angiosarcoma of the skin - dermpedia of the skin deba p sarma, md omaha. f 58, right retroauricular...
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Angiosarcoma of the skinAngiosarcoma of the skin
Deba P Sarma, MDDeba P Sarma, MD
OmahaOmaha
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F 58, right F 58, right retroauricularretroauricular
scalpscalp
Ulcerated, purple-blue
mass behind the right ear
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Dermal neoplasm composed of infiltrating irregular,
vascular or sinusoidal anastomosing channels
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Vessels are lined by a disorganized proliferation of
polyhedral atypical endothelial cells with scant amphophilic
cytoplasm, and dark blue nuclei. Micropapillae of the
neoplastic cells with a hobnail appearance are seen
projecting into the lumen of the neoplastic vessels.
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CD 34: Positive
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Factor VIII: Positive
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Ki 67: High proliferative activity
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Diagnosis: AngiosarcomaDiagnosis: Angiosarcoma
CutaneousCutaneous angiosarcoma primarily affects elderly patients angiosarcoma primarily affects elderly patients
and is commonly located on the head and neck, especiallyand is commonly located on the head and neck, especially
the scalp.the scalp.
Microscopically, the classic angiosarcoma is composed of a
disorganized vascular or sinusoidal anastomosing network with
infiltration into the dermis; the neoplastic slit-like vessels
dissect the dermal collagen. The tumor cells are polyhedral,
atypical endothelial cells with a high nucleus to cytoplasm ratio
and scant amphophilic cytoplasm. Angiosarcoma may also
have other histological variants that include the spindle type,
solid epithelioid type, hemangioma-like type, granular cell
variant, and pleomorphic type
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The prognosis for patients with angiosarcomas of the scalp is poor
because these tumors recur and metastasize by lymphatic or
hematogenous routes. In our case, the patient died soon after
diagnosis with metastasis.
Ref:
Angiosarcoma of the scalp mimicking a sebaceous cyst
Zenggang Pan MD PhD1, Daniel Albertson MD1, Amardip Bhuller
MD2, Bo Wang MD1, James M Shehan MD3, Deba P Sarma MD1
Dermatology Online Journal 14 (6): 13
1. Department of Pathology, Creighton University Medical Center, Omaha,
Nebraska. [email protected]
2. Department of Surgery, Creighton University Medical Center, Omaha,
Nebraska
3. Department of Medicine, Division of Dermatology, Creighton University
Medical Center, Omaha, Nebraska