analyzing nchs drug data: nhanes and n/hamcs
DESCRIPTION
Analyzing NCHS Drug Data: NHANES and N/HAMCS. Amy B. Bernstein, Sc.D. Presented at the AcademyHealth Annual Research Meeting San Diego, California June 6, 2004. National Center for Health Statistics. Topics. Definition of “drug” Issues in drug utilization analyses Coding issues - PowerPoint PPT PresentationTRANSCRIPT
![Page 1: Analyzing NCHS Drug Data: NHANES and N/HAMCS](https://reader036.vdocument.in/reader036/viewer/2022081513/5681594b550346895dc688ea/html5/thumbnails/1.jpg)
Analyzing NCHS Drug Data:
NHANES and N/HAMCSAmy B. Bernstein, Sc.D.
Presented at the AcademyHealth Annual Research Meeting
San Diego, California
June 6, 2004
National Center for Health Statistics
![Page 2: Analyzing NCHS Drug Data: NHANES and N/HAMCS](https://reader036.vdocument.in/reader036/viewer/2022081513/5681594b550346895dc688ea/html5/thumbnails/2.jpg)
• Definition of “drug”
• Issues in drug utilization analyses
• Coding issues
• Examples of trend analyses
Topics
![Page 3: Analyzing NCHS Drug Data: NHANES and N/HAMCS](https://reader036.vdocument.in/reader036/viewer/2022081513/5681594b550346895dc688ea/html5/thumbnails/3.jpg)
Definition of “Drug”
NHANES
•A drug is defined as a unique combination of generic ingredients.
N/HAMCS
•Recorded on visit record and abstracted verbatim
![Page 4: Analyzing NCHS Drug Data: NHANES and N/HAMCS](https://reader036.vdocument.in/reader036/viewer/2022081513/5681594b550346895dc688ea/html5/thumbnails/4.jpg)
NHANES Drug Data
• All drugs used in the past month at time of survey interview
• Only prescription drugs are included, with a few exceptions
• Example:--penicillin--penicillin, clavulanate potassium
More closely approximates “prevalence” of use
![Page 5: Analyzing NCHS Drug Data: NHANES and N/HAMCS](https://reader036.vdocument.in/reader036/viewer/2022081513/5681594b550346895dc688ea/html5/thumbnails/5.jpg)
N/HAMCS Drug Data
• Up to six drugs recorded (until 2003)—possible biases for drugs that are not salient to the physician or patient (e.g., PRN drugs)
• Both prescription and non-prescription drugs are included
• No information is available on compliance or use
Approximates prescribing patterns of drugs associated with medical care visits
![Page 6: Analyzing NCHS Drug Data: NHANES and N/HAMCS](https://reader036.vdocument.in/reader036/viewer/2022081513/5681594b550346895dc688ea/html5/thumbnails/6.jpg)
Issues in Drug Utilization AnalysesNHANES
Strengths:• Nationally representative and
population-based
• Examination, laboratory and questionnaire data on conditions, biochemical markers, nutrition, health status, and other items
• Respondent-reported sociodemographic data (e.g., race and ethnicity are collected from respondent)
![Page 7: Analyzing NCHS Drug Data: NHANES and N/HAMCS](https://reader036.vdocument.in/reader036/viewer/2022081513/5681594b550346895dc688ea/html5/thumbnails/7.jpg)
Issues in Drug Utilization AnalysesNHANES
Possible Limitations:•Small sample size for less
frequently prescribed drugs and small population subgroups
• No trade names that help to determine therapeutic use on public use file
•Respondents may not report use of some drugs
![Page 8: Analyzing NCHS Drug Data: NHANES and N/HAMCS](https://reader036.vdocument.in/reader036/viewer/2022081513/5681594b550346895dc688ea/html5/thumbnails/8.jpg)
Issues in Drug Utilization AnalysesN/HAMCS
Strengths:
•Nationally representative
•Physician/hospital characteristics
•Conditions (from medical record—but limited number)
•Selected procedures and tests
•Relatively large sample size of visits
![Page 9: Analyzing NCHS Drug Data: NHANES and N/HAMCS](https://reader036.vdocument.in/reader036/viewer/2022081513/5681594b550346895dc688ea/html5/thumbnails/9.jpg)
Issues in Drug Utilization AnalysesN/HAMCS
Possible Limitations:• Limited sociodemographic data
• Race/ethnicity data are reported by provider, not patient
• Limited information on episodes or continuity of care
• No data on compliance or actual utilization
• Censoring of both drugs and diagnoses
• Drugs are recorded verbatim from visit records, with possible misspelling
![Page 10: Analyzing NCHS Drug Data: NHANES and N/HAMCS](https://reader036.vdocument.in/reader036/viewer/2022081513/5681594b550346895dc688ea/html5/thumbnails/10.jpg)
Issues in Drug Utilization AnalysesN/HAMCS
Factors influencing N/HAMCS counts of drugs:
• Person must have visited a physician or OPD
• The more visits made for a specific condition requiring a specific drug, the greater the count of that drug on the N/HAMCS
![Page 11: Analyzing NCHS Drug Data: NHANES and N/HAMCS](https://reader036.vdocument.in/reader036/viewer/2022081513/5681594b550346895dc688ea/html5/thumbnails/11.jpg)
Coding Drug DataInto Therapeutic Classes: Why?
Therapeutic classes are useful in determining trends in treatment because:
• There may be competing drugs that are used for the same condition
• Guidelines may suggest a class of drugs for treatment of a condition, not a specific drug
• There are too many individual drugs to analyze each individually!
Ideally, one wants to group “like” drugs together
![Page 12: Analyzing NCHS Drug Data: NHANES and N/HAMCS](https://reader036.vdocument.in/reader036/viewer/2022081513/5681594b550346895dc688ea/html5/thumbnails/12.jpg)
FDA’s National Drug Code (NDC) Therapeutic Classes
• Used by both N/HAMCS and NHANES on public use files
• Code set is nonproprietary and downloadable from the FDA website
• Identifies each of 20 major drug classes
• Two-digit categories are general and represent all sub-categories (e.g., 03, Antimicrobial agents)
• Specific four-digit categories represent the breakouts of the general category (e.g., 0346, Penicillins).
![Page 13: Analyzing NCHS Drug Data: NHANES and N/HAMCS](https://reader036.vdocument.in/reader036/viewer/2022081513/5681594b550346895dc688ea/html5/thumbnails/13.jpg)
Coding IssuesWith FDA’s National Drug Code (NDC)
Therapeutic Classes
Some therapeutic categories are based on indication, while others are based on chemical composition or chemical mechanism
--Examples:
NDC Class 1374/Anticonvlusants
or
NDC Class 1945/Cough and Cold remedies
or
NDC Class 0512/Beta Blocker
![Page 14: Analyzing NCHS Drug Data: NHANES and N/HAMCS](https://reader036.vdocument.in/reader036/viewer/2022081513/5681594b550346895dc688ea/html5/thumbnails/14.jpg)
• When using any therapeutic drug class codes, need to review the drugs that are included under that category.
• Ask yourself- “Is this the list of products I am interested in?”
• When using NAMCS/NHAMCS or NHANES, look at FDA’s therapeutic drug classes and each drug under those classes.
• Is the drug class coding sufficient for your research?
• If not, manually review drugs and recategorize using the generic name codes
FDA’s Therapeutic Drug FDA’s Therapeutic Drug Class CodesClass Codes
![Page 15: Analyzing NCHS Drug Data: NHANES and N/HAMCS](https://reader036.vdocument.in/reader036/viewer/2022081513/5681594b550346895dc688ea/html5/thumbnails/15.jpg)
Coding Issues
•Only generic ingredients provided on NHANES public use file, and some N/HAMCS drugs are reported as generic drugs (e.g., “aspirin”)
•“Main reason for use” is collected and coded into ICD-9-CM classification
• Some drugs have the same ingredients but different strengths, or different routes of administration that help determine therapeutic use
Examples: Asthma drugs
![Page 16: Analyzing NCHS Drug Data: NHANES and N/HAMCS](https://reader036.vdocument.in/reader036/viewer/2022081513/5681594b550346895dc688ea/html5/thumbnails/16.jpg)
Coding IssuesChanges Over Time
•N/HAMCS 1980-2001: one NCD therapeutic class on PUF for each drug recorded
•N/HAMCS 2002-2006: up to three NCD therapeutic classes on PUF for each drug recorded
•NHANES 1988-94: three NDC therapeutic classes on PUF for each drug reported
•NHANES 1999-2000: six NDC therapeutic classes on PUF for each drug reported
![Page 17: Analyzing NCHS Drug Data: NHANES and N/HAMCS](https://reader036.vdocument.in/reader036/viewer/2022081513/5681594b550346895dc688ea/html5/thumbnails/17.jpg)
Coding IssuesChanges Over Time
• Approved indications for drugs change over time (added or subtracted)
• “Major” uses for drugs with multiple therapeutic uses change over time
• Drugs may be replaced by other similar drugs
• Codes and categories are periodically revised
• Codes do not reflect “off-label” use
![Page 18: Analyzing NCHS Drug Data: NHANES and N/HAMCS](https://reader036.vdocument.in/reader036/viewer/2022081513/5681594b550346895dc688ea/html5/thumbnails/18.jpg)
Coding IssuesChanges Over Time
•Because therapeutic indications change over timeAnalysts can merge the most current
classifications to drug data from previous years
Otherwise drugs may be classified differently in different data years
This is less of an issue when analyzing specific drugs
![Page 19: Analyzing NCHS Drug Data: NHANES and N/HAMCS](https://reader036.vdocument.in/reader036/viewer/2022081513/5681594b550346895dc688ea/html5/thumbnails/19.jpg)
Drugs Prescribed, Administered or Provided During Physician Office or OPD Visits, by NDC Therapeutic Drug Class,
1995-96 and 2001-02
0 5 1 0 1 5 2 0 2 5
a n t id e p r e s s a n t s
a n t ih is t a m in e s
a c id / p e p t ic d is o r d e r s
A C E in h ib it o r s
t h y r o id
p e n ic i l l in s
d r u g s p e r 1 0 0 p e r s o n s
1 9 9 5 - 9 6
2 0 0 1 - 0 2
SOURCE: Centers for Disease Control and Prevention, National Center for Health Statistics, National Ambulatory Medical Care Survey and National Hospital Ambulatory
Medical Care Survey.
![Page 20: Analyzing NCHS Drug Data: NHANES and N/HAMCS](https://reader036.vdocument.in/reader036/viewer/2022081513/5681594b550346895dc688ea/html5/thumbnails/20.jpg)
Coding IssuesMultiple Therapeutic Indications
• Do you allow drugs with multiple approved indications to be double counted?
• Example:Aspirin has multiple therapeutic uses.
• More of an issue when comparing or ranking categories than for analyses within a given therapeutic category
![Page 21: Analyzing NCHS Drug Data: NHANES and N/HAMCS](https://reader036.vdocument.in/reader036/viewer/2022081513/5681594b550346895dc688ea/html5/thumbnails/21.jpg)
Coding IssuesDrugs with Overlapping Classifications
in FDA NDC Therapeutic Classes• Aspirin:
1724 Antiarthritics
1722 Non-Narcotic analgesics
1728 Antipyretics
• Acetaminophen1722 Non-Narcotic Analgesics
1728 Antipyretics
• Ibuprofen1724 Antiarthritics
1722 Non-Narcotic Analgesics
1727 NSAID
• Toradol1720 General Analgesics
1722 Non-Narcotic Analgesics
1727 NSAID
• Celebrex1724 Antiarthritics
1727 NSAID
• Meloxicam1724 Antiarthritics
1727 NSAID
![Page 22: Analyzing NCHS Drug Data: NHANES and N/HAMCS](https://reader036.vdocument.in/reader036/viewer/2022081513/5681594b550346895dc688ea/html5/thumbnails/22.jpg)
Antidepressant Use in N/HAMCS and NHANES
0 1 0 2 0 3 0 4 0
M a l e
F e m a l e
v i s i t s p e r 1 0 0 p o p u la t io n
N /H A M C S 2 0 0 1 - 0 2
N /N A M C S 1 9 9 5 - 9 6
Sources: National Health and Nutrition Examination Surveys, National Ambulatory Medical Care Surveys and National Hospital Ambulatory Medical Care Surveys
0 5 1 0 1 5
M a l e
F e m a l e
P e r c e n t o f p o p u l a t i o n
N H A N E S 1 9 9 9 - 2 9 9 9
N H A N E S 1 9 8 8 - 9 4
![Page 23: Analyzing NCHS Drug Data: NHANES and N/HAMCS](https://reader036.vdocument.in/reader036/viewer/2022081513/5681594b550346895dc688ea/html5/thumbnails/23.jpg)
Cholesterol Drugs Prescribed, Administered Or Provided During Physician Office And
Outpatient Department Visits, By Age Group: United States, 1995-2001
0
2 0
4 0
6 0
8 0
1 0 0
1 2 0
1 9 9 5 - 9 6 1 9 9 7 - 9 8 1 9 9 9 - 2 0 0 0 2 0 0 1
80 years and over
65-79 years
40-54 years
65-79 yearsSOURCE: Centers for Disease Control and Prevention, National Center for Health
Statistics, National Ambulatory Medical Care Survey and National Hospital Ambulatory Medical Care Survey.
Statin only
Other anti-cholesterol
drugs
![Page 24: Analyzing NCHS Drug Data: NHANES and N/HAMCS](https://reader036.vdocument.in/reader036/viewer/2022081513/5681594b550346895dc688ea/html5/thumbnails/24.jpg)
![Page 25: Analyzing NCHS Drug Data: NHANES and N/HAMCS](https://reader036.vdocument.in/reader036/viewer/2022081513/5681594b550346895dc688ea/html5/thumbnails/25.jpg)
Coming Soon…..
Watch for Health, United States, 2004, with Special Feature on Drugs!
• Overall use
• Asthma drugs
• Psychotherapeutic drugs used by children
• Antidepressant use by adults
• Anti-cholesterol drugs
• NSAIDs
![Page 26: Analyzing NCHS Drug Data: NHANES and N/HAMCS](https://reader036.vdocument.in/reader036/viewer/2022081513/5681594b550346895dc688ea/html5/thumbnails/26.jpg)
Prescription Drug Use in Past Month, by Race and Ethnicity,
1999-2000
0 2 0 4 0 6 0 8 0
3 o r m o r ed r u g s
N o d r u g s
M e x i c a n B la c k n o n - H i s p a n i c W h i te n o n - H i s p a n i c
Source: Centers for Disease Prevention and Control, National Center for Health Statistics, National Health and Nutrition Examination Survey
![Page 27: Analyzing NCHS Drug Data: NHANES and N/HAMCS](https://reader036.vdocument.in/reader036/viewer/2022081513/5681594b550346895dc688ea/html5/thumbnails/27.jpg)
Percent of Asthma Visits with Long-Term Control Drugs Prescribed, Ordered or
Provided, 1995-2002
3 0
3 5
4 0
4 5
5 0
5 5
6 0
1 9 9 5 - 9 6 1 9 9 7 - 9 8 1 9 9 9 - 2 0 0 0 2 0 0 1 - 0 2
P e r c e n t o f a s t h m a v i s i t s
SOURCE: Centers for Disease Control and Prevention, National Center for Health Statistics, National Ambulatory Medical Care Survey and National Hospital Ambulatory Medical Care Survey.