annexures 4.2 sage university, bhopal

1

Annexures 4.2

SAGE University, Bhopal

School of Sciences

M.Sc.(CHEMISTRY)

I and II Year Syllabus

SESSION: 2020-21

3

M. Sc. CHEMISTRY

PROGRAM EDUCATIONAL OUTCOMES (PEOs)

The Program M. Sc. Chemistry will develop the ability of the student to think like aresearcher. It also develops an

aptitude to apply principle of Chemistry in academia as well as in chemical/pharmaceutical industry.

PEO 1. Students will become successful professional by exhibiting logical as well as analytical reasoning capabilities.

PEO 2. They will be able to apply their theoretical knowledge in the broad area of chemistry.

PEO 3. They will have the basic analytical and technical skills to work effectively in the various fields of chemistry.

PEO 4. They will be able to work and communicate in interdisciplinary domain individually/independently or in a

team.

PEO 5. They will prosper as scientific leaderin academia and industry.

PROGRAM OUTCOMES (POs)

After completion of the program, the student will be:

PO 1. Able to apply the scientific knowledge in well defined area of research.

PO 2. Able to use research-based knowledge and methods.

PO 3. Able to build knowledge of designing of experiments.

PO 4. Able to work in the interdisciplinary and multidisciplinary areas of chemical sciences.

PO 5. Able to progress in oral as well as written communication skills.

PO 6. Able to gain confidence in any scientific activities.

PO 7. Able to work effectively and safely in laboratory.

PO 8. Able to explain environmental pollution and the remedies for lowering pollution.

PO 9. Able to analyze and interpret data obtained from sophisticated instruments.

PO 10. Able to apply green chemistry approach towards research in frontier areas of chemical sciences.

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DISTRIBUTION OF CREDITS ACROSS ALL COMPONENTS FOR

M. Sc. CHEMISTRY

Sem

No.

Program

Core

(PC)

Discipline

Specific

Electives

(DSE)

Project

Based

Learning

(PBL)

Project Total

Credits

I

CC-I (4)

DSE-I

(3) 2 25

CC-II (4)

CC-III (4)

CC-IV (4)

CC-P1 (2)

CC-P2 (2)

II

CC-I (4)

DSE-II

(3) 2 25

CC-II (4)

CC-III (4)

CC-IV(4)

CC-P3(2)

CC-P4(2)

III

CC-I (4)

DSE-III

(3) 2 25

CC-II (4)

CC-III (4)

CC-IV(4)

CC-P5(4)

IV

DSE/

MOOCS

(4)

20

24

Total 60 13 6 20 99

5

SCHEME FOR M. Sc. CHEMISTRY

SemesterFirst

Course Code Course Title

Contact Hours per

Week

Cre

dit

s

ESE

Du

rati

on

(Ho

urs

) Weightage (Theory) Weightage (Practical)

Total

L T P MSE ASG TA ATTD ESE TOT CE^ ESE TOT GT

CH20M101 Nuclear Analytical Chemistry- I 4 - - 4 3 30 05 05 10 50 100 - - - 100

CH20M102 Inorganic Chemistry- I 4 - - 4 3 30 05 05 10 50 100 - - - 100

CH20M103 Organic Chemistry- I 4 - - 4 3 30 05 05 10 50 100 - - - 100

CH20M104 Physical Chemistry- I 4 - - 4 3 30 05 05 10 50 100 - - - 100

Refer Table 3 DSE- I 3 - - 3 3 30 05 05 10 50 100 - - - 100

CH20M107 LAB- I - - 4 2 2 - - - - - - 50 50 100 100

CH20M108 LAB- II - - 4 2 2 - - - - - - 50 50 100 100

PB20M101 Project Based Learning- I - - 4 2 2 - - - - - - 50 50 100 100

Total 25 800

^Two assessment by panel of expert L-Lecture, T-Tutorial, P-Practical, ESE-End Semester Exam,MSE- Mid Semester Exam, ASG- Assignment, TA- Teacher’s Assessment, ATTD-Attendance, TOT-Total, CE-Continuous Evaluation, GT- Grand Total

6

Semester Second


Contact Hours per

Week

Cre

dit

s

ESE

Du

rati

on

(Ho

urs

) Weightage (Theory) Weightage (Practical)

Total


CH20M201 Nuclear Analytical Chemistry- II 4 - - 4 3 30 05 05 10 50 100 - - - 100

CH20M202 Inorganic Chemistry- II 4 - - 4 3 30 05 05 10 50 100 - - - 100

CH20M203 Organic Chemistry- II 4 - - 4 3 30 05 05 10 50 100 - - - 100

CH20M204 Physical Chemistry- II 4 - - 4 3 30 05 05 10 50 100 - - - 100

Refer Table 4 DSE- II 3 - - 3 3 30 05 05 10 50 100 - - - 100

CH20M207 LAB- III - - 4 2 2 - - - - - - 50 50 100 100

CH20M208 LAB- IV - - 4 2 2 - - - - - - 50 50 100 100

PB20M201 Project Based Learning- II - - 4 2 2 - - - - - - 50 50 100 100

Total 25 800

^Two assessment by panel of expert L-Lecture, T-Tutorial, P-Practical, ESE-End Semester Exam. MSE- Mid Semester Exam, ASG- Assignment, TA- Teacher’s Assessment, ATTD-Attendance, TOT-Total, CE-Continuous Evaluation, GT- Grand Total

7

Semester Third

Course Code

Course Title

Contact

Hours per

Week

Cre

dit

s

ES

E

Du

rati

on

(Ho

urs

)

Weightage

(Theory)

Weightage

(Practical)

L T P MSE ASG TA ATTD ESE CE ESE TOT GT

CH20M301 Green Chemistry 4 - - 4 3 30 05 05 10 50 - - 50 100

Refer Table DSE III

4 - - 4 3 30 05 05 10 50 - - 50 100

Refer Table DSE IV 4 - - 4 3 30 05 05 10 50 - - 50 100

Refer Table DSE V 4 - - 4 3 30 05 05 10 50 - - 50 100

Refer Table DSE VI 4 - - 4 3 30 05 05 10 50 - - 50 100

Refer Table DSE VII (Lab) - - 6 3 - 50 50 100

PB20M301 Project Based Learning-III - - 4 2 2 50 50 50 50 100

Total 25 700


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Semester Fourth


Contact Hours per

Week

Cre

dit

s

ESE

Du

rati

on

(Ho

urs

) Weightage (Theory) Weightage (Practical) Total


Refer Table 6 DSE-IV/ MOOC- I

4 - - 4 2 30 05 05 10 50 100 - - - 100

CH20M402 Project - - 20 20 2 - - - - - - 250 250 500 500

Total

24

600


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LIST OF DISCIPLINE SPECIFIC ELECTIVES (DSE)

Semester First (DSE-I)

S.No Course Code Course Title

1 CH20M105 Molecular Spectroscopy

2 CH20M106 Physical Methods in Chemistry

Semester Second (DSE-II)


1 CH20M205 Biological Chemistry

2 CH20M206 Medicinal Chemistry

Semester Third (DSE III-VII)

S.No DSE Course

Code Track* Course Title

1 III CH20M302 I Advanced Organometallic Chemistry

CH20M312 A Advanced Medicinal Chemistry

2 IV CH20M303 I Advanced Bio-inorganic Chemistry

CH20M313 A Natural Products

3 V CH20M304 I Physical Methods in Inorganic Chemistry

CH20M314 A Stereochemistry and Spectroscopy

4 VI CH20M305 I Advanced Topics in Inorganic Chemistry

CH20M315 A Reaction Mechanism, Reagents and Heterocycles

5 VII CH20M306 I Inorganic Chemistry Lab

CH20M316 A Organic Chemistry Lab

Semester Fourth (DSE VIII)


1. CH20M401 Material Chemistry

MOOC-I

* If a student selects any track (Dor S), then he/she has to study all courses of that track.

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Syllabus

SEMESTER I

11

Core Course-I

COURSE

CODE NUCLEAR-ANALYTICAL CHEMISTRY I

Total

Lec.:60

CH20M101 4-0-0

Learning

Objectives:

Prepare students with the skills to critically assess and solve problems requiring the application

of chemical principle in analytical chemistry.

To produce students whose basic concepts are clear in both analytical and nuclear chemistry.

Pre-

requisite: Elementary idea about basic analytical chemistry.

UNIT CONTENT HOURS

I Introduction:Scope& objectives, analytical chemistry and chemical analysis,

classification of analytical methods, sample selection, sample processing, steps in a

quantitative analysis, quantitative range (bispartite classification), data organisation,

analytical validations, limit of detection and limit of quantisation, the tools of

analytical chemistry and good lab practices.

8

II Calculations used in Chemistry:Chemical stoichiometry, molarity, molality,

etc.Concepts of sampling and experimental errors in chemical analysis: Gross errors

and their sources, statistical treatment and evaluation of data, standard deviation (and

other metrics) for quantifying reproducibility of data and their calculation, scientific

reporting of data.

Preparing samples for analysis: primary, secondary standard etc., classical methods

of analysis: gravimetric, volumetric, titrimetric, potentiometric methods.

10

III Analytical Chemometrics:Propagation of measurement uncertainties (inaccuracy and

imprecision), useful statistical test: test of significance, the F test, the student ‘T’ test,

the ‘Chi’ test, ‘Q’ test the correlation coefficient, confidence limit of the mean,

comparison of two standard values, comparison of standard deviation with average

deviation, comparison of mean with true values, significant figures, regression

analysis (least square method for linear and non-linear plots), statistics of sampling

and detection limit evaluation, chemometrics for optimization, modeling and

parameter estimation, factor analysis, resolution and pattern recognition.

20

IV Automation in the Laboratory:rinciples of automation, process control through

automated instruments, autoanalyzers (single channel and multi-channel),basic

sequences of multi-fold operational analyzers in segmented and non-segmented

flows.

12

V Nuclear Properties and Structure I Fundamentals, Rutherford’s experiments, nuclear

composition and qualitative idea of different nuclear forces; mass-energy

relationship, nuclear binding energy and its role in nuclear stability, concept of

nuclear angular momentum, magnetic dipole moment and electronic quadruple

moment (elementary idea), parity of nuclear energy states; nuclear size and root

mean square radius of atomic nucleus.

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Course Outcomes as per Bloom’s Taxonomy

CO1 Students will understand2the foundation ofanalytical chemistry, classification of analytical

methods and the tools of analytical chemistry.

CO2 They will be able to explain2concepts of sampling and experimental errors in chemical analysis.

CO3 They will understand2 the Analytical Chemo-metrics.

CO4 They will be able to apply3 the principles of automation in laboratory.

CO5 They will understand2thenuclear properties and structure of atoms.

Text Books:

S M Khopkar, Basic Concepts of Analytical Chemistry, 2008, 3rd Edition, New Age

International Publishers.

J. A. Dean, Analytical Chemistry Notebook, 2nd Edition 2004, McGraw Hill.

R. M. Berma, Analytical Chemistry Theory and Practice, 3rd Edition, 2019, CBS Pulication.

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G. D. Christian, Analytical Chemistry, 6th Edition, 2007, Wiley pulication.

P. Malhotra, Analytical Chemistry - Basic Concepts, 2016, Anne Book Publishers.

Reference

Books:

D A Skoog, D M West, F J Holler, S R Crouch, Analytical Chemistry - An Introduction, 2000,

7th Edition, Saunders College Publishing, Philadelphia, London.

J H Kennedy, Analytical Chemistry: Principles, 1990,2nd Edition, Saunders Holt, London.

B. B. L Srivastava, A. Mishra, Fundamental of Analytical Chemistry, 2016, IP Innovative

Publication Pvt. Ltd.

G. Sharma, Basic Analytical Chemistry, 2009, Campus Books International Publisher.

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Core Course-II

COURSE

CODE INORGANIC CHEMISTRY-I

Total

Lec.: 60

CH20M102 4-0-0

Learning

Objectives: Prepare students with the fundamentals of main group chemistry and transition metal

chemistry.

To produce students whose basic concepts are clear in symmetry based concepts.

Pre-

requisite: Knowledge about main group elements and transition metals.

UNIT CONTENT HOURS

I Main Group Chemistry-Introduction: Periodic trends in properties of elements, atomic

size, ionization potential, electron affinity, electro negativity, diagonal relationship,

inert-pair effect, shielding effect, octet rule, resonance, bonding in main group

elements, VSEPR theoryVBT& MOT.

9

II Main Group Chemistry: Hydrides and their classification ionic, covalent and

interstitial, basic beryllium acetate and nitrate, study of the following compounds with

emphasis on structure, bonding, preparation, properties and uses, boric acid and

borates, boron nitrides, borohydrides (diborane) carboranes and graphitic compounds,

silanes, oxides and oxoacids of nitrogen, phosphorus and chlorine, peroxo acids of

sulphur, interhalogen compounds, polyhalide ions, pseudohalogens and properties of

halogens.

12

III Metal-Ligand Bonding in Transition Metal Complexes: Crystal field splitting

diagrams in complexes of low symmetry; spectrochemical and nephelauxetic series;

thermodynamic and structural effects; site selection in spinels, Jahn-Teller distortions;

experimental evidence for metal-ligand orbital overlap; ligand field theory, molecular

orbital theory as applied to metal complexes, brief introduction to angular overlap

model.

12

IV Electronic spectra of Transition Metal Complexes: Spectroscopic ground states; Orgel

energy level and Tanabe-Sugano diagrams for transition metal complexes; charge

transfer spectra; electronic spectra of Oh and TdCo(II) and Ni(II) complexes and

calculation of ligand-field parameters, spectra of lanthanoids.

11

V Symmetry based concepts: Energy level diagrams of metal complexes,symmetry

elements and operations, determination of point group of a molecule, group

representations, features of specific character tables in reference to Orgel diagrams,

symmetry based concepts of Orgel energy level diagrams of metal complexes.

16


CO1 Students will be able to define1main group elements, their properties and bonding.

CO2 Students will be able to apply3 the knowledge about different compounds of main group

elements.

14

CO3 They will acquire an understanding2 of metal ligand bonding in transition metal complexes.

CO4 They will be able to analyze4 the electronic spectra of transition metal complexes.

CO5 They will understand2 the symmetry based concepts for inorganic molecules.

Text Books:

R Sarkar, General and Inorganic Chemistry (vol I), 2011, 3rd Edition, New Central Book

Agency.

FA Cotton and G. Wilkinson,Advanced Inorganic Chemistry, 1999, 6th Edition, John Wiley

& Sons, New York.

J EHuheey, E.A. Keiter and R.L. Keiter, Inorganic Chemistry, 2006, 4th Edition,Addison-

Wesley Pub. Co., New York.

AKar, Advanced Inorganic Chemistry, 2017, Vol I & II, CBS.

J D Lee, Concise Inorganic Chemistry, 5th edition, 2008,Oxford University Press.

Reference

Books:

R S Drago, Physical Methods in Inorganic Chemistry, 197, International Edition, Affiliated

East-West Press, New Delhi,.

K F Purcell and John C. Kotz, Inorganic Chemistry, 1987, W. B. Sauders Com., Hong Kong.

KVeera Reddy, Symmetry and Spectroscopy of Molecules, 1999, New Age International Pvt.

Ltd.

15

Core Course-III

COURSE

CODE ORGANIC CHEMISTRY-I

Total

Lec.: 60

CH20M103 4-0-0

Learning

Objectives :

Prepare students with the skills to critically assess and solve problems requiring the

application of mechanism of organic reactions.

To produce students whose basic concepts are clear in asymmetric synthesis and pericyclic

reactions.

Pre-

requisite Basic reaction mechanism in organic chemistry

UNIT CONTENT HOURS

I Aromaticity: Benzenoid and nonbenzenoid systems, antiaromaticity,

homoaromaticity, alternant and non-alternant hydrocarbons.

5

II Reaction intermediates: General methods of generation, detection, stability, reactions

and structure of classical and non-classical carbocations and carbanions; free radicals

including radical cations and radical anions; carbenes; arynes and nitrenes.

10

III Nucleophilic Substitution at Saturated Carbon: Mechanism and stereochemistry of

SN1, SN2, SNi reactions, reactivity: the effect of substrate structure, attacking

nucleophile, leaving group and reaction medium,phase transfer catalysis and

ultrasound, ambient nucleophiles: regioselectivity, competition between SN1 and SN2

mechanisms.Neighbouring Group Participation: Evidences of N.G.P.; the phenonium

ion, participation by pi and σ bonds, anchimericassistance,classical versus non-

classical carbonium ions–the present status.

20

IV Asymmetric Synthesis: The chiral pool, chiral auxiliaries, enantiomeric excess, chiral

catalysts and reagents.

10

V Pericyclic Reactions:Conservation of orbital symmetry, Woodward-Hoffmann rules,

frontier molecular orbital (FMO) theory, orbital overlap effects in cycloadditions,

electrocyclizations, sigmatropic rearrangements and chelotropic reactions, Paterno-

Buchi, Norrish type I and II reactions.

15


CO1 Students will understand2 foundation of aromaticity of organic molecules.

CO2 Students will be able to illustrate2thereaction intermediate.

CO3 They will acquire an understanding2 of mechanism of organic reactions.

16

Core Course-IV

COURSE

CODE PHYSICAL CHEMISTRY-I

Total

Lec.: 60

CH20M104 4-0-0

Learning

Objectives: Prepare students with the basic knowledge of symmetry and group theory and molecular

spectroscopy.

To produce students whose basic concepts are clear in quantum mechanics and

nanotechnology.

Pre-

requisite: Basic knowledge of thermodynamics.

UNIT CONTENT HOURS

I Symmetry and group theory I: Point symmetry operations, groups and group

multiplication tables, similarity transformation and conjugate classes, identification of

point groups and stereographic projection, representation of symmetry operators and

groups; characters of symmetry operators in a representation, invariance of character

under similarity transformation

15

II Quantum mechanics I: Overview of experimental findings; identification of classical

and quantum systems, Bohr’s correspondence principle, postulates of quantum

mechanics, properties of wave functions, operators and related theorems; degeneracy,

spread of observation and uncertainty principle.

10

III Principles of molecular spectroscopy: Fundamentals; rotational spectra: classification

of molecules into spherical, symmetric and asymmetric tops; diatomic molecules as

rigid rotors - energy levels, selection rules and spectral features, isotope effect,

intensity distribution, effect of non-rigidity on spectral features; vibrational spectra of

diatomics: potential energy of an oscillator, Harmonic Oscillator approximation,

energy levels and selection rules, anharmonicity and its effect on energy levels and

spectral features: overtones and hot bands, vibration-rotation spectra of diatomics:

origin; selection rules; P, Q and R branches; Raman spectra: origin, selection rules,

classical and quantum treatment of rotational and vibrational Raman spectra of

diatomics, resonance Raman spectroscopy; NMR spectra: theory, relaxation process,

spin interactions - its origin, equivalent protons, qualitative idea of energy levels of

15

CO4 They will be able to define1asymmetric synthesis.

CO5 They will get knowledge to explain2 the different types of pericyclic reactions.

Text Books:

A Bahl, B SBahl, Advanced Organic Chemistry: Reactions and Mechanism,2012, 2nd Ed, S.

Chand Publishing

M B Smith & J March, March’s Advanced Organic Chemistry, 2001, 5th Edition, John Wiley

& Sons, New York.

G Clayden, Warren and Wothers, Organic Chemistry, 2001, Oxford University Press.

P Sykes, A Guide book to Mechanism in Organic Chemistry, 1997, 6th Edition, Orient

Longman Ltd., New Delhi.

M S Singh, Advanced Organic Chemistry: Reactions and Mechanism: Pearson Education

(Singapore) Pte. Ltd. (2005)

Reference

Books:

S M Mukherjee and S P Singh, Reaction Mechanism in Organic Chemistry, 1990, 1st Edition,

Macmillan India Ltd., New Delhi.

TH Lowry and K.S. Richardson, Mechanism and Theory in Organic Chemistry, 3rd Edition

(1998), Addison – Wesley Longman Inc. (IS Edition)

G S Zweifel and M H Nantz,Modern Organic Synthesis, 2007, Freeman and Company, NY

17

AX, AX2 and AX3 systems, a few representative examples.

IV Thermodynamics and statistical mechanics: Legendre transformation with

applications; Maxwell-Boltzmann distribution with degeneracy (for both

distinguishable and indistinguishable particles), partition function and its properties,

interpretation of thermodynamic laws, thermodynamic function in terms of partition

functions, molecular partition functions (translational, rotational, vibrational and

electronic) for ideal gas, calculation of thermodynamic functions for monoatomic and

diatomic gases, equipartition principle, equilibrium constant in terms of partition

function.

10

V Elementary nanotechnology: Principles and practices,density of states – zero

dimensional solid, one dimensional quantum wire, thin film and three dimensional

box; some special nanomaterials – fullerenes, carbon nanotubes and nanodiamonds;

optical properties of metallic nanoparticles; nanolithography.

10


CO1 The students willbe able to demonstrate2 the symmetries of physical systems.

CO2 Theywillunderstand2 of the Quantum Mechanics postulate on the physical systems.

CO3 Students will learn to classify2 the combination of spectroscopic methods and techniques are

optimal for solving the specific scientific problem.

CO4 They will understand2 the concepts of statistical thermodynamics.

CO5 They will develop3theknowledge of common applications for nanotectnology.

Text Books:

A K Mukherjee, Group Theory in Chemistry: Bonding and Molecular Spectroscopy,2018, 1st

Edition, The Orient Blackswan.

C N R Rao, A Müller, A K Cheetham, The Chemistry of Nanomaterials: Synthesis, Properties

and Applications, Vols 1 and 2, 2004Wiley-VCH, Weinheim,.

C N Banwell and E. M. McCash, Fundamentals of Molecular Spectroscopy, 1994, 4th

Edition, Tata McGraw-Hill Publishing Company Ltd, New Delhi.

R. C. Mukherjee, Modern Approach to Physical Chemistry I, 2016, BharatiBhawan

Publishers & Distributors.

T. Varghese, K. M. Balakrishna, Nanotechnology: an Introduction to Synthesis Properties

and Applications of Nanomaterials, 2012, Atlantic Publishers & Distributors Pvt Ltd.

Reference

Books:

F A Cotton, Chemical Applications of Group Theory, 3rd Edition, John Wiley & Sons, New

York, 1999.

S C Rakshit, Molecular Symmetry Group and Chemistry, 1988, The New Book Stall,

Kolkata.

R Taylor, The Chemistry of Fullerenes, Advanced Series in Fullerenes, Vol 4, 1995, World

Scientific, Singapore

C. Poole, Introduction to Nanotechnology, Wiley Student Edition, 2016, Wiley.

18

Discipline Specific Elective I

COURSE

CODE MOLECULAR SPECTROSCOPY

Total

Lec.: 45

CH20M105 3-0-0

Learning

Objectives: Prepare students with the knowledge of molecular spectroscopy.

To produce students whose concepts are clear in all types of spectroscopy

Pre-

requisite Basic knowledge of spectroscopy.

UNIT CONTENT HOURS

I Introduction: Interaction of electromagnetic radiation with matter, transition

probabilityand selection rules, line-widths and line shapes, Fourier Transforms in

spectroscopy.Rotational and rotation-vibrational spectroscopy: Microwave and

infrared spectroscopy of di- and polyatomic molecules, normal coordinates and their

symmetry (CO2), skeletal vibration and group frequency, FT-IR instrumentation.

10

II Raman spectroscopy: Raman Effect, rotational and rotation- vibrational Raman

transitions, nuclear spin effects, polarization of Raman lines.

Lasers and laser spectroscopy: Principles of laser action, laser characteristics, pulsed

lasers, laser cavity modes, Q-switching, mode locking, non-linear effects,

harmonicgeneration, examples of lasers: He-Ne, Nd-YAG, titanium-sapphire., dye

lasers. Lasers in spectroscopy: Raman, hyper-Raman, CARS, femtosecond

spectroscopy.

10

19

III Electronic spectroscopy: Vibronic spectroscopy of diatomic molecules, Franck-

Condon factor, dissociation and pre-dissociation, rotational fine structure, solvent

effects, hotoelectron spectroscopy (PES): UV and X-ray PES of molecules.Single

molecule spectroscopy: Single molecule detection, confcocal detection optics and

configuration, applications

10

IV Magnetic resonance: A review of spin angular momentum, basic principles and

relaxation times, intensity of NMR signals, electronic shielding, NMR in liquids:

chemical shifts, spinspin couplings, NMR spectra of AX, A3X and AB systems. ESR

of hydrogen, first order hyperfine energies, ESR of organic radicals in solution.

10

V FT-NMR: Rotating frame of reference, effect of RF pulses, FID, multipulse

operation, measurement of T1 by inversion recovery method, spin echo and

measurement of T2, 2-D NMR, NMR hardware.

5


CO1 The students will be able to understand2theconcepts of spectroscopy.

CO2 They will be able to illustrate2 Raman and laser spectroscopy.

CO3 Students will understand2 the concepts of electronic spectroscopy.

CO4 They will learn to apply3 the concepts of magnetic resonance spectroscopy.

CO5 They will develop3theknowledgeofFT-NMR spectroscopy.

Text Books:

J M Hollas,Modern Spectroscopy, 2004, 4th edition, John Wiley & Sons, Ltd.,Chichester.

G MBarrow,Introduction to Molecular Spectroscopy, (1962) McGraw-Hill.

C N Banwell and E.M. McCash,Fundamentals of Molecular Spectroscopy, 1994, 4th edition,

Tata McGraw Hill, New Delhi.

D L Pavia, Introduction to Spectroscopy, 5th Edition, 2015, Cengage Learning India Private Ltd.

Reference

Books:

A Carrington and A. D. McLachlan,Introduction to Magnetic Resonance, 1979,Chapman and

Hall, London.

RKHarris,Nuclear Magnetic Resonance Spectroscopy, 1986, Addison Wesley,Longman Ltd,

London.

Discipline Specific Elective I

COURSE

CODE PHYSICAL METHODS IN CHEMISTRY

Total

Lec.: 45

CH20M106 3-0-0

Learning

Objectives Prepare students with the knowledge of physical methods of chemistry.

To produce students whose concepts are clear in different types of techniques of

spectroscopy.

Pre-

requisite None.

UNIT CONTENT HOURS

I Photoelectron Spectroscopy and Related Techniques: Principle and applications to

studies of molecules and surface, UPES and XPS, auger electron and X-ray

fluorescence spectroscopy (AES and XRF).

10

II Techniques for Studying Surface Structure: Low energy electron diffraction

(LEED),scanningtunneling and atomic force microscopy (STM and AFM).

10

III Neutron Diffraction: Principle and applications. 5

20

IV Fluorescence techniques: Steady-state fluorescence spectroscopy,time-resolved

(Time correlated single photon counting-TCSPC).

10

V Fluorescence Imaging. Introduction to single molecule fluorescence and

fluorescence imaging.

10


CO1 The students will be able to understand2some techniques related to spectroscopy.

CO2 They will be able to illustrate2techniques for Studying Surface Structure.

CO3 Students will understand2 the concepts of neutron diffraction.

CO4 They will learn to apply3fluorescence techniques.

CO5 They will develop3 the knowledge offluorescence imaging.

Text Books:

J M Hollas, Modern Spectroscopy, 2004, 4th edition, John Wiley and Sons, Chichester.

C N Banwell and E.M. Mc Cash, Fundamentals of Molecular Spectroscopy, 1994, 4th

edition, Tata McGraw Hill, New Delhi,

E M Mc Cash, Surface Chemistry, 2001, Oxford University Press, Oxford.

S Ghosal, A S Avasthi, Fundamentals of Bioanalytical Techniques and Instrumentation, 2nd

Edition, 2018, PHI Learning Publishing.

Reference

Books:

A K Cheetham and P Day, Solid State Chemistry Techniques, 1988, Oxford Univ. Press,

Oxford.

J R Lakowicz, Fluorescence Spectroscopy, 1999, 2nd edition, Plenum Press, New York.

Practical paper

COURSE

CODE CHEMISTRY LAB - I Practical: 60

CH20M107 2

Analytical Chemistry Practical

1. Ion Exchange: Separation and Spectroscopic Analysis of Magnesium and Zinc

2. Thin Layer chromatographic separation of amino acids

3. Separation of Compounds Using Column Chromatography

4. Determination of total, temporary & permanent hardness of water by EDTA method

Organic Chemistry Practical

21

1. Preparation and characterization of two steps organic compounds

I Step- Dil HNO3 + Phenol------------------------4-Aminophenol

II Step- 4-Aminophenol+ Acetic Anhydride -----------------------Paracetamol

2. Benzilic acid from benzoin Synthesis (Benzilic acid rearrangement)

3. Stilbene from benzyl chloride Wittig reaction.

4. Quinoline from aniline Skraup synthesis.

COURSE

CODE CHEMISTRY LAB - II Practical: 60

CH20M108 2

Inorganic Chemistry Practical

1. Preparation of [Ni(NH3)6]Cl2 and [Ni(en)3]Cl₂

2. UV-vis spectroscopy of [Ni(H2O)6]Cl2, [Ni(NH₃)₆]Cl₂, and [Ni(en)3]Cl₂ : Analysis of ligand

field strength

3. Demonstration of cis-transisomerisation in Cobalt(III) complexes

4. Chemistry of a five-coordinate d1 complex: case of vanadylacetylacetonate, VO(acac)2

Physical Chemistry Practical (any 4 experiments)

1. Conductometric titration of a weak acid with strong base.

2. Conductometric titration of a mixture of weak and strong acids.

3. Potentiometric titration of a strong acid with strong base using quinhydrone electrode.

4. Conductometric titration of KCl with AgNO3.

5. Degree of hydrolysis of urea hydrochloride by kinetics method.

6. Equilibrium constant of KI + I2 ⇌KI3 by distribution method.

Project Based Learning I

COURSE

CODE

PROJECT BASED LEARNING

PB20B101

22

Learning

Objectives:

Integrating the knowledge and skills of various courses on the basis of multidisciplinary projects.

Develop the skill of critical thinking and evaluation.

To develop 21st century success skills such as critical thinking, problem solving, communication,

collaboration and creativity/innovation among the students.

To enhance deep understanding of academic, personal and social development in students.

Employ the specialized vocabularies and methodologies.

General

Guidelines:

PBL will be an integral part of UG/PG Programs at different levels.

Each semester offering PBL will provide a separate Course Code, two credits will be allotted to it.

Faculty will be assigned as mentor to a group of 30 students minimum by HoS.

Faculty mentor will have 4 hours/week to conduct PBL for assigned students.

Student will select a topic of their choice from syllabus of any course offered in

respectiveSemester (in-lines with sustainable development goals).

Student may work as a team maximum 3 or minimum 2 members for single topic.

For MSE, student's performance will be assessed by panel of 2 experts either from other

Department/school, or from same department/school based on chosen topic. This will becomprised

of a presentation by student followed by viva-voce. It will be evaluated for 30 marks.

20 marks would be allotted for continuous performance assessment by concerned guide/mentor.

For ESE, student will need to submit a project report in prescribed format, duly signed

byconcerned guide/mentor and head of the school. The report should be comprised of

followingcomponents:

1. Introduction

2. Review of literature

3. Methodology

4. Result and Discussion

5. Conclusion and Project Outcomes

6. References

In ESE, viva-voce of students will be conducted on the basis of report, by one external and one

internal faculty which is of 50 Marks.

Student will need to submit three copies for

1. Concerned School

2. Central Library

3. Self.

The integrity of the report should be maintained by student. Any malpractice will not

beentertained.

Writing Ethics to be followed by student, a limit of 10 % plagiarism is permissible. Plagiarism

report is to be attached along with the report.

Project could be a case study/ analytical work /field work/ experimental work/ programming or as

per the suitability of the program.

23

Syllabus

SEMESTER II

24

Core Course-I

COURSE

CODE NUCLEAR-ANALYTICAL CHEMISTRY II

Total

Lec.: 60

CH20M201 4-0-0

Learning

Objectives:

Prepare students with the skills to critically assess and solve problems requiring the application

of chemical principle in analytical chemistry.

To produce students whose basic concepts are clear in both analytical and nuclear chemistry.

Pre-requisite Basic idea of Nuclear-Analytical Chemistry

UNIT CONTENT HOURS

I Radioactive equilibrium: Successive disintegration, Bateman equation, secular and

transient equilibrium, no equilibrium; analysis of special types of successive

disintegration, formation of radioelement in a nuclear reaction, activation analysis

(introductory),interaction of radiation with matter different radiations, interactions of

heavy charged particles, charged particles and photons, energy loss, stopping power

and related semiemperical calculations, Bethe formula, collisional and radiative

stopping power,

15

II Separation techniques: Preamble, successive extraction and separation; techniques of

solvent extraction: Craig extraction and counter current distribution; ionic liquid

assisted and supercritical solvent extraction, problems; chromatography:

mathematical relations of capacity, selectivity factor, distribution constant and

retention time; chromatogram, elution in column chromatography: band broadening

and column efficiency; van Deemter equation; column resolution, numerical

problems, gas chromatography, high performance chromatography and supercritical

fluid chromatography: principles, methods, comparison and applications; size-

exclusion chromatography, ion chromatography and capillary electrophoresis:

principles, methods and applications.

15

III Thermal methods: Different methods of analysis: TGA, DTA, DSC; thermogram,

applications, thermal stability of covalent and non-covalent bonds, thermal

degradation, single crystal phase transformation, thermochemiluminescence, different

types of titrations and their applications, solid state reaction kinetics.

10

IV Polarography: Origin of polargraphy, Current-voltage relationship, Theory of

polarographic waves (DC and sampled DC (tast) polarograms), Instrumentation,

Ilkovic equation, qualitative and quantitative applications.

10

V Green chemistry and environmental chemistry: Sustainable development, twelve

principles of green chemistry and implementations, atom economy, environmental E-

factor, role of catalysts, microwave and ultrasound irradiation in green synthesis,

traditional and alternative commercial syntheses of ibuprofen, adipic acid and maleic

acid etc, green chemistry in action developing foam, whitening agent, detergent

builders, green insecticides, biosynthesis of synthetic chemical, photochemical

reactions in atmosphere, photochemical smog and stratospheric ozone depletion;

chemicals from renewable feedstocks.

10


CO1 Students will understand2nuclear chemistry and radioactive equilibrium.

CO2 They will be able to define1learn the separation techniques.

CO3 They will build3 knowledge of thermal methods.

CO4 They will understand2theprinciple of polarography.

CO5 They will be able to demonstrate2green chemistry and environmental chemistry.

25

Text Books: S MKhopkar, Basic Concepts of Analytical Chemistry, 3rd Ed, 2008 New Age International

Publishers.

J. A. Dean, Analytical Chemistry Notebook, 2nd Edition 2004, McGraw Hill.

R. M. Berma, Analytical Chemistry Theory and Practice, 3rd Edition, 2019, CBS Pulication.

G. D. Christian, Analytical Chemistry, 6th Edition, 2007, Wiley pulication.

P. Malhotra, Analytical Chemistry - Basic Concepts, 2016, Anne Book Publishers.

Reference

Books:

D A Skoog, D.M. West, F.J. Holler, S.R. Crouch, Analytical Chemistry - An Introduction,

2000, 7th Edition, Saunders College Publishing, Philadelphia, London.

J H Kennedy, Analytical Chemistry: Principles, 1990, 2nd Edition, Saunders Holt, London.

26

Core Course-II

COURSE

CODE INORGANIC CHEMISTRY II Total

Lec.: 60

CH20M202 4-0-0

Learning

Objectives

Prepare students with the in-depth knowledge of organometallic chemistry.

To produce students with increased familiarity with modern research topics in

organometallic chemistry.

Pre-

requisite Basic idea about organometallic chemistry.

UNIT CONTENT HOURS

I Organometallic Chemistry: Structure and bonding: brief overview of transition

metal orbitals, electron counting, formal oxidation state, 18-e rule and its

exceptions, isoelectronic and isolobal analogies, common geometries for transition

metal complexes (Crystal Field Theory, MO description), σ- and π-bonding, types

of ligands and their properties,metalcarbonyl complexes - synthesis - structure and

reactions of metal carbonyls - the nature ofM- CO bonding - binding mode of CO

and IR spectra of metal carbonyls, soft vs hard ligands.

10

II Reactions of organometallic complexes: Ligand substitution/ exchange/dissociation

processes and thermochemical considerations, catalyzed and assisted ligand

substitution reactions, oxidative addition (definition, mechanism, thermodynamic

consideration), oxidative addition of non-polar and polar electrophilic reagents,

reductive elimination (bite angle effects, π-acid effects), transmetallation

(definition, mechanism, utility), insertion/de-insertion, nucleophilic and

electrophilic attack on coordinated ligands, Metallocenes - synthesis of

metallocenes, bonding in metallocenes, reactions ofmetallocenes

15

III Solids:Crystal systems and lattices, Miller planes, crystal packing, crystal defects,

Bragg’s law, ionic crystals, structures of AX, AX2, ABX3 type compounds, spinels,

band theory, metals and semiconductors.

10

IV Bioinorganic Chemistry: Background, myoglobin, heamoglobin, heamocyanin,

hemerythrin, cytochromes, rubredoxin, feredoxins; biological nitrogen fixation,

bioenergetics and ATP cycle, glucose storage, PS I and PS II, Na+/K+ ion pump,

ionophores, metalloenzyme, , cytochrome oxidase, carbonic anhydrase, carboxy

peptidase, chemistry of respiration; vitamin B12 and B12-enzyme.

15

V Molecular Magnetism:Curie Law and Curie-Weiss Law, (Temperature dependent

Magnetic Susceptibility), spin-orbit coupling and orbital contribution to the

magnetic moment, magnetic exchanges, spin-crossover complexes, spin-

frustration, magnetism of lanthanide complexes, single molecule magnets.

10


CO1 Students will have an advanced understanding2 of structure and bonding in organometallic

chemistry.

CO2 They will develop3 the knowledge of several organometallic complexes.

CO3 They will be able to define1 solids and crystal systems.

CO4 They will be able to analyze4 their knowledge of bio-inorganic chemistry.

27

CO5 They will have clear understanding2about molecular magnetism.

Text Books:

R Sarkar, General and Inorganic Chemistry (vol I), 2011, 3rd Ed, New Central Book

Agency.

FA Cotton and G. Wilkinson,Advanced Inorganic Chemistry, 1999, 6th Edition., John

Wiley & Sons, New York.

J EHuheey, E.A. Keiter and R.L. Keiter, Inorganic Chemistry, 2006, 4th Edition. Addison-


AKar, Advanced Inorganic Chemistry, Vol I & II, 2017, CBS publication.

J D Lee, Concise Inorganic Chemistry, 5th edition, 2008,Oxford University Press.

Reference

Books:

R S Drago, Physical Methods in Inorganic Chemistry, 1971, International Edition,

Affiliated East-West Press, New Delhi.

K F Purcell and John C. Kotz, 1987, Inorganic Chemistry, W. B. Sauders Com., Hong

Kong

28

Core Course-III

COURSE

CODE ORGANIC CHEMISTRY II Total

Lec.: 60

CH20M203 4-0-0

Learning

Objectives

Prepare students with the in-depth knowledge of organometallic chemistry.

To produce students with increased familiarity with modern research topics in

organometallic chemistry

Pre-requisite Organic chemistry reaction mechanism.

UNIT CONTENT HOURS

I Conformation and reactivity of acyclic and cyclic systems: Acyclic compounds: The

FelkinAnh model, the Howk model and Sharpless asymmetric epoxidation; cyclic

compounds: monocyclic (3- to 8-membered rings) and bicyclic compounds

(bridged, fused and spiro).

10

II Basic of Photochemistry: Absorption, excitation, photochemical laws, quantum

yield,electronically excited states- life times-measurements of the times. Flash

photolysis, stopped Flow techniques, Energy dissipation by radiative andnon-

radiative processes, absorption spectra, Franck-Condon principle,photochemical

stages-primary and secondary processes. Photochemistry of Aromatic Compounds

Isomerisations, additions and substitutions.Intromolecular reactions of the olefinic

bond-geometrical isomerism, cyclisation reactions, rearrangement of 1,4 and 1,5-

dienes

10

III Structure-reactivity relationship: A quantitative approach Linear free energy

relations: Hammett equation, Hammett’s σx and ρ values and their physical

significance through-conjugation; deviations from straight line plots; steric effects:

Taft equation; solvent effects: Grunwald-Winstein equation.

10

IV Polymerization: Monomer, dimer, dendrimer and polymer; mechanism of

formation: carbonyl substitution reactions, electrophilic aromatic substitution, the

SN2 reaction and nucleophilic attack on isocyanates; polymerization of alkenes; co-

polymerization; biodegradable polymers and plastics; reactions on polymers.

10

V EnantioselectiveReactions:Principlesof enantioselective reactions, resolution of

racemic compounds and biodiscrimination of stereoisomers (amino acids,

thalidomide, DOPA, nicotine, morphine), enantioselective reduction of carbonyl

compounds (Corey’s oxazaborolidinecatalyzed reductions and Noyori’s BINAP

reduction), Enantioselective epoxidation of olefins (Sharpless, Jacobsen, Shi, etc.)

Retrosynthesis:Basic concepts of retrosynthesis, demonstration of its utility with

examples.

20


CO1 Students will have an advanced understanding2 of conformation and reactivity of cyclic and

acyclic systems.

CO2 They will be able to apply3 their knowledge of reaction intermediates.

CO3 They will understand2thestructure-reactivity relationship.

CO4 They will build3 the in-depth knowledge of polymerization.

CO5 They will be able to analyze4enantioselective reaction and their applications.

Text Books: ABahl, B S Bahl, Advanced Organic Chemistry: Reactions and Mechanism, 2012, 2nd

29

Edition, S. Chand Publishing.

MB Smith & J March, March’s Advanced Organic Chemistry, 2001, 5th Edition, John Wiley

& Sons, New York.

Clayden, Greeves, Warren and Wothers, Organic Chemistry, 2001, Oxford University Press.

P Sykes, A Guide book to Mechanism in Organic Chemistry, 1997, 6th Edition, Orient

Longman Ltd., New Delhi.

M S Singh, Advanced Organic Chemistry: Reactions and Mechanism: Pearson Education

(Singapore) Pte. Ltd. (2005)

Reference

Books:

S M Mukherjee and S.P. Singh, Reaction Mechanism in Organic Chemistry, 1990, 1st

Edition, Macmillan India Ltd., New Delhi.

T H Lowry and K.S. Richardson, Mechanism and Theory in Organic Chemistry, 3rd Edition

(1998), Addison – Wesley Longman Inc (IS Edition).

G SZweifel and M. H. Nantz, Modern Organic Synthesis, 2007, Freeman and Company, New

York.

M S Singh, Advanced Organic Chemistry: Reactions and Mechanism: 2005, Pearson

Education (Singapore) Pte. Ltd.

30

Core Course-IV

COURSE

CODE PHYSICAL CHEMISTRY II Total

Lec.: 60

CH20M204 4-0-0

Learning

Objectives

Prepare students with the in-depth and advanced knowledge of symmetry, group theory and

quantum mechanics.

To produce students with increased familiarity of electrochemistry, chemical kinetics and

crystal structure.

Pre-requisite Elementary idea about symmetry, quantum mechanics, electrochemistry and

chemical kinetics.

UNIT CONTENT HOURS

I

Symmetry and group theory II: Rules (without derivation) for construction of

character tables with illustrations, symmetry elements and symmetry operations of

the platonic solids, symmetry of the fullerene structure.The Great Orthogonality

Theorem: statement and interpretation, proof of important corollaries; construction of

character tables of simple molecules projection operators (without derivations) and

vanishing of integrals,

15

II Quantum mechanics II: Equation of motion, constants of motion; Ehrenfest’s

theorem, exactly solvable problems: step potential and tunneling, harmonic

oscillator, rigid rotator; elementary discussion of the H-atom solution.

10

III Electrochemistry: Introduction, ion-solvent interaction: Born model and Born

equation, enthalpy of ion-solvent interaction and its calculation, Eley-Evan model,

solvation number and methods for determination of solvation number, ion

association: Bjerrum equation, fraction of ions associated, ion association constant;

electrode kinetics: relation between current and rate of electrode reaction, current-

over potential relationship, Tafel equation and its importance.

10

IV Chemical kinetics:Theories of reaction rates: applications to uni-, bi- and ter-

molecular reactions, thermodynamic formulation of reaction rate, reactions in

(elementary

idea), dielectric effect on ion-ion reaction, electrostriction, volume of activation,

effect of pressure on reaction rate, classification of reactions on the basis of volume

of activation, Curtin-Hammett principle, linear free energy relationship, Hammett

10

V Crystal structure: Crystal symmetry, translation, glide plane and screw axis, Bravis

lattice, space groups and its determination, stereographic projection, Fourier series,

electron density and structure factor, methods for solving the phase problems, B-

zones and Fermi level in lattice, concept of particle-hole in conduction process, band

theory, theory of conductors, semiconductors and insulators.

15


CO1 Students will have an advanced understanding2of symmetry and group theory.

CO2 They will develop3 the knowledge about advanced quantum chemistry.

CO3 They will be able to apply3 the knowledge of electro-chemistry.

CO4 They will acquire the in-depth understanding2 of chemical kinetics.

CO5 They will be able to define1learn about the crystal structure.

Text Books:

A K Mukherjee, Group Theory In Chemistry: Bonding and Molecular Spectroscopy,2018,

1st Edition, The Orient Blackswan

L Pauling and E. B. Wilson, Introduction to Quantum Mechanics, McGraw-Hill, New York,

1939.

31

C N R. Rao, A. Müller, A. K. Cheetham, The Chemistry of Nanomaterials: Synthesis,

Properties and Applications, Vols 1 and 2, Wiley-VCH, Weinheim, 2004.

C N Banwell and E. M. McCash, Fundamentals of Molecular Spectroscopy, 4th Edn, Tata

McGraw-Hill Publishing Company Ltd, New Delhi, 1994.

P Atkins, J de Paula, J Keeler, Atkins' Physical Chemistry11th Edition, 2018, Oxford

University Press

Reference

Books:

F A Cotton, Chemical Applications of Group Theory, 3rd Edn, John Wiley & Sons, New

York, 1999

S C Rakshit, Molecular Symmetry Group and Chemistry, The New Book Stall, Kolkata,

1988

R Taylor, The Chemistry of Fullerenes, Advanced Series in Fullerenes, Vol 4, World

Scientific, Singapore, 1995.

32

Discipline Specific Elective-II

COURSE

CODE BIOLOGICAL CHEMISTRY

Total Lec:

45

CH20M205 3-0-0

Learning

Objectives Prepare students with the knowledge of enzymes, coenzymes and their mechanism.

To produce students whose concepts are clear in nuclic acids and bio-synthesis

Pre-

requisite None.

UNIT CONTENT HOURS

I Enzymes, co-enzymes and their mechanism of action: enzymes, classification,

inhibition,mechanism of action of chymotrypsin, aldolase, alcohol,

lysozyme,cofactors as derived from vitamins, co-enzymes, prosthetic, prosthetic

group and apoenzymes.

10

II Structure and biological functions of coenzyme-A, thiamine pyrophosphate, pyridoxal

phosphate, NAD+ , NADP+ , FAD, lipoicacid,mechanisms of reactions catalysed by

the above cofactors.

10

III Nucleic Acids:Retro-synthetic analysis of Nucleic Acids - nucleotides, nucleosides,

nucleobases (A,T, G, C and U), sugars (Ribose and deoxyribose),assembly of

oligonucleotide chain: synthesis of polymer support, nucleosides and nucleotides,

solid phase synthesis of oligo-nucleotides (DNA/RNA) through phosphoramidite and

phosphorothionate approach.

9

IV Application of protecting groups (-NH2 and –OH functions, Base and Acid labile)

and their deprotection and purification, concept of depurination.

9

V Bio-synthesis: Terpenoids - C5, C10, C15, C20 units; alkaloids - quinine and

morpholine.

7


CO1 The students will be able to understand2themechanism and action of enzymes and co-enzymes.

CO2 They will be able to illustrate2structure and biological function of some enzymes.

CO3 Students will understand2 the details of nucleic acid.

CO4 They will learn2 the application of protecting groups.

CO5 They will develop3 the knowledge ofbio-synthesis.

Text Books:

AL Lehninger, Principles of Biochemistry, 1992CBS Publishers, Delhi.

DVoet, J G Voet& CW Pratt, Fundamentals of Biochemistry, 1999 John Wiley & Sons, New

York.

H R Mahler and E HCordes, Biological Chemistry, 1971, 2nd Edition, Harper and Row Pub.,

New York

Reference

Books:

C Walsh, Enzymatic Reaction Mechanisms(1979), W.H. Freeman & Co., New York.

I LFinar, Organic Synthesis, 1975, 5th edition. Vol.2, Longman Press, USA.

33

Discipline Specific Elective-II

COURSE

CODE MEDICINAL CHEMISTRY

Total

Lec.: 45

CH20M206 3-0-0

Learning

Objectives Prepare students with the knowledge of relationship between chemical structure and biological

activity.

To produce students whose concepts are clear in different types of drugs.

Pre-

requisite None

UNIT CONTENT HOURS

I Structure and activity: Relationship between chemical structure and biological

activity(SAR). Receptor Site Theory. Approaches to drug design. Introduction to

combinatorialsynthesis in drug discovery.

9

II Drugs based on a substituted benzene ring: Chloramphenicol, salmeterol, tolazamide,

diclophenac, tiapamil, intryptyline. Drugs based on five-membered heterocycles:

Tolmetin, spiralpril, oxaprozine,sulconazole, nizatidine, imolamine, isobuzole. Drugs

based on six-membered heterocycles: Warfarin, quinine, norfloxacinandciprofloxacin,

methylclothiazide, citrine, terfenadine.

9

III Drugs based on seven-membered heterocyclic rings fused to benzene:

Chlordiazepoxide, diazepam, diltiazem. Drugs based on heterocycles fused to two

benzene rings: Quinacrine, tacrine

9

IV β-Lactam antibiotics: Penicillin, cephalosporin, Drugs based on five-membered

heterocycles fused to six-membered rings: Acyclovir, methotrexate.

9

V New Chemical Entities as Clinical agents: Synthetic: Ritonavir, erbumine

Natural: Hamamelitannin, pinophilin A & B.

9


CO1 The students will be able to understand2relationship between structure and biological activity.

CO2 They will be able to illustrate2different types of drugs.

CO3 Students will understand2 the concepts drugs based on heterocycles.

CO4 They willlearn2 about β-Lactam antibiotics

CO5 They will develop3 the knowledge ofNew Chemical Entities as Clinical agents

Text

Books:

A Burger, Medicinal Chemistry, Vol. I-III, 1995, Wiley Interscience Publications, New York.

W O Foye, Principles of Medicinal Chemistry, 1989, 3rd Edition, Lea &ebiger/Varghese

Publishing House, Bombay.

V Alagarswamy, Textbook of Medicinal Chemistry, 3rd Edition, 2020, CBS Pulication.

A. Kar, Medicinal Chemistry, 7th Edition, 2018, New Age International Publisher.

Reference

Books:

N KTerrett, Combinatorial Chemistry, 1998, Oxford Univ. Press, Oxford New York, (1999).

S G Walode, R Somani, R S Chandan, Medicinal Chemistry, 2019, NiraliPrakashanPulication.

34

Practical paper

COURSE

CODE CHEMISTRY LAB - III Practical: 60

CH20M207 2

Analytical Chemistry Practical

1. Estimation of HCl using Na2CO3 as primary standard and Determination of alkalinity in water

sample.

2. Analysis of Calcium Carbonate Tablets

3. Determination of the formula of a complex by spectrophotometry

4. Determination of half-life of a radionuclide.


1. Piperine from pepper (Soxhlet extraction)

2. Lycopene from tomatoes

3. Eucalyptus oil from leaves (Steam distillation)

4. Determination of neutralization equivalent of organic acids.

5. Separation and Identification of compounds having one or more functional groups

COURSE

CODE CHEMISTRYLAB - IV Practical: 60

CH20M208 2


1. Estimation of Cu(II) and Zn(II) in a mixture

2. Estimation of Fe(II) and Ca (II) in a mixture

3. Estimation of the amount of Calcium and Magnesium in a sample of Dolomite.

Physical Chemistry Practical (any 4 experiments)

1. Rate constant of acid catalyzed hydrolysis of sucrose by polarimetric method.

2. Rate constant of acid catalyzed hydrolysis of sucrose by chemical method.

3. Rate constant of FeCl3-catalyzed H2O2 decomposition by gasometric method.

4. Phase diagram of a binary organic system (Naphthalene and Diphenyl).

5. Determination of solubility and solubility product of sparingly soluble salt conductometrically.

6. Saponification of ethyl acetate with sodium hydroxide by chemical method.

7. Comparison of acid strengths through acid catalyzed methyl acetate hydrolysis.

8. Energy of activation of acid catalyzed hydrolysis of methyl acetate.

9. Distribution coefficient of I2 between two immiscible solvents.

10. Molecular weight of a non-electrolyte by cryoscopy method.

35

Project Based Learning II

COURSE

CODE


PB20B201

Learning

Objectives:







General

Guidelines:















1. Introduction


3. Methodology



6. References




1. Concerned School

2. Central Library

3. Self.


beentertained.





36

Syllabus

SEMESTER III

37

Core Course

COURSE

CODE GREEN CHEMISTRY

Total

Lec.: 45

CH20M306 3-0-0

Learning

Objectives Prepare students with the concept of green chemistry.

To demonstrate students who can evaluate a process with greener alternatives.

Pre-

requisite None.

UNIT CONTENT HOURS

I What is Green Chemistry? Need for Green Chemistry. Goals of Green Chemistry,

limitations/ obstacles in the pursuit of the goals of Green Chemistry. Twelve

principlesof Green Chemistry with their explanations.

8

II Designing a Green synthesis using these principles: prevention of

waste/byproducts;maximum incorporation of the materials used in the process into

the final products, atomeconomy, and calculation of atom economy of the

rearrangement, addition, substitutionand elimination reactions. Green solvents–

supercritical fluids, water as a solvent for

organic reactions, ionic liquids, fluorous biphasic solvent, PEG, solvent less

processes,immobilized solvents and how to compare greenness of solvents.

10

III Alternative sources of Energy: Energy requirements for reactions – alternative

sources of energy: use of microwaves andultrasonic energy. Microwave assisted

reactions in water: Hofmann elimination, methylbenzoate to benzoic acid,

oxidation of toluene and alcohols; microwave assisted reactionsin organic solvents.

Diels-Alder reaction and decarboxylation reaction.

9

IV Green synthesis/reaction: Green starting materials, Green reagents, Green

solvents, reaction conditions, Greencatalysis and Green synthesis- Real world

cases (Traditional processes and green ones)Synthesis of Ibuprofen, Adipic acid,

disodium iminodiacetate (alternative to Streckersynthesis).Naturalproduct,inspired

synthesis &OnePot synthesis

9

V Hazard assessment and mitigation in chemical industry: Future trends in Green

Chemistry-oxidation-reduction reagents and catalysts; biomimetic,

multifunctional reagents; Combinatorial green chemistry; Proliferation of

solventlessreactions; Noncovalentderivatization. Biomass conversion, emission

control andbiocatalysis.

9


CO1 The students will be able to recall1 the concepts of green chemistry.

CO2 The students will understand2the 12 principles of green chemistry.

CO3 They will be able to apply3 the concept of green reaction whenever required.

CO4 They will develop3the awareness for reducing waste, minimizing energy consumption

in organic synthesis.

CO5 Students will be able to analyse4 chemical products and processes that reduce or

eliminate the use and generation of hazardous substances.

Text Books:

I. T.Sidhwani, R K Sharma, An Introductory Text on Green Chemistry, 2020, Wiley

Pulication.

V. K. Ahaluwalia, Green Chemistry, 2012, Narosa Publishing House Pvt. Ltd.

38

M. A. Ryan, & M. Tinnesand, Introduction to Green Chemistry,Washington, 2002,

American Chemical Society.

V. K Ahluwalia & M. Kidwai, New Trends in Green Chemistry,2nd Edition, 2012 Germany:

Kluwer Academic Publisher.

Reference

Books:

M. C. Cann, &M. E. Connely, Real-World cases in Green Chemistry, 2000, Washington:

American Chemical Society.

A. S. Matlack, Introduction to Green Chemistry,2001, New York: MarcelDekker.

V. Kumar, An introduction to green chemistry, 2013, Vishal Publishing Co.

39

Discipline Specific Elective III

Inorganic Chemistry Specialization

COURSE

CODE ADVANCED ORGANOMETALLIC CHEMISTRY

Total

Lec.:60

CH20M302 4-0-0

Learning

Objectives:

Prepare students with the in-depth understanding in organometallic chemistry.

To produce students who can apply the concept of organometallic chemistry in various catalysis.

Pre-

requisite: Elementary idea about basic organometallic chemistry.

UNIT CONTENT HOURS

I Organometallic Chemistry: Complexes with classic Lewis base donors: amines,

phosphines and other related donors. 8

II Complexes with metal-carbon σ-bonds: (a) Metal carbonyl complexes: synthesis,

structure and bonding; IR spectroscopy; reactions; related complexes with cyanide,

nitrosyl, and dinitrogen ligands. (b) Metal alkyl complexes: synthesis, stability and

structure; reactions; activation of C-H bonds. (c) Alkylidene and alkylidyne

complexes: Synthesis; structure and bonding; Reactivity; Olefin metathesis.

12

III Metal-element multiple-bonded complexes: Oxo, sulfido, imido, hydroazido, nitrido-

complexes: Synthesis, bonding, structure, spectroscopy, and reactivity.

Complexes with metal-metal multiple bonds: Synthesis, structure and bonding,

spectroscopic and magnetic properties, and reactions.

12

IV Metal complexes of π-ligands: (a) Alkene complexes: synthesis; bonding; Reactivity.

(b) Alkyne complexes: synthesis; bonding; reactivity. (c) Cyclopentadienyl complexes:

Discovery of ‘sandwich’ complexes; bonding; properties of Cp complexes of 3d

metals; substituted metallocenes; Zigler-Natta polymerization; Half-sandwich

complexes. (d) Allyl and dienyl complexes: synthesis; structure and properties;

reactivity. (e) Arene complexes: bis-arene complexes; arene half-sandwich complexes;

η2 to η4 coordinated arenes; seven and eight-membered ring ligands.

20

V Applications of organometallic chemistry: Various catalytic reactions.

8


CO1 Students will understand2the different types of organometallic complexes with different types of

donors.

CO2 They will be able to explain2the structure of organometallic complexes with metal-carbon sigma

bonds.

CO3 They will understand2 the significance of metal-element multiple-bonded complexes.

CO4 They will be able to apply3 the knowledge of bonding of pi-ligands in the formation of complexes.

CO5 They will be able to explain2 the role of catalysts in various catalytic reactions.

Text Books:

R. H. Crabtree, The Organometallic Chemistry of the Transition Metals, 3rd Ed.; Wiley-

Interscience: New York, 2001

D. F. Shriver, P. W. Atkins, Inorganic Chemistry, 3rd Edition, 1999,New York.

Cotton, F. A.; Murillo, C. A.; Walton, R. A. Multiple Bonds between Metal Atoms, 3rd

Edition2005.Springer Science Inc. New York.

A. Illius, B. D. Gupta, Basic Organometallic Chemistry, 2013, Universities Press.

J EHuheey, E.A. Keiter and R.L. Keiter, Inorganic Chemistry, 4th Edition, 2006, Addison-


40

Reference

Books:

R. B. Jordan, Reaction Mechanisms of Inorganic and Organometallic Systems;2nd Ed.; Oxford

University Press: Oxford, 1998.

J. F. Hartwig, Organotransition Metal Chemistry From Bonding to Catalysis, 1st Ed.;

University Science Books: Sausalito, CA, 2010.

41

Discipline Specific Elective-IV

COURSE

CODE ADVANCED BIO-INORGANIC CHEMISTRY

Total Lec.:

60

CH20M303 4-0-0

Learning

Objectives: To produce students who understands the significance of transition metal complexes in

different biological processes.

Prepare students with the knowledge of specific roles and working models of metal complexes

in various biological process

Pre-

requisite: Knowledge about transition metal chemistry.

UNIT CONTENT HOURS

I Storage and transport by metalloproteins: Oxygen storage and transport, metal ion

storage and transport with examples of myoglobin, hemoglobin, hemocyanin,

hemerythrin, ferritin, metallothioneins, etc.

12

II Electron transfer: Concepts of electron transfer (ET) within the context of redox

(bio) chemistry, role of protein matrix in ET, proton coupled electron transfer.

Electron transfer proteins: Examples of metalloproteins involved in electron

transfer like azurin, Cytochrome-c, Fe-S proteins, etc., examples of small molecule

synthetic complexes which mimic the activity.

12

III Oxygen activation: Metalloproteins involved in O2 activation with specific

examples of monooxygenase, dioxygenase, oxidase, superoxide dismutase,

catalase and peroxidase activity. Examples of small molecule synthetic complexes

which mimic such reactivity.

Hydrogenase/Nitrogenase: Catalytic activity of Ni-Fe, Fe-Fe and Ni hydrogenase,

nitrogenase and their relationship with each other and oxidases. Biomimetic model

complexes.

12

IV Oxygen Evolution and Photosynthesis: Energy harvesting, charge separation, role

of various cofactory involved in PS1, PSII, active site of PSII, etc.,biomimetic

complexes that are capable of splitting water.

12

V Non-redox enzymes: Zn containing carbonic anhydrase, carboxypeptidase, etc

along with their biomimetic complexes.Metals in medicine/health: diseases due to

deficiencies, carcinogenesis, applications of chelators and metal chelates of

different generations; antitumour, anticancer and anti-AIDS drugs, mechanistic

pathway, limitation.

12


CO1 Students will be able to define1metalloproteins.

CO2 Students will understand3the concepts and examples of electron transfer proteins.

CO3 They will build3the knowledge of catalytic activity of different enzymes.

CO4 They will be able to interpret2 the oxygen evolution and photosynthesis process.

CO5 They will be able to apply3 the knowledge of non-redox enzymes wherever necessary.

Text

Books: Lippard, S. J., and Berg, J. M. Principles of Bioinorganic Chemistry, 2005, University

Science Books.

G N Mukherjee, A Das, Bioinorganic Chemistry, 2016, U.N. Dhur& Sons Private Ltd.

R Sarkar, General and Inorganic Chemistry (vol I), 2011, 3rd Ed, New Central Book Agency.

I. Bertini, et al., Bioinorganic Chemistry, 1st Ed., 1998.

J EHuheey, E.A. Keiter and R.L. Keiter, Inorganic Chemistry, 2006, 4th Edition. Addison-

42


Reference

Books: A K Sharma, Bioinorganic Chemistry, 2012, Random Publications.

A K Das, Bioinorganic Chemistry, 2004, New central Publication.

43

Discipline Specific Elective-V

COURSE

CODE Physical Methods in Inorganic Chemistry

Total

Lec.: 60

CH20M304 4-0-0

Learning

Objectives : Prepare students with the characterization techniques of inorganic molecules.

To produce students whose basic concepts are clear in the thermal methods that are widely

used to characterize the thermodynamic properties of solids.

Pre-

requisite Molecular spectroscopy

UNIT CONTENT HOURS

I Nuclear Magnetic Resonance Spectroscopy: Use of Chemical shifts and spin-spin

couplings for structural determination, double resonance, and dynamic processes in

NMR, decouplingphenomenon, DEPT spectra and structural applications in 13C

NMR, use of chemicals as NMR auxiliary reagents (shift reagents and relaxation

reagents),1H NMR of paramagnetic substances, NMR of Metal nuclei, multinuclear

NMR of various inorganic and organometallic compounds.NuclearQuardrupole

Resonance spectroscopy- principal & Applications

12

II Electron Paramagnetic Resonance Spectroscopy: Theory, analysis of EPR spectra of

systems in liquid phase, radicals containing single and multiple set of protons, triplet

ground states,transition metal ions, rare earth ions, ions in solid state, EPR spectra of

various inorganic compounds

10

III Mossbauer Spectroscopy: Physical concepts, spectral line shape, isomer shift,

quadrupole splitting, magnetic hyperfine interaction,interpretation of Mossbauer

parameters of 57Fe and 119Sn. Applications to Solid-state reactions, thermal

decomposition, ligand exchange, electron transfer and isomerism.

Mass Spectroscopy: Introduction and Applications to Isotopic systems.

14

IV Electrochemical Methods: Heterogeneous electron transfer and concept of

capacitative and Faradic current. CV, DPV and coulometry. Applications of CV in

organic and inorganic chemistry.

X Ray Photoelectron spectroscopy: Principles, Core level PES, Valence-electron

PES, and Valence excitation spectroscopy.

14

V Thermal methods of characterization: DSC and TGA. 10


CO1 Students will understand2NMR spectra of different types of molecules.

CO2 Students will be able to illustrate2 the EPR spectra of various compounds.

CO3 They will be able to apply3Mossbauer and Mass spectroscopy to different systems where

applicable.

CO4 They will be able to utilize3electrochemical methods to inorganic/organic compounds

CO5 They will get knowledge to explain2 the different types of thermal methods of characterization.

Text Books:

A. K.Brisdon, Inorganic Spectroscopic Methods, 2005, Oxford University Press.

R. S. Drago, Physical Methods in Inorganic Chemistry, 2012,East-West Press Pvt. Ltd.

R. A. Scott and C. M.Lukehart, Applications of Physical Methods to Inorganic and

Bioinorganic Chemistry, 2007, Wiley.

J. A. Iggo, NMR Spectroscopy in Inorganic Chemistry,2011, Oxford University Press.

R. V. Parrish, NMR, NQR, EPR and Mossbauer spectroscopy in Inorganic Chemistry,

1990, Ellis Horwood Limited.

44

Reference

Books:

D. W. H. Rankin, N. Mitzel, C. Morrison, Structural Methods in Molecular Inorganic

Chemistry, 2013, Wiley Pulication

E. A. V.Ebsworth et al., Structural Methods in Inorganic Chemistry, 2nd Ed., 1991, CRC

Press.

45

Discipline Specific Elective-VI

COURSE

CODE ADVANCED TOPICS IN INORGANIC CHEMISTRY

Total

Lec.: 60

CH20M305 4-0-0

Learning

Objectives: Prepare students with the basic knowledge of some special concepts in Inorganic

Chemistry.

To produce students with clear idea about modern topics of Inorganic Chemistry.

Pre-requisite: Basic knowledge of thermodynamics.

UNIT CONTENT HOURS

I Metal Clusters: Metal-metal bonds,concept of quadrupolar bond and its

comparison with a C-C bond, types of metal clusters and multiplicity of

M-M bonds,simple and condensed metal carbonyl clusters,applications

of PSEPT and Wade’s-Mingo’s and Lauhr’s rule over

metalcarbonylclusters,metal halide and metal chalcogenide clusters.

12

II Inorganic Polymers: Classification, types of inorganic polymerization,

comparison with organic polymers, boron-oxygen and boron-nitrogen

polymers, silicones, coordinationpolymers, sulphur-nitrogen, sulphur-

nitrogen-fluorine compounds, - binary and multicomponentsystems,

haemolytic inorganic systems.

12

III Supramolecular Chemistry: Concept of supramolecular chemistry,

nomenclature, molecular recognition, metallo-macrocylces as receptors:

Applications in transportprocesses.

12

IV Molecular Magnetic Materials:Types of magnetic interactions, inorganic

and organicferro-magnetic materials, low-spin–high-spin transitions,

molecular magnets andapplications.

12

V New trends in transition metal coordination chemistry: Photochemistry

and photo physicsof transition metal complexes, water splitting reaction

using coordination compounds.

12


CO1 The students will be able to understand2 the chemistry of metal clusters.

CO2 Theywill be able to explain3all types of Inorganic Polymers.

CO3 Students will develop3 in-depth knowledge of supramolecular chemistry.

CO4 They will be able to apply3 the knowledge of molecular magnetic materials in further

study

CO5 They will be able to understand new trends in Coordination Chemistry.

Text Books:

B. E. Douglus, Concepts and Models of Inorganic Chemistry, 2007, Wiley

Publication

R. H. Crabtree, The Organometallic Chemistry of the Transition Metals, 3rd

Ed.; Wiley-Interscience: New York, 2001

F. A. Cotton and G. Wilkinson, Advanced Inorganic Chemistry, 6th Edn., John-

Wiley & Sons, New York, 1999.

J. E. Huheey, Inorganic Chemistry, 4th Edn, Addison Wesley Pub. Co.,

NewYork, 1993.

Reference

Books:

Jean-Marie Lehn, Supramolecular Chemistry, 1995, VCH, Weinheim.

O. Kahn, Molecular Magnetism, 1993, VCH, Weinheim.

46

Discipline Specific Elective-VII

COURSE

CODE INORGANIC CHEMISTRY LAB Practical: 120

CH20M306 4


1. Synthesis and catalytic application of a solid acid, 12-tungstosilicic acid.

2. Synthesis, purification and metalation of a bio-inorganically important

porphyrine ligand.

3. Organometallic synthesis: synthesis and acetylation reaction of ferrocene.

4. Synthesis and electrochemistry of [Ru(bpy)3]2+.

5. Determination of zinc oxide in pharmaceutical preparations by EDTA

titration.

6. Green Chemistry Experiment: Quantitative Analysis of iron in supplement

tablets with vis-spectrophotometry using tea extract as a chromogenic agent.

7. The preparation of hexamminecobalt(III) chloride and

pentammineaquocobalt(III) chloride:Synthesis, isolation and

characterization of the complex.

8. Preparation of nitro- and nitrito-pentamminecobalt(III) chloride: Linkage

isomers: synthesis and identification using various spectroscopic techniques.

9. Synthesis and characterization of a macrocyclic nickel complex.

10. Synthesis of [Ti(urea)6]I3: An air stable d1 Complex

47

Track-2

Applied Chemistry Specialization

Discipline Specific Elective-III

COURSE

CODE ADVANCED MEDICINAL CHEMISTRY

Total

Lec.:60

CH20M312 4-0-0

Learning

Objectives:

Prepare students with the in-depth knowledge of biomedical, pharmaceutical and clinical

sciences.

To produce students whose concepts are clear in the mechanisms of different class of medicinal

compounds.

Pre-

requisite: None.

UNIT CONTENT HOURS

I Pharmacokinetics: Drug Absorption, drug distribution, drug elimination, drug

disposition, pharmacokinetic parameters, uses of pharmacokinetics in drug

development process.

Pharmacodynamics: Enzyme stimulation, inhibition, sulphonamides, membrane

active drug, biotransformation, xenobiotics.

Drug Metabolism: Introduction, oxidation, reduction, hydrolysis, conjugation.

12

II Antineoplastic agents: Introduction, cancer, classification of antineoplastic agents,

role of alkylating agents and antimetabolites in treatment of cancer, carcinolytic

antibiotics, synthesis use and side effects antineoplastic agents: mechlorethamine,

cyclophosphamide, melphalan, mustards (mode of action) fluorouracil, 6-

mercaptopurine.

Cardiovascular drugs: Cardiovascular diseases, synthesis mode of action, uses and

side effects of cardiovascular drugs.

Local anti-infective agents: Introduction, mode of action, sulphonamides, synthesis

mode of action and side effects of sulphar drugs: sulphanilamide, sulphapyridien,

sulphadiazine, sulphathiazole, sulphaquanidine, sulphamerazine, ulphamethiazote,

sulphadimidine, antileprotic drugs: synthesis, mode of action and side effect of

dapsone, tuberculosis, antitubercular drugs: Synthesis, mode of actions, and side

effects of (a) para amino salicylic acid, ethionamide, isoniazid, ethambutol.

16

III Antibiotics: Introduction and classification, synthesis uses and side effects of

antibiotics (a) penicillin-V (b) penicilline –G (c) tetracycline (d) ampicillin, (e)

chloramphenicol (f) cephalosposin (g) tetracyccine (h) streptomycin, �-lactam sings,

antibiotics inhibiting protein synthesis, cell-wall biosynthesis, inhibitors of cell-wall

biosynthesis, mode of action of penicillin and cephalosporin, mode of action of

penicillin and cephalosporin, microorganisms

12

IV Drug Design: Development of new drugs: Introduction, procedure followed in drug

design, the search for lead compainds, Molecular modification of lead compounds.

Prodrugs: Introduction, prodrug formation of compounds containing various

chemical groups, multiple prodrug formation, Soft Drugs: Design of soft drugs

10

V Chemical parameters in Drug Design: Stereochemistry, biological, Isosterism,

biological properties of simple functional groups.

Physiochemical parameters in drug design: Ionization constant, chelation, solubility

and partition coefficient, surface activity, redox potential, QSAR methods,

introduction, hansch method, free wilson method, advantages and disadvantages of

10

48

free-wilson approach.


CO1 The students will understand2the synthesis procedure of drugs.

CO2 They will be able to demonstrate2 the mechanism pathways of different class of medicinal

compounds.

CO3 They will be able to explain3 the chemistry of drugs with respect to their pharmacological

activity.

CO4 They will be able to develop3the knowledge of chemical parameters of drug design.

CO5 They will be able to analyse4 the quantitative structural activity relationship of different

class of drugs.

Text Books:

G.L. Patrick, Introduction to Medicinal Chemistry 1st Ed, UK: Oxford, University Press, 2013.

V Alagarswamy, Textbook of Medicinal Chemistry, 3rd Edition, 2020, CBS Pulication.

A. Kar, Medicinal Chemistry, 7th Edition, 2018, New Age International Publisher.

S. N. Pandeya and J. R. Dimmock, Medicinal chemistry, 1997, New Age International

A Burger, Medicinal Chemistry, Vol. I-III, 1995, Wiley Interscience Publications, New York.

Reference

Books:

S. N. Pandeya and J. R. Dimmock, An Introduction to Drug Design, 1997, New Age

International.

W O Foye, Principles of Medicinal Chemistry, 1989, 3rd Edition, Lea &ebiger/Varghese

Publishing House, Bombay.

49

Discipline Specific Elective-IV

COURSE

CODE NATURAL PRODUCTS

Total

Lec.: 60

CH20M313 4-0-0

Learning

Objectives: Prepare students with the fundamental knowledge of natural products.

To produce students who can understand the structure of natural products and

their classification and isolation.

Pre-requisite: None.

UNIT CONTENT HOURS

I Terpenoids: Introduction-General properties of terpenoids- Isolation-

Isoprene rule-Gemdialkylrule-Classification of terpenoids–general

methods of determining structure ofterpenoids –structural elucidation and

synthesis of Zingiberene, Eudesmol, Abieticacid,Caryophyllene and

Santonin-biosynthesis of monoterpenoids.

12

II Steroids: Introduction – structural elucidation and synthesis of Cholesterol

(synthesis notnecessary), Ergosterol, Vitamin D, Equilenin, Oestrone,

Testosterone and Progesterone.Bile acids – biosynthesis of sterols.

12

III Alkaloids: Definition of an alkaloid-extraction of alkaloids-general

properties –generalmethods of determining structure of alkaloids –

structural elucidation and synthesis ofAtropine, Morphine and Quinine -

biosynthesis of quinoline alkaloids

12

IV Proteins: General nature of proteins - classification of proteins –the

peptide linkage-theprimary structure of peptides- synthesis of peptides–

oxytocin-insulin. The spatialarrangements of protein molecules-

introduction-secondary, tertiary, and structureofproteins-quaternary

structure of proteins.

Enzymes: General nature of enzymes-nomenclature and classification-

cofactors–specificity of enzyme action- mechanism of enzyme action.

12

V Nucleic acids:Introduction-classification of nucleic acids-relation

among nucleic acids, nucleotides and nucleosides-isolation of

nucleic acids-components of nucleic acid sconstitution of nucleic

acids-structure of nucleosides- structure of nucleotides-sequence of

nucleic acids-structure of DNA- structure of RNA.

12


CO1 Students will be able to explain3 isolation, classification and structure

determination of terpenoids, steroids and alkaloids.

CO2 They will be able to demonstrate2 the enzyme action.

CO3 They will be able toexplain3the mechanism of enzyme action.

CO4 They will be able to classify2 simple steroids and alkaloids.

CO5 They will be able to analyse4 the structure of proteins, enzymes and nucleic

acids.

Text Books: I. L.Finar, Organic Chemistry Vol. II: Stereochemistry and the Chemistry of

Natural Products 5th Ed. New Delhi: Pearson Education, Ltd., 2013.

G. R.Chatwal, Organic Chemistry of Natural Products. Vol. I. New Delhi,

Himalaya Publishing House, 2015.

50

G. R.Chatwal, Organic Chemistry of Natural Products. Vol. II. New Delhi,

Himalaya Publishing House, 2015.

O. P. Agrawal, Organic Chemistry of Natural Products, 2015, Krishna Prakashan

Media (P) Ltd

J. Singh., Natural Product Chemistry, 2010, PragatiPrakashan.

Reference

Books: M. P. Saluja, R. Kumar & A. Agarwal. Advanced Natural Products, Revised 4th

Ed., Meerut: Krishna Prakashan Media (P) Ltd., 2017.

V. K. Ahluwalia, Chemistry of Natural Products, 2nd Edition, 2013, Vishal

Publishing Co.

V. K. Ahluwalia, L. S. Kumar, S Kumar, Chemistry of Natural Products: Amino

Acids, Peptides Proteins and Enzymes, 2009, ANE Books Publication

51

Discipline Specific Elective-V

COURSE

CODE STEREOCHEMISTRY AND SPECTROSCOPY

Total

Lec.: 60

CH20M314 4-0-0

Learning

Objectives: Prepare students with the characterization techniques of inorganic molecules.

To produce students whose basic concepts are clear in the thermal methods that are widely

used to characterize the thermodynamic properties of solids.

Pre-

requisite

UNIT CONTENT HOURS

I Stereochemistry and Conformation: Enantioselcetive synthesis with chiral non racemic

reagents and catalysts: hydroboration with chiral boranes (ipcbh2), (ipc)2bh, carbonyl

group reduction with chiral complex hydride (binal-h, chiral oxazaborolidines), chiral

organometal complex –(-)daib; 3-exo-dimethylamino

isoborneol,enantioselectiveepoxidation of alkene: sharplessepoxidation,

enantioselective hydrogenation with [rh(dipamp)]+. diastereoselectivesynthesis:aldol

reactions (chiral enolate& achiral aldehyde and achiral enolate and chiral

aldehyde),opticalactivity in absence of chiral carbon: biphenyls and allenes and

atropisomerism, conformational analysis of decalines and cyclohexene.

15

II Infrared spectroscopy: Theory of IR spectroscopy, Modes of stretching and bending,

Fourier Transform Spectrometers, Background spectrum, Survey of important

functional groups with examples, Chemical environment and chemical shift.

12

III Nuclear Magnetic Resonance: Physical basis of Nuclear Magnetic Resonance

spectroscopy, chemical shift and spin-spin coupling as functions of structure, analysis

of high-resolution NMR spectra, FT and pulse-NMR, NOE, 2D NMR (COSY,

INADEQUATE, HMQC, HSQC, HMBC, NOESY, HETCOR, ROESY, TOCSY).

12

IV Mass spectroscopy: Principles of Mass Spectrometry, Ion sources (EI, CI, field

Ionization, FAB, plasma desorption, field desorption, laser desorption, MALDI,

Thermospray, API, ESI, APCI, APPI, atmospheric pressure secondary ion mass

spectrometry, inorganic ionization techniques, formation and fragmentation of ions,

fragmentation reactions, mass analyzers (Quadrople, ion trap, ToF, orbitrap, magnetic

and electromagnetic analyzers), ion cyclotron resonance and FT-MS.

12

V Structure elucidation based on spectroscopic data (IR, NMR and Mass). 9


CO1 Students will understand2stereochemistry of large organic molecules.

CO2 Students will be able to illustrate2 IR spectra of complexes.

CO3 They will be able to explain2 complicated NMR spectra of compounds.

CO4 They will be able to analyze3 mass spectra of compounds.

CO5 They will get be able to determine5 the structure of a compound from spectroscopic data.

Text

Books:

S Sen Gupta, Basic Stereochemistry of Organic Molecules, 2014, Oxford University Press.

D. Nasipuri, Stereochemistry of Organic Compounds, 3rd Edition, 2018, New Age International

Publication.

P S Kalsi, Stereochemistry: Conformation and Mechanism, 9th Edition, 2017,New Age

International Publication.

R. M. Silverstein,F. X. Webster, D. Kiemle, Spectrometric identification of organic

compounds, 7th Ed., 2005, Wiley.

D. Pavia, L. et al., Introduction to Spectroscopy, 4th Edition, 2008, Brookes Cole.

52

Reference

Books:

E. de Hoffmann, and V.Stroobant, Mass Spectrometry, Principles and applications, 3rd

Edition, 2007, Wiley.

H. Gunther, NMR spectroscopy: Basic principles, concepts, and applications in chemistry, 3rd

Edition 2013, Wiley.

53

Discipline Specific Elective-VI

COURSE

CODE REACTION MECHANISM, REAGENTS AND HETEROCYCLES

Total

Lec.: 60

CH20M315 4-0-0

Learning

Objectives: Prepare students with the knowledge of reaction mechanism in Organic Chemistry.

To produce students with clear idea about heterocycles.

Pre-

requisite: None.

UNIT CONTENT HOURS

I Addition reactions and Concepts in organic synthesis: Electrophilic, nucleophilic and

free radical addition to double and triple bonds- hydration,hydroxylation, Michael

addition, hydroboration and epoxidation.

Addition reactions to carbonyl compounds – Mannich reaction, MeerweinPondroff-

Verley reduction, Grignard, Claisen, Dieckmann, Stobbe, Knovenagel, Darzen,

Wittig,Thorpe and Benzoin reactions.

Concepts in organic synthesis: An introduction to retrosynthesis, types of

synthesislinearand convergent synthesis.

12

II Aromatic electrophilic substitution reactions-formylations–Gattermann,

GattermannKoch, RiemerTiemann and Vilsmeier-Haack reactions. Kolbes, Bischler-

NapieralskiandHofmann-Martius reactions. Friedel crafts alkylation and acylations.

Aliphatic electrophilic substitution reactions - mechanisms- SE1, SE2 and SEi–

structurereactivity relationship, typical electrophilic substitution reactions -

Friedelcraftsacylation at olefinic carbon, Stork enamine reaction and decarboxylation

of aliphaticacids.

12

III Aliphatic nucleophilic substitution reactions- mechanisms - SN1, SN2, ion pair and

SNisubstitutionat vinyl carbon. Stereochemistry of nucleophilic substitution reaction

–effectof substrate structure - solvent effects - leaving group effect – nucleophilicity,

ambidentnucleophiles and ambident substrates- neighbouring group participation.

Aromatic nucleophilic substitution reactions - benzyne mechanism, intermediate

complexmechanism and SN1 mechanism, structure reactivity relationship.Ziegler

alkylation and Chichibabin reaction.

12

IV Elimination reactions: E1, E2, Ei and E1cB mechanisms - stereochemistry

ofeliminations. Hofmann rule-Saytzeff rule-Bredts rule– substitution versus

elimination, typical elimination reaction - Chugaev reaction, Hofmann degradation

and Cope elimination, carbenes and nitrenes-structure, generation and reactions.

Reagents in organic synthesis: Preparations and synthetic applications of DDQ,

DBU,Dimethyl sulfoxide, trimethylsilyl iodide, Osmium tetroxide, Selenium

dioxide,Dicyclohexylcarbodiimide (DCC), LDA, DIBAL-H and Mercuric acetate.

12

V Heterocycles: Structure, synthesis and reactivity,synthesis and reactions of the

following ring systems:a. Three-membered rings: Aziridines, b. Four-membered

rings: Azetidines and their 2-oxo derivatives, c. Five-membered rings containing two

heteroatoms: Oxzoles, Imidazoles, Thiazoles,Isoxazoles, Pyrazoles, d. Pyrimidines, e.

Purines: Uric acid and Caffeine, f. Five-membered ring heterocycles with three or

four heteroatoms.

12


CO1 The students will be able to describe2different types of addition, substitution and elimination

54

reactions.

CO2 They will understand2 the concept of reaction intermediate.

CO3 They will be able to explain3familiar name reactions.

CO4 They will be able to apply3the knowledge of reagents in organic synthesis.

CO5 They will build3 knowledge about synthesis, structure and reactivity of heterocycles.

Text Books:

M. B. Smith, March’s Advanced Organic Chemistry: Reactions,Mechanisms, and Structure

7thEdition,2015, New Jersey: John Wiley & Sons, Inc., Hoboken.

P S Kalsi, Organic Reactions and Their Mechanisms, 5th Edition, 2020, New Age International

Publication.

S Sen Gupta, Reaction Mechanisms in Organic Chemistry, 1st Edition, 2016, Oxford University

Press.

P. Sykes, A guidebook to mechanism in Organic Chemistry 6th Ed,1995, New York: John

Wiley & sons Inc.

S. N. Sanyal, Reactions, Rearrangements and Reagents 4th Ed, 2014,NewDelhi:

BharathiBhawan (Publishers and Distributors).

Reference

Books:

N. Tewari, Advanced Organic Reaction Mechanism, 3rd Ed, 2011, Kolkata: Books and

Allied (P) Ltd.

J. Clayden, N. Greeves &S. Warren, Organic Chemistry 2nd Ed, 2012, Oxford University Press,

Oxford.

55

Discipline Specific Elective-VII

Practical paper

COURSE

CODE ORGANIC CHEMISTRY LAB - V Practical: 120

CH20M316 4


I. Organic Estimations

1. Estimation of Phenol.

2. Estimation of ethyl methyl ketone.

3. Estimation of glucose.

4. Estimation of nitro compound.

5. Estimation of amino compound.

6. Estimation of methoxy groups.

7. Unsaturation of an organic compound.

II. Analysis of Oils

1. Iodine value of an oil(Reichert- Meissl value),

2. Saponification value of an oil

3. Acetylvalue of an oil.

III. Extraction from Natural Products (Extraction and estimation of active

constituents)

1. Lactose from milk.

2. Caffeine from tea.

3. Nicotine from tobacco extract.

4. Citric acid or ascorbic acid from a tablet or from a natural source.

5. Curcumin from turmeric.

6. Lycopene from tomato

IV. Double stage preparations

1. Anthranilic acid and pthalimides.

56

Project Based Learning III

COURSE

CODE


PB20B301

Learning

Objectives:







General

Guidelines:















1. Introduction


3. Methodology



6. References




1. Concerned School

2. Central Library

3. Self.


beentertained.





57

SEMESTER IV

Discipline Specific Elective VIII

COURSE

CODE MATERIALS CHEMISTRY

Total

Lec.: 60

CH20M401 4-0-0

Learning

Objectives Prepare students with the conceptof materials chemistry

To produce students with knowledge of various inorganic and organic materials.

Pre-

requisite None.

UNIT CONTENT HOURS

I Introduction: Materials and their classification, inorganic and organic materials.

7

II Inorganic materials: Design and synthesis of inorganic materials, requirements

andconstraints, combination properties of composites, functional materials, active

materials;solid state reactions for synthesis of inorganic materials: ceramic

methods, precursormethod and sol-gel synthesis, physical and chemical vapour

depositions;

12

III Properties of inorganic materials: carbides, nitrides,structural and functional

ceramics, intermetallics; intrinsic and extrinsic properties:electrical, optical and

magnetic properties; ceramic superconductors, magnetic ceramics.

12

IV Molecular electronics: molecular materials for electronics andmolecular scale

electronics: Molecular properties, molecular arrangement and

molecularinteractions, piezoelectric and pyroelectric organic materials; molecular

magnets based ontransition metal complexes and organic ferromagnets.

15

V Organic non-linear optical materials:photochromic organic materials and their

classes; conducting polymers: polyacetylene,polypyrrole, polyaniline and

polythiophene; conductive change transfer materials: TTFTCNQ,metal–dithiolate

systems, fullerenes.

14


CO1 The students will be able to understand2the concept of material chemistry

CO2 They will be able to illustrate2techniques for synthesis of inorganic materials.

CO3 Students will understand2 the properties of inorganic materials.

CO4 They will learn to apply3the knowledge of molecular material wherever required.

CO5 They will develop3 the knowledge of properties of organic materials.

Text Books: E. Sambandan, Short Notes on Applied and Advanced Inorganic Materials Chemistry,

2006, iUniverse.

C. N. R. Rao, K Biswas, Essentials of Inorganic Materials Synthesis, 2015, Wiley

Pulication.

D. Sangeeta, J R. LaGraff, Inorganic Materials Chemistry Desk Reference, 2nd Edition,

2005, CRC Press.

P.J. Vander Put, Inorganic Chemistry of Materials, 1998, Plenum Press, New York.

Reference

Books:

M.C. Petty, M.R. Bryce and D. Bloor,An Introduction to Molecular Electronics, 1995,

Edward Arnold, London.

U. S. Schubert, N. Hüsing, Synthesis of Inorganic Materials, 4th Edition, 2019, Wiley

58

Pulication.

annexures 4.2 sage university, bhopal

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