animated interactive cerebellum connections

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10/06/22 Interactive cerebellar circuits Dr Sanjoy Sanyal MBBS, MS, MSc, ADPHA, ADHRD

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Cerebellar connections

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Page 1: Animated interactive cerebellum connections

11/04/23

Interactive cerebellar circuits

Dr Sanjoy Sanyal

MBBS, MS, MSc, ADPHA, ADHRD

Sanjoy Sanyal
Copyright (C) Sanjoy Sanyal 2008 - 2009 Educational Medical Imaging Informatics
Page 2: Animated interactive cerebellum connections

Overview of cerebellar circuits• Inputs to cerebellum

• Intracerebellar circuits

• Outputs from cerebellum

• 9-click summary of cerebellar circuits

• Guide to abbreviationsIn order to make the study of cerebellum easy it has been divided into three sections, followed by a summary slide at the end. In order to make it interesting, it has been rendered as interactive as possible.

Click on any link above to go to the appropriate slide. Click on the appropriate links in individual slides (if any) to go to further slides. Click on back button at bottom right of any slide to come back to menu / sub-menu slide. The 2nd last slide summarizes the entire cerebellar circuitry in 9 clicks. Guide to abbreviations is in last slide

Page 3: Animated interactive cerebellum connections

Inputs to cerebellum

Spinalcord

Vestibularsystem

Cerebralcortex

CBLM

Corticopontocerebellar

Cerebro-olivocerebellar

Cerebroreticulocerebellar

Dorsal spinocerebellar

Ventral spinocerebellar

Cuneocerebellar

Primary vestibular fibers

Vestibulocerebellar

Page 4: Animated interactive cerebellum connections

Inputs to cerebellum

CBLMPons

Cerebralcortex

CORTICO-PONTO-CEREBELLAR TRACT

Page 5: Animated interactive cerebellum connections

Inputs to cerebellum

CBLMInferior olivary

nucleus

Cerebralcortex

CEREBRO-OLIVO-CEREBELLAR TRACT

Only Climbing fibers; all others are Mossy fibers

Page 6: Animated interactive cerebellum connections

Inputs to cerebellum

CBLM

Reticular(Pons)

Cerebralcortex

CEREBRO-RETICULO-CEREBELLAR TRACT

Page 7: Animated interactive cerebellum connections

Inputs to cerebellum

CBLM

Reticular(Medulla)

Cerebralcortex

CEREBRO-RETICULO-CEREBELLAR TRACT

Page 8: Animated interactive cerebellum connections

Inputs to cerebellum

CBLM

ICP

Spinal cord

DORSAL SPINO-CEREBELLAR TRACT

Uncrossed tract

Page 9: Animated interactive cerebellum connections

Inputs to cerebellum

CBLM

SCP

Spinalcord

VENTRAL SPINO-CEREBELLAR TRACT

Crossed tract

Page 10: Animated interactive cerebellum connections

Inputs to cerebellum

CBLM

Cuneatenucleus

(Medulla)

Spinalcord

CUNEO-CEREBELLAR TRACT

Uncrossed tract

Page 11: Animated interactive cerebellum connections

Inputs to cerebellum

CBLM(FN lobe)

ICP

PrimaryVestibular

fibers

Page 12: Animated interactive cerebellum connections

Inputs to cerebellum

CBLM

ICP

Vestibularnucleus

VESTIBULO-CEREBELLAR TRACT

Page 13: Animated interactive cerebellum connections

Intracerebellar circuitsAll inputs

Mossy fibersClimbing fibers

Purkinje cell

Granular cell

Purkinje cell

Deep nucleiDeep nuclei

Specific direct

excitation

General indirect

excitation

Page 14: Animated interactive cerebellum connections

Intracerebellar circuitsPurkinje cells from Deep nuclei in medulla

and outside

Vermis Fastigial nucleus

Intermediate hemisphere

Interposed nuclei

Lateral hemisphere Dentate nucleus

Flocculonodular lobe Lateral vestibular nucleus

Left click once outside to see all circuits, or click on any link above to see that circuit

Page 15: Animated interactive cerebellum connections

Intracerebellar circuits

Lat vestibnucleus

Dentatenucleus

Interposednucleus

Fastigialnucleus

Purkinjecells

From Vermis

From intermediate hemisphere

From lateral hemisphere

From FN lobe

Left click once to see an individual circuit

Page 16: Animated interactive cerebellum connections

Intracerebellar circuitsFastigialnucleus

Purkinjecells

From Vermis

Left click once to see next circuit

Page 17: Animated interactive cerebellum connections

Intracerebellar circuits

Interposednucleus

Purkinjecells

From intermediate hemisphere

Left click once to see next circuit

Page 18: Animated interactive cerebellum connections

Intracerebellar circuits

Dentatenucleus

Purkinjecells

From lateral hemisphere

Left click once to see next circuit

Page 19: Animated interactive cerebellum connections

Intracerebellar circuits

Lateralvestibularnucleus

Purkinjecells

From FN lobe

Page 20: Animated interactive cerebellum connections

Outputs from cerebellumDeep nuclei in cerebellar medulla

Nuclei outside cerebellum

Fastigial nucleus Lateral vestibular nucleus in brainstem

Fastigial nucleus Reticular formation in brainstem

Interposed nuclei (Globose, Emboliform)

Red nucleus in midbrain

Dentate nucleus VL nucleus in thalamus

Left click once outside to see all outputs, or click on any link above to see that output

Page 21: Animated interactive cerebellum connections

Outputs from cerebellum

Motorcortex

Spinalcord

Spinal cord

Spinal cord

FastigialInterposed

Dentate

Vestib nRetic nRed n

Thalamus

Vestibulospinal

tract (uncrossed)

Reticulospinal

tract (uncrossed)

Rubrospinal tract

(double-crossed)

Thalamocortical tract

(double-crossed)

Fastigial-vestibular Fastigial-reticular

Interposed-rubral Dentato-thalamic

Left click once to see an individual output

Page 22: Animated interactive cerebellum connections

Outputs from cerebellum

Spinal cord

Fastigialnucleus

Vestibularnuclei

ICP

Vestibulospinal

tract (uncrossed)

Left click once to see next output

Page 23: Animated interactive cerebellum connections

Outputs from cerebellum

Spinal cord

Fastigialnucleus

Reticularformation

ICP

Reticulospinal

tract (uncrossed)

Left click once to see next output

Page 24: Animated interactive cerebellum connections

Outputs from cerebellum

Spinalcord

Interposednuclei

Rednucleus

SCP decussation

Rubrospinal tract

(double-crossed)

Left click once to see next output

Page 25: Animated interactive cerebellum connections

Outputs from cerebellum

Cerebralcortex(motor)

Dentatenucleus

Thalamus VL

nucleus

SCP decussationThalamocortical tract

(double-crossed)

Page 26: Animated interactive cerebellum connections

Spinal cord

Cerebral cortex

Primary vestibular fibers

Vermis

Intermediate hemisphere

Lateral hemisphere

FN lobe

Fastigial nucleus

Interposed (Globose, Emboliform)

Dentate nucleus

Lat vestibular nucleus

Vestibular nucleus

Brainstem reticular formation

Red nucleus

VL nu thalamus

Pontine nuclei

Inf oliv n (medulla)

Br st ret formation

F-V (ICP)

F-R (ICP)

Vest spinal tract (Uncrossed)

Ret spinal (Uncrossed)

G-E Rubral (SCP decussation)

Rubro spinal (Crossed)

Dorsal SCB (ICP) Ventral SCB (SCP)

Cuneo CB (ICP)

CPC (MCP)

COC (ICP)

CRC (ICP, MCP)

Dentato-thalamic (SCP decussation)

Thalamo-cortical (Internal capsule, Corona radiata)

ICP ICP

ICP

Corticospinal (decussation)

8th cranial nerve

Click once and wait for one complete circuit animation before clicking for the next circuit. Click 9 times in total.

Page 27: Animated interactive cerebellum connections

Abbreviations guideBr st ret: Brainstem Reticular

CB: Cerebellar

COC: Cerebro-Olivo-Cerebellar

CPC: Cortico-Ponto-Cerebellar

CRC: Cerebro-Reticulo-Cerebellar

FN: Flocculo-Nodular

FR: Fastigial-Reticular

FV: Fastigial-Vestibular

GE: Globose-Emboliform

ICP: Inferior Cerebellar Peduncle

Inf oliv n: Inferior Olivary Nucleus

Lat: Lateral

MCP: Middle Cerebellar Peduncle

Nu: Nucleus

SCB: Spinocerebellar

SCP: Superior Cerebellar Peduncle

VL: Ventral Lateral