ann berger, msn, md chief pain and palliative care service ...€¦ · ann berger, msn, md chief...
TRANSCRIPT
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Ann Berger, MSN, MD
Chief Pain and Palliative Care ServiceNational Institutes of Health Clinical Center
Integrative Pain Management-Physical, Emotional and Spiritual, Issues
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Objectives: Understand
• nature of palliative care services.• nature of physical, emotional and spiritual
pain• assessment and management of various
pain syndromes• Complementary approaches to pain
management
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The Myths and Facts About Palliative Care•Palliative Care IS:
– A philosophy of care– The management of physical,
emotional, social, and spiritual “suffering”
– Best utilized at the onset of diagnosis and throughout the disease course
– Symptoms related to a chronic, life-threatening, or terminal disease process
– A collaborative effort of the Interdisciplinary team, patient, family, caregiver, and research team.
•Palliative Care IS NOT:
– A treatment modality– Restricted to pain
management– Utilized during end-of-
life care only– Limited to cancer-
related diagnosis– Paternalistic/maternalis
tic
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Palliative Care Philosophy• To cure sometimes, to relieve often, and
to comfort always• Bridge science and humanism to provide
competent and compassionate care• Enable the patient and family to become
“empowered” through education and support
• Provide early intervention of symptom management and coping skills
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Palliative Care Philosophy• Promote collaborative relationship-
centered communication . . . “break down hierarchical relationships”
• Relieve suffering and improve quality of life
• Validate and disseminate information through research-based investigation and documentation
• Integrate palliative care services into mainstream of medical therapy
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Core Team• Comprehensive
Assessment• Coordinate Interventions• Discharge Planning
Recreational Therapy• Relaxation• Stress Management• Pet, Music, & Art Therapy
Rehabilitation• Functional Interventions• Assistive Devices• Energy Conservation
Social Work• Socioeconomic Support• Community Resources• Coping Skills
Thanatology• Grief Counseling• Family Support,
End-of-Life Issues• Community Transition
Complementary• Acupuncture/
Acupressure• Tai Chi• Trigger Point Release
SpiritualMinistry• Pastoral Presence• Prayer• Hope & Peace
Nutrition• Satiety, Dysphagia• Nausea• Intake Modification,
TPN/Tube Feedings
Pharmacy• Pharmacological Counseling• Equianalgesia• Adjuvant Agents
Symptoms
It takes a nurturing interdisciplinary team to practice the nature of palliative care
Co-morbidityConcomitant
Disorder
Spirituality
Roles and Relationships
Isolation
EmotionalState
GriefEconomic
Burden
Level ofFunction
PsychologicalPredisposition
DiseaseProcess
Treatment Regimen
Suffering
Individuals’Quality of Life
Clinical Trials
Protocol
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Essence of a Palliative Care Service
• Utilizing liaisons as integral interdisciplinary team members
• Providing palliative symptom management in conjunction with aggressive treatment modalities
• Ensuring continuity of symptom management /support throughout the stages of the disease process & across healthcare settings
• Implementing integrative medicine
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Quality of Life Palliative Care Symptoms
• Lack of energy (74.2%)• Worrying (70.9%)• Feeling sad (66.1%)• Pain (62.7%)• Feeling nervous (61.9%)• Drowsiness (61.0%)• Dry mouth (56.5%)• Difficulty sleeping (53.7%)• Feeling irritable (48.3%)
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Quality of Life Palliative Care Symptoms
• Nausea (45.5%)• Dizziness (24.4%)• Loss of appetite (45.5%)• Diarrhea (24.3%)• Sexual problems (23.9%)• Shortness of breath (23.5%)• Vomiting (21.0%)• Hair loss (17.8%)• Urination problems (15.7%)
Portenoy, R. K., Thaler, H. T., Kronblith, A. B., et al: “Symptom prevalence, characteristics and distress in a cancer population.” Qual Life Res 1994, 3:183-189.
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Acute vs. Chronic Pain
ChronicvegetativeSleep disturbancesanorexiadecreased libidoanhedoniaconstipationSomatic pre-occupationPersonality changelethargy
Acutetime course-transientfeatures-fight or flightpupillary dilatation
sweating increased RRincreased HR
Increased shunting of blood fromviscera to muscles
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PathophysiologicMechanisms of PainTypeSomatic
Visceral
Neuropathic
CauseNociceptor activation
Nociceptor activation
Destruction of a nerve
CharacteristicsAching or gnawing,localized
Aching, vaguelylocalized, oftenreferred
Severe or dullshooting pain onbackground of burning, aching sensations
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Somatic Nociceptive Pain
• Responsive to:– narcotics– chemical or surgical blockade of proximal
innervation provides effective analgesia and anesthesia
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Key Points of Comprehensive Assessment
• Recognize pain and its location, subjective quality, and severity
• Assess not only the type and intensity of pain but how it impacts life of patient
• Use pain assessment to determine the pathophysiology and select treatment strategies
• Determine the best time(s) to assess and reassess the pain
• Establish comfort/function goals with the patientVallerand. Semin Oncol Nurs 1997;13:16.McCaffery and Pasero. Pain Clinical Manual; 1999:67.
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Pain Management
• Pharmacotherapy– analgesic ladder
• opioid analgesics• nonopioid analgesics• adjuvant analgesics
• Adjuvant techniques– noninvasive
• psychosocial interventions
• relaxation techniques• distraction techniques
– invasive• nerve blocks• surgical or chemical
ablation• spinal opioid infusions
Jacox et al. Management of Cancer Pain. Clinical Practice Guideline Number 9; 1994:39.Arbit. Assessment and Treatment of Cancer Pain; 1998:213.
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Extended Release andLong Half-Life Opioids
• Longer half-lives (12-24 hours)• Release drugs over 8, 12, 24, 72
hours.• Extended release tablets (do not
crush)• Extended release capsules (may
open)• Extended release patches
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Opioids for Moderate to Severe Pain
Long Acting• Morphine (MS Contin, Oramorph SR,
Kadian• Oxycodone (Oxycontin)• Fentanyl (Duragesic)• Methadone (Dolophine)• Levorphanol (Levo-Dromoran)
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Opioids for Moderate to Severe Pain
Short Acting
• Morphine (Roxanol, MSIR)
• Oxycodone (Roxicodone, Oxy IR)
• Fentanyl (Actiq)
• Hydromorphone (Dilaudid)
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Continuous Subcutaneous Infusion (CSCI)Intravenous InfusionIntraspinal Infusion
– Epidural– Intrathecal– Intraventricular
Direct Neuro-Axial Dosing– Epidural– Intrathercal (spinal)
Other Routes
•••
•
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Methadone
• Consider for high tolerance, hyperalgesia, and neuropathic pain, or when cost is significant barrier.– Lacks neuroactive metabolites– Has two nonopiate analgesic receptor
activities:• Prevents MAO reuptake in periaqueductal gray• Prevents N-methyl-d-aspartate (NMDA) receptors
– Negative: long half-life and association with addiction
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Transdermal System
•Fentanyl– 100 times more potent than
Morphine.•Advantages of using fentanyl in transdermal system:-lipid solubility-capillary penetration-high analgesic potency
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WHO IS NOT APPROPRIATE FOR TRANSDERMAL FENTANYL?
• Patients who are:- Anorexic or Cachexic-Sweating profusely-Experiencing “Fluid in Funny Places”
-Ascites -Pleural Effusion-Peripheral Edema
-Currently taking less than 50 mg of Oral Morphine or the equivalent.
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Breakthrough PainA transitory exacerbation of pain that occurs
on a background of otherwise stable pain in a patient receiving chronic opioid therapy
Portenoy, R (1990)
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BREAKTHOUGH DOSING
• Treatment of pain at rest or with movement.
• Immediate release preparation of same medication.
• Dosing: 10-20 % of 24 hour dose of opioid.-PO q 1-4 hours PRN-SQ q 15-30 minutes PRN-IV q 5-15 minutes PRN
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OT Fentanyl Use:Optimal Absorption Through Oral
Mucosa
• Rate of consumption: 15 minutes.• Saliva production: enough for
dissolution.• Swallowing of drug: minimize.• Area of mucosa: buccal.• pH of mouth: avoid low pH fluids i.e..
OJ
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OT Fentanyl Bioavailability
•50% Total Bioavailability–25% Rapid OT absorption.–25% Slow GI absorption.–50% Lost to liver metabolism or not
absorbed.
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Onset of Pain Relief: OTFC vs IV Morphine
Adapted from Sevarino FB, et al. Anesth Analg 1997;84:S330.
Perc
ent P
atie
nts w
ithM
eani
ngfu
l Pai
n R
elie
f
Time (minutes)
50
0
25
75
100
0 105 15 20 25 30 35
10 mg Morphine2 mg Morphine800 µg OTFC200 µg OTFC
OTFC Admin Time
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• Constipation- prophylactic use of laxatives and stool softeners
• Nausea and vomiting- neuroleptics, metoclopramide, cisapride,
antivertigenous drugs• Sedation
- discontinue other CNS depressants- add psychostimulants
• Respiratory depression- monitor if not severe; carefully titrate naloxoneif severe
Management of Common Opioid Side effects
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Neuropathic Pain
• involves neuronal malfunction• after insult to distal or proximal neural
element • marked by aberrant receptor function or
sensory processing resulting in a sensation of pain
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Neuropathic Pain-common examplesMetabolic
Diabetic neuropathyInfectious
Herpes zosterTraumatic
Post-surgical nerve impingementBrachial or lumbosacral plexopathyPost CVA neuropathyPhantom limb phenomenaPost spinal cord injury pain
Chemotherapy induced
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Neuropathic Pain
• Less sensitive to standard analgesic regimens than somatic pain– NSAID’s usually ineffective– opioids usually required in large doses – tolerance quickly develops
• Adjuvant analgesics may be helpful
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Neuropathic Pain-Adjuvant Analgesics• Tricyclic antidepressants• Anticonvulsants• Clonidine• Corticosteroids• Local anesthetics
– Mexilitine
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Intractable, local pain syndromesRegional neurolytic blocksAblative; Radiofrequency
Central analgesiaIntrathecal/epidural
Procedures
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AcupressureAcupunctureMassageTrigger Point ProTens
Complementary Approaches
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Nature of PainNeuropathicMechanismSomatic, Visceral
NociceptionPsychosocial
Influences
PsychosocialState and Traits
PhysicalDisability
Loss of Work
TotalPain
Suffering
Pain
Financial Concerns Fear of Death
Social / FamilyFunctioning
Spiritual
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Emotional Pain “ hurts all over”
Most common palliative care symptoms Anxiety; may present as sleeplessness,
reluctant to be left alone or overt frightAnticipatory Anxiety; previous negative
experience becomes overwhelmingTreatment: relaxation & imagery,
acupressure, massage, music therapy, hypnosis…. then maybe pharmacotherapy such as lorazepam, haloperidol
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Emotional Pain;Care Giver Burden “ communication, communication, communication”
Spirit of cooperationComplex family dynamics emergeSupport to work through accumulated emotionsCan not take away all of the symptoms all the timeImposing own expectations Sense of presence is the very best medicine
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Spirituality
The part of self where search for meaning takes place.
Distinction between religion and spirituality
Intimate connection with life through family, home, friends, leisure and work
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SpiritualitySpiritual Assessment
Spiritual History Developed for PhysiciansF = Faith & Belief
“Do you consider yourself spiritual or religious?” or “Do you have spiritual
beliefs that help you cope with stress?”
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Spiritual History
I = ImportanceWhat importance does your faith or belief have in your life? Have your beliefs influenced how you take care of yourself in this illness? What role do your beliefs play in regaining your health?
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Spiritual History
C = CommunityAre you part of a spiritual or religious community? Is this of support to you and how? Is there a group of people you really love or who are important to you?
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Spiritual History
A = Address in CareHow would you like me, your health care provider, to address these issues in your health care?
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Spiritual Pain
Disconnection threatened by or challenges the individuals ability to make meaning
Treatment plan may include:Chaplain interventionsLabyrinth; prayerful reflection and focus
following an octagonal/circular, interchanging pathway Mandalas’; a sacred circle of meditation
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Non Pharmacological Methodsof Pain Management
• Distraction• Hypnosis• Relaxation Exercise• Biofeedback• Guided Imagery•Acupuncture
• Meditation• Pet Therapy• Art Therapy• Music Therapy• Reiki• Tea Party
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Biofeedback
• Training technique used for relaxation and self-regulation. First and foremost, it provides direct feedback to client of their bodily processes.
• Goals:– Self regulation– Decrease anxiety– Educational experience providing validation
and guidance for self-regulation
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Guided Imagery
1. cognitive tool to achieve desired therapeutic outcome
2. method of deliberate use of imagery to modify behavior, perceptions, feelings, or internal psychological state
3. A process that uses thoughts to evoke and use the senses (thinking in pictures instead of in words)
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Guided Imagery- Benefits
• Decrease muscular tension• ‘Reinforces the message’ to Relax• Pain control• Amelioration of other symptom• Distracts the mind (from bothersome
symptom or state to reduce suffering)• Accesses feelings
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Hypnosis
• Purposeful altered state of consciousness• Focus of attention• Ability to accomplish psycho physiologic changes
which are otherwise more difficult to accomplish• Often accompanied by relaxation
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Hypnosis Benefits/Uses
• Accrue from direct response to suggestion• Pain, anxiety, sleep, nausea and physical
symptoms• Addiction, habits, phobias• Coping with internal or external stressors
or stimuli
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Reiki
Universal life force energy or spirit
Conveyed through touch and intention
It can do no harm
Follows 7 chakras; it is not given bv the healer, but rather accepted by the healee
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The Secret to Success In Palliative Care
• “Back to the Basics” of bedside caring
• One success at a time, “actions speak louder than words”
• Teach by “recommendation rather than prescription”
• Palliate staff as well as patients/families
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You can’t die cured, but you can die healed. Healing is about a sense of wholeness as a person, and that wholeness includes understanding our mortality, our place in the world—death is not a betrayal of life, but a part of it.
• Dan Frimmer M.D. • TIME Magazine,
2000
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”
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You matter because you are you. You matter to the last moment of your life, and we
will do all that we can not only to help you die
peacefully, but also to live until you die.
• Dame Cicely Saunders
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”