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AnnuAl REPORT2004 - 2005

Cardiovascular SciencesCollaborative Program

FitzGerald Bldg., 150 College Street, Room 83D, Toronto ON M5S 3E2Tel: 416/978-0746 Fax: 416/946-5713 E-mail: cv.program@utoronto.caWeb site: www.cscp.utoronto.ca

University of Toronto

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COnTEnTS

Director’s Report. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4

Mission Statement. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6

Collaborating Departments. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6

Committees. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 - Executive - Program

Courses Offered . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7

Program Sponsored Activities . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 - Annual Student Research Day - Student Forum Night - Human Biology Job Fair - Summer Program

Awards . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 - Medtronic Travel Award - Bigelow Book Prize - Lorne Phenix Graduate Award - Ontario Student Opportunity Trust Funds (OSOTF) Award - Ontario Graduate Scholarships in Science and Technology (OGSST) - Life Sciences Committee Summer Undergraduate Research Fellowships

Advertising Material . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15

Acknowledgements . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15

Students . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16 - Currently Enrolled - Convocated/Follow-Up - Awards

Faculty . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 21 - Members - Awards and Honors - Peer Reviewed Funding

Publications. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 42 - Students - Faculty

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DIRECTOR’S REPORT

This past year has been one of great sadness but also a year of new and creative directions.

We said good-bye to a great leader in the cardiovascular field and friend of the CSCP, Dr. Wilfred ‘Bill’ Bigelow, who died this past spring. His legacy and memory will live on in the “Bigelow Book Prize” that we have given out since 1995. He will be missed!

However, it is with pride to see how much we have evolved since the Program’s inception. Specifically, we were invited to present the CSCP to the Council of Health Sciences and Social Work Deans where the Program received resounding endorsement. This resulted in the Program becoming even more multidisciplinary and encompassing with all relevant Faculties (Dentistry, Nursing, Pharmacy and Social Work) planning to sign the MOA as part of the CSCP. As this will have a dramatic impact on all aspects of our activities, we will be busy revisiting our education mandate to be sure that all our partners are well served by the Program. This new initiative is fully multidisciplinary and captures the essence of the University’s “Stepping Up Program” as well as the Faculty of Medicine’s “Academic Plan”, providing further linkages both within and across various disci-plines within the University of Toronto. To that end, it is clear that the new cardiovascular graduate initiative will ultimately supersede the CSCP.

Parallel to this, a joint initiative with the University of Waterloo continues to be under discussion and I antici-pate exciting times ahead for cardiovascular graduate education at the University of Toronto. Linkages with the University of Waterloo will further enrich the students’ experience and we will be utilizing state-of-the-art distance learning tools such as web casting and other e-learning media.

Last year the JCV series graduate courses were rendered more web-based with the course’s seminars and notes mounted on our password protected course section of the CSCP website. One class was actually web cast and if funding applications are successful, we anticipate these courses will be fully web cast.

Our students continue to work hard and congratulations to them for all their successfully organized events on behalf of the CSCP including a very successful “Annual Student Research Day”, “Student Forum and Dinner”, and “Circulation Rounds”.

In this academic year we had 23 Masters and 16 PhD trainees in the Program (see graph below).

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Our annual student interviews reiterate a high degree of satisfaction. They have expressed particular enthusi-asm for the expansion of the Program into the other Faculties as it is their contention that is enriches the inter-action they have with a diverse group of trainees from varied backgrounds. This past year also saw a number of our students completing their graduate training and going on to pursue either academic or research careers (see Convocated section), which has affected our totals for student numbers. This will be addressed with our upcoming student recruitment initiative. As part of our ongoing tradition, bound copies of each graduating student’s thesis continue to be kept in the Program office (total: 44 MSc/MaSc and 22 PhD).

For the 2005-2006 academic year we plan to continue our current activities and pursue the following priorities:

• Develop innovative curriculum to more appropriately serve the diverse nature of this now multi-Faculty graduate training initiative

• Continue developing endowments to provide permanent infrastructure support

• Establish and launch the joint initiative with the University of Waterloo

• Aggressive student recruitment

• Graduate training grant applications for both local and external agencies

• Further develop CME programs in cardiovascular sciences

• Continue developing web-based courses and web casting

As you read through this report, you will see that the Program continues to grow and enrich our trainee’s expe-riences. Specific details on all activities can be found on our web site at www.cscp.utoronto.ca. I would like to once again recognize the outstanding efforts of Victoria Simpson, our Business Officer, as well as the Executive Committee for their hard work and contributions that have made the Cardiovascular Sciences Collaborative Program the success it is today. And finally, I would like to take this opportunity to thank all our faculty and students for another successful year and to those individuals who have continued to provide both moral and tangible support for this Program.

I continue to be proud to present this Annual Report that summarizes the achievements of the Program’s stu-dents and faculty over the past academic year.

Dr. Carin Wittnich, O.Ont.Director, CSCPProfessor of Surgery & PhysiologyNorthrop Frye Scholar

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MISSIOn STATEMEnT

“The Cardiovascular Sciences Collaborative Program, approved by the University and Ontario Council on Graduate Studies in 1992, and listed in the calendar of the School of Graduate Studies, exists to give formal, organized expression to cardiovascular studies and research at the graduate level. It builds on the strengths of all participating academic units, and other agencies, to enhance the visibility of cardiovascular studies and to facilitate collaborative, interdisciplinary training and research.”

The above mission is achieved by advertising and promoting the importance of, and opportunities in, car-diovascular studies, by making known the results of such studies, by recruitment of excellent students, and by coordinating the graduate collaborative program in cooperation with the academic units in which they are registered. Students in this collaborative program must fulfill the requirements of their home units as well as the Program. Upon graduation the notation “Specialization in Cardiovascular Sciences” will appear on the student’s academic transcript and the Program will present the student with a certificate and gift.

COllABORATInG FACulTIES Medicine

Physical Education and Health

COllABORATInG GRADuATE unITS Department of Exercise Sciences Department of Health Policy, Management & Evaluation Department of Laboratory Medicine and Pathobiology Department of Medical Biophysics Department of Pharmacology Department of Physiology Department of Public Health Sciences Department of Rehabilitation Science Institute of Biomaterials and Biomedical Engineering Institute of Medical Science

SuPPORTInG ClInICAl DEPARTMEnTS Department of Anesthesia Department of Medicine Department of Surgery

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COMMITTEES

ExecutiveThe Executive Committee consists of 4 members of the Program Committee representing as wide a range of disciplines as possible and includes the Director. They also act as Chairs of the various subcommittees as detailed in the Director’s Report. The Executive Committee provides student counseling, screens applicants, provides advice and acts as a Steering Committee. Meetings are held as needed.

Dr. C. Wittnich (Fundraising)Dr. M. Rand (Scholarships & Awards)Dr. S. Thomas (Student Affairs)Dr. V. Rao (Membership)

ProgramThe Program Committee consists of a representative from each collaborating department as well as two student representatives. It administers the Program, selects the Director, and generally meets twice per year.

C. Wittnich (Chair)M. Borger (Department of Surgery)D. Brooks (Rehabilitation Science)D. Mazer (Anesthesia)R.I. Ogilvie (Pharmacology)M. Ojha (Institute of Biomaterials and Biomedical Engineering)M. Rand (Laboratory Medicine and Pathobiology)V. Rao (Institute of Medical Science)S. Thomas (Exercise Sciences)R. Tsushima (Physiology)J. Tu (Health Policy, Management and Evaluation)G. Wright (Medical Biophysics)President, CSCP Student AssociationVice-President, CSCP Student Association

COuRSES OFFERED

EXS5508H Cardiovascular Disease and Exercise JCV3060H* Advanced Topics in Cardiovascular Sciences – Molecular Biology & Signal Transduction JCV3061H* Advanced Topics in Cardiovascular Sciences – Hormones in the Cardiovascular System JCV3062H* Advanced Topics in Cardiovascular Sciences – Heart Function JCV3063H* Advanced Topics in Cardiovascular Sciences – Vascular JEB1365H Ultrasound: Theory and Applications in Biology and MedicineJTC1331H Biomaterials ScienceLMP1015H Vascular PathobiologyLMP1504H Cell and Molecular Biology of Cardiovascular DiseasesPSL1060H Developmental Cardiovascular Physiology PSL1462H Molecular Aspects of Cardiac Function

* Core Courses for PhD Trainees (2 of 4 modules required); JCV denotes joint listing with most of our collaborating departments.

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Suggested Courses (Considered valuable but does not fulfill Program requirements)

CHL5201 Introducing Biostatistics for Students in Biological SciencesLMP1404S Cellular and Molecular Mechanisms of DiseasePSL1052H Fundamentals on Ion Channel Function

PROGRAM SPOnSORED ACTIVITIES

Annual Student Research Day 2005The Cardiovascular Sciences Collaborative Program held its 6th Annual Student Research Day on February 16, 2005. All CSCP trainees were in attendance. The morning session began with a retreat where the Student Association highlighted activities from the past year as well as upcoming events. Selected trainees presented their research concepts, designs or results in a series of 10-minute presentations followed by a question period. The presentations were especially polished and professional this year, and covered a broad range of hot topics.

SESSIOn I: Chair -- Ali Pourdjabbar Erin Butler (MSc – Institute of Medical Sciences)

“Quantitated Cell Engraftment and Functional Myocardial Assessment Following Post-acute Myocardial Infarction Injection of Endothelial Progenitor Cells”

Danny Quaglietta (MSc – Physiology)“Effects of Oxygen Stress in the Neonate”

Adam Gwozdz (MSc – Institute of Medical Sciences)“Platelet Procoagulant Surface Expression”

Grace Chan (MSc – Physiology)“The Role of Interferon-Beta in the Reversal of Fibrosis Induced by Myocarditis”

John Sun (MSc – Physiology)“Pre- and Postnatal Cardiovascular Changes in a Growth-Restricted Mouse Model”

SESSIOn II: Chair -- Warren Foltz Golnaz Karoubi (PhD – Biomedical Engineering)

“Microencapsulation-Implications for Cell Therapy to the Lung”

Eser Adiguzel (PhD – Laboratory Medicine and Pathobiology)“The Role of Type VIII Collagen in Vascular Smooth Muscle Cell Migration”

Danny Ramzy (PhD – Institute of Medical Sciences)“Elevated Levels Of Endothelin-1 Impairs Nitric Oxide Bioavailability: Role of Protein Kinase C”

Elizabeth Frey (MSc – Exercise Sciences)“The Effects of Prolonged Exercise on Left Ventricular Function in Middle-Aged and Older Male Recreational Athletes”

Michael Ward (PhD – Institute of Medical Sciences)“Genetically Modified Endothelial Progenitor Cells for the Enhancement of Neovascularization”

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Prior to lunch, winners of the Bigelow Book Prize, Karim Bandali, and the Phenix Graduate Award, Rachel Mitchell were announced. We were honoured to have Dr. Bigelow and Kathryn Phenix, daughter of Mrs. Phenix, present to hand out the awards.

Certificates and gifts were presented to students who had successfully completed the Cardiovascular Sciences Collaborate Program.

After the award ceremony, the meeting broke for lunch.

The afternoon consisted of an informal presentation by two leading cardiovascular scientist/clinicians, Dr. Donna Stewart, Chair of Women’s Health at UHN and U of T and Dr. Fred Keeley, Professor of Biochemistry and Laboratory Medicine & Pathobiology. The pre-sentations were followed by a lively discussion in which students had an opportunity to discuss the trials and tribulations of living a life devoted to edu-cation and research with these highly respected and successful individuals.

Pictured: Sandra Merklinger, PhD and Dr. Carin Wittnich, CSCP Director

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The Student Research Day met with resounding success. This day would not have been possible without the efforts of the Planning Committee:

Chair: Patricia RoseMembers: Eser Adiguzel Christina Whelan Michael WardAdvisor: Golnaz Karoubi

The committee also gratefully acknowledges the educational grant from Aventis Pharma and the support of Victoria Simpson in making this a very successful day.

Congratulations on a job well done!!

Debate NightThis exciting event was organized for the cardiovascular community and was attended by diverse members of the university community, including graduate students, medical students, undergraduate students, faculty as well as a strong attendance by the research community. The goal of the debate night is to provide graduate students with the chance to learn and form their own opinions in delicate subject matters that challenge the scientific community. It also provides faculty an opportunity to voice their point-of-view and to allow other levels of trainees to appreciate the issues concerning the community.

The debate was held on March 29, 2005 in the Debates Room at Hart House where the audience participated in “Be it resolved that in the increasingly stressed healthcare system, greater emphasis should be placed on prevention of heart diseases rather than on the development of novel therapies”. Dr. Thomas Parker chaired the debate, which included discussions on many levels. Dr. Cameron Mustard (Public Health Sciences) made very strong arguments for the importance of behavioral prevention, using many historical and epidemiological arguments. While unable to disagree with Dr. Mustard about the importance of disease prevention, Dr. David Alter (Institute for Clinical Evaluative Sciences) focused on the priority of the healthcare system, with limited resources, in treating the sick as well as possible. The debate included discussion regarding the role of govern-ment, academia, biomedical research and ethics in what is a very complex discussion.

Thank you to Bristol-Myers Squibb for their generous support of an education grant helping us make this a successful event.

Student Forum NightThe 3rd Annual CSCP Student Forum and Dinner was held on Wednesday, December 6, 2004 at the Chestnut Residence. Established to provide CSCP students a social highlight at the end of the year, the trainees dis-cussed the selected topic in a forum round table setting. This year’s topic of “MSc vs. PhD: Are we letting just anyone get a PhD and is the MSc an extinct degree?” appeared to be close to the heart of most all students in attendance. The relaxed and informal setting allowed for candid conversation, which the majority found ben-eficial. A few senior members of the CSCP program were able to shed some light onto the value of completing a MSc first before proceeding to train for their PhD, while other MSc-PhD transfer students provided their honest advice in the reasoning of by-passing the MSc degree. Current MSc students shared their thoughts and reasons for pursuing an MSc at the moment. The evening was a great success where open and candid discus-sions about the students’ concerns regarding their current and future states were addressed. Furthermore, it

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was noted that the event was highly beneficial to some junior attendees in searching for their ideal academic career path. The value of the event and the work of the organizing committee was well received. The evening’s program was followed by a festive dinner.

Women’s Cardiovascular HealthThe Cardiovascular Sciences Collaborative Program participated in the Centre for Research in Women’s Health Annual General Meeting on November 23, 2004 with a display table. Various students in the Collaborative Program manned a table and provided information to attendees. Thanks to Clifford Lin for setting this up.

CSI: Toronto (Cardiovascular Summer Initiative)This year’s Annual Cardiovascular Sciences Collaborative Summer Program was revamped. CSCP graduate students showcased their research work and discussed the practical aspects of research to the students. Summer students also participated by presenting their own work. This was particularly beneficial as it gave the students an opportunity to try out their presentation skills in an informal, non-judgmental environment. Helpful feed-back was given and the students were able to discuss the skills they were learning in greater detail.

The student’s visited the Toronto Rehabilitation Institute’s Cardiac Centre (Rumsey Centre). They sat in on an introduction/orientation session with new patients and received a tour of the facility. In addition, they also got the opportunity to meet and interact with the patients about their experiences and got a first hand look at the benefits of cardiac rehabilitation. Thank you to Rob Bertelink at the Centre for making this an exciting aspect of the Program. A second field trip was organized to the Toronto Western Hospital, Retinal Blood Flow Lab. Students served as subjects for demonstrations of state of the art instruments like the Retinal Thickness Analyser, Laser Blood Flowmeter, and the Optical Coherence Tomographer.

Thanks to Pat Rose for organizing such an interesting and successful program.

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CSI Agenda:10 June Mini-symposium 1 Erin Butler Healing the broken heart: progenitor cells Adam Gwozdz Platelets & apoptosis Grace Chan Pathophysiology of viral myocarditis Dan Quaglietta Newborn development & response to oxygen stress

8 July Mini-symposium 2 Albert Tsui Hemodilutional anemia & cerebral blood flow Mark Ormiston “Sugar Coated” cells for cardiovascular therapy Mila KisilevskyAutonomic dysfunction

13 July Field Trip: Toronto Rehab, Rumsey Centre

5 Aug Mini-symposium 3 Rami Bishay Echocardiography & cardiac graft rejection Tetyana Bodnaruk Neuraminidase & smooth muscle cell proliferation John Sun Heart structure and function in small babies

12 Aug Field Trip: Toronto Western Hospital, Retinal Blood Flow Lab

19 Aug Student presentations/Certificate presentations

AWARDS

Medtronic Travel AwardTwo competitions were held (spring and fall) for the Medtronic Travel Award. This award, established in 1995, helps to defray costs of travel for Program students presenting their research work at recognized scientific meet-ings. Students supported by this award this academic year were:

Fall 2004:Ali Pourdjabbar, MSc, Institute of Medical Science: “Losartan and Acute Myocardial Infarction in Insulin Resistant Zucker Fatty Rats: Reduced Ventricular Arrhythmias and Improved Survival” and “The Effects of Pre-Peri-and Post Myocardial Infarction Treatment with Losartan in Rats: The Effects of Dose on Survival, Ventricular Arrhythmias, Function and Remodelling”, Canadian Cardiovascular Society Annual Meeting (Supervisor: Dr. T. Parker)Nazneen Tata, MSc, Department of Physiology: “Remodeling in the Vasculature: Diurnal Gene Expression in Normal vs. Diseased Murine Aorta”, Canadian Cardiovascular Society Annual Meeting (Supervisor: Dr. M. Sole)

Spring 2005:Rachel Mitchell, MSc, Institute of Medical Science: “Depression in Women Improves After Coronary Artery Bypass Graft Surgery”, American College of Cardiology (Supervisor: Dr. D. Stewart)John Sun, MSc, Department of Physiology: “Transgenic Mice Overexpressing Insulin-Like Growth Factor Binding Protein-1 (IGFBP-1) in the Liver Pre-and Postnatally Show Cardiac Morphological and Functional Changes”, Society for Gynecologic Investigation (Supervisor: Dr. L. Adamson)

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Pat Rose, PhD, Institute of Medical Science: “Variability of Retinal Arteriolar and Venular Blood Flow During Isocapnec Hyperoxia in Normal Subjects”, Society of Vascular Medicine and Biology (Supervisor: Dr. C. Hudson)

Bigelow Book PrizeThis prize was established in 1995 by the Cardiovascular Sciences Collaborative Program to recognize and honor a pioneer clinician and scientist in the field of cardiovascular sciences. Awardees should exemplify the personal traits of Dr. Bigelow - curiosity, drive, and scientific integrity. The award is given in every year that a qualified student is identified. Qualifications include sustained academic scientific excellence, innovative experimental approaches, original discoveries and good scientific productivity. Some weight is given to work that has recognizable clinical relevance, especially that which promises to improve patient care. The Bigelow Book Prize consists of 2 books written by Dr. W.G. Bigelow entitled “Cold Hearts” and “Mysterious Heparin” and a keeper plaque created to honor Dr. Bigelow. Appropriate candidates are identified and the final deci-sion is made by the Program Committee. This award is presented at the Annual Student Research Day and we were extremely pleased that Dr. Bigelow was once again able to participate in this years’ award ceremony and interact with the trainees.

1995 – Dr. John S. Ikonomidis1996 – Ms. Shona M. Torrance1997 – Dr. Vivek Rao1998 – Dr. Bryce Cowan1999 – Dr. Gideon Cohen2000 – Dr. Michael Borger2001 – Dr. Saeid Babaei2002 – Mr. Wm. Jack Wallen2003 – Dr. Paul W.M. Fedak2004 – Dr. Nathalie Lapointe2005 – Dr. Karim Bandali

Karim Bandali received his PhD from the Department of Physiology. His research focused on children undergoing corrective heart surgery who are often exposed to high oxygen levels (hyperoxia). Since oxygen is essential to life, its potentially detrimental effects when administered in excess are rarely consid-ered. Karim’s Ph.D. thesis showed that exposure to hyperoxia can lead to the development of a variety of detrimental metabolic and functional cardiovascular complications in the newborn in an experimental setting. These novel findings have significant impli-cations in the clinical use of hyperoxia which impact on pediatric cardiac patient care. After completing his PhD, Karim joined The Michener Institute for Applied Health Sciences as a member of the faculty and an associate researcher. L-R: Dr. Karim Bandali, Dr. Wilfred Bigelow,

Dr. Margaret Rand

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Lorne Phenix Graduate AwardThis award was made possible by a generous donation in the memory of Mr. Lorne Phenix by Mrs. Geraldine Phenix. It is her hope that this award will focus attention on the issue of heart disease – which is still the #1 killer of both men and women in Canada. In addition, women who have heart problems are at least equal if not at greater risk than men and Mrs. Phenix hopes that this award will serve to encourage trainees to pursue this area of research to address this particular problem. It is awarded to a graduate student in the Faculty of Medicine on the basis of research and academic excellence. The award consists of a cash prize and certificate and is presented to the recipient at the Annual Student Research Day. Appropriate candidates are identified and a winner is selected by a subcommittee chaired by Dr. Donna Stewart. This award is presented at the Annual Student Research Day.

2001 – Wm. Jack Wallen, PhD2002 – Wm. Jack Wallen, PhD2003 – Shathiyah Kulandavelu, PhD2004 – Rachel Mitchell, MSc

Rachel Mitchell is an MSc candidate in the Institute of Medical Science. Her research is on the differences between men and women undergoing coronary artery bypass graft (CABG) surgery with a focus on mental health and depression. Approximately 30% of the 500,000 CABG procedures performed a year in North America are on women, who are thought, by some to fare worse. Rachel’s research followed men and women undergoing elective CABG surgery to try to get a better understanding of depression patterns and how they differ. Her work found that women were more depressed than men before surgery but improved to a level comparable to men after surgery, even after controlling for other relevant factors. This work has important implications and suggests that depression should not preclude women from CABG surgery. Upon completion of her MSc, Rachel hopes to attend medical school and pursue a career as a clinician/scientist with a special interest in women’s health.

Ontario Student Opportunity Trust Funds (OSOTF) AwardThe OSOTF award refers to a class of awards that have resulted from the Ontario government’s “matching” program. Under the program every dollar of donation received for student assistance has been matched by the government as well as the university on a dollar-for-dollar basis. The Cardiovascular Sciences Collaborative Program participates in this program. There are two major conditions for all OSOTF awards; recipients must be Ontario residents and demonstrate financial need. However, the Program has additional eligibility criteria that must be adhered to, including excellence in science and academic performance. One competition is held per academic year.

L-R: Rachel Mitchell, Dr. Margaret Rand, Ms. Kathryn Phenix

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The applications are handled centrally through the Office of the Associate Dean, Inter-Faculty and Graduate Affairs. Applications pertaining to the CSCP are sent to us and are then adjudicated by a subcommittee chaired by Dr. Margaret Rand. Committee recommendations are then forwarded to the OSOTF Awards Committee (Faculty of Medicine). This year’s recipients were Nesime Askin, PhD, Physiology; Rami Bishay, MSc, Physiology, and Danny Quaglietta, MSc, Physiology

Ontario Graduate School Science and Technology (OGSST) The OGSST program is designed to encourage excellence in graduate studies in science and technology. The program is supported through funds provided by the Ministry of Training, Colleges and Universities and by funds raised by the University of Toronto and the Heart & Stroke Foundation of Ontario. To be awarded to graduate students at the University of Toronto who are pursuing cardiovascular/stroke research. Students must have maintained an overall A- average over the last two years of study at the post-secondary level and exhibit research ability/potential, good communication skills and interpersonal/leadership abilities.

2004-2005 Awardees

Name Degree Dept. SupervisorCathy Boscarino PhD PSL J. ColesPeter Sabatini MSc LMP L. LangilleI. Eser Adiguzel PhD LMP M. BendeckBernard Ho MSc LMP M. BendeckChristopher Kim MSc PSL B. McCrindleAdam Gwozdz MSc IMS M. RandSteven Gu MSc PSL S. HeximerDanny Quaglietta MSc PSL C. WittnichNesime Askin PhD PSL C. Wittnich

ADVERTISInG MATERIAl

The Cardiovascular Sciences Collaborative Program maintains and updates its web site (www.cscp.utoronto.ca) on a regular basis. Faculty information is updated whenever we are notified of relevant changes. This year Victoria Simpson revamped the entire website look to optimize efficient use by visitors. The Program students took an active part in creating their own sections, including short bios on each student, course summaries/surveys to help other students pick courses suitable for their needs, and they are working on a bulletin board section to keep everyone updated on cardiovascular activities. Collaborating departments are encouraged to provide hypertext links to the Collaborative Program on their web site.

The Program distributes brochures at the various campus activities and the collaborating departments are encouraged to have links with the CSCP’s web site and distribute brochures.

ACKnOWlEDGEMEnTS:

The Cardiovascular Sciences Collaborative Program would like to thank the following industry sponsors for their generous support: Biovail Pharmaceuticals Canada; Bristol-Myers Squibb Company; and Medtronic Canada.

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STuDEnTS

Name Supervisor Degree DepartmentI. Eser Adiguzel M. Bendeck PhD LMPNesime Askin C. Wittnich PhD PSLRami Bishay L. West MSc PSLTetyana Bodnaruk A. Hinek MSc IMSErin Butler T. Parker MSc IMSKirsteen Burton G. Tomlinson MSc CHL (inactive status)Grace Chan P. Liu MSc PSLElizabeth Frey J. Goodman MSc EXSAdam Gwozdz M. Rand MSc IMSGolnaz Karoubi D. Courtman PhD BMEMila Kisilevsky C. Hudson MSc IMSShathiyah Kulandavelu L. Adamson PhD PSLClifford Lin D. Courtman MaSc BMEVaska Micevski D. Stewart PhD IMS (inactive status)Santiago Miriuka V. Rao MSc IMSRachel Mitchell D. Stewart MSc IMSMaureen Mountford C. Wittnich MSc PSLBrooke Murphy A. Hinek MSc LMPMark Ormiston D. Courtman PhD BMEDanny Quaglietta C. Wittnich MSc PSLDanny Ramzy V. Rao MSc IMSSonja Reichert J. Goodman MSc EXS (inactive status)Patricia Rose C. Hudson PhD IMSRenee Suen D. Stewart PhD IMSJohn Sun L. Adamson MSc PSLNazneen Tata M. Sole MSc PSLShona Torrance C. Wittnich PhD IMS (inactive status)Albert Tsui G. Hare MSc PSLMichael Ward D. Stewart PhD IMSChristina Whelan S. Thomas MSc EXSLiana Zucco D. Stewart MSc LMP

Convocated Students/Follow-Up

David Ashburn, MSc, Institute of Medical Science(Supervisor: Dr. J. Coles)“Utility of Competing Risks in Analyzing Outcomes of Repair of Congenital Heart Defects”(Cardiothoracic Surgery, Michigan)

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Asim Cheema, PhD, Institute of Medical Science(Supervisor: Dr. B. Strauss)“Arterial Repair After Baloon Angioplasty and Stenting: Role of Matrix and Microvessels”(Cardiology Staff Physician, St. Michael’s Hospital, Toronto)

Sandra Merklinger, PhD, Institute of Medical Science(Supervisor: Dr. M. Rabinovitch)“Progression and Regression of Pulmonary Vascular Disease Related to Smooth Muscle Cell Apoptosis, S100A4/Mts1 and Fibulin-5”(Cardiovascular Research, Hospital for Sick Children, Toronto)

Ali Pourdjabbar, MSc, Institute of Medical Science(Supervisor: Dr. T. Parker, Dr. J. Rouleau)“The Effect of Angiotensin II Receptor Blockade, Prior to, During and After a Myocardial Infarction in Rats With and Without Insulin Resistance”(Medical School)

William Jack Wallen, PhD, Department of Physiology(Supervisor: Dr. C. Wittnich)Sex-Hormones Modulate Whole-Body and Myocardial Responses in Both Wistar-Kyoto and Spontaneously Hypertensive Rats”(Medical School – University of Toronto)

Angela Wang, MSc, Institute of Medical Science(Supervisor: Dr. R-K Li)“Effect of Estrogen on Angiogenic Factor Expression in Cultured Uterine Cells”(Medical School)

Note: Should discrepancy arise between total number of students enrolled and number convocated can be accounted for students that are incomplete or terminate graduate studies.

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Awards and HonorsEser Adiguzel OGSST – Heart & Stroke Foundation of Ontario Meredith & Malcolm Silver Scholarship in Cardiovascular Sciences

Nesime Askin OGSST – Heart & Stroke Foundation of Ontario

Rami Bishay Department of Physiology Fellowship, UofT Tetyana Bodnaruk Institute of Medical Science Entry Award, UofT Institute of Medical Science Continuing Fellows Award, UofT Ontario Graduate Scholarship, UofT

Erin Butler Open Fellowship Award, UofT OGSST Open Fellowship Award, UofT

Adam Gwozdz OGSST – Heart & Stroke Foundation of Ontario Graduate of Ontario Student Opportunity Trust Funds Award, Restracomp, Hospital

for Sick Children

Golnaz Karoubi Ontario Graduate Scholarship, UofT Kennan Fellowship & Studentship Award

Shathiyah Ontario Graduate Scholarship, UofTKulandavelu

Clifford Lin NSERC Postgraduate Scholarship, UofT

Santiago Miriuka Trainee Award for best Basic Science Abstract, Canadian Society of Transplantation Annual Meeting, Alberta

Research Grant: Effects of immunosupressors on endothelial progenitor cells, Wyeth

Rachel Mitchell Centers for Disease Control and Prevention Travel Award, American Heart Association, Second International Conference on Women, Heart Disease and Stroke

Lorne Phenix Graduate Award, Cardiovascular Sciences Collaborative Program, UofT

Brooke Murphy University of Toronto Fellowship

Mark Ormiston PGS-A Scholarship, NSERC

Danny Quaglietta OGSST – Heart & Stroke Foundation of Ontario Department of Physiology Open Fellowship, UofT

Danny Ramzy Thoracic Surgery Foundation for Research and Education Research Fellowship Nellie L. Farthing Fellowship, UofT William S. Fenwick Fellowship, UofT Chisholm Memorial Fellowship, UofT Patty Rigby and John Wedge Graduate Scholarships in Science and Technology, UofT

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Patricia Rose Vision Science Research Program Scholarship, UofT Heart & Stroke Foundation of Canada Doctoral Studentship Award, UofT AAO Student Travel Fellowship, American Academy of Optometry Sandra & David Smith Award, Vision Science Research Program, UofT Medtronic Travel Award, Cardiovascular Sciences Collaborative Program, UofT

Renee Suen Pfizer/CHS/CIHR RxD Doctoral Research Award

John Sun School of Graduate Studies Open Fellowship Award, UofT Research Training Centre Travel Award, Samuel Lunenfeld Research Institute, Mount

Sinai Hospital President’s Presenter Award, Society for Gynecologic Investigation OBGYN Scholarships in Science & Technology, Government of Ontario/Pharmacia

Canada Inc./Genesis Research Foundation Medtronic Travel Award, Cardiovascular Sciences Collaborative Program, UofT

Nazneen Tata Department of Physiology, Open Fellowship, UofT Medtronic Travel Award, Cardiovascular Sciences Collaborative Program, UofT HSRLCE Studentship Award, UofT

Albert Tsui UofT Open Fellowship Dr. James A. & Connie P. Dickson Scholarship in the Sciences & Mathematics G.H. Ferguson Scholarship

Michael Ward CIHR Jessie Boyd & Charles Scriver MD/PhD Studentship

Liana Zucco University of Toronto Fellowship

PublicationsDelgado DH, MiriukaSG, Cusimano RJ, Feindel C, Rao V, Ross HJ: Use of basiliximab and cyclosporine in heart transplant patients with preoperative renal dysfunction. J Heart Lung Trans, 2005;24(2):166-169.

Fedak PWM, Rao V, Verma S, RamzyD, Tumiati L, MiriukaS, Boylen P, Weisel RD, Feindel CM: Combined endothelial and myocardial protection by endothelin antagonism enhances transplant allograft preservation. J Thorac Cardiovasc Surg, 2005;129(2):407-415.

MiriukaSG, Langman J, Evrovski J, Miner SES, et al: Genetic polymorphisms predisposing to hyperhomo-cysteinemia in cardiac transplant patients. Transplant International, 2005;18(1):29-35.

Leytin V, Allen DJ, GwozdzA, Garvey B, Freedman J: Role of platelet surface GPIba and P-selectin in the clearance of transfused platelet concentrates. Transfusion, 2004;44:1488-1496.

Liu PP, Fuse K, Chan G, Liu Y, Opavsky A: Viral myocarditis: From pathophysiology to the clinic. IN: Braunwald’s Heart Failure. Eds: Schultheiss HP, Poller W. Springer Verlag, 2004.

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Liu PP, ChanG, Fuse K, Liu Y: Immunomodulatory Therapies in Heart Failure. IN: Viral Myocarditis as a Paradigm. Ed: Feldman AM. Blackwell Publications, 2005.

RamzyD, Rao V, Tumiati LC, Ning X, MiriukaS, Delgado D, Ross HJ: Tetrahydrobiopterin prevents cyclo-sporine-induced vasomotor dysfunction. Transplantation, 2005;79(8):876-881.

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FACulTY

MembersFaculty are divided into 3 categories (Full, Associate, Affiliate). Details on faculty research interests and contact information are available on the web site. Departmental affiliations listed are those within the CSCP.

Name Departmental Affiliation(s) LocationFullLee Adamson BME/IMS/PSL Mount Sinai HospitalKhosrow Adeli LMP Hospital for Sick ChildrenPeter Backx IMS/Medicine/PSL UofT – HSRLCEJaques Belik IMS/PSL Hospital for Sick ChildrenMichelle Bendeck LMP/Medicine UofT – MSBDouglas Bradley IMS/Medicine Toronto General HospitalDina Brooks REH UofT – Rehabilitation ScienceJohn Coles IMS/Surgery Hospital for Sick ChildrenPhilip Connelly LMP/Medicine St. Michael’s HospitalDavid Courtman BME/Surgery St. Michael’s HospitalPaul Dorian IMS/Medicine/PCL St. Michael’s HospitalC. Ross Ethier BME UofT – Mechanical EngineeringJohn Flanagan IMS Toronto Western HospitalJohn S. Floras IMS/Medicine Mount Sinai HospitalChristopher Forrest IMS/Surgery Hospital for Sick ChildrenStephen Fremes IMS/Surgery SWCHSC – SunnybrookAdria Giacca PSL UofT - MSBJack M. Goodman EXS UofT - Physical Ed & HealthLen S. Goodman EXS Def & Civil Inst Environ MedAvrum I. Gotlieb LMP Toronto General HospitalAleksander Hinek IMS/LMP Hospital for Sick ChildrenChris Hudson IMS Toronto Western HospitalMansoor Husain IMS/LMP/Medicine Toronto General HospitalK. Wayne Johnston BME/IMS/Surgery Toronto General HospitalPeter G. Kalman IMS/Surgery CommunityFred Keeley LMP Hospital for Sick ChildrenB. Lowell Langille LMP Toronto General HospitalMichelle Letarte MBP Hospital for Sick ChildrenGary F. Lewis IMS/Medicine Toronto General HospitalRen-Ke Li IMS/LMP/Surgery Toronto General HospitalPeter Liu IMS/Medicine Toronto General HospitalMarius Locke EXS/CHL UofT – Physical Ed & HealthPeter McLaughlin IMS/Medicine Toronto General HospitalDonald A.G. Mickle LMP/Surgery Toronto General Hospital David Naylor IMS/Medicine/CHL/Surgery UofT – MSBHeyu Ni LMP St. Michael’s HospitalMatadial Ojha BME/Surgery UofT – Rosebrugh Bldg.John Parker IMS/Medicine Mount Sinai Hospital

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Tom Parker IMS/Medicine Toronto General HospitalMargaret Rand IMS/LMP Hospital for Sick ChildrenVivek Rao IMS/Surgery Toronto General HospitalMichael Sefton BME UofT – Wallberg Bldg.Craig Simmons BME UofT – Mechanical EngineeringArthur S. Slutsky IMS/Medicine/Surgery Mount Sinai HospitalMichael J. Sole IMS/Medicine/PSL Toronto General HospitalDonna E. Stewart Anesthesia/IMS/Surgery/Medicine Toronto General HospitalDuncan Stewart IMS/LMP/Medicine St. Michael’s HospitalBradley Strauss LMP/Medicine St. Michael’s HospitalScott G. Thomas EXS/PSL UofT – Physical Ed & HealthGeorge Tomlinson CHL Toronto General HospitalRobert Tsushima IMS/Medicine/PSL UofT - MSBJack Tu HPME SWCHSC - Sunnybrook Robert Wald IMS/Medicine Mount Sinai HospitalRichard D. Weisel IMS/Surgery Toronto General HospitalGregory Wilson IMS/LMP/PSL/Surgery Toronto General HospitalCarin Wittnich IMS/PSL/Surgery UofT - MSBGraham Wright MBP SWCHSC - SunnybrookTai-Wing Wu LMP Toronto General HospitalErik L. Yeo IMS/Medicine Toronto General Hospital

AssociateJoel Fisher Anesthesia Toronto General HospitalGregory Hare PSL St. Michael’s HospitalScott Heximer PSL UofT - MSBJane Irvine CHL Toronto General HospitalValery Leytin LMP St. Michael’s HospitalTom Lindsay IMS/Surgery Toronto General HospitalNisar A. Shaikh LMP CommunityLori West IMS Hospital for Sick Children

AffiliateMichael Borger Surgery Toronto General HospitalJagdish Butany LMP/Medicine Toronto General HospitalChris M. Feindel Surgery Toronto General HospitalDavid Mazer Anesthesia St. Michael’s HospitalPatricia Murphy Anesthesia Toronto General HospitalRichard I. Ogilvie Medicine/PCL Toronto Western HospitalLen Schwartz Medicine Toronto General Hospital

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Awards and HonorsM. Borger Roscoe Reid Graham Department of Surgery Award, UofT

D. Brooks New Investigator Award, Canadian Institutes of Health Research Mentorship Award, Canadian Physiotherapy Association Recognition in Teaching Award, Department of Physical Therapy, UofT

J. Butany Vice President and President Elect, International Society for Cardiovascular Pathology Vice President and President Elect, Canadian Association of Pathologists Judge, Annual Cardiovascular Scientific Day, HSRLCE

R. Ethier Tier I Canada Research Chair in Computational Technology Faculty Teaching Award

J. Fisher 1st Prize: A New Method for Noninvasive Measurement of Cardiac Output During Spontaneous Breathing. Assoc of the Industry for Health Technologies and Univ. of Montreal

J.G. Flanagan Chair, Admittance Committee, Section 6 (Academic), American Academy of Optometry

Glenn A Fry Award, American Optometric Foundation Keynote Speaker, Meeting of Deutsch Ophthalmologische, Germany Appointed to Technical Advisory Group for Glaucoma, Carl Zeiss Meditec Top Ranked Grant Application, Glaucoma Research Society of Canada

J. Floras Canada Research Chair (Tier 1) in Integrative Cardiovascular Biology Career Investigator Award, HSFO

C.R. Forrest W.K. Lindsay Research Supervisor Award 2004 Chairman, Plastic Surgery Research Council

A. Gotlieb J.B. Walter Teaching Award, Dept. of Laboratory Medicine and Pathobiology (shared with D. Templeton). Innovation in Undergraduate Teaching, Specialist Program in Pathobiology

C. Hudson Canadian Institutes of Health Research, New Investigator Director, Retinal Research, University Health Network

M. Husain Career Investigator Award: Molecular regulation of vascular smooth muscle cell pro-liferation and contractility. Heart & Stroke Foundation of Ontario

Premier’s Research Excellence Award: Molecular regulation of vascular smooth muscle cell proliferation: The role of calcium pumps in atherosclerosis and hypertension. Government of Ontario

Allan Bruce Robertson Young Investigator Award, Clinical Research Society of Toronto Member, Scientific Review Committee “Cardiovascular C”, Canadian Institutes of

Health Research External Reviewer, Medical Research Council, United Kingdom

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J. Irvine Faculty of Graduate Studies Teaching Award, York Univ.

G. Lewis Canada Research Chair, Tier 2

R-K Li Adjunct Scientist Cross Appointment, St. Michael’s Hospital TGRI Space Committee Chair, Toronto General Research Institute, University

Health Network, Toronto

P. Liu Visiting Professor Award, Royal College of Physicians & Surgeons of Canada 2005 American College of Cardiology Merit Award for Continued Excellence in

Extramural Education Programs Distinguished CV Research Lecturer, UBC 2004` University Lecturer, University of Saskatchewan

M.L. Rand Member, Board of Directors, Heart & Stroke Foundation of Ontario

V. Rao Alfredo and Teresa DeGasperis Chair in Surgical Management of Heart Failure, University Health Network, UofT

C.A. Simmons William Gies Award, IADR/AADR, Best Biomaterials/Bioengineering paper pub-lished in the Journal of Dental Research for past year

A.S. Slutsky Elected to the Fleischner Society for Thoracic Imaging and Diagnosis at its Annual World Congress, Florence, Italy

Recognition for Scientific Accomplishments, American Thoracic Society, San Diego, California

D.J. Stewart Associate Director Research, Basic Science, St. Michael’s Hospital Program Director, Regenerative Medicine, R. Samuel McLaughlin Centre for

Molecular Medicine

B. Strauss Promotion to Full Professor, UofT

R. Tsushima New Investigator Award, Heart & Stroke Foundation of Canada Premier’s Research Excellence Award, Government of Ontario

J. Tu Career Investigator Award, Heart & Stroke Foundation of Ontario Renewal of Canada Research Chair in Health Services Research, Faculty of Medicine,

UofT

R.D. Weisel Wilfred Bigelow Lectureship 2004 Award, Canadian Society of Cardiac Surgeons, Calgary, AB

Distinguished Achievement Award, Council on Cardiovascular Surgery and Anesthesia, American Heart Association, New Orleans, LO

Guest Lecturer, American Association for Thoracic Surgery, San Francisco, CA Director, Toronto General Research Institute, University Health Network

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C. Wittnich Sustained Contribution to Excellence in Graduate Teaching, Graduate & Inter-Faculty Affairs Award, Faculty of Medicine, UofT

Distinguished Alumni Award, Ontario Veterinary College, University of Guelph

Peer Reviewed FundingAlter D, Austin P, TuJV(Co-Inv),NaylorCD, Mustard C, Irvine M, Morgan C, Wheaton B: Socioeconomic status and outcomes after acute myocardial infarction. CIHR, 2004 – 2007

Austin PC, TuJV(Co-Inv),Alter DA, Stukel T, NaylorCD: Improving the accuracy of health ‘report cards’. CIHR, 2003 – 2005

Austin PC, TuJV(Co-Inv),NaylorCD:Examining the accuracy of cardiac report cards. HSFO, 2003 – 2005

BackxP(PI),HusainM(Co-PI): Role of ACE2 in the regulation of cardiac and vascular function. CIHR Operating Grant, 2003 – 2008

Beanlands R (PI), Haddad H, Leech J, Burwash IG, FlorasJ, DaSilva J, deKemp RA (Co-Inv): Effects of continuous positive airway pressure on myocardial energetics and sympathetic nerve function in patients with heart failure and obstructive sleep apnea. HSFO, 2005 – 2007

Beattie WS, RaoV, Chan C: The PRIME (Perioperative Renal Insufficiency Management) study: A random-ized, double-blind, placebo-controlled trial of N-Acetylcysteine for preventing renal injury after cardiac surgery. HSFC, 2003 – 2005

Belik,J(CoPI): Ventilator-induced lung injury: Linking gene expression, physiology and outcome (co-applicant). CIHR Operating Grant, 2003 – 2006

BelikJ(Co-PI): Application of novel ultrasound techniques for basic and translational research models. CIHR Equipment Grant, 2004

Belik,J(PI): Airway modulation of pulmonary vascular tone during development and following pulmo-nary hypertension. CIHR Operating Grant, 2004 – 2009

Ivanov J, BorgerMA,David TE, TuJV(Co-Inv): A propensity score, pairmatched study of late outcomes for off-pump versus on-pump coronary artery bypass graft surgery. HSFC, 2004 – 2005

BorgerMA, Djaiani G, Green RE, Ivanov J, FeindelCM: Minimal invasive cardiac surgery: Is it safe for the brain? HSFO, 2005 – 2007

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BorgerMA, David TE, FeindelCM: Clinical assessment of the BioPhysio valve. Edwards Lifesciences Inc., 2005 – 2007

Brodland W (PI), EthierR: Measurement of biomechanical properties of the optic nerve with application to glaucoma. CIHR/NSERC Collaborative Health Research Program, 2004 – 2007

Brown TJ (PI), LetarteM(Co-Ap): Functional characterization of androgen-altered genes with a putative role during early events in ovarian carcinogenesis. CIHR Operating Grant, 2005 – 2009

Cheung AM, LiuP, Abramson B, StewartDE: Clinical trial of Raloxifene use in the heart (RUTH). Eli Lilly, 1998 – 2007

Cohen G, et al… WrightGA (Col): Left ventricular mass regression following aortic valve replacement with stentless versus stended valves: Follow-up of a randomized trial delivery and tracking of stem cells in acute myocardial infarction. HSFC, 2004 – 2006

ConnellyPW: Identification of the mechanisms of oxidation of high density lipoproteins in vivo in the mouse. HSFO, 2005

ConnellyPW, Hanley AJ (PI): Longitudinal associations of adipocytokines and markers of sub-clinical inflammation with changes in insulin resistance and beta-cell function in women with a history of gestational diabetes mellitus. CIHR, 2004 – 2007

CourtmanD,StewartDJ: Arterial remodeling. HSFO, 2005 – 2007

Dennis CL (PI), StewartDE(Co-Ap): An RCT to evaluate the effectiveness of peer support for PPD. CIHR, 2004 – 2007

Dick A, WrightGA,StewartDJ: Delivery and tracking of stem cells in acute myocardial infarction. HSFO, 2004 – 2006

EthierR(PI): Computational Hemodynamics. NSERC, 2005 – 2009

EthierR(PI): Factors controlling aqueous outflow resistance in glaucoma. CIHR, 2001 – 2008

EthierCR(PI),FlanaganJG(Co-Ap):Cell culture model of glaucoma using ischemia. Glaucoma Research Society of Canada, 2004

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EthierR(PI): Human anterior segment perfusion studies: Phase I Bausch and Lomb (contract), 2004 – 2005

Fan MZ, Liu Q, Mine Y, Yada R, Bakovic M, LiR-K(Co-Ap),Hellerstein M: Functionality of resistant starch and bioactive peptides in preventing chronic diseases and promoting gut functions in studies with the pig model. Ontario Ministry of Agriculture & Food, University of Guelph Food Research Program, 2004 – 2008

Fedak P, ButanyJ: Matrix remodeling and ascending aortic aneurysm. PSI, 2005

FeindelCM,RaoV: Hypertonic saline for cardiac transplantation. HSFO, 2004 – 2006

FeindelCM,RaoV: Preservation of endothelial function following prolonged storage of cardiac allografts with shed donor blood. HSFO, 2001 – 2004

FlanaganJG(PI): Diurnal changes in ocular perfusion, IOP and optic nerve topography. Glaucoma Research Society of Canada, 2001 – 2005

FlanaganJG(PI),EthierR:Development of a hypoxic cell culture model of glaucoma. Glaucoma Research Society of Canada, 2004 – 2005

FlanaganJG(PI): The development of a sterile, universal, barrier systems for use with contact ophthalmic devices. Department of Health (UK), 2003 – 2004

FlanaganJG(PI),EthierR(CoPI): The role of lamina cribrosa biomechanics and ischemia in glaucoma-tous optic neuropathy. CIHR, 2001 – 2006

FlorasJS: Canada Research Chair (Tier I) in integrative cardiovascular biology. CIHR, 2004 – Present

FlorasJS: Career Investigator Award. HSFO, 2001 – 2006

FlorasJS(ProgDir),ParkerJD, Newton GE, BradleyTD, Chauhan VJ (Co-Aps): Multidisciplinary group for the investigation and therapy of human cardiovascular disease. HSFO Program Grant, 2003 – 2007

FlorasJS: Cardiovascular regulation in men and women with heart failure and hypertension. HSFO, 2002 – 2007

FlorasJS: Peptidergic and purinergic modulation of the autonomic nervous system in humans. CIHR Operating Grant, 2002 – 2007

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FlorasJS(PI),BradleyTD (Co-Inv): Cardiopulmonary interactions in health and disease. MRC, 2000 – 2005

FlorasJS(PI), Chan C, Miller J, Pierratos A (Co-Inv): By what mechanisms does conversion from conven-tional intermittent dialysis to nocturnal hemodialysis lower blood pressure? CIHR, 2005 – 2008

FlorasJS(PI),Chan D, Dzavik V, Bradley TD (Co-Inv): Cardiovascular, autonomic and neurohumoral impact of nocturnal hemodialysis. CIHR, 2005 – 2010

ForrestC, Gevorgyan A: Apoptosis in cultured calvarial cells following radiation. Plastic Surgery Educational Foundation, 2004 – 2005

ForrestCR, Gevorgyan AM: Bernd Spiessel Award 2004: Radiation-induced craniofacial bone growth retar-dations: Relationship between p53 expression, apoptosis and cell cycle arrest following radiation and cyto-protection in vitro. Am Soc Maxillofacial Surgeons, Synthes Maxillofacial Grants, 2004 – 2005

Freedman J (PI), Semple J, Lazarus A, Lau H, NiH,LeytinV(Co-Inv): Investigations of novel mecha-nisms of IVIG function using a murine model of idiopathic thrombocytopenic purpura (ITP). Canadian IVIG Steering Committee, 2004 – 2005

Gagnon AJ (PI), Dennis C, Oxman-Martinez J, StewartDE, et al (Co-PI’s): The childbearing health and related service needs of newcomers (CHARSNN). CIHR, 2004 – 2008

Gaisano HY (PI), TsushimaRG(Co-Inv): SNARE protein regulation of voltage-gated potassium channels in neurosecretory cells. CIHR, 2004 – 2007

Galipeau J, LiuP,StewartDJ, Lansdorp PM, Karsan A, Megeney LA: Cardiovascular and respiratory stem cell plasticity – CARE project. CIHR, 2004 – 2009

Gevorgyan A, ForrestCR:Radiation induced craniofacial bone growth inhibition: In vitro investigation of the molecular mechanisms and cytoprotection. Am Soc Maxillofacial Surgeons, 2004 – 2005

GiaccaA(PI): Metabolic determinants of vascular damage. HSFC, 2002 – 2005

GiaccaA(PI): Anti-atherogenic effect of insulin. HSFC, 2005 – 2008

GiaccaA(PI): Mechanisms of fatty acid induced insulin resistance. CDA, 2004 – 2006

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GiaccaA(PI):Interaction between lipotoxicity and glucotoxicity on glucose stimulated insulin secretion. CIHR, 2004 – 2007

GiaccaA(Co-PI): Glucose toxicity: Prevention of compliations and preservation of beta cell function. CIHR, 2002 – 2007

GiaccaA(Co-PI),Tsiani E: Investigation of the biological effects of the polyphenol resveratrol on skeletal muscle glucose transport. NSERC, 2004 – 2007

GotliebAI,LangilleBL(Dir): Member, Cell Biology of Atherosclerosis Program Grant. HSFO Infrastructure Support, 2000 – 2005

GotliebAI,LangilleBL(Co-PI’s): The endothelium in atherogenesis: Influences of hemodynamic stresses. HSFO, 2001 – 2006

GotliebAI,BendeckM,(Co-PI):Heart valve repair: Regulation of cell and matrix. HSFO, 2002 – 2004

GotliebAI(Member),Deschepper C (Proj. Leader): Operational and ethical issues associated with banking human biologic materials. New Frontiers Program. CIHR, 2004 – 2005

Grace SL, StewartDE(PI’s), Abramson B, BrooksD, Jaglal S, Scholey P, Suskin N, Arthur H, Evindar E (Co-App’s): An Evidence-Based Health Services Evaluation of Informational and Management Continuity in Heart Patients Canadian Health Services Research Foundation, 2003 – 2006

Grace SL, StewartDE, Suskin A, Alter DA, Higginson L (Co-PI’s): Contribution of patient and physician factors to cardiac rehabilitation referral and participation: A prospective, multi-level study. CIHR, 2005 – 2008

Guidos CJ (PI), LetarteM(Co-Ap): Shared flow cytometry facility. CIHR Maintenance Grant, 2001 – 2006

Hakim A, TuJV(Co-Inv), et al: Canadian Stroke Network. Networks of Centres of Excellence, 2000 – 2007

Henkelman M, et al…WrightGA: Medical imaging for cancer. NCI, Canada Program Project, 2001 – 2006

HinekA(PI): Career Investigator Award HSFC, 2004 – 2007

HinekA(Co-Inv),LiuP(PI): Aldosterone receptor and non-receptor based mechanism of repair and remodeling following cardiac injury. HSFC Operating Grant, 2004 – 2007

HinekA(PI): Comparison of biological effects of different preparations of elastin-derived peptides on skin fibroblasts. Human Matrix Sciences Operating Grant, 2004 – 2006HudsonC(PI): Pre-clinical detection, and improved monitoring, of early sight-threatening diabetic reti-nopathy. CIHR, New Investigator Award, 2001 – 2006

Hunter J, Barker K (Co-PI’s), Geruge S, McNally MJ, StewartDE(Co-Ap’s): Cultural care patterns in a mobile health unit. Nursing Research Award, 2004 – 2005

HusainM(PI): c’Myb’dependent vascular smooth muscle cell proliferation. CIHR Operating Grant, 2001 – 2004 2004 – 2009

HusainM(PI): The role of plasma membrane Ca2+-ATPase isoforms in vascular smooth muscle cell biol-ogy. CIHR Operating Grant, 2003 – 2008

HusainM(PI): The role of plasma membrane Ca2+-ATPase isoforms in vascular pathophysiology. HSFO Operating Grant, 2003 – 2006

IrvineJ(Co-Inv): Developing and testing a comprehensive telemanagement system to improve chronic disease treatment in primary health care: A demonstration project in diabetic patients with uncontrolled hypertension. OMH, Primary Health Care Transition Fund, 2005 – 2006

IrvineJ(PI): Psychological support for patients with an implantable cardioverter defibrillator. HSFO, 2003 – 2006

IrvineJ(Co-Inv): Sexual dysfunction and adaptation in couples affected by prostate cancer surgery: Steps towards a biopsychosocial model of treatment. CIHR, 2005 – 2008

Johnson M (PI), EthierR (CoPI): The Hydrodynamics of Aqueous Humor Outflow NIH, 2004 – 2009

JohnstonKW(PI),EthierR (CoPI): Fundamental Ultrasound Studies CIHR, 2002 – 2006

JohnstonKW(PI),EthierR: Fundamental ultrasound studies. CIHR, 2002 – 2006

Johnson M (PI), EthierR: The hydrodynamics of aqueous humor outflow. NIH (subgrant), 2004 – 2009

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Karbouti K, Beattie WS, RaoV, Chan C, Ivanov J: The RICH (Renal Insufficiency in Cardiac Surgery: Role of Hemodilution) study. Earl Wynands Award in Cardiovascular Anaesthesis, 2004 – 2005

KeeleyFW: Post-transcriptional regulation of vascular elastin synthesis in development and disease. CIHR Program Grant, 2001 – 2006KeeleyFW: Recombinantly expressed polypeptides of human elastin as a novel tool for investigations of the structure and assembly of elastin. HSFO, 2004 – 2009

KeeleyFW(Co-Ap), Parkinson J: A combined theoretical/experimental approach to understanding sequence-structure-function relationships in elastin and elastin-like peptides. HSFO, 2005 – 2007

KeeleyFW(Co-Ap), Wright GM: Characterization of extracellular matrix proteins in lamprey cartilage. NSERC, 2005 – 2010

KeeleyFW: Production and characterization of human elastin polypeptides as vascular graft materials. Elastin Specialties, Inc, 2004 – 2006

Keith M, StewartDJ: Does nutrient supplementation influence cardiac structure and function following MI by altering energy metabolism? CIHR, 2005 – 2007

Khan K, Gardam M, SlutskyAS,Jha P: Optimizing clinical and public health management of influenza-like-illnesses of undetermined etiology in a world changed by SARS. CIHR, 2004 – 2005

LangilleBL(PI): Developmental arterial remodeling: Influence of shear stress. CIHR, 2000 – 2005

LangilleBL,GotliebAI: Influence of hemodynamics on arterial endothelium. CIHR, 2001 – 2006

LangilleBL(PI): Influence of hemodynamics on arterial endothelium. HSFO, 2002 – 2007

LangilleBL(PI),BendeckM: Cadherins and regulation of smooth muscle cell function. HSFO, 2004 – 2007

LangilleBL(Director),BendeckM,CourtmanD,CybulskyM,GotliebA,HeximerS,HusainM,Marsden P, StewartD,StraussB,Ward M: Cell biology of atherosclerosis. HSFO Group Grant, 2000 – 2005 2005 – 2010

LangilleBL, Lye SJ (Director): Development and Fetal Health CIHR Group Grant, 2000 – 2005 2005 – 2010

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Leask R, ButanyJ: Local tissue changes in dilated ascending aortas. NSERC – CHIR: Collaborative Heart Research Projects, 2005 – 2008

Leong-Pol H, StewartDJ: Novel diagnostic and therapeutic applications of myocardial contrast echocar-diography and targeted microbubbles for therapeutic angiogenesis. CIHR, 2003 – 2006

LetarteM(PI): Setting up protein microarray analysis of ovarian cancer. UHN Operating Grant, 2005 – 2006

LetarteM(PI): Structure and function of endoglin. CIHR Operating Grant, 2000 – 2005

LetarteM(PI): The role of endoglin in the normal vasculature and in the pathology of hereditary hemor-rhagic telangiectasia. HSF Grant in Aid, 2002 – 2005

LetarteM(PI): A molecular diagnostic test for hereditary hemorrhagic telangiectasia. CIHR, 2004 – 2005

LewisG: Canada Research Chair, 2006 – 2011

LewisG: Career Investigator Award HSFC, 2003 – 2008

LewisG(PI):Determining the mechanisms of hepatic and intestinal lipoprotein overproduction in insulin resistant states. CIHR Operating Grant, 2004 – 2007

LewisG(PI): Regulation of HDL metabolism. HSFO Operating Funds, 2005 – 2008

LewisG(PI): Mechanism of fatty acid-induced impairment of glucose-stimulated insulin secretion. CDA Operating Funds, 2005 – 2007

LewisG(Co-Inv): Glucose toxicity: Prevention of diabetes complications and preservation of pancreatic beta cell function. CIHR New Emerging Team Grant, 2002 – 2007

LewisG(PI): Mechanisms of insulin sensitization with vasopeptidase inhibitors. HSFO Operating Funds, 2003 – 2006

LeytinV(PI), Freedman J (Co-App): Platelet apoptosis in vitro and in the circulation. HSFC, 2003 – 2005

LiR-K(PI): Cell transplantation for cardiovascular disease. HSFO, 2001 – 2006

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LiR-K(PI): Cell transplantation to improve heart function. Ontario Ministry of Energy, Science & Technology, 2001 – 2006

LiR-K(PI): Autologous tissue-engineered grafts for congenital heart surgery. CIHR, 2003 – 2008

LiR-K(PI): Vasculogenesis induced by cell transplantation. HSFO, 2003 – 2007

LiR-K(PI), Fedak PW: Gene-enhanced cell transplantation to reverse heart failure. HSFO, 2004 – 2007

LiR-K(PI), Fazel S: The interplay of recruited stem cells and the matrix after myocardial infarction: Shifting the balance toward repair. CIHR, 2004 – 2009

LindsayTF: Ruptured abdominal aortic aneurysm: Molecular mechanisms to clinical studies. PSI, 2004 – 2006

LiuP: Biomarkers in cardiovascular disease. Genome Canada, 2004 – 2007

LiuP: Gene-environment factors in heart failure (CHFNET). CIHR, 2002 – 2007

LiuP: Cardiovascular health research advancements molecule to populations (TACTICS). CIHR, 2002 – 2008

LiuP: Host response patterns in heart failure (CHF-CORE). CIHR, 2003 – 2008

LiuP: Molecular mechanisms of viral myocarditis. CIHR, 2004 – 2009

LiuP: Cytokines in heart failure. CIHR, 2001 – 2006

LiuP: Oxidative stress & iron overload cardiomyopathy. CIHR, 2001 – 2006

LiuP: Chlamydia & atherosclerosis: Immune insights (Rated #1 by Panel). HSF, 2003 – 2008

LiuP: The role of aldosterone in cardiovascular remodeling. HSF, 2004 – 2007

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LiuP: The role of inflammation in stem cell homing post cardiac injury. HSF, 2003 – 2006

LiuP: Cardiovascular complications in diabetes. CIHR New Frontiers Program, 2005

LiuP, 31 Co-Applicants including WittnichC: Training program in cardiovascular research: Molecules to humans, heart failure to prevention (TACTICS). CIHR, 2002 – 2007

LiuP,StewartDJ: T-cell based immune mechanisms of chlamydia vascular injury. HSFC, 2003 – 2008

LiuP(Director),BackxP,HusainM, MacLennan D, ParkerT,SoleMJ,StewartDJ(Members): Determinants of host susceptibilities of heart failure. CIHR Group Grant, 2003 – 2008

LiuP,BackxP,HusainM,MacLennan DH, ParkerT,SoleMJ,StewartDJ: Coordinated original research in elucidation of mechanisms in heart failure (CHF-CORE). CIHR, 2004 – 2009

LiuPP,BackxPH, Dhalla NS, Dixon IMC, Kirshenbaum LA, TuJV(Co-Inv), et al: A training program in cardiovascular research: Molecules to populations, heart failure to prevention. CIHR, 2002 – 2008

MazerCD(Co-I): A randomized trial of a lung-open ventilation strategy (LOVS) in acute lung injury. CIHR, 2000 – 2006

MazerCD(Co-I): Blood conservation using antifibrinolytics: A randomized trial in a cardiac surgery pop-ulation – The BART Study. CIHR, 2002 – 2005

McIlroy W,BrooksD: Early exercise intervention after stroke: Influence on functional capacity, sensorimo-tor recovery and risk of future strokes. CIHR Operating Grant, 2003 – 2006

McIllroy W (PI), ThomasSG, et al: Early exercise intervention after stroke: Influence on functional capac-ity, sensorimotor recovery, and risk of future strokes. CIHR, 2003 – 2005

Mentzer SJ (PI), LetarteM(Co-Ap): Physiology of systemic and pulmonary microangiectasias. NIH Operating Grant, 2003 – 2007

Nag S, StewartDJ: Regulation of cerebrovascular homeostasis and repair by angiogenic factors. HSFO, 2004 – 2006

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NiH(PI), Freedman J (CoPI): Investigation of pathogenesis of immune thrombocytopenia and efficacy and mechanism of action of IVIG in a novel mouse model. CIHR/Canadian Blood Services Partnership Fund, 2003 – 2006

NiH(PI), Freedman J (CoPI): Pathogenesis of fetal and neonatal alloimmune thrombocytopenia and mechanism of action of IVIG in a novel mouse model. CIHR, 2004 – 2007

NiH(PI): Novel mechanisms of platelet aggregation: Roles of alternative ligands of b3 integrins in throm-bosis and hemostasis. HSFO, 2005 – 2008

NiH(PI), Freedman J (Co-PI): Study of fetal and neonatal alloimmune thrombocytopenia in a novel mouse model and investigation of efficacy and mechanism of action of IVIG in these disorders. Bayer/Canadian Blood Services/Hema-Quebec/CIHR Partnership Fund, 2004 – 2005

NiH(PI): Freedman J (Co-PI): Novel mechanisms of platelet aggregation independent of von Willebrand factor and fibrinogen, and their effect on thrombosis and hemostasis. HSFO, 2003 – 2005

Nicholas B, Antle B, Beaune L, Coates A,… WestLJ: Exploring the psychosocial and health service conse-quences of SARS on children and their families: Lessons learned for pediatric health care practice and policy. CIHR, 2004 – 2006

Nolan RP (PI), Ruckholm E, StewartDE(Co-PI’s): Community outreach and heart health risk reduction trials (COHRT) component study 1: Efficacy of group outreach methodology. HSFO, 2002 – 2006

Pang CY, ForrestCR, Neligan PC: Global protection of skeletal muscle against ischemic necrosis and vas-cular dysfunction by non-invasive remote ischemic preconditioning: Efficacy and mechanism. CIHR Operating Grant, 2003 – 2006

ParkerJ(PI): Neurochemical effects of different pacing modalities in CHF. HSF, 2004- 2007

ParkerJ(PI):Studies concerning the vascular effects of the organic nitrates. HSF, 2004- 2007

ParkerJ(PI): Studies concerning the vascular effects of the organic nitrates. CIHR, 2004- 2007

ParkerT(PI): Regulation of cardiac structure and function by the EF-hand proteins. CIHR Operating Grant, 2003 – 2006

ParkerT(Co-Inv):Coordinated original research in elucidation of mechanisms in heart failure (CORE-CHF). CIHR Group Grant, 2003 – 2008

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ParkerT(PI): Inhibition of the cardiac hypertrophic phenotype by the calcium-binding protein, S100B. CIHR Operating Grant, 2002 – 2005

ParkerT(PI): Role of S100B-dependent pathways in the cardiac response to disease. CIHR, 2005 – 2010

Pilote L, Cox JL, Ghali WA, Humphries KH, O’Louglin JL, TuJV(Co-Inv), et al: Gender and sex deter-minants of cardiovascular disease: From bench to beyond. CIHR, 2004 – 2009

Pilote L, Abrahamowicz M, Eisenberg MJ, Humphries KH, Joseph L, Rahme E, TuJV(Co-Inv):A popu-lation-based analysis of the effectiveness and determinants of use of cardiac drugs for congestive heart failure. CIHR, 2004 – 2007Puri M (PI), LetarteM(Co-Ap): Role of endoglin in mammalian cardiovascular development. HSF Grant in Aid, 2004 – 2006

RandML: The procoagulant surface of activated platelets: Persistence in vivo and in vitro. HSFO, 2004 – 2007

RaoV:Transplant vasculopathy: The role of endothelium. Am Assoc Thorac Surgeons, Robert E. Gross Scholarship, 2003 – 2005

RaoV: Transplant vasculopathy: The role of endothelium. CIHR, 2003 – 2008

Romans SE (PI), Benazon LR, Einstein G, Kreindler D, Laredo SE, Morgan K, StewartDE,Toner BB (Co-PI’s): Mood changes and daily life. CIHR, 2005 – 2008

Rowlands J, WrightGA, et al: Imaging Research Centre for Cardiac Intervention Canadian Foundation for Innovation, 2002 – 2006

SeftonM(PI),GotliebAI,YeoE(Coll): Modular tissue engineering components for vascularized con-structs. NIH, 2002 – 2005

SimmonsCA: Novel devices for high throughput mechanobiology. Connaught Foundation, 2005 – 2006

Singer P (PI), Cheung AM, Deber R… StewartDE, Till J (Co-Ap’s): Canadian program on genomics and global health: International and comparative perspectives on health systems and insurance implications of new genetic testing. Genome Canada, 2001 – 2006

SlutskyAS, St. Michael’s Hospital: Critical Care Unit for Research Excellence (CCURE) [Group grant including approximately 20 critical care physicians/specialists from southern Ontario]. Canada Foundation for Innovation & Ontario Innovative Trust, 2002 – 2006

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SlutskyAS: Biotrauma: Mechanisms of lung injury and distal organ dysfunction. CIHR, 2004 – 2009

SlutskyAS(PI),DorianP(CoI), Morrison L: Clinical research consortium to improve resuscitation out-comes: From bench to bedside to curbside. NIH/CIHR/HSFC, 2004 – 2009

SoleM(PI): Molecular cardiology. G.H. Wood Foundation, 2000 – 2005

SoleM: Heart failure. CIHR Group Grant, 2001 – 2004

SoleM: Coordinated original research in elucidation of mechanisms of HR. CIHR Group Grant, 2003 – 2008

SoleM(PI):Circadian rhythms in the heart. HSFO, 2003 – 2006

StewartDE(PI), Gucciardi E (CoPi): Psychosocial determinants of attrition in diabetes education service use and its impact on diabetes management outcomes. Can Diabetes Assoc, 2003 – 2005

StewartDE(PI), Barata P: Housing discrimination against victims of domestic violence. Canada Mortgage and Housing Corp, 2004 – 2005.

StewartDE,Robertson EK, Weller IMR (Co-PI’s): The relation between work related factors and mental health and well being in Canadian men and women. CIHR, 2003 – 2004

StewartDE, Bercovitz K, Poland BD, et al: Reducing infant exposure to environmental tobacco smoke in private places: A qualitative study. Can Tobacco Control Res Initiative, 2001 – 2005

StewartDJ: Mechanisms of angiogenesis: Biological and therapeutic potential of angiopoietins. CIHR, 2003- 2006

StewartDJ,CourtmanD: Microvascular endothelial cell loss in pulmonary hypertension. CIHR, 2002 – 2006

StewartDJ(PI),HusainM(CoPI): Pathophysiological relevance of endothelin-1. CIHR Operating Grant, 2001 – 2004 2005 – 2010

StewartDJ,HusainM: Targeted over-expression of inducible NO synthase: Relevance for the pathogenesis of cardiovascular disease. HSFO Operating Grant, 2002 – 2005 2005 – 2008

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StewartDJ,HusainM, Han R: NO-Synthase in cardiovascular health and disease. HSFO, 2005 – 2008

StewartDJ,CourtmanD: Microvascular endothelial cell loss in pulmonary arterial hypertension. CIHR, 2005 – 2010

StraussB(PI):The role of adventitial angiogenesis in the arterial response to injury. CIHR. 2002 – 2005

StraussB(PI): The role of perlecan in the pathophysiology of cardiovascular disease. CIHR, 2004 – 2007

StraussB(Co-Inv): Role of matrix metalloproteinase in atrial remodeling in heart failure. CIHR, 2004 – 2007

StraussB(PI),WrightGA,et al: Microvessel formation in chronic total occlusions: Pathophysiology and role in successful guide-wire crossing. CIHR, 2005 – 2008

Strauss SE, Goel V, David DA, Evans MF Laupacis A, TuJV(Co-Inv): Randomized trial of an internet-based evidence-based medicine continuing education intervention. CIHR, 2002 – 2006

Tanswell AK, BelikJ(CoPI), Chan A, O’Brodovich H, et al: Group in Lung Development. CIHR Group Grant, 2004 – 2009

ThomasSG, Franche R-L: Cardiac rehabilitation and readiness to return to work in patients with cardio-vascular disease. Toronto Rehabilitation Institute, Toronto Cardiac Care Network, 2002 – 2004

ThomasSG,BrooksD: Predicting participation in cardiac rehabilitation after coronary artery bypass surgery. TRI Research Fund, 2002 – 2004

ThomasSG: Target detection and marksmanship under noise stress (TD&M). DRDC, 2003 – 2005

Tourangeau AE, Doran DM, McGillis Hall L, O’Brien-Pallas L, Pringle D, TuJV(Co-Inv): Nursing and other determinants of hospital level outcomes such as 30-day mortality and readmission rates. CIHR, 2002 – 2005

Tourangeau AE, TuJV(Co-Inv), Doran DM, Pringle D, et al: Nurse staffing work environments: Relationships with hospital-level outcomes. CIHR, 2002 – 2005

Trope GE (PI), EthierR: In vivo testing and licensing of a glaucoma shunt valve: Phase II. PSI, 2005 – 2006

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TsushimaRG(PI): Expression of TRP channels in the heart. Premier’s Research Excellence Award, 2001 – 2006

TsushimaRP(PI): Regulation of cardiac nonselective cation channels. HSFO, 2002 – 2005

TsushimaRG(PI), Gaisano HY (Co-PI): SNARE protein interactions with cardiac and vascular Kv channels. HSFO, 2004 – 2006

TuJV, Ghali WA, Pilote L, Cox JL, Humphries KH, et al: Canadian cardiovascular outcomes research team II. CIHR, 2005 – 2006

TuJV, Novick RJ, Anderson J, Geoffrey M, FeindelCM, et al: Understanding the link between quality of care and outcomes report cards for coronary artery bypass graft (CABG) surgery in Ontario. HSFO, 2004 – 2006

TuJV(PI),FremesSE,NaylorCD, Austin PC, Anderson GM, FeindelCM, Novick RJ: Understanding the link between quality of care and outcomes report cards for coronary artery bypass graft surgery in Ontario. HSFO, 2004 – 2006

Tu K, Hux JE, Mamdani M, Jaakimanian L, Manuel D, TuJV(Co-Inv): Evaluation project of primary health care payment and delivery models on screening, detection and control of hypertension. Ministry of Health and Long-Term Care, 2004 – 2006

TuJV(PI), Ghali WA, Cox JL, Knudtson M, Laupacis A, et al: Canadian cardiovascular outcomes research team. HSFC, 2001 – 2005

TuJV(PI), Ghali WA, Cox JL, Knudtson M, Laupacis A, et al: Canadian cardiovascular outcomes research team. CIHR, 2001 – 2005

TuJV(PI): Canada Research Chair in Health Services Research, Tier 2. CIHR, 2001 – 2006

TuJV(PI), Chan B, Naylor CD: Quality of acute myocardial infarction care. MRC, 2000 – 2005

Verma S, WeiselRD (Co-PI): Modulating endothelial progenitor cells for myocardial regeneration: Role of PPARγ. HSFO, 2004 – 2006

Weintraub WS, BorgerMA, Multiple Other Co-Investigators: Outcome Assessment of Mitral Valve Replacement and Repair NIH, 2003 – 2005

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WeiselRD(PI),Verma S, Yau TM: Stem cells and restenosis: Defining the new paradigm. HSFO, 2003 – 2005

WeiselRD(PI),Verma S, Fazel S: Cardiac regeneration by cell transplantation. HSFO, 2004 – 2006

WestLJ: Investigation of neonatally-induced allograft acceptance in a mouse model. PSI, 2003 – 2005

WestLJ: Cardiac allograft tolerance induction during immaturity. HSFO, 2003 – 2007

WestLJ: Investigation of neonatal tolerance induced by ABO-incompatible infant heart transplantation. CIHR, 2004 – 2007

WestLJ: Investigation of neonatal immune tolerance induced by ABO-incompatible heart transplantation in a murine model. HSFO, 2004 – 2007

WilsonGJ(PI),BackxPH(Co-Inv): Ischemic preconditioning of the myocardium: Role of cell volume regulation. HSFO, 2002 – 2006

WilsonGJ(PI): Research on acellular matrix; tissue engineering approaches for pediatric cardiovascular reconstruction. CIHR

Wilson H (PI), FlanaganJG(Co-Ap):CIHR strategic training program in vision health research. NSERC, 2003 – 2009

WittnichC: Oxygen stress in newborn hearts (renewal). HSFO, 2002 – 2006

WittnichC: Impact of gender on myocardial pathology & ischemia/reperfusion (renewal). HSFO, 2004 – 2007

Wolfson C, Kirkland S, Raina P, StewartDE(Co-Ap), et al: The Canadian Longitudinal Study of Aging: Developmental Activities – Phase I. CIHR, 2004 – 2006

WrightGA: Magnetic resonance imaging for ischemic heart disease. CIHR, Investigator Award, 2000 – 2006

WrightGA, Prato F: Ontario Consortium for Cardiac Imaging. Ontario Research and Development Challenge Fund, 2000 – 2006

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WrightGA, Dick A, Merchant N: Magnetic resonance imaging for ischemic heart disease. CIHR, 2003 – 2007

WrightGA,Merchant N, Rubin BB: Magnetic resonance imaging for ischemia. CIHR, 2000 – 2005

WrightGA, Dick AJ: A 6-degree-of freedom device for 3D navigation in real-time. CIHR, 2004 – 2005

Zingg DW (PI), EthierR(CoPI):Development and application of LES algorithms for simulation of tur-bulent flows. Connaught Foundation, 2002 – 2005

Zu JW, LiR-K(Co-Ap): Development of a new, portable biomedical device for in vivo measurement of regional heart tissue elasticity. NSERC, 2004 – 2007

Zwarenstein M, Cox J, Chan B, Abrahams C, Sherrard H, TuJV(Co-Inv), Tepper J: Demand of cardiovas-cular care in Canada: Modules to use available human resources to best deliver care. CIHR, 2004 – 2007

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Ahmad F, Shik A, Vanza R, Cheung AM, George U, StewartDE: Voices of South Asian women: Immigration and mental health. Women Health, 2004;40:113-130.

Ahmad F, Shik A, Vanza R, Cheung AM, George U, StewartDE: Popular health promotion strategies among Chinese and East Indian immigrant women. Women Health, 2004;40:21-40.

Ahmad F, StewartDE: Predictors of clinical breast examination among South Asian immigrant women. J Immigr Health, 2004;6(3):119-126.

Al-Hesayen A, Azevedo ER, FlorasJS, Hollingshead S, Lopaschuk GD, ParkerJD: Selective versus nonselec-tive beta-adrenoceptor blockade in heart failure: Differential effects on myocardial energy substrate utilization. Eur J Heart Fail, 2005;7:618-623.

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Barata P, McNally MJ, Sales I, StewartDE: Defining and responding to wife abuse: Using women’s words in prevention education. Womens Health Issues, 2005;15:134-144.

Beaune L, ForrestCR, Keith T: Adolescents’ perspective on living and growing up with Treacher Collins Syndrome: A qualitative study. Cleft Palate Craniofac J, 2004;41(4):343-350.

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Bogaty P, Buller CE, Dorian P, O’Neill BJ, Armstrong PW: Applying the new STEMI guidelines: 1. Reperfusion in acute ST-segment elevation myocardial infarction. CMAJ, 2004;171(9):1039-1041.

BorgerMA, Preston M, Ivanov J, Fedak PWM, Davierwal P, Armstrong A, David TE: Should the ascending aorta be replaced more frequently in patients with bicuspid aortic valve disease? J Thorac Cardiovasc Surg, 2004;128:677-683.

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BorgerMA: Preventing stroke during coronary bypass: Are we focusing on the wrong culprit? J Card Surg, 2005;20:58-59.

BorgerMA, David TE, Doll N, Mohr FW: Intraoperative fracture of the right coronary artery: Recognition and management. Ann Thorac Surg, 2005;79:693-696.

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BrooksD, Solway S, MacDermid J, Switzer-McIntyre S, Brosseau L, Graham ID: The quality of clinical practice guidelines in physical therapy. Physiother Can, 2005;57:123-134.

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Bunda S, Kaviani N, HinekA: Fluctuations of intracellular iron modulate elastin production. J Biol Chem, 2005;280:2341-2351.

Burt VK, Wohlreich MM, Mallinckrodt CH, Detke MJ, Watkin JG, StewartDE: Duloxetine for the treat-ment of major depressive disorder in women aged 44-55 years. Psychosomatics, 2005;46(4).

ButanyJW, Naseemuddin A, Nair V, BorgerMA, Daniel L: Infective endocarditis in a Hancock biopros-thetic heart valve. J Card Surg, 2005;20:389-392.

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ButanyJ, Nair V, Ahluwalia MS, Graba J, Demellawy DE, RaoV, Ross H: Hypersensitivity myocarditis complicating hypertrophic cardiomyopathy heart. Can J Cardiol, 2004;20(9):911-914.

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Butany J, Maseemuddin A, Nair V, Feindel CM: DeBakey Surgitool mechanical heart valve prosthesis, explanted at 32 years. Cardiovasc Pathol, 2004;128(12):1346-1350.

ButanyJ, Nair V, Ahluwalia M, Woo A, Graba J, David TE: Honeycomb-like healed abscess: An unusual complication of infective endocarditis. J Card Surg, 2005;20(1):81-84.

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ButanyJ, Collins MJ: Analysis of prosthetic cardiac devices: A guide for the practicing pathologist. J Clin Pathol, 2005;58(2):113-124.

ButanyJ, Collins MJ, Duchnay M, El Demellawy D, Karski J, Ralph-Edwards AC: A quadricuspid aortic valve. J Card Surg, 2005;20(2):193-197.

ButanyJ, Nair V, Naseemuddin A, Nair GM, Catton C, Yau T: Cardiac tumors: Diagnosis and management. Lancet Oncol, 2005;6:219-228.

ButanyJ, Leong SW, Carmichael K, Komeda M: A 30-year analysis of cardiac neoplasms at autopsy. Can J Cardiol, 2005;21(8):675-680.

Cameron JI, Shin JL, Williams D, StewartDE: A brief problem solving intervention for family caregiver to individuals with advanced cancer. J Psychosom Res, 2004;57(2):137-143.

Carpentier A, Patterson BW, Uffelman KD, Salit I, LewisGF: Mechanism of highly active anti-retroviral therapy-induced hyperlipidemia in HIV infected individuals. Atherosclerosis, 2005;178:165-172.

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Clark AF, Brotchie D, Read AT, Hellberg P, English-Wright S, Pang IH, EthierCR, Grierson I: Dexamethasone alters F-actin architecture and promotes cross-linked actin network formation in human trabecular meshwork tissue. Cell Motil Cytoskeleton, 2005;60:83-95.

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Connelly PW, Maguire GF, Draganov DI: Separation and quantitative recovery of mouse serum aryles-terase and carboxylesterase activity by size-exclusion chromatography and ultracentrifugation. J Lipid Res, 2004;45:561-566.

ConnellyPW, Draganov DI, Maguire GF: Paraoxonase-1 does not reduce oxidation of phospholipids by peroxynitrite. Free Radic Biol Med, 2005;38:164-174.

Copland IB, Kavanagh BP, Engelberts D, McKerlie C, BelikJ, Post M: High tidal volume ventilation causes different inflammatory responses in neonatal versus adult lung. Am J Respir Crit Care Med, 2004;169:739-748.

Cox JL, Ramer SA, Lee DS, Humphries K, Pilote L, Svenson L, Tu JV for the Canadian Cardiovascular Outcomes Research Team Investigators: Pharmacological treatment of congestive heart failure in Canada: A description of care in five provinces. Can J Cardiol, 2005;21:337-343.

Cui N, Kang Y, He Y, Leung YM…TsushimaRG, Gaisano HY: H3 domain of syntaxin 1A inhibits KATP channels by its actions on the sulfonylurea receptor 1 mucleotide-binding folds-1 and -2. J Biol Chem, 2004;17:279(51):53259-53265.

Cunningham K, GotliebAI: The role of shear stress in atherogenesis. Lab Invest, 2005;85:1-15.

Damignani R, Klar K, ForrestC: Positional plagiocephaly among infants: Identification, management and prevention. UofT Med J, 2004;81(3):202.

David TE, FeindelCM, Ivanov J, Armstrong S: Aortic root replacement in patients with previous heart sur-gery. J Card Surg, 2004;19(4):325-328.

Davies PF, Passerini AG, SimmonsCA: The aortic valve: Turning over a new leaf(let) in endothelial pheno-typic heterogeneity. Arterioscler Thromb Vasc Biol, 2004;24:1331-1333.

Delgado D, Miriuka SG, Cusimano RJ, FeindelCM,RaoV, Ross HJ: Use of basiliximab and cyclosporine in heart transplant patients with preoperative renal dysfunction. J Heart Lung Transplant, 2005;24:166-169.

Dennis CL, StewartDE: Treatment of postpartum depression, part 1: A critical review of biological interven-tions. J Clin Psychiatry, 2004;65(9):1242-1251.

Deonarain R, Cerullo D, Fuse K, LiuPP, Fish EN: Protective role for interferon-beta in coxsackievirus B3 infection. Circulation, 2004;110:3540-3543.

DesMeules M, Kazanjian A, Maclean H, Payne J, StewartDE, Vissandjee B: Women’s health surveillance report: Introduction. BMC Women’s Health, 2004;25(4):S1.

Dharmakumar R, Hong J, Brittain J, Plewes DB, WrightGA: Oxygen-sensitive contrasts in blood for studay-state free precession imaging. Magn Reson Med, 2005;53(3):574-583.

Dharmakumar R, WrightGA: Understanding steady-state free precession: A geometric perspective. Concepts in Magn Reson, 2005;26(a):1-10.

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Diaz RJ, Zobel C, Cho HC, Batthish M, HinekA,BackxPH,WilsonGJ: Selective inhibition of inward rectifier K+ channels (Kir2.1 or Kir2.2) abolishes protection by ischemic preconditioning in rabbit ventricular cardiomyocytes. Circ Res, 2004;95(3):325-332.

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Doenst T, Velazquez EJ, Beyersdorf F… RaoV for the STICH Investigators: To STICH or not to STICH – We know the answer, but do we understand the question? J Thorac Cardiovasc Surg, 2005;129:246-249.

Dorian P, Bogaty P, Buller CE, O’Neill BJ, Armstrong PW: Applying the new STEMI guidelines: 2. Disturbances of cardiac rhythm after ST-segment elevation myocardial infarction. CMAJ, 2005;171(9):1042-1044.

DorianP, Philippon F, Thibault B, Kimber S et al, for the ASTRID Investigators: Randomized controlled study of detection enhancements versus rate-only detection to prevent inappropriate therapy in a dual-chamber implantable cardioverter-defibrillator. Heart Rhythm, 2004;1(5):540-547.

DorianP, Borggrefe M, Al-Khalidi HR, Hohnloser SM, et al: Placebo-controlled, randomized clinical trial of azimilide for prevention of ventricular tachyarrhythmias in patients with an implantable cardioverter defibril-lator. Circulation, 2004;110:3646-3654.

DorianP, Talajic M, Tang A: Implanted cardioverter defibrillators for the prevention of sudden death. Can J Cardiol, 2005;21(Suppl A):31-36.

Dos Santos CC, Han B, Andrade CF…SlutskyAS, Liu M: DNA microarray analysis of gene expression in alveolar epithelial cells in response to TNF-(alpha), LPS and cyclic stretch. Physiol Genomics, 2004;19(3):331-342.

Dos Santos CC, Zhang H, Liu M, SlutskyAS: Bench-to-bedside review: Biotrauma and modulation of the innate immune response. Crit Care, 2005;9(3):280-286.

Durbin A, Nadir N-A, Rosenthal A, GotliebAI: Nitric oxide promotes in vitro interstitial cell heart valve repair. Cardiovasc Pathol, 2005;15:12-18.

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Esposito JG, ThomasSG, Kingdon L, Ezzat S: Growth hormone treatment improves arteriovenous oxygen difference during exercise in patients with human immunodeficiency virus-associated wasting: A randomized controlled trial. J Clin Endocrinol Metab, 2004;89(10):5124-5131.

EthierCR, Read AT, Chan D: Biomechanics of Schlemm’s canal endothelial cells: Influence on F-actin archi-tecture. Biophys J, 2004;87:2828-2837.

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Faingold D, HudsonC,FlanaganJG, Guan K, et al: Assessment of retinal hemodynamics using the Canon laser blood flowmeter after a single dose of dorzolamide hydrochloride 2% eyedrops. Can J Ophthalmol, 2004;39:506-510.

Fan X, Ang A, Pollock-Barziv SM, Dipchand AI, Ruiz P, WilsonG: Donor-specific B-cell tolerance after ABO-incompatible infant heart transplantation. Nat Med, 2004;10(11):1227-1233 (Epub Oct 24).

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