A

nn

ual

Rep

ort

2009

 

RED

MO

              

 

 

  

2  

VOLUNTARY DONORS

• Available typed donors on December 31st, 2009 80314

Donors per Autonomous Community

Autonomous Community Typed Donors

x 100.000 hab.

Andalucía 12758 153.66Aragón 1113 82.72Asturias 2138 197.00Baleares, Islas 1502 137.12Canarias, Islas 4210 200.10Cantabria 493 83.67Castilla y León 5262 205.26Castilla – La Mancha 2250 108.10Catalunya 13563 181.43Comunidad Valenciana 7786 152.83Extremadura 3067 278.21Galicia 1990 71.17Madrid 8534 133.62Murcia 5819 402.28Navarra 5294 839.55País Vasco 3724 171.44Rioja, La 537 166.92Ciudad Autónoma de Ceuta 96 122.02Ciudad Autónoma de Melilla 39 53.09Andorra 139 NATotal 80314

0

10000

20000

30000

40000

50000

60000

70000

80000

90000

1993 1995 1997 1999 2001 2003 2005 2007 2009

Registered donors

Donors typed in 2009: 9539

  

3  

VOLUNTARY DONORS

• Donors cancelled during 2009 1474

Reasons for donor cancellation Older than 55 years 1173Disease 106Non traceable 63Voluntary 55Transfer to other registries 24Effective peripheral blood donation 30Decease 13Ethical reasons 11Other reasons 8

• Effective Hematopoietic Stem Cells Donors 39

Per product

Bone marrow 9Peripheral blood stem cells 30(lymphocyte donation) (2)

Collection Centres BM/PBSC

Hospital BM PBSC TotalCentro Hospitalario Ramón y Cajal 2 2 4Hospital Gregorio Marañón 1 4 5Hospital de la Princesa 2 2 4Hospital Puerta de Hierro 0 2 2Hospital Carlos Haya 0 4 4Hospital de Navarra 1 1 2Complejo Hospitalario de Santiago 0 1 1Hospital Virgen de la Arrixaca 0 1 1Hospital de Jerez de la Frontera 1 0 1Hospital Clínico de Valencia 1 0 1Hospital Clínico d Salamanca 0 4 4Hospital Dr. Negrín 0 2 2Hospital Son Dureta 0 2 2Hospital Central de Asturias 0 1 1Hospital Virgen del Rocío 1 1 2Hospital Xeral-Cies 0 1 1Centre de Transfusió i Banc de Teixitis 0 2 2Total 9 30 39

  

4  

UMBILICAL CORD BLOOD

• Available Cord Blood Units on December 31st, 2009 41771

CBU – Cord blood bank distribution

Cord Blood Bank Number TNC >1x109

CD34+ Available

Malaga Castilla-La Mancha: 312

14613 45% 59-3%

Barcelona Navarra:682 Extremadura:256 Aragón:305 Islas Baleares:185 Cantabria:63

12880 69% 99.6%

Galicia Castilla y León: 66

5234 31% 98.1%

Madrid La Rioja: 7

5343 58% 88.6%

Valencia 3245 54% 96.6%Tenerife 456 34% 26.3%

7932029

46687779

1087712566

1527117421

20732

24462

28801

36005

41 771

0

5000

10000

15000

20000

25000

30000

35000

40000

45000

1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009

CBU cryopreserved in 2009: 6404

  

5  

UMBILICAL CORD BLOOD

• Spanish CBU transplanted during 2009

229

Per banks of origin

Bank of origin Total National Patients

International Patients

Barcelona 142 (62%) 41 101Madrid 26 (11%) 9 17Malaga 31 (14%) 3 28Galicia 13 (6%) 0 13Valencia 15 (6%) 3 12Tenerife 2 (1%) 0 2Total 229 56 173

0

200

400

600

800

1000

1200

1400

'94 '95 '96 '97 '98 '99 '00 '01 '02 '03 '04 '05 '06 '07 '08 '09

CBU (n= 966)

PBSC (n= 197)

BM (n= 153)

Total Spanish donations n= 1264

  

6  

NATIONAL PATIENTS

A. Started Searches

• Searches initiated during 2009 687

Type of search Bone marrow / Peripheral blood stem cells 143Cord blood 10Bone marrow / Peripheral blood stem cells and cord blood 534

Started evolution searchesfor Spanish patients

0

100

200

300

400

500

600

700

1991 1993 1995 1997 1999 2001 2003 2005 2007 2009

CBU

PBSC/BM + CBU

PBSC/BM

Searches initiated in 2009: 687

  

7  

NATIONAL PATIENTS

Searches initiated according to patient’s residence Autonomous Community Number x100.000 habCatalunya 138 1.85Andalucía 98 1.18Madrid 88 1.38Comunidad Valenciana 68 1.33Galicia 42 1.5Asturias 38 3.5Murcia 36 2.49Castilla y León 33 1.29País Vasco 29 1.34Islas Canarias 25 1.19Castilla – La Mancha 16 0.77Cantabria 15 2.55Navarra 14 2.22Aragón 11 0.82Islas Baleares 11 1Extremadura 9 0.82La Rioja 9 2.8Ciudad Autónoma de Ceuta 2 2.54Ciudad Autónoma de Melilla 2 2.72Overseas 3 NA

Searches initiated according to Diagnosis Acute Myeloblastic Leukaemia 206Acute Lymphoblastic Leukaemia 138Non Hodgkin Lymphoma 97Myelodisplastic Syndrome 68Severe Aplastic Anaemia 33Chronic Myeloid Leukaemia 32Hodgkin Lymphoma 32Inherited Erythrocyte Diseases 21Other Leukaemia 16Other Malignancies 13Plasma Cell Disorders 12Inherited Immune System Diseases / Disorders 10Histiocytosis 4Inherited Metabolic Diseases 3Other non Malignant Diseases 2

  

8  

NATIONAL PATIENTS Evolution of diagnosis in started searches

Mean age of started searches

22 2123

25 2426 27 28

30 3133

34

37

15

20

25

30

35

40

'97 '98 '99 '00 '01 '02 '03 '04 '05 '06 '07 '08 '09

age

year

0

50

100

150

200

250

2002 2003 2004 2005 2006 2007 2008 2009

ALLAMLCMLMDSAMGLymphomasCong. Dis

  

9  

NATIONAL PATIENTS

• CBU Selections performed by REDMO Office (September - December)

40

• Active searches on January 1st , 2009

236

• Active searches on December 31st, 2009

251

• Cancelled searches during 2009 661 

Reasons for search cancellation Unrelated transplantation 356National rules (See detailed information below) 118Exitus 106Clinical status 47Related transplantation 16Unrelated lymphocyte infusion 8Autologous transplantation 5Other (modification HLA typing, different therapy, transfer to other registries) 4Patient decision 1

• Detailed information about cancelled searches according to

national rules Suspended searches for >1 year without eligible donor 1*Suspended searches for >1 year with eligible donor 52Active searches for more than 2 years 21Active searches between <1 and >2 years 44

* Search previously deactivated due to patient’s clinical status, pending medical evaluation.

• Suspended searches on December 31st, 2009 216

Reasons for search suspension Eligible donor found 200Selected CBU (data of infusion pending) 11Clinical status 2Different therapy 1

  

10  

NATIONAL PATIENTS B. Compatible donors found

• Patients with one or more eligible donor(s) found (BM/PBSC)

450

• Donors found during 2009 (BM/PBSC)

682

• Mean period of time in which BM/PBSC searches are deactivated after donor found (days) Standard deviation: ±116.16

88.3

• Median search duration in 2009 (days) Extremes: 7 y 882

50

Time to find BM/PBSC donor expressed in percentages Less than 3 months 77.74Between 3 and 6 months 12.29Between 6 and 10 months 4.64Between 10 and 12 months 1.85More than 12 months 3.48

Evolution of total number of donors found

0

100

200

300

400

500

600

700

1993 1995 1997 1999 2001 2003 2005 2007 2009

Compatible donors found in 2009: 682

  

11  

NATIONAL PATIENTS

Actuarial probability of 7/8 or 8/8 donor

Median time to find a donor (BM/PBSC)

  

12  

NATIONAL PATIENTS C. Transplants

• Hematopoietic stem cells transplants performed during 2009

356

According to product Bone marrow 78Peripheral blood stem cells 145Umbilical cord blood 133(ilymphocyte infusion) (8) Evolution of performed transplants

0

50

100

150

200

250

300

350

400

1993 1995 1997 1999 2001 2003 2005 2007 2009

CBU (n= 133)

PBSC (n= 145)

BM (n= 78)

Transplants performed in 2009: 356

  

13  

NATIONAL PATIENTS

Transplants according to coutry of origin BM/PBSC Germany 126United States 50Spain 17France 7United Kingdom 6Italy 4Australia 2Denmark 2Portugal 2Canada 1Cyprus 1The Netherlands 1Israel 1Lithuania 1Czech Republic 1Sweden 1

Transplants according to coutry of origin CBU *

Spain 56United States 41France 13Australia 7Germany 6Belgium 3Italy 3United Kingdom 2The Netherlands 2Czech Republic 1Switzerland 1

(* 2 double CBU transplants carried out)

  

14  

Transplants performed per Autonomous Community (2009)

(n=356) REDMO activity summary (national patients)

Andalucia 50 14%

Cantabria 20 6%

Castilla y León18 5%

Catalunya 93 26%

Madrid 50 14%

Murcia 22 6%

Valencia 57 16%

Galicia 21 6%

País Vasco 51%

Asturias 15 4%

Islas Baleares 3 1% Navarra 2 1%

0

1000

2000

3000

4000

5000

6000

Inicial Searches

Eligible donors

Transplants

  

15  

INTERNATIONAL PATIENTS

• Performed preliminary searches 15288

• Activated searches 1253

• Requested tests 2045

• Performed tests 1590

Searches initiated for international patients

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

0

2000

4000

6000

8000

10000

12000

14000

16000

18000

1993 1995 1997 1999 2001 2003 2005 2007 2009

Activated searches (n= 1 253)

Iniciated searches (n= 15 288)

  

16  

INTERNATIONAL PATIENTS

• Hematopoietic stem cell transplants performed 195

Transplants per product

Bone Marrow 3Peripherical Blood Stem Cells 19Umbilical Cord Blood 173(lymphocyte infusion) (1)

Transplants per country of destination BM/PBSC

United States 5Australia 4France 2Germany 2Italy 2Austria 1Belgium 1Czech Republic 1United Kingdom 1Greece 1Israel 1Switzerland 1

Transplants per country of destination CBU

France 46United States 43United Kingdom 15Germany 12Israel 8The Netherlands 7Canada 6Italy 6Greece 5Colombia 4Mexico 4New Zealand 3Argentina 2Belgium 2Australia 2Bulgary 2Chile 1Hungary 1Ireland 1Portugal 1Sweden 1Turkey 1