AnimalExperiments...

There arealternatives

FRAME is an independent science charity

dedicated to the development of new and

valid methods that will replace the need for

laboratory animals in medical and scientific

research, education, and testing.

PublicationsFRAME publishes

a renowned

scientific journal

called ATLA

(Alternatives to

Laboratory

Animals) which is

distributed

worldwide. It also

produces regular

issues of FRAME News

for its supporters and other interested

parties. In addition it has a website

www.frame.org.uk that helps disseminate the

latest news in alternatives research.

PoliticsThere is a UK parliamentary

group dedicated to promotion

of the Three Rs, which FRAME

supports with practical help

and advice. The charity also

consults with European

legislators and advises on

regulations governing

laboratory animal welfare

across the EU.

ResearchFRAME supports an alternatives laboratory

at the University of Nottingham where

replacement (non-animal) methods are

developed. It also carries out desk-based

research on all the Three Rs.

Education & trainingAs well as issuing

educational leaflets

and CDs, FRAME

supports school

projects and takes

part in education

events.

It also runs regular

training schools for laboratory staff and

researchers to demonstrate how careful

design and planning can reduce the number

of animals needed for experiments.

Will you help?FRAME relies entirely on grants and

donations to carry out its vital work

promoting the development of new and valid

methods that will replace the need for

laboratory animals in medical and scientific

research, education, and testing.

It receives no financial support from local or

central government so any gifts from

supporters are always gladly received.

As an independent charity, FRAME welcomes

any donation, however small, either from

individuals or companies.

FRAMEFund for the Replacement of Animals

in Medical Experiments

Registered charity number 259464

Every year millions of

procedures are carried

out on live animals in

UK laboratories and the

number is growing.

Although there are strict controls on the

way research is carried out, these

procedures can cause considerable

suffering and stress to the animals

involved.

FRAME believes that the current scale of

animal experimentation is unacceptable,

but recognises that laboratory animal use

cannot be ended immediately.

Essential research must continue, so that

effective treatments for diseases in

humans and animals can be

found. New products, such as

medicines and vaccines, or

industrial and agricultural

chemicals, must be tested

to prevent potential damage

to health and the

environment.

But a growing number of

alternatives to animal use

are available and FRAME is dedicated to

the development of new and valid non-

animal methods in medical and scientific

research, education, and testing.

FRAME’s ultimate aim is the elimination of the

need to use laboratory animals in any kind of

medical or scientific procedures.

Where the use of animals is currently

necessary, FRAME supports the reduction of

numbers involved to an unavoidable minimum

and refinement of the experimental

procedures to minimise

any suffering caused.

The Three RsAlternatives to the conventional use of

animals in laboratory-based research.

Replacement: Replacement alternatives are

methods, strategies and techniques that

do not require live animals.

Reduction: Any means of lowering the

number of animals used to an unavoidable

minimum.

Refinement: Refinement techniques reduce

the amount of pain and distress suffered by

laboratory animals to an absolute minimum.

FRAME needs your supportPlease complete the forms below and return

the page to the address at the bottom.

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FRAME (Account No. 20392529)

Barclays Bank Ltd (20-63-25)

Nottingham Group. PO Box 18

Nottingham NG1 6FF

The sum of £ ( pounds)

on the (day) of (month) 20

and on the same day each succeeding month/

year (delete as appropriate) until further notice.

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donation could be worth much more to us

without costing you any extra. We can claim

back the tax you paid on the money you donate

to us, so your gift is much more valuable.

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Fund for the Replacement of Animals in MedicalExperimentsRussell and Burch House96-98 North Sherwood StreetNottinghamNG1 4EERegistered charity number 259464

You must pay an amount of Income Tax and/or

Capital Gains Tax for each tax year (6 April one

year to 5 April the next) that is at least equal to

the amount of tax that the charity will reclaim on

your gifts for that tax year.

What are the alternatives?

Ethical human volunteer studies

The

development of

new non-invasive

methods is making it possible

to carry out direct

measurements of various

kinds on human patients and

volunteers, without any risk to

them.

Computer modelsBy using computers, scientists can predict

possible outcomes of tests, based on

experiments carried out in the past. This

means that many test compounds can be

eliminated from drug studies or safety

investigations before animal tests begin,

reducing the number of animals used.

Use of human cellsSometimes

scientists use

donated human tissue. Not all animals react

the same way to the same substance, so using

donated cells removes the problems that

arise from species differences. Results are

more directly relevant to the eventual use of

the drug or substance under test.

Computer databasesRepetition of experiments that have already

taken place can be avoided by sharing results

and consulting databases before experiments

are begun. So animals’ lives are not wasted in

producing results that are already known.

Cell and tissue cultureIt is possible to

carry out some

tests on cells or

tissues that have been

cultured in the

laboratory.

Although animals

might supply the

original cells, from

blood samples for

example, the

experiments are

not carried out on

live animals.

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