Dr Matthew B. Avison, Senior Lecturer in MicrobiologySchool of Cellular & Molecular Medicine

AMR Collaborative Grants at the University of Bristol

AMR transmission in the real world.

• Dairy Farming uses a lot of cephalosporins.• Is there a link with AMR and can it be reversed?• Do dogs and people pick up E. coli from the environment?• Is there a link to UTIs caused by Cephalosporin Resistant

E. coli in humans?• And can this be reversed?

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AMR transmission in the real world.

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Driving Down Antibiotic Usage on Farms.

Proteomics to Identify AMR.6

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•Comparative proteomics to identify putative mechanisms of resistance. E.g. coming out of pK/pD models.

•Knockouts/over-expression studies to confirm involvement in AMR and relative importance.

•Surveys of clinical isolates to identify if novel AMR mechanism is present; how different mechanisms work together.

•Impact includes development of strain collections.

Identifying AMR Mechanisms.

8Finding New Antibiotic Lead Compounds

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