A José L C P Santos, J Manuel P S Casanova
Session 2 - Molecular Carcinogenesis
O5 Regulation of DNA damage responses by mismatch repairAnatoly Zhitkovich
O6 Insoluble Ni compound-induced gene amplification/gene silencing causes over-expression of microtubules/microfilaments, cell shape changes, and de-regulation of global gene expression/Ca+2 gradients, inducing morphological/ neoplastic transformation of 10T1/2 mouse embryo cellsJoseph Landolph, Aruni DeSilva, Duy Mai, Jim K. Lin, Jimmy Zheng
Volume 4 Supplement 2September 2010
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Contents
O7 The bioenergetic signature of cancerJosé M. Cuezva
O8 Roles of beta-arrestin1/2 in prostaglandin-mediated signaling and tumor developmentRobert Langenbach, Huei-Chen Lao, Kyung-Soo Chun
O9 PINK1/BRPK inhibits apoptotic cell death and enahances cellular invasiveness through an activation of mTORC2 pathwayHitoshi Murata, Masakiyo Sakaguchi, Ken Kataoka, Nam-ho Huh
O10 Receptor for activated C-kinase (RACK1) plays a central role in Ras-mediated signal transductionJohan R Lillehaug, Line M Myklebust, Arnt Raae, Bodil Bjørndal
P9 The role of CD26 and CD40 expression in therapeutic response - experimental study in oral cancer linesJoana P N Batista, Sílvia S Neves, A Cristina Gonçalves, Vera Alves, Ana Sarmento-Ribeiro, Marília Dourado
P10 Abstract not submitted for publishing
P11 Evaluation of the role of miR-34b in modulation of radioresistance in non-small cell lung cancerJoana B Silva, Sílvia S Neves, A Cristina Gonçalves, Margarida Marques, Luís Mesquita, Filomena Botelho, A Bela Sarmento-Ribeiro, Henriqueta C Silva
P12 P-cadherin expression in feline mammary tissuesA Catarina Figueira, Júlio Carvalheira, M Manuela Lacerda, M Fátima Gärtner
P13 Regucalcin, a calcium-binding protein, is a new target gene in human prostate cancer?Cláudio J Maia, Cátia V Vaz, Carina G Peres, Cecília R A Santos, Sílvia Socorro
P14 MicroRNA-21 in lung cancer: overexpression in metastasis of pulmonary adenocarcinomas and squamous cell carcinomasMaria R Silva, Paulo Santos, Isabel Velada, Catarina Gomes, M João d’Aguiar, Lia Teixeira, João Dinis, Susana Carmona, Luisa Cortes, Lina Carvalho
P15 Involvement of mitochondrial and survival signaling in berberine-induced apoptosis in melanoma cellsAna Burgeiro, Consuelo Gajate, El H Dakir, Paulo J Oliveira, Faustino Mollinedo
P16 Metabolic changes in human bronchial epithelial cells upon chronic exposure to hexavalent chromiumLeonardo M R Ferreira, Maria S Santos, M Carmen Alpoim, Ana M Urbano
P17 Cr(VI)-induced malignant transformation of a bronchial epithelial cell line association with altered mitochondria and bioenergetic phenotypesAna Sampaio, Luís Mendes, Ana C Gonçalves, Margarida Abrantes, Ana B Sarmento, Filomena Botelho, Paulo Oliveira, Vilma Sardão, Rui Carvalho, Ana M Urbano and M Carmen Alpoim
Session 3 - Tumor Microenvironment and Tumor Cell Biology
O11 Tumor Microenvironment Controls the Rate of Cancer Progression and MetastasisRaghu Kalluri
O12 Metabolism and metastasis: in the bone marrow and beyondSérgio Dias
O13 The Immune Biology of Microsatellite Unstable CancerMagnus von Knebel-Doeberitz
O14 Targeting secreted heat shock protein-90alpha (Hsp90α) to prevent breast cancer progressionZhengwei Zhao, Chieh-Fang Cheng, Rosie Kim, Mei Chen, David T Woodley, Wei Li
Volume 4 Supplement 2September 2010
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Contents
O15 JAKs and STATs in ChemoresistanceAna Costa-Pereira
O16 Autophagy turns specific: the discovery of p62 and NBR1 as autophagy cargo receptorsGeir Bjørkøy
P18 Abstract not submitted for publishing
P19 Abstract not submitted for publishing
P20 Relation between autophagy and the resistence of glioblastoma cells to temozolomideAnália Carmo, Helena Carvalheiro, Maria C Lopes
P21 GLUT expression and 18F-FDG uptake in breast cancer cell linesAna M Abrantes, Mónica Martins, Ana C Gonçalves, Maria C Rodrigues, Ana C Mamede, Sónia D Tavares, José M Lima, Adriano Rodrigues, Ana B Sarmento-Ribeiro, Maria F Botelho
P22 MDR modulation in colorectal adenocarcinoma cell lines: kinetic studies using 99mTc-sestamibiJoão Casalta-Lopes, A Margarida Abrantes, Joana Rio, Mafalda Laranjo, Bárbara Oliveiros, A Cristina Gonçalves, Ana B. Sarmento-Ribeiro, M. Filomena Botelho
P23 Phenotypic analysis of breast cell lines – triple negative cells vs expressing hormonal receptorsMafalda Laranjo, Maria J Carvalho, Artur Paiva, A Margarida Abrantes, Isabel Torgal, Carlos F Oliveira, M Filomena Botelho
P24 Abstract not submitted for publishing
P25 A nonconjugated naphthalene derivative of meso-tetra-(3-hydroxy)-phenyl-porphyrin as a sensitizer for photodynamic therapyAbílio J F N Sobral, Ana M Urbano, Pedro Silva, Sofia M Fonseca, Cláudia T Arranja, Hugh D Burrows
P26 Polyaromatic hydrocarbons accentuate malignant phenotype of the PC3 prostate cancer cell lineMariana O Freitas, José Oliveira, Ana M Fernandes, Maria I Coutinho, Vera Alves, Anabela Mota-Pinto, Ana B Sarmento-Ribeiro
P27 MGBG–cisplatin combination chemotherapy against breast cancerRaquel F Gonsalves, Maria P M Marques
P28 Melanoma skin cancer: could chromone derivatives be efficient chemopreventors?Mafalda M Dias, Maria P M Marques
P29 Exosomes from human ovarian carcinoma SKOV3 cells are enriched in glycosylated proteins Cristina Escrevente, Peter Altevogt, Júlia Costa
P30 Delocalized lipophilic cations as a new therapeutic approach in cancerA Barbosa Ribeiro, A Luísa Ferreira, A Cristina Gonçalves, Sílvia Neves, A Maria Araújo, Filipa Carvalho, João Carvalho, Rui M Santos, Vera Alves, Teresa Silva, José M Nascimento-Costa, Ana B Sarmento-Ribeiro
P31 Cytotoxic effect induced by combination of polyamines metabolites and endocannabinoid, anandamide, on human cancer cells: a new anticancer strategy A Lúcia M Batista-de-Carvalho, G Tempera, N Viceconte, S Saccoccio, E Bidollari, M Nalli, Enrico Morera, Giorgio Ortar, Enzo Agostinelli
P32 An in vitro tumor-fibroblast interaction model of human oral squamous cell carcinomaJozséf Dudás, M Bitsche, V Schartinger, G M Sprinzl, H Riechelmann
P33 Physiologic parameters variation in ICR mice during a chemical induced liver carcinogenesis experimentIvo Conceição-Pereira, Nuno M Paula-Santos, Filipa O Pereira, Maria J Pires, Luis F Palomino, Aura A Colaço, Paula A Oliveira
P34 Role of VEGF signalling in the regulation of KDR expression in endothelial and tumoral microenvironmentJacinta Serpa, Cheila Torre, Francisco Caiado, Sérgio Dias
Volume 4 Supplement 2September 2010
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Contents
P35 EP4-mediated prostanoid signalling promotes oral cancer progressionKaren Sapienza, Stewart Sale, Angela Hague, Ian.R. Hart, J.ohn F. Marshall, Gareth.J. Thomas
P36 Role of notch pathway and HNF1 in cell death induced by HDACs inhibitors in ovarian cancer cell lines, serous and clear cellsFernanda Silva, Jacinta Serpa, Germana Domingues, Gabriela Silva, António Almeida, Ana Félix
P37 TRAP1 and SORCIN cooperate in a survival pathway responsible for inducing drug-resistance in human colorectal carcinoma (CRC)Matteo Landriscina, Francesca Maddalena, Gabriella Laudiero, Maria R Amoroso, Annamaria Piscazzi, Valentina Lombardi, Alberto Fersini, Franca Esposito
P38 Dll4 blockade interferes with the bone marrow vascular niche and perturbs hematopoietic recovery following myeloablationLeonor Remédio, Tânia Carvalho, Sérgio Dias
P39 Short-chain sphingolipids for enhanced cellular uptake of liposome-encapsulated amphiphilic anti-cancer drugsLília R C Pedrosa, Albert van Hell, Wim van Blitterswijk, Ann L B Seynhaeve, Alexander M M Eggermont, Timo L M ten Hagen, Marcel Verheij, Gerben A Koning
P40 Osteosarcoma contains a subpopulation of cancer stem-like cells that are highly resistant to radiotherapySara R M Neves, Aurio O G Lopes, Anália do Carmo, Antero J Abrunhosa, Paulo C P S Simões, Artur A Paiva, M Filomena Botelho, Célia M F Gomes
P41 Indentification of cancer stem-like cells in osteosarcoma and their implications in response to chemotherapyÁurio O Lopes, Sara R Neves, Anália do Carmo, Artur A Paiva, Maria Botelho, Célia M Gomes
P42 Metabolic responses of A549 lung cells to cisplatin and radiation exposure studied by 1H NMR spectroscopyAna F Ladeirinha, Inês D Lamego, Ana M Gil, Joana B Melo, Isabel M Carreira, Iola F Duarte
P43 In vivo pulmonary metastatic profile of breast cancer cell lines expressing hormonal receptors versus triple negativeM João Carvalho, A Margarida Abrantes, Mafalda Laranjo, Francisco Falcão, Sofia Cabrita, M Filomena Botelho, Carlos F de Oliveira, Isabel Torgal
P44 New targeted therapies in myelodysplastic syndrome: the role of farnesyltransferase and proteasome inhibitorsA Cristina Gonçalves, Ana Oliveira, Diana Moreira, Silvia Neves, Vera Alves, Teresa Silva, Luís Mesquita, Henriqueta Coimbra, Marília Dourado, José M Nascimento-Costa, Ana B Sarmento-Ribeiro
P45 Targeted gene silencing for cancer treatmentLígia C G da Silva, José S Ramalho, M Conceição P de Lima, Sérgio Simões, João N Moreira
P46 Recombinant trail: a synergistic effect in myeloid leukemiasFilipa Carvalho, A Sofia Coelho, Cátia Domingues, João A Carvalho, André Ribeiro, Rui M Santos, A Cristina Gonçalves , Vera Alves, Teresa Silva, Marília Dourado, José M Nascimento-Costa, Ana B Sarmento-Ribeiro
P47 Co-expression of E- and P-cadherin in breast cancer: role as an invasion suppressor or as an invasion promoter?Ana S Ribeiro, Laura C Carreto, André Albergaria, Bárbara Sousa, Sara Ricardo, Fernanda Milanezi, Raquel Seruca, Manuel A Santos, Fernando Schmitt, J oanaParedes
P48 Contribution of Thomsen-Friedenreich antigens to bladder cancer malignancy: Characterization of cell line modelsPaulo F Severino, Mylène A Carrascal, Helena Gouveia, M Guadalupe Cabral, Manuela Correia, Nadia Malagolini, Mariella Chiricolo, Fabio Dall’Olio, Paula AVideira
P49 Antitumoral effect of farnesiltransferase and mtor inhibitors in hepatocellular carcinoma: in vitro studiesAna M Araújo, Sílvia S Neves, Ana L Ferreira, Diogo Branco, Ana B Sarmento-Ribeiro, José M Nascimento-Costa
Volume 4 Supplement 2September 2010
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Contents
P50 Metalloproteinase inhibitors as a potential therapeutic approach in multiple myeloma: a preliminary studyA Sofia Pais, A Cristina Gonçalves, Catarina Geraldes, José M Nascimento-Costa, Ana B Sarmento-Ribeiro
P51 Novel antitumor DNA monoalkylating agents: Synthesis and biological evaluationAna F Brito, M Isabel Soares, Mafalda Laranjo, A Margarida Abrantes, José A Paixão, Ana M Beja, Manuela R Silva, Teresa P Melo, M Filomena Botelho
P52 The effect of cisplatin in 5637 bladder cancer cell lineRosário Pinto-Leite, Regina Arantes-Rodrigues, M Luís Cardoso, Lúcio Santos, Paula A Oliveira
Session 4 - Cancer Genetics and Epigenetics
O17 CDH3/P-cadherin overexpression in breast carcinomas: its regulatory mechanisms, the role in cell invasion, and the association with cancer stem cell propertiesJoana Paredes
O18 Spontaneous development of lung adenocarcinoma in the CADM1 gene-deficient miceMasayoshi Nagata, Mika Sakurai-Yageta, Daisuke Yamada, Taketo Kawai, Yumi Tsuboi, Takeshi Ito, Akihiko Ito, Midori Yoshida, Yoshinori Murakami
O19 The FRAGILOME project, a strategy for the discovery of new gene biomarkers in cancerManfred Schwab
O20 Gene amplification in breast cancer – looking for the molecular mechanismsSergei Kovalenko
O21 Molecular Genetic Study of Female Cancers in Novosibirsk, RussiaLyudmila F Gulyaeva
O22 E-cadherin mediated cellular effects and molecular partners. Gastric cancer as an invasive modelJoana Figueiredo, Joana Simões-Correia, Joana Fernandes, Ana R Mateus, Gianpaolo Suriano, Joana Paredes, Carla Oliveira, Raquel Seruca
P53 Identification of copy number variations of chromosomes 7, 9 and 10 in human glioblastomas by SNP-arraysInês Crespo, Maria D Tabernero, Ana B Nieto, Olinda Rebelo, Hermínio Tão, Fernando Gomes, Catarina R Oliveira, Maria C Lopes, Alberto Orfao
P54 Circadian gene variants and MT6s level in nurses under different work shifts – preliminary resultsEdyta Reszka, Beata Peplonska, Edyta Wieczorek, Jolanta Gromadzinska, Wojciech Sobala, Wojciech Wasowicz, Agnieszka Bukowska, Jenny A Lie
P55 MFSD2A is a novel lung tumour suppressor gene whose expression is modulated by a 5’-region polymorphismFrancesca Colombo, Monica Spinola, Felicia S Falvella, James P Sullivan, David S Shames, Luc Girard, Paola Spessotto, John D Minna, Tommaso A Dragani
P56 FGFR4 GLY388ARG polymorphism modulates cancer patients’ survival in pooled analysisElisa Frullanti, Tommaso A Dragani
P57 KRAS and EGFR mutations coexisting in lung adenocarcinomaVitor Sousa, Ana Alarcão, Patricia Couceiro, Maria R Silva, Maria J d’Aguiar, Lia Teixeira, Lina Carvalho
P58 Modulation of DNA damage prevention and signaling pathways in diet induced colon cancer preventionDalila F N Pedro, Alice A Ramos, Cristóvão F Lima, Fátima Baltazar, Cristina Pereira-Wilson
Volume 4 Supplement 2September 2010
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Contents
P59 MIR-143 over-expression reduces the growth of xenograft tumors from colon carcinoma cellsPedro M Borralho, Sofia Gomes, Raquel T Lima, Rui E Castro, Maria H Vasconcelos, Cecília M P Rodrigues
P60 Histone deacetylation - a new epigenetic target in cancer João A Carvalho, Emília Cortesão, José D Branco, Ana C Gonçalves, Sílvia Neves, Filipa Carvalho, André Ribeiro, Vera Alves, Teresa Silva, Marília Dourado, José M Nascimento-Costa, Ana B Sarmento-Ribeiro
P61 EGFR unusual mutation status in lung adenocarcinomasAna Alarcão, Vitor Sousa, Patrícia Couceiro, Maria Silva, Maria J. d’Aguiar, Lia Teixeira, Lina Carvalho
P62 Identification of a common deletion region in 10q26 associated with human gliomasMargarida Alves, Paulo Liberato, Ana Rita Conde, Manuela Mafra, Alexandra Inverno, Ana Teresa Maia, Denise Bagrel, Isabel Carreira, Miguel Brito, Carolino Monteiro
P63 STEAP1 expression in prostate cancer and its regulation by androgensInês Gomes, Cecília R A Santos, Sílvia Socorro, Carlos Lopes, Cláudio J Maia
P64 EGFR/erb-1, HER2/erb-2, CK7, LP34, Ki67 and p53 expression in preneoplastic lesions of bronchial epitheliumLina Carvalho, Joana E Santo, Ana Alarcão, Patricia Couceiro, Maria R Silva, Ana Gomes, Maria J d’Aguiar, Lia Teixeira, Vitor Sousa
Session 5 - Translational Cancer Medicine
O23 Quality control in colon and rectal cancer surgeryKarl-Heinrich Link
O24 Detecting tumor responses to treatment using hyperpolarized 13C magnetic resonance spectroscopic imagingKevin M Brindle
O25 Tumor-tailored treatment of colorectal cancer: from bench to bedside?Marko Kornmann
O26 Targeting non-viral vectors to tumor cells and the tumor microenvironmentVera Moura, Manuela Lacerda, Paulo Figueiredo, M Luísa Corvo, M Eugénia M Cruz, M Conceição P. de Lima, Sérgio Simões, João N Moreira
O27 Adjuvant therapy in colorectal cancer – studies of the FOGT groupLudger Staib, Marko Kornmann, Karl-Heinrich Link
O28 “Omic” landscapes of breast cancer - the end of the beginningCarlos Caldas
O29 Bacterial anticancer weapons: a promising tool to fight cancerAnanda M Chakrabarty
P65 Improving the classification of brain tumors in mice with perturbation enhanced (PE)-MRSIRui V Simões, Sandra Ortega-Martorell, Teresa Delgado-Goñi, Yann le Fur, Marti Pumarola, Ana P Candiota, Patrick J Cozzone, Margarida Juliá-Sapè, Carles Arús
P66 NMR metabonomic study of lung cancer: metabolic profiling of tissuesCláudia M Rocha, António S Barros, Ana M Gil, Brian J Goodfellow, Isabel M Carreira, João Bernardo, Ana Gomes, Vítor Sousa, Lina Carvalho, Iola F Duarte
P67 NMR metabonomic study of lung cancer: metabolic profiling of urine and blood plasmaJoana Carrola, Cláudia M Rocha, António S Barros, Ana M Gil, Brian J Goodfellow, Isabel M Carreira, João Bernardo, Ana Gomes, Vitor Sousa, Lina Carvalho, Iola F Duarte
http://www.uc.pt/en/congressos/16ICHSCR | 16chscr@uc.pt
SCIENTIFIC PROGRAM
DDAAYY 11 Sunday, 26 September 2010
09H00−09H30 OOppeenniinngg CCeerreemmoonnyy Joseph Landolph (USA), Eliezer Huberman (USA), Maria Carmen Alpoim (Portugal) and Carlos de Oliveira (Portugal)
09H30−10H30
OOppeenniinngg LLeeccttuurree Curtis Harris, Laboratory of Human Carcinogenesis, National Cancer Institute, Bethesda, MD, USA
Interweaving p53, Innate Immune and MicroRNA Networks in Human Carcinogenesis and Molecular Epidemiology
10H30−11H00 Coffee Break
SSeessssiioonn 11 –– CCaanncceerr EEttiioollooggyy aanndd EEppiiddeemmiioollooggyy
11H00−11H30 Herman Autrup
School of Public Health, University of Aarhus, Aarhus, Denmark
Gene-environment Interaction in Cancer Development
11H30−12H00
Aage Haugen Section of Toxicology, National Institute of Occupational Health, Oslo,
Norway Institute of Biotechnology, Norwegian University of Science and
Technology, Trondheim, Norway
Gene Variants and Lung Cancer Risk
12H00−12H30
Richard Gallagher Cancer Control Research, British Columbia Cancer Agency,
Vancouver, BC, Canada School of Population and Public Health, University of British Columbia,
Vancouver, BC, Canada
Polychlorinated Biphenyls (PCB), UV Radiation, and Cutaneous Malignant Melanoma
12H30−14H00 Lunch
SSeessssiioonn 22 −− MMoolleeccuullaarr CCaarrcciinnooggeenneessiiss
14H00−14H30 Anatoly Zhitkovich
Department of Pathology and Laboratory Medicine, Division of Biology and Medicine, Brown University, Providence, RI, USA
Regulation of DNA Damage Responses by Mismatch Repair
14H30−15H00
Joseph Landolph
Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
School of Pharmacy, University of Southern California, CA, USA
USC/Norris Comprehensive Cancer Center, University of Southern California, CA, USA
Insoluble Ni Compound-induced Gene Amplification/Gene Silencing Causes Over-expression of Microtubules/Microfilaments, Cell Shape Changes, and Deregulation of Global Gene Expression/Ca
2+
Gradients, Inducing Morphological/Neoplastic Transformation of 10T1/2 Mouse Embryo Cells
15H00−15H30
José Manuel Cuezva
Centro de Biología Molecular “Severo Ochoa”, Universidad Autónoma de Madrid, Spain
CIBER de Enfermedades Raras, Instituto de Salud Carlos III, Universidad Autónoma de Madrid, Madrid, Spain
The Bioenergetic Signature of Cancer
15H30−16H00 Coffee Break
16H00−16H30
Robert Langenbach
Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA
Roles of Beta-arrestin1/2 in Prostaglandin-mediated Signaling and Tumor Development
16H30−17H00 Nam-ho Huh
Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
PINK1/BRPK Inhibits Apoptotic Cell Death and Enhances Cellular Invasiveness Through an Activation of mTORC2 Pathway
17H00−17H30 Johan Lillehaug
Department of Molecular Biology, University of Bergen, Bergen, Norway
Receptor for Activated C-Kinase (RACK1) Plays a Central Role in Ras-mediated Signal Transduction
DDAAYY 22 Monday, 27 September 2010
SSeessssiioonn 33 −− TTuummoorr MMiiccrrooeennvviirroonnmmeenntt aanndd TTuummoorr CCeellll BBiioollooggyy
09H00−09H30 Raghu Kalluri
Harvard Medical School, Harvard University, Boston, MA, USA Beth Israel Deaconess Medical Center, Boston, MA, USA
The Role of Fibroblasts and Pericytes in Cancer Progression and Metastasis
09H30−10H00
Sérgio Dias
Centro de Investigação em Patobiologia Molecular (CIPM), Portuguese Institute of Oncology (IPOFG), Lisbon, Portugal
Instituto Gulbenkian de Ciência, Oeiras, Portugal
Metabolism and Metastasis: In the Bone Marrow and Beyond
10H00−10H30
Magnus von Knebel Doeberitz
Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany
Clinical Cooperation Unit, Applied Tumor Biology (G105), German Cancer Research Center (DKFZ), Heidelberg, Germany
The Immune Biology of Microsatellite Unstable Cancer
10H30−11H00 Coffee Break
11H00−11H30
Wei Li
Department of Dermatology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
USC-Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA
Targeting Secreted Heat Shock Protein-90alpha (Hsp90α) to Prevent Breast Cancer Progression
11H30−12H00
Ana Costa-Pereira
Division of Cancer, Department of Surgery and Cancer, Faculty of Medicine, Imperial College, London, UK
Hammersmith Hospital, London, UK
JAKs and STATs in Chemoresistance
12H00−12H30 Geir Bjørkøy
AFT, Sør-Trøndelag University College (HiST), Trondheim, Norway
Autophagy Turns Specific: The Discovery of p62 and NBR1 as Autophagy Cargo Receptors
12H30−14H00 Lunch
SSeessssiioonn 44 −− CCaanncceerr GGeenneettiiccss aanndd EEppiiggeenneettiiccss
14H00−14H30 Joana Paredes
Cancer Genetics Group, Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
CDH3/P-Cadherin Overexpression in Breast Carcinomas: Its Regulatory Mechanisms, the Role in Cell Invasion, and the Association With Cancer Stem Cell Properties
14H30−15H00 Yoshinori Murakami
Division of Molecular Pathology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
Spontaneous Development of Lung Adenocarcinoma in the Cadm1 Gene-Deficient Mice
15H00−15H30 Manfred Schwab
German Cancer Research Center (DKFZ), Heidelberg, Germany
The FRAGILOME Project, a Strategy for the Discovery of New Gene Biomarkers in Cancer
15H30−16H00 Coffee Break
16H00−16H30
Sergei Kovalenko
Laboratory of Gene Engineering, Institute of Molecular Biology and Biophysics, Academy of Medical Sciences, Siberian Branch, Novosibirsk, Russia
Novosibirsk State University, Novosibirsk, Russia
Gene Amplification in Breast Cancer Cells: Molecular Mechanisms and Possible Prognostic Value
16H30−17H00
Lyudmila Gulyaeva
Laboratory of Molecular Carcinogenesis, Institute of Molecular Biology and Biophysics, Russian Academy of Medical Sciences, Siberian Division, Novosibirsk, Russia
Medical Department, Novosibirsk State University, Novosibirsk, Russia
Molecular Genetic Study of Female Cancers in Novosibirsk, Russia
17H00−17H30 Raquel Seruca
Cancer Genetics Group, Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal
E-Cadherin Mediated Cellular Effects and Molecular Partners. Gastric Cancer as an Invasive Model
DDAAYY 33 Tuesday, 28 September 2010
SSeessssiioonn 55 −− TTrraannssllaattiioonnaall CCaanncceerr MMeeddiicciinnee
09H00−09H30 Karl-Heinrich Link
Surgical Center and Asklepios Tumor Treatment Center Rhein-Main (ATC), Asklepios Paulinen Klinik (APK), Wiesbaden, Germany
Quality Control in Colon and Rectal Cancer Surgery
09H30−10H00 Kevin Brindle
Department of Biochemistry, University of Cambridge, UK Cancer Research UK, Cambridge Research Institute, Cambridge, UK
Detecting Tumour Responses to Treatment Using Hyperpolarized 13
C Magnetic Resonance Spectroscopic Imaging
10H00−10H30 Marko Kornmann
Hospital for General, Visceral and Transplantation Surgery, Ulm University, Ulm, Germany
Tumor-tailored Treatment of Colorectal Cancer: From Bench to Bedside?
10H30−11H00 Coffee Break
11H00−11H30 João Nuno Moreira
Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal Centre for Neurosciences and Cell Biology, Coimbra, Portugal
Targeting Non-viral Vectors to Tumor Cells and the Tumor Microenvironment
11H30−12H00 Ludger Staib
Department of General and Visceral Surgery, Klinikum Esslingen, Esslingen, Germany
Adjuvant Therapy in Colorectal Cancer – Studies of the FOGT Group
12H00−12H30
Carlos Caldas
Department of Oncology, University of Cambridge, Cambridge, UK Cambridge Experimental Cancer Medicine Centre, Cambridge, UK Cancer Research UK, Cambridge Research Institute, Cambridge
Breast Cancer Research Unit, Cambridge, UK NIHR Cambridge Biomedical Research Centre, Cambridge, UK
'Omic' Landscapes of Breast Cancer – The End of the Beginning
12H30−13H00 Ananda M. Chakrabarty
Department of Microbiology & Immunology, University of Illinois College of Medicine, Chicago, IL, USA
Bacterial Anticancer Weapons: A Promising Tool to Fight Cancer
13H00−14H30 Lunch
Afternoon Half-day Tour
Committees
Symposium Chairs
Carlos Freire de Oliveira (Portugal), Eli Huberman (USA), Joseph Landolph (USA), Maria Carmen Alpoim (Portugal)
Local Organizing Committtee
Ana Castro Jardim (FMUC), Ana Daniela Sampaio (FCTUC), Ana Margarida Urbano (FCTUC), António Jorge Guiomar (FCTUC), Armando Cristovão (FCTUC), Carlos Freire de Oliveira (FMUC), Isabel Maria Abrantes (FCTUC), Isabel Marques Carreira (FMUC), Joana Felício Cerveira (FCTUC), Leonardo Manuel Ferreira (FCTUC), Luís Miguel Pires (FMUC), Maria Carmen Alpoim (FCTUC), Maria Filomena Botelho (FMUC), Marta Pinto Coelho (FMUC), Paula Vasconcelos Morais (FCTUC)
Local Programme Committee
Ana Margarida Urbano (FCTUC), Carlos Freire de Oliveira (FMUC), Isabel Marques Carreira (FMUC), Maria Carmen Alpoim (FCTUC), Maria Filomena Botelho (FMUC), Paula Vasconcelos Morais (FCTUC)
International Advisory Committee
Eli Huberman (USA), Johan Lillehaug (Norway), Joseph Landolph (USA), Karl Heinrich Link (Germany), Robert Langenbach (USA), Toshio Kuroki (Japan)
Symposium Executive Committee
Eli Huberman (USA), Johan Lillehaug (Norway), Joseph Landolph (USA), Karl Heinrich Link (Germany)
Secretariat
Ana Paula Parreira
Acknowledgements
The Organization of the 16th International Charles Heidelberger Symposium on Cancer Research acknowledges the support of:
• FCTUC (Faculdade de Ciências e Tecnologia da Universidade de Coimbra)
• CIUC (Centro de Informática da Universidade de Coimbra)
• DIIC-UC (Divisão de Identidade, Imagem e Comunicação da Universidade de Coimbra)
• Turismo de Coimbra
• Turismo Centro de Portugal
• Bentham Science Publishers
LIST OF PARTICIPANTS
AUSTRALIA
Stewart, Bernard W. SE Sydney Public Health Unit, Sidney, Australia Bernard.Stewart@sesiahs.health.nsw.gov.au
AUSTRIA
Dudás, Jozséf Medical University Innsbruck, ENT-Clinic, Innsbruck, Austria jozsef.dudas@i-med.ac.at
CANADA
Gallagher, Richard P. Cancer Control Research Program, British Columbia Cancer Agency, Vancouver, BC, Canada; School of Population and Public Health, University of British Columbia; Vancouver, BC, Canada rgallagher@bccrc.ca
CZECH REPUBLIC
Mejsnar, George A. Cytolab Ltd, Praha, Czech Republic fawna.cytolab@seznam.cz
DENMARK
Autrup, Herman School of Public Health, University of Aarhus, Aarhus, Denmark ha@mil.au.dk
GERMANY
von Knebel Doeberitz, Magnus Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany, and Clinical Cooperation Unit, Applied Tumor Biology (G105), German Cancer Research Center (DKFZ), Heidelberg, Germany knebel@med.uni-heidelberg.de
Kornmann, Marko Department of General, Visceral, and Transplantation Surgery, University of Ulm, Ulm, Germany marko.kornmann@uniklinik-ulm.de
Link, Karl-Heinrich Surgical Center and Asklepios Tumortreatment Center Rhein-Main (ATC), Asklepios Paulinen Klinik (APK), Wiesbaden, Germany k-h.link@asklepios.com
Schwab, Manfred German Cancer Research Center (DKFZ), Heidelberg, Germany m.schwab@dkfz-heidelberg.de
Staib, Ludger Department of General and Visceral Surgery, Klinikum Esslingen, Esslingen, Germany l.staib@klinikum-esslingen.de
IRAN
Forghanifard, Mohammad M. Islamic Azad University, Damghan, Iran forghanifard@gmail.com
ITALY
Colombo, Francesca Fondazione IRCCS Istitito Nazionale Tumori, Milan, Italy francesca.colombo@istitutotumori.mi.it
Frullanti, Elisa Fondazione IRCCS Istitito Nazionale Tumori, Milan, Italy elisa.frullanti@istitutotumori.mi.it
Landriscina, Matteo University of Foggia, Department of Medical Sciences, Clinical Oncology Unit, Foggia, Italy m.landriscina@unifg.it
JAPAN
Huh, Nam-ho Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan namu@md.okayama-u.ac.jp
Kuroki, Toshio University of Tokyo, Research Center for Science Systems t96tree@yahoo.co.jp
Murakami, Yoshinori Division of Molecular Pathology, Institute of Medical Science, University of Tokyo,Tokyo, Japan ymurakam@ims.u-tokyo.ac.jp
NORWAY
Bjørkøy, Geir AFT, Sør-Trøndelag University College (HiST), Trondheim, Norway University College of Sør-Trøndelag; University of Tromsø, Norway geir.bjorkoy@hist.no
Haugen, Aage Section of Toxicology, National Institute of Occupational Health, Oslo Norway; Institute of Biotechnology, Norwegian University of Science and Technology, Trondheim, Norway age.haugen@stami.no
Lillehaug, Johan R. Department of Molecular Biology, University of Bergen, Bergen, Norway johan.lillehaug@mbi.uib.no
POLAND
Bukowska, Agnieszka Noffer Institute of Occupational Medicine, Lodz, Poland bukowska@imp.lodz.pl
Reszka, Edyta Noffer Institute of Occupational Medicine, Lodz, Poland edyta@imp.lodz.pl
PORTUGAL
Abrantes, Ana M. Biophysics/Biomathematics Institute, IBILI, Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal mabrantes@ibili.uc.pt
Abrantes, Isabel M. Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia da Universidade de Coimbra, Coimbra, Portugal isabel.abrantes@zoo.uc.pt
Alarcão, Ana
Instituto de Anatomia Patológica - Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal amalarcao@fmed.uc.pt
Alpoim, Maria C. Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia da Universidade de Coimbra, Coimbra, Portugal mcalpoim@gmail.com
Alves, Susana M. Serviço de Genética Médica da Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal su_alves_21@hotmail.com
Arantes, Regina M. Department of Veterinary Sciences, CECAV, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal arantesregina@hotmail.com
Araújo, Ana M. Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal anamfa@gmail.com
Batista, Joana P. Faculdade de Ciências e Tecnologia da Universidade de Coimbra, Coimbra, Portugal juananevesbatista@gmail.com
Batista de Carvalho, Ana Molecular Physical-Chemistry R&D Unit, Faculty of Sciences and Technology, University of Coimbra, Coimbra, Portugal almbc@ci.uc.pt
Borralho, Pedro M. Research Institute for Medicines and Pharmaceutical Sciences (iMed.UL), Faculty of Pharmacy of the University of Lisbon (FFUL), Lisbon, Portugal borralho@ff.ul.pt
Botelho, Maria F. Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal filomena@ibili.uc.pt
Brito, Ana F. Biophysics/Biomathematics Institute; Faculty of Medicine; University of Coimbra, Coimbra, Portugal. anabrito816@gmail.com
Burgeiro, Ana A. CNC - Centro de Neurociências e Biologia Celular, Coimbra, Portugal ana_burgeiro@hotmail.com
Carmo, Anália G. CNBC - Center for Neuroscience and Cell Biology, Coimbra, Portugal analiacarmo@gmail.com
Carrola, Joana Q. CICECO, Aveiro, Portugal joanacarrola@ua.pt
Carvalho, Filipa V. Medicine Faculty of the University of Coimbra, Coimbra, Portugal filipavcarvalho@gmail.com
Carvalho, João A. Faculty of Medicine of the University of Coimbra, Coimbra, Portugal andre_carvalho_7@hotmail.com
Carvalho, Lina M. Instituto de Anatomia Patológica, FMUC, Coimbra, Portugal lcarvalho@huc.min-saude.pt
Carvalho, M. João CIMAGO, Medicine Faculty of the University of Coimbra /Gynaecology Service, University Hospitals of Coimbra / Biophysics and Biomathematics Institute, IBILI, Medicine Faculty of Coimbra, Coimbra, Portugal mariaj.carvalho@sapo.pt
Carreira, Isabel M. Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal i_marques@hotmail.com
Cerveira, Joana F. Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia da Universidade de Coimbra, Coimbra, Portugal joanacerveira7@gmail.com
Coelho, Marta P. Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal mrt_pinto@yahoo.com
Cortesão, Emília N. University Hospitals of Coimbra/ACIMAGO, Coimbra, Portugal ecortesao@sapo.pt
Crespo, Ana I. Faculdade de Farmácia da Universidade de Coimbra, Coimbra, Portugal ines.r.crespo@gmail.com
Cristovão, Armando J. Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia da Universidade de Coimbra, Coimbra, Portugal ajamc@zoo.uc.pt
Cruz, Rui S. College of Health Technologies of Coimbra, Coimbra, Portugal ruic@estescoimbra.pt
Dias, Mafalda M. Molecular Physical-Chemistry R&D Unit, University of Coimbra, Coimbra, Portugal mafaldamdias@gmail.com
Dias, Sérgio Angiogenesis Laboratory, Centro de Investigação em Patobiologia Molecular (CIPM), Portuguese Institute of Oncology (IPOFG), and Instituto Gulbenkian de Ciência, Lisbon, Portugal. sergidias@ipolisboa.min-saude.pt
Dourado, Marília A. Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal mdourado@fmed.uc.pt
Escrevente, Cristina I. Instituto de Tecnologia Química e Biológica, Oeiras, Portugal cice@itqb.unl.pt
Ferreira, Ana L. Faculty of Medicine, University of Coimbra, Coimbra, Portugal alferreir@gmail.com
Ferreira, Leonardo M. Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia da Universidade de Coimbra, Coimbra, Portugal leonardo_m_r_ferreira@yahoo.com
Figueira, Ana C. Instituto de Ciências Biomédicas de Abel Salazar, Universidade do Porto (ICBAS-UP), Porto, Portugal acfigueira@gmail.com
Freitas, Mariana O. General Pathology Institute, Faculty of Medicine, University of Coimbra, Coimbra, Portugal freitas.mariana@gmail.com
Gomes, Ana I. Banco de Tumores, Hospitais da Universidade de Coimbra, Coimbra, Portugal anagomes@huc.min-saude.pt
Gomes, Célia M. Biophysics/Biomathematics Institute, IBILI, Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal cgomes@ibili.uc.pt
Gonçalves, Ana C. Medicine Faculty, Coimbra University, Coimbra, Portugal acgoncalves@fmed.uc.pt
Gonsalves, Raquel F. Molecular Physical-Chemistry R&D Unit, University of Coimbra, Coimbra, Portugal raquel.fg7@gmail.com
Guiomar, António J. Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia da Universidade de Coimbra, Coimbra, Portugal aguiomar@ci.uc.pt
Jardim, Ana C. Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal anacastrojardim@gmail.com
Ladeirinha, Ana F. Cytogenetics Laboratory and CNC, Faculty of Medicine, University of Coimbra, Coimbra, Portugal analadeirinha@gmail.com
Laranjo, Mafalda S. Biophysics/Biomathematics Institute, IBILI, Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal mafaldalaranjo@gmail.com
Lopes, Áurio O. Institute of Biophysics and Biomathematics - IBILI - FMUC, Coimbra, Portugal olopes10@hotmail.com
Lopes, João C. Biophysics/Biomathematics Institute, IBILI, Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal jelopes@fmed.uc.pt
Lopes, Maria C. Centro de Neurociências e Biologia Celular; Universidade de Coimbra; CIMAGO/FMUC, Coimbra, Portugal mcflopes@ibili.uc.pt
Maia, Cláudio J.
Universidade da Beira Interior, Covilhã, Portugal cmaia@fcsaude.ubi.pt
Matafome, Paulo N. Centro de Investigação em Meio Ambiente, Genética e Oncobiologia (CIMAGO), Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal paulomatafome@gmail.com
Mendes, Luís Faculdade de Ciências e Tecnologia, Universidade de Coimbra lalgm1988@gmail.com
Monteiro, Carolino J. Faculdade de Farmácia, Universidade de Lisboa, Lisboa, Portugal cm@ff.ul.pt
Morais, Paula V. Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia da Universidade de Coimbra, Coimbra, Portugal pvmorais@iav.uc.pt
Moreira, João N. Faculty of Pharmacy and Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal jmoreira@ff.uc.pt
Mota, Paula M. Instituto de Genética Médica, Faculdade de Medicina, Universidade de Coimbra, Coimbra, Portugal motapaula8@gmail.com
Mota-Pinto, Anabela Faculdade de Medicina da Unievsridade de Coimbra, Coimbra, Portugal apinto@fmed.uc.pt
Moura, Vera L. Centro de Neurociências e Biologia Celular, Coimbra, Portugal vdantasmoura@gmail.com
Nascimento-Costa, José Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal jncosta@fmed.uc.pt
Neves, Sara R. IBILI, Coimbra, Portugal sara.neves87@gmail.com
Neves, Sílvia S. ACIMAGO, Faculty of Medicine, University of Coimbra, Coimbra, Portugal ssneves@gmail.com
Nobre, Rui J. CNBC - Center for Neuroscience and Cell Biology, Coimbra, Portugal rui.jorge.nobre@gmail.com
Oliveira, Carlos F. Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal cmdf.deoliveira@gmail.com
Oliveira, Paula A. Department of Veterinary Sciences, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal pamo@utad.pt
Pais, Ana S. Faculty of Medicine of the University of Coimbra, Coimbra, Portugal anasofiaanasofia@gmail.com
Paredes, Joana Cancer Genetics Group, Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal jparedes@ipatimup.pt
Paulo, Judy V. Faculdade de Medicina da Universidade de Coimbra / IPO-FG Coimbra, Coimbra, Portugal judypaulo@gmail.com
Pedro, Dalila F. CBMA, Department of Biology, Minho University, Braga, Portugal daliped@hotmail.com
Pires, Luís M. Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal lmlmpires@gmail.com
Pissarro, Cristina A. Portuguese Oncology Institute, Coimbra, Portugal cristina.azv@gmail.com
Prazeres, Hugo IPATIUP, Porto, Portugal hugo.prazeres@gmail.com
Remédio, Leonor V. CIPM, IPOLFG, EPE, Lisbon, Portugal leonor.remedio@gmail.com
Ribeiro, Ana S. IPATIMUP, Porto, Portugal aribeiro@ipatimup.pt
Ribeiro, André B. Faculdade de Medicina, Universidade de Coimbra, Coimbra, Portugal andre.barbosa.ribeiro@gmail.com
Rocha, Cláudia M. CICECO, Aveiro, Portugal claudia.rocha@ua.pt
Rodrigues, Vítor L. Faculdade de Medicina, Universidade de Coimbra, Coimbra, Portugal vrodrigues@netcabo.pt
Sampaio, Ana D. Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia da Universidade de Coimbra, Coimbra, Portugal anocasampaio@hotmail.com
Santos, Ana T. Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal anateresasantos@ci.uc.pt
Santos, Catarina G. Hospitais da Universidade de Coimbra (HUC), Coimbra, Portugal catarinageraldes@hotmail.com
Santos, Nuno R. IBB/CBME, Universidade do Algarve, Faro, Portugal nrsantos@ualg.pt
Santos, Rui C. Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal rui.mcsantos@gmail.com
Sarmento-Ribeiro, Ana B. CIMAGO, Faculty of Medicine, University of Coimbra, Coimbra, Portugal absarmento@fmed.uc.pt
Serpa, Jacinta Grupo de Angiogénese-CIPM-Instituto Português de Oncologia de Lisboa Francisco Gentil, EPE, Lisboa, Portugal jacinta.serpa@gmail.com
Seruca, Raquel Cancer Genetics Group, Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal rseruca@ipatimup.pt
Severino, Paulo F. Departamento de Imunologia da Faculdade de Ciências Médicas da Universidade Nova de Lisboa, Lisboa, Portugal paulo.severino@fcm.unl.pt
Silva, Daniela S. CIMAGO, Faculty of Medicine, University of Coimbra, Coimbra, Portugal diss_12@hotmail.com
Silva, Fernanda Faculdade de Ciências Médicas da Universidade Nova de Lisboa, Lisboa, Portugal fs.fernandasilva.fs@gmail.com
Silva, Henriqueta C. Genetic Department, Faculty of Medicine, University of Coimbra, Coimbra, Portugal hsilva@fmed.uc.pt
Silva, Joana B. Faculty of Medicine of the University of Coimbra, Coimbra, Portugal joanabalca.silva@gmail.com
Silva, Lígia C. Center for Neuroscience and Cell Biology, Coimbra, Portugal ligia.cgs@gmail.com
Silva, Maria R. Instituto de Anatomia Patológica, Faculdade de Medicina da Universidade de Coimbra (FMUC), Coimbra, Portugal mrsilva@fmed.uc.pt
Sobral, Abílio J. Chemistry Department, Faculty of Sciences and Technology of the University of Coimbra, Coimbra, Portugal asobral@ci.uc.pt
Socorro, Sílvia M. Universidade da Beira Interior, Covilhã, Portugal ssocorro@fcsaude.ubi.pt
Sousa, Vítor M. Faculty of Medicine of the University of Coimbra, Coimbra, Portugal vitorsousa77@netcabo.pt
Urbano, Ana M. Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia da Universidade de Coimbra, Coimbra, Portugal amurbano@ci.uc.pt
REPUBLIC OF KOREA
Kim, Ji-hyun Department of Life and Nanopharmaceutical Science, Kyung-hee University, Seoul, Republic of Korea erica32@hanmail.net
Yang, Yeong-in Department of Life and Nanopharmaceutical Science, Kyung-hee University, Seoul, Republic of Korea juin601@naver.com
RUSSIA
Gulyaeva, Lyudmila M. Laboratory of Molecular Carcinogenesis, Institute of Molecular Biology and Biophysics, Russian Academy of Medical Sciences, Siberian Division, Novosibirsk, Russia; Medical Department, Novosibirsk State University, Novosibirsk, Russia gulyaeva@soramn.ru
Kovalenko, Sergei Laboratory of Gene Engineering, Institute of Molecular Biology and Biophysics, Academy of Medical Sciences, Siberian Branch, Novosibirsk, Russia; Novosibirsk State University, Novosibirsk, Russia skoval@sibmail.ru
SPAIN
Cuezva, José M. Centro de Biología Molecular Severo Ochoa, CIBER de Enfermedades Raras, ISCIII Universidad Autónoma de Madrid, Madrid, Spain jmcuezva@cbm.uam.es
UNITED KINGDOM
Brindle, Kevin M. Department of Biochemistry, University of Cambridge, UK; Cancer Research UK Cambridge Research Institute, Cambridge, UK kmb1001@cam.ac.uk
Caldas, Carlos Department of Oncology, University of Cambridge, Cambridge, UK; Cambridge Experimental Cancer Medicine Centre, Cambridge, UK; Cancer Research UK Cambridge Research Institute; Cambridge Breast Cancer Research Unit; NIHR Cambridge Biomedical Research Centre, Cambridge, UK cc234@cam.ac.uk
Costa-Pereira, Ana Division of Cancer, Department of Surgery and Cancer, Faculty of Medicine, Imperial College, London, UK; Hammersmith Hospital, London, UK a.costa-pereira@imperial.ac.uk
Sapienza, Karen Institute of Cancer, Department of Tumour Biology, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK k.sapienza@qmul.ac.uk
THE NETHERLANDS
Pedrosa, Lília R. Erasmus MC, Rotterdam, The Netherlands l.cordeiropedrosa@erasmusmc.nl
UNITED STATES OF AMERICA
Chakrabarty, Ananda M. Department of Microbiology & Immunology, University of Illinois College of Medicine, Chicago, IL, USA pseudomo@uic.edu
Harris, Curtis C. Laboratory of Human Carcinogenesis, National Cancer Institute, Bethesda, MD, USA curtis@harris@nih.gov
Huberman, Eliezer NovaDrug, Chicago, IL, USA and School of Pharmacy University of Illinois in Chicago, IL, USA huberman@prodigy.net
Jurka, Elzbieta Peninsula Pathologists Medical Group, San Francisco, USA ejurka@gmail.com
Kalluri, Raghu Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA, USA rkalluri@bidmc.harvard.edu
Landolph, Joseph Cancer Research Laboratory, USC Cancer Center, Departments of Molecular Microbiology/Immunology and Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA landolph@usc.edu
Langenbach, Robert Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA langenb1@niehs.nih.gov
Li, Wei Department of Dermatology and the USC-Norris Comprehensive Cancer Center, the University of Southern California Keck School of Medicine, Los Angeles, CA, USA wli@usc.edu
Samaniego, Felipe UT M.D. Anderson Cancer Center, Houston, USA lesmith1@mdanderson.org
Simões, Rui V. Memorial Sloan-Kattering Cancer Center, New York, USA simoesr@mskcc.org
Zhitkovich, Anatoly Department of Pathology and Laboratory Medicine, Division of Biology and Medicine, Brown University, Providence, RI, USA anatoly_zhitkovich@brown.edu
Volume 4 Supplement 2September 2010
BMCProceedings
Abstracts of the 16th International Charles Heidelberger
Symposium on Cancer Research
Coimbra, Portugal26-28 September 2010
Committees
The Organization of the 16th International Charles Heidelberger Symposium on Cancer Research acknowledges the support of:• FCTUC (Faculdade de Ciências e Tecnologia da Universidade de Coimbra)• CIUC (Centro de Informática da Universidade de Coimbra)• DIIC-UC (Divisão de Identidade, Imagem e Comunicação da Universidade de Coimbra)• Turismo de Coimbra• Turismo Centro de Portugal• Bentham Science Publishers
International Advisory Committee
Eli Huberman (USA)Johan Lillehaug (Norway)Joseph Landolph (USA)Karl Heinrich Link (Germany)Robert Langenbach (USA)Toshio Kuroki (Japan)
Symposium Executive Committee
Eli Huberman (USA)Johan Lillehaug (Norway)Joseph Landolph (USA)Karl Heinrich Link (Germany)
Secretariat
Ana Paula Parreira
Symposium Chairs
Carlos Freire de Oliveira (Portugal) Joseph Landolph (USA)Eli Huberman (USA) Maria Carmen Alpoim (Portugal)
Local Organizing Committee
Ana Castro Jardim (FMUC) Joana Felício Cerveira (FCTUC)Ana Daniela Sampaio (FCTUC) Leonardo Manuel Ferreira (FCTUC)Ana Margarida Urbano (FCTUC) Luís Miguel Pires (FMUC)António Jorge Guiomar (FCTUC) Maria Carmen Alpoim (FCTUC)Armando Cristovão (FCTUC) Maria Filomena Botelho (FMUC)Carlos Freire de Oliveira (FMUC) Marta Pinto Coelho (FMUC)Isabel Maria Abrantes (FCTUC) Paula Vasconcelos Morais (FCTUC)Isabel Marques Carreira (FMUC)
Local Programme Committee
Ana Margarida Urbano (FCTUC) Maria Carmen Alpoim (FCTUC)Carlos Freire de Oliveira (FMUC) Maria Filomena Botelho (FMUC)Isabel Marques Carreira (FMUC) Paula Vasconcelos Morais (FCTUC)
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Volume 4 Supplement 2September 2010
BMCProceedings
Contents
Opening Lecture
O1 Inflammation, senescence and cancer: interweaving microRNA, inflammatory cytokines and p53 networksCurtis C. Harris
Session 1 - Cancer Etiology and Epidemiology
O2 Gene-environment in the induction of cancerHerman Autrup
O3 Gene variants and lung cancer riskNina E Landvik, Shanbeh Zienolddiny, Vidar Skaug, Aage Haugen
O4 Polychlorinated biphenyls (PCB), UV radiation, and cutaneous malignant melanomaRichard P Gallagher, Tim K Lee, Jean-Philippe Weber, Alain Leblanc, Marilyn Borugian, J Mark Elwood, Amy C MacArthur, Zenaida Abanto, John J Spinelli
P1 Abstract not submitted for publishing
P2 Association between night shift work, melatonin and estradiol in nursesBeata Peplonska, Agnieszka Bukowska, Jolanta Gromadzinska, Wojciech Sobala, Edyta Reszka, Jenny A S Lie
P3 Mastermind-like 1 (MAML-1) as a new metastatic marker in esophageal squamous cell carcinomaMohammad M Forghanifard, Moein Farshchian, Reza Raeisossadati, Mohammad N Forghani, Meysam Moghbeli, Hussein Naseh, Mohammad R Abbaszadegan
P4 Polymorphisms of GSTM1, GSTT1, GSTP1 and CYP1A1 genes and susceptibility to lung cancerPaula Mota, Michelle Horta, Luis Mesquita, Henriqueta Silva
P5 Obesity and breast cancer: inflammatory and adipocytokine correlations
Paulo C Matafome, Ana L Gomes, Manuel Gomes, Lélita C Santos, Ana B Sarmento, Raquel F Seiça
P6 Polymorphisms of estrogen receptors, ERα and GPR30: association with breast cancer susceptibility and prognosisSusana M Alves, Luís Mesquita, Rita Sousa, Fátima Peralta, Henriqueta C Silva
P7 Breast cancer and environmental factorsJ Vicente Paulo, Lélita Santos, Graça Fernandes
P8 Primary bone lymphomaC Pissarro C Azevedo, P José A F F Tavares, M Isabel P Portela, A José L C P Santos, J Manuel P S Casanova
Session 2 - Molecular Carcinogenesis
O5 Regulation of DNA damage responses by mismatch repairAnatoly Zhitkovich
O6 Insoluble Ni compound-induced gene amplification/gene silencing causes over-expression of microtubules/microfilaments, cell shape changes, and de-regulation of global gene expression/Ca+2 gradients, inducing morphological/ neoplastic transformation of 10T1/2 mouse embryo cellsJoseph Landolph, Aruni DeSilva, Duy Mai, Jim K. Lin, Jimmy Zheng
Volume 4 Supplement 2September 2010
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Contents
O7 The bioenergetic signature of cancerJosé M. Cuezva
O8 Roles of beta-arrestin1/2 in prostaglandin-mediated signaling and tumor developmentRobert Langenbach, Huei-Chen Lao, Kyung-Soo Chun
O9 PINK1/BRPK inhibits apoptotic cell death and enahances cellular invasiveness through an activation of mTORC2 pathwayHitoshi Murata, Masakiyo Sakaguchi, Ken Kataoka, Nam-ho Huh
O10 Receptor for activated C-kinase (RACK1) plays a central role in Ras-mediated signal transductionJohan R Lillehaug, Line M Myklebust, Arnt Raae, Bodil Bjørndal
P9 The role of CD26 and CD40 expression in therapeutic response - experimental study in oral cancer linesJoana P N Batista, Sílvia S Neves, A Cristina Gonçalves, Vera Alves, Ana Sarmento-Ribeiro, Marília Dourado
P10 Abstract not submitted for publishing
P11 Evaluation of the role of miR-34b in modulation of radioresistance in non-small cell lung cancerJoana B Silva, Sílvia S Neves, A Cristina Gonçalves, Margarida Marques, Luís Mesquita, Filomena Botelho, A Bela Sarmento-Ribeiro, Henriqueta C Silva
P12 P-cadherin expression in feline mammary tissuesA Catarina Figueira, Júlio Carvalheira, M Manuela Lacerda, M Fátima Gärtner
P13 Regucalcin, a calcium-binding protein, is a new target gene in human prostate cancer?Cláudio J Maia, Cátia V Vaz, Carina G Peres, Cecília R A Santos, Sílvia Socorro
P14 MicroRNA-21 in lung cancer: overexpression in metastasis of pulmonary adenocarcinomas and squamous cell carcinomasMaria R Silva, Paulo Santos, Isabel Velada, Catarina Gomes, M João d’Aguiar, Lia Teixeira, João Dinis, Susana Carmona, Luisa Cortes, Lina Carvalho
P15 Involvement of mitochondrial and survival signaling in berberine-induced apoptosis in melanoma cellsAna Burgeiro, Consuelo Gajate, El H Dakir, Paulo J Oliveira, Faustino Mollinedo
P16 Metabolic changes in human bronchial epithelial cells upon chronic exposure to hexavalent chromiumLeonardo M R Ferreira, Maria S Santos, M Carmen Alpoim, Ana M Urbano
P17 Cr(VI)-induced malignant transformation of a bronchial epithelial cell line association with altered mitochondria and bioenergetic phenotypesAna Sampaio, Luís Mendes, Ana C Gonçalves, Margarida Abrantes, Ana B Sarmento, Filomena Botelho, Paulo Oliveira, Vilma Sardão, Rui Carvalho, Ana M Urbano and M Carmen Alpoim
Session 3 - Tumor Microenvironment and Tumor Cell Biology
O11 Tumor Microenvironment Controls the Rate of Cancer Progression and MetastasisRaghu Kalluri
O12 Metabolism and metastasis: in the bone marrow and beyondSérgio Dias
O13 The Immune Biology of Microsatellite Unstable CancerMagnus von Knebel-Doeberitz
O14 Targeting secreted heat shock protein-90alpha (Hsp90α) to prevent breast cancer progressionZhengwei Zhao, Chieh-Fang Cheng, Rosie Kim, Mei Chen, David T Woodley, Wei Li
Volume 4 Supplement 2September 2010
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Contents
O15 JAKs and STATs in ChemoresistanceAna Costa-Pereira
O16 Autophagy turns specific: the discovery of p62 and NBR1 as autophagy cargo receptorsGeir Bjørkøy
P18 Abstract not submitted for publishing
P19 Abstract not submitted for publishing
P20 Relation between autophagy and the resistence of glioblastoma cells to temozolomideAnália Carmo, Helena Carvalheiro, Maria C Lopes
P21 GLUT expression and 18F-FDG uptake in breast cancer cell linesAna M Abrantes, Mónica Martins, Ana C Gonçalves, Maria C Rodrigues, Ana C Mamede, Sónia D Tavares, José M Lima, Adriano Rodrigues, Ana B Sarmento-Ribeiro, Maria F Botelho
P22 MDR modulation in colorectal adenocarcinoma cell lines: kinetic studies using 99mTc-sestamibiJoão Casalta-Lopes, A Margarida Abrantes, Joana Rio, Mafalda Laranjo, Bárbara Oliveiros, A Cristina Gonçalves, Ana B. Sarmento-Ribeiro, M. Filomena Botelho
P23 Phenotypic analysis of breast cell lines – triple negative cells vs expressing hormonal receptorsMafalda Laranjo, Maria J Carvalho, Artur Paiva, A Margarida Abrantes, Isabel Torgal, Carlos F Oliveira, M Filomena Botelho
P24 Abstract not submitted for publishing
P25 A nonconjugated naphthalene derivative of meso-tetra-(3-hydroxy)-phenyl-porphyrin as a sensitizer for photodynamic therapyAbílio J F N Sobral, Ana M Urbano, Pedro Silva, Sofia M Fonseca, Cláudia T Arranja, Hugh D Burrows
P26 Polyaromatic hydrocarbons accentuate malignant phenotype of the PC3 prostate cancer cell lineMariana O Freitas, José Oliveira, Ana M Fernandes, Maria I Coutinho, Vera Alves, Anabela Mota-Pinto, Ana B Sarmento-Ribeiro
P27 MGBG–cisplatin combination chemotherapy against breast cancerRaquel F Gonsalves, Maria P M Marques
P28 Melanoma skin cancer: could chromone derivatives be efficient chemopreventors?Mafalda M Dias, Maria P M Marques
P29 Exosomes from human ovarian carcinoma SKOV3 cells are enriched in glycosylated proteins Cristina Escrevente, Peter Altevogt, Júlia Costa
P30 Delocalized lipophilic cations as a new therapeutic approach in cancerA Barbosa Ribeiro, A Luísa Ferreira, A Cristina Gonçalves, Sílvia Neves, A Maria Araújo, Filipa Carvalho, João Carvalho, Rui M Santos, Vera Alves, Teresa Silva, José M Nascimento-Costa, Ana B Sarmento-Ribeiro
P31 Cytotoxic effect induced by combination of polyamines metabolites and endocannabinoid, anandamide, on human cancer cells: a new anticancer strategy A Lúcia M Batista-de-Carvalho, G Tempera, N Viceconte, S Saccoccio, E Bidollari, M Nalli, Enrico Morera, Giorgio Ortar, Enzo Agostinelli
P32 An in vitro tumor-fibroblast interaction model of human oral squamous cell carcinomaJozséf Dudás, M Bitsche, V Schartinger, G M Sprinzl, H Riechelmann
P33 Physiologic parameters variation in ICR mice during a chemical induced liver carcinogenesis experimentIvo Conceição-Pereira, Nuno M Paula-Santos, Filipa O Pereira, Maria J Pires, Luis F Palomino, Aura A Colaço, Paula A Oliveira
P34 Role of VEGF signalling in the regulation of KDR expression in endothelial and tumoral microenvironmentJacinta Serpa, Cheila Torre, Francisco Caiado, Sérgio Dias
Volume 4 Supplement 2September 2010
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Contents
P35 EP4-mediated prostanoid signalling promotes oral cancer progressionKaren Sapienza, Stewart Sale, Angela Hague, Ian.R. Hart, J.ohn F. Marshall, Gareth.J. Thomas
P36 Role of notch pathway and HNF1 in cell death induced by HDACs inhibitors in ovarian cancer cell lines, serous and clear cellsFernanda Silva, Jacinta Serpa, Germana Domingues, Gabriela Silva, António Almeida, Ana Félix
P37 TRAP1 and SORCIN cooperate in a survival pathway responsible for inducing drug-resistance in human colorectal carcinoma (CRC)Matteo Landriscina, Francesca Maddalena, Gabriella Laudiero, Maria R Amoroso, Annamaria Piscazzi, Valentina Lombardi, Alberto Fersini, Franca Esposito
P38 Dll4 blockade interferes with the bone marrow vascular niche and perturbs hematopoietic recovery following myeloablationLeonor Remédio, Tânia Carvalho, Sérgio Dias
P39 Short-chain sphingolipids for enhanced cellular uptake of liposome-encapsulated amphiphilic anti-cancer drugsLília R C Pedrosa, Albert van Hell, Wim van Blitterswijk, Ann L B Seynhaeve, Alexander M M Eggermont, Timo L M ten Hagen, Marcel Verheij, Gerben A Koning
P40 Osteosarcoma contains a subpopulation of cancer stem-like cells that are highly resistant to radiotherapySara R M Neves, Aurio O G Lopes, Anália do Carmo, Antero J Abrunhosa, Paulo C P S Simões, Artur A Paiva, M Filomena Botelho, Célia M F Gomes
P41 Indentification of cancer stem-like cells in osteosarcoma and their implications in response to chemotherapyÁurio O Lopes, Sara R Neves, Anália do Carmo, Artur A Paiva, Maria Botelho, Célia M Gomes
P42 Metabolic responses of A549 lung cells to cisplatin and radiation exposure studied by 1H NMR spectroscopyAna F Ladeirinha, Inês D Lamego, Ana M Gil, Joana B Melo, Isabel M Carreira, Iola F Duarte
P43 In vivo pulmonary metastatic profile of breast cancer cell lines expressing hormonal receptors versus triple negativeM João Carvalho, A Margarida Abrantes, Mafalda Laranjo, Francisco Falcão, Sofia Cabrita, M Filomena Botelho, Carlos F de Oliveira, Isabel Torgal
P44 New targeted therapies in myelodysplastic syndrome: the role of farnesyltransferase and proteasome inhibitorsA Cristina Gonçalves, Ana Oliveira, Diana Moreira, Silvia Neves, Vera Alves, Teresa Silva, Luís Mesquita, Henriqueta Coimbra, Marília Dourado, José M Nascimento-Costa, Ana B Sarmento-Ribeiro
P45 Targeted gene silencing for cancer treatmentLígia C G da Silva, José S Ramalho, M Conceição P de Lima, Sérgio Simões, João N Moreira
P46 Recombinant trail: a synergistic effect in myeloid leukemiasFilipa Carvalho, A Sofia Coelho, Cátia Domingues, João A Carvalho, André Ribeiro, Rui M Santos, A Cristina Gonçalves , Vera Alves, Teresa Silva, Marília Dourado, José M Nascimento-Costa, Ana B Sarmento-Ribeiro
P47 Co-expression of E- and P-cadherin in breast cancer: role as an invasion suppressor or as an invasion promoter?Ana S Ribeiro, Laura C Carreto, André Albergaria, Bárbara Sousa, Sara Ricardo, Fernanda Milanezi, Raquel Seruca, Manuel A Santos, Fernando Schmitt, J oanaParedes
P48 Contribution of Thomsen-Friedenreich antigens to bladder cancer malignancy: Characterization of cell line modelsPaulo F Severino, Mylène A Carrascal, Helena Gouveia, M Guadalupe Cabral, Manuela Correia, Nadia Malagolini, Mariella Chiricolo, Fabio Dall’Olio, Paula AVideira
P49 Antitumoral effect of farnesiltransferase and mtor inhibitors in hepatocellular carcinoma: in vitro studiesAna M Araújo, Sílvia S Neves, Ana L Ferreira, Diogo Branco, Ana B Sarmento-Ribeiro, José M Nascimento-Costa
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Contents
P50 Metalloproteinase inhibitors as a potential therapeutic approach in multiple myeloma: a preliminary studyA Sofia Pais, A Cristina Gonçalves, Catarina Geraldes, José M Nascimento-Costa, Ana B Sarmento-Ribeiro
P51 Novel antitumor DNA monoalkylating agents: Synthesis and biological evaluationAna F Brito, M Isabel Soares, Mafalda Laranjo, A Margarida Abrantes, José A Paixão, Ana M Beja, Manuela R Silva, Teresa P Melo, M Filomena Botelho
P52 The effect of cisplatin in 5637 bladder cancer cell lineRosário Pinto-Leite, Regina Arantes-Rodrigues, M Luís Cardoso, Lúcio Santos, Paula A Oliveira
Session 4 - Cancer Genetics and Epigenetics
O17 CDH3/P-cadherin overexpression in breast carcinomas: its regulatory mechanisms, the role in cell invasion, and the association with cancer stem cell propertiesJoana Paredes
O18 Spontaneous development of lung adenocarcinoma in the CADM1 gene-deficient miceMasayoshi Nagata, Mika Sakurai-Yageta, Daisuke Yamada, Taketo Kawai, Yumi Tsuboi, Takeshi Ito, Akihiko Ito, Midori Yoshida, Yoshinori Murakami
O19 The FRAGILOME project, a strategy for the discovery of new gene biomarkers in cancerManfred Schwab
O20 Gene amplification in breast cancer – looking for the molecular mechanismsSergei Kovalenko
O21 Molecular Genetic Study of Female Cancers in Novosibirsk, RussiaLyudmila F Gulyaeva
O22 E-cadherin mediated cellular effects and molecular partners. Gastric cancer as an invasive modelJoana Figueiredo, Joana Simões-Correia, Joana Fernandes, Ana R Mateus, Gianpaolo Suriano, Joana Paredes, Carla Oliveira, Raquel Seruca
P53 Identification of copy number variations of chromosomes 7, 9 and 10 in human glioblastomas by SNP-arraysInês Crespo, Maria D Tabernero, Ana B Nieto, Olinda Rebelo, Hermínio Tão, Fernando Gomes, Catarina R Oliveira, Maria C Lopes, Alberto Orfao
P54 Circadian gene variants and MT6s level in nurses under different work shifts – preliminary resultsEdyta Reszka, Beata Peplonska, Edyta Wieczorek, Jolanta Gromadzinska, Wojciech Sobala, Wojciech Wasowicz, Agnieszka Bukowska, Jenny A Lie
P55 MFSD2A is a novel lung tumour suppressor gene whose expression is modulated by a 5’-region polymorphismFrancesca Colombo, Monica Spinola, Felicia S Falvella, James P Sullivan, David S Shames, Luc Girard, Paola Spessotto, John D Minna, Tommaso A Dragani
P56 FGFR4 GLY388ARG polymorphism modulates cancer patients’ survival in pooled analysisElisa Frullanti, Tommaso A Dragani
P57 KRAS and EGFR mutations coexisting in lung adenocarcinomaVitor Sousa, Ana Alarcão, Patricia Couceiro, Maria R Silva, Maria J d’Aguiar, Lia Teixeira, Lina Carvalho
P58 Modulation of DNA damage prevention and signaling pathways in diet induced colon cancer preventionDalila F N Pedro, Alice A Ramos, Cristóvão F Lima, Fátima Baltazar, Cristina Pereira-Wilson
Volume 4 Supplement 2September 2010
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Contents
P59 MIR-143 over-expression reduces the growth of xenograft tumors from colon carcinoma cellsPedro M Borralho, Sofia Gomes, Raquel T Lima, Rui E Castro, Maria H Vasconcelos, Cecília M P Rodrigues
P60 Histone deacetylation - a new epigenetic target in cancer João A Carvalho, Emília Cortesão, José D Branco, Ana C Gonçalves, Sílvia Neves, Filipa Carvalho, André Ribeiro, Vera Alves, Teresa Silva, Marília Dourado, José M Nascimento-Costa, Ana B Sarmento-Ribeiro
P61 EGFR unusual mutation status in lung adenocarcinomasAna Alarcão, Vitor Sousa, Patrícia Couceiro, Maria Silva, Maria J. d’Aguiar, Lia Teixeira, Lina Carvalho
P62 Identification of a common deletion region in 10q26 associated with human gliomasMargarida Alves, Paulo Liberato, Ana Rita Conde, Manuela Mafra, Alexandra Inverno, Ana Teresa Maia, Denise Bagrel, Isabel Carreira, Miguel Brito, Carolino Monteiro
P63 STEAP1 expression in prostate cancer and its regulation by androgensInês Gomes, Cecília R A Santos, Sílvia Socorro, Carlos Lopes, Cláudio J Maia
P64 EGFR/erb-1, HER2/erb-2, CK7, LP34, Ki67 and p53 expression in preneoplastic lesions of bronchial epitheliumLina Carvalho, Joana E Santo, Ana Alarcão, Patricia Couceiro, Maria R Silva, Ana Gomes, Maria J d’Aguiar, Lia Teixeira, Vitor Sousa
Session 5 - Translational Cancer Medicine
O23 Quality control in colon and rectal cancer surgeryKarl-Heinrich Link
O24 Detecting tumor responses to treatment using hyperpolarized 13C magnetic resonance spectroscopic imagingKevin M Brindle
O25 Tumor-tailored treatment of colorectal cancer: from bench to bedside?Marko Kornmann
O26 Targeting non-viral vectors to tumor cells and the tumor microenvironmentVera Moura, Manuela Lacerda, Paulo Figueiredo, M Luísa Corvo, M Eugénia M Cruz, M Conceição P. de Lima, Sérgio Simões, João N Moreira
O27 Adjuvant therapy in colorectal cancer – studies of the FOGT groupLudger Staib, Marko Kornmann, Karl-Heinrich Link
O28 “Omic” landscapes of breast cancer - the end of the beginningCarlos Caldas
O29 Bacterial anticancer weapons: a promising tool to fight cancerAnanda M Chakrabarty
P65 Improving the classification of brain tumors in mice with perturbation enhanced (PE)-MRSIRui V Simões, Sandra Ortega-Martorell, Teresa Delgado-Goñi, Yann le Fur, Marti Pumarola, Ana P Candiota, Patrick J Cozzone, Margarida Juliá-Sapè, Carles Arús
P66 NMR metabonomic study of lung cancer: metabolic profiling of tissuesCláudia M Rocha, António S Barros, Ana M Gil, Brian J Goodfellow, Isabel M Carreira, João Bernardo, Ana Gomes, Vítor Sousa, Lina Carvalho, Iola F Duarte
P67 NMR metabonomic study of lung cancer: metabolic profiling of urine and blood plasmaJoana Carrola, Cláudia M Rocha, António S Barros, Ana M Gil, Brian J Goodfellow, Isabel M Carreira, João Bernardo, Ana Gomes, Vitor Sousa, Lina Carvalho, Iola F Duarte
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