AndrosteindioneAndrosteindioneBy Peter Sherman and Rob Vail

What is Androstene Used ForWhat is Androstene Used For

As a bodybuilding supplementAs an athletic performance enhancerAs a testosterone boosting agent

Where you can get itWhere you can get it

General Nutrition Center

Online Bodybuilding sites such as Bodybuilding.com & muscles.com

Health Food stores

Producers of AndroProducers of Andro

Twinlabs: AndrofuelMuscleTech: Nortestin

Side Effects of AndroSide Effects of Andro

Acne Promotes heart disease Causes several types of cancer Increased estrogen levels in men Increase body hair Increases voice Decreases sex drive Hair lose on lop of scalp Prostate enlargement

FDA’s Opinion on AndroFDA’s Opinion on Andro

They feel that Andro and other prohormones should be outlawed

Suggest that Andro is not an effective testosterone increaser

Using Andro for an extended amount of time can cause serious health risks

Andro as a SteroidAndro as a Steroid

Andro is a prohormoneIs not technically a steroidThe body converts andro into a steroid in

the body

Androstein NewsAndrostein News

Recent studies found that Andro significantly increases estrogen levels

Sales of Andro plummeted as more effective supplements increased in popularity

Professional sports ban Andro

Health Problems Caused by Health Problems Caused by Increased EstrogenIncreased Estrogen

Growth of breasts (in men )

Altered menstrual cycle

Decreased sex-drive

Andro in Professional SportsAndro in Professional Sports

Andro is banned by the NFL, NHL, and the NBA

The NCAA has banned Andro in all sportsAndro is banned in international track &

field and all Olympic eventsAndro remains “non-banned” in

professional baseball

Andro’s History as a Andro’s History as a SupplementSupplement

Was developed in East Germany in early 1900’s

Was first used as a testosterone enhancer in East German Olympic athletes

Use was popularized in mid 90’s by several nutritional supplement companies

How Andro Works in the BodyHow Andro Works in the Body

Androsteindione is converted by the body into a steroid

increases testosterone levels

increases estrogen levels

H3C

H3C

O

H

H

H

OH

TestosteroneTestosterone

Androstane: The Parent Androstane: The Parent StructureStructure

H3C

H3C

H

H

H

Other Forms of AndroOther Forms of Andro

H3C

H3C

O

H

H

H

O

H3C

H3C

HO

H

H

H

OH

4-Androstene-3,17-dione

5-Androstene-3,17-diol

Steroids side effectsSteroids side effects

Water retention Acne Gynecomastia Aggression Hypertension Cardiovascular Disease Palpitations Impotence Jaundice

Risks vs. BenefitsRisks vs. Benefits

The side effects outweigh the benefitsNot an effective nutritional supplementOther supplements are more effective with

less risk