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Ministry of AYUSH, Govt.of India

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CENTRAL COUNCIL FOR RESEARCH IN SIDDHA Ministry of AYUSH, Govt. of India

SCRI Building, Anna Govt. Hospital Campus, Arumbakkam, Chennai - 600106 Phone: 26211621, 2621 2421 Fax: 044-26211621

Website: www.siddhacouncil.in, E.Mall: [email protected]

Table of Contents

COMMITTEES 4

INTRODUCTION 9

OBJECTIVES OF THE COUNCIL 10

ORGANIZATION STRUCTURE 10

BUDGET 12

ACTIVITIES OF VARIOUS INSTITUTES/UNIT 13

PROJECTS 18 INTRAMURAL RESEARCH PROJECTS 18

CLINICAL RESEARCH PROJECTS 18

PRE-CLINICAL RESEARCH PROJECTS I9

DRUG STANDARDIZATION PROJECTS 20

DRUG DEVELOPMENT PROJECTS 2I

LITERARY RESEARCH AND DOCUMENTATION PROJECTS 22

MEDICINAL PLANT RESEARCH PROJECTS 23

COLLABORATIVE PROJECTS 24

EXTRAMURAL RESEARCH PROJECTS .......•.......•.......•.......•.•...•.•.•...•.•.•. 25

PUBLICATIONS 30 I. RESEARCH PUBLICATION IN INDEXED/PEER VIEWED JOURNALS. 30

2. PUBLICATIONS OF BOOKS 36

A. I.

2.

3.

4.

5.

6.

7.

B.

3. PATENT 36

PARTICIPATION/ PRESENTATION 37 I. SEMINAR/ CONFERENCE /WORKSHOP ORGANIZED BY THE INSTITUTE 37

2. THE FIRST SIDDHA DAY 39

3. THIRD INTERNATIONAL DAY OF YOGA 40

4. SCIENCE CLUB MEETING 40

5. TRAINING/WORKSHOP ATTENDED BY OFFICERS OF CCRS - PERIPHERAL INSTITUTES/UNITS 41

6. EXPO ..•.......•.......•.......•.....................................................................•.......•....... 45

7. PRESENTATION IN SEMINARS/CONFERENCES 46

ANNUAL REPORT 2017-18 [ CCRS

8. PARTICIPATION IN SEMINARS/CONFERENCES 48

9. EVENTS 48

I 0. RESEARCH PAPERS AND PRESENTATION OF GUEST LECTURERS50

I I. PARTICIPATION IN AROGYA FAIRS 56

MEMORANDUM OF UNDERSTANDING (MOU) 57

CLINICAL RESEARCH 59 I. HEALTH CARE SERVICES THROUGH OPD AND IPD •.•.•...•.•.•...•.•.•...•.•. 59

2. SPECIAL OPDS 60

3. SWASTHYA RAKSHAN PROGRAMME 61

4. DEPARTMENT OF PATHOLOGY •...•...•...•...•...•...•.......•.•.•.•.•...•.•.•...•.•.•...•.•. 61

5. DEPARTMENT OF BIOCHEMISTRY •.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•. 62

6. PHARMACO-VIGILANCE PROGRAMME 62

DRUG RESEARCH 65 I. DRUG DEVELOPMENT 65

2. PHARMACY .•...•.•.•...•.•.•...•.•.•...•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•...•.•.•...•.•.•.•.•. 65

3. LICENSING & CERTIFICATION •.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•. 65

4. DEPARTMENT OF CHEMISTRY .•.......•.......•.......•......................................... 68

5. DRUG STANDARDIZATION .•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•...•.•.•...•.•.•...•.•.•...•••.•.•.•. 68

PRE-CLINICAL RESEARCH 70 I. DEPARTMENT OF PHARMACOLOGY .•.•.•...•.•.•...•.•.•...•.•.•...•.•.•...•.•.•...•.•.•. 70

MEDICINIAL PLANT RESEARCH 72 I. MEDICO-ETHNO BOTANICAL RESEARCH 72

2. CULTIVATION OF MEDICINAL PLANTS •.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•. 72

3. DIGITIZATION AND COMPILATION OF HERBARIUM AND FOLKLORE CLAIMS .•.•.•.•.•.•.•...•.•.•...•.•.•...•.•.•...•.•.•...•.•.•.....•.•...•.•.•...•.•.•...•.•.•...•.•. 72

4. 365 DAYS NATIONAL CAMPAIGN ON MEDICINAL PLANT AWARENESS ................................•.•.....•.•.....•.......•.......•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•...•..•.. 73

5. PHARMACOGNOSY ....•.•.....•.•.....•.•.....•.•.•.....•.•.....•.•.....•.•.....•.•.....•.•.....•.•..... 73

LITERARY RESEARCH AND DOCUMENTATION 75 I. KEY ACTIVITIES OF LR & DD •.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•••. 75

2. ACTIVITIES IN THE CURRENT YEAR •.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•. 76

3. AYUSH RESEARCH PORTAL •.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•. 79

4. DIGITIZATION •.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•.•. 79

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SIDDHA PHARMACOPOEIA COMMITTEE (SPC) 80 OBJECTIVES AND ACHIEVEMENTS OF SIDDHA PHARMACOPOEIA COMMITTEE (SPC) 80

HUMAN RESOURSE DEVELOPMENT 80 I. IEC MATERIALS/ PAMPHLETS 80

2. OTHER TOOLS 80

3. THE RESEARCH APPLICATION NETWORK (TH ERAN) 80

INAUGURATION OF NEW WING AT SRRI, THIRUVANANTHAPURAM 81

MISCELLANEOUSE ACTIVITIES 81 I. INSTITUTIONAL HUMAN ETHICS COMMITTEE (IHEC) 81

2. ICD I 1-TM-SIDDHA 81

3. PROMOTION OF OFFICIAL LANGUAGE 82

4. INTERNAL COMPLAINTS COMMITTEE CONSTITUTED UNDER SEXUAL HARASSMENT OF WOMEN AT WORK PLACE (PREVENTION, PROHIBITION AND REDRESSAL) 82

5. WEBSITE 82

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COMMITTEES General Body

•!• Minister of State (IC), A YUSH - President

•!• Secretary, A YUSH - Vice-president

•!• Secretary / DG, Health Research - Member

•!• Director General, CSIR - Member

•!• Special Secretary & FA, Ministry of Health & Family Welfare - Member

•!• Joint Secretary, Ministry of AYUSH - Member

•!• Director, National Institute of Siddha, Chennai - Member

•!• Dy. Advisor (Siddha)/Jt. Advisor (Siddha) -Member

•!• Director, PLIM, Ghaziabad - Member

•!• Prof. Dr. G. Ganapathy, Siddha Expert - Non Official Member

•!• Dr. I. Sornamariammal, Siddha Expert - Non Official Member

•!• Dr. S.P. Thiyagarajan, Expert in Modern Medicine - Non Official Member

•!• Director General, Central Council for Research in Siddha - Member Secretary

Executive Committee

S.No. Name / Designation Position

1. Secretary, A YUSH Chairperson

2. Additional Secretary & Financial Advisor, Member Ministry of Health & Family Welfare

3. Joint Secretary, Ministry of AYUSH Member

4. Deputy Advisor (Siddha)/ Jt. Advisor (Siddha) Member

5. Dr. I. Sornamariammal, Expert in Siddha Non-Official

Member

6. Dr. S. P. Thiyagarajan, Expert in Modern Medicine Non-Official

Member

7. Director General, CCRS Member Secretary

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Scientific Advisory Board

S.No. Name Designation Position 1. Dr. G. Veluchamy Former Director, Chairman

Central Research Institute for Siddha, Chennaiwi

2. Prof. Dr. V. Banumathi Director, Member National Institute of Siddha, Chennai

3. Dr. Manoj Vasant Director, i/ c, Member Murhekar National Institute of Epidemiology (NIE),

ICMR, Chennai 4. Dr. B. Chandrasekaran Director, Member

CSIR-Central Leather Research Institute, Chennai

5. Dr. K. Kolandaswamy Director, Member Director of Public Health and Preventive Medicine, Chennai

6. Dr. N. Murgesan Director, Member Central Drug Testing Laboratory, Chennai

7. Dr. P. Gunasekaran Director, Member Kings Institute for Preventive Medicine and Research, Chennai

8. Dr. T.S. Chandra Professor, Member Dept. of Biotechnology, Inclian Institute of Technology, Chennai

9. Prof. Dr. R.S. Director General, Member Ramaswamy CCRS, Chennai secretary

Internal Complaints Committee related to Sexual Harassment of Woman at workplace (prevention, prohibition and redressal) act, 2013

S.No Name Designation Position 1. Dr. Shyamala Research Officer (Siddha) S-II Chairman

Rajkumar CCRS, Chennai 2. Dr. R. ShakiJa Research Officer (Chemistry) S-II Member

SCRI Chennai 3. Dr. R. Meena Research Officer (Siddha) Member

SCRI, Chennai 4. Dr. V. Aarthi Research Officer (Siddha) Member

CCRS, Chennai 5. Dr. S. Bhavani Research Officer (Siddha) Member

SCRI, Chennai 6. Ms. T. Divya. Advocate, Chennai Member

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Technical Audit Committee S.No Name Designation

1. Prof. Dr. P. Jeyaprakash Former Vice-Principal, Narayanan GSMC, Chennai.

2. Prof. Dr. A. Kumaravel Former Professor, GSMC, Palayamkottai.

3. Dr. S. Thirunavukkarasu Former A.D. (Siddha), CCRAS New Delhi.

4. Dr. S. Rajalakshmi Former A.D. (Siddha), SRRI, Puducherry

5. Dr. V Gopal Professor-cum-Principal & HOD (Pharmacognosy), Mother Therasa Post Graduate and Research Institute of Health Sciences, Puducherry

6. Dr. Sasikala Ethirajulu Former Research Officer (Pharmacognosy) S-III, SCRI, Chennai

Siddha Pharmacopoeia Committee S.No. Name/ Designation Position

1. Dr. P. Jeyaprakash Narayanan Chairman Ex-Official Member

2. Joint Advisor (Siddha) Member 3. Director, PCIM &H Member 4. Director, PLIM Member 5. Director General, CCRS Member

Non-Official Member Organic/ Plant Chemistry

6. Dr. P.T. Perumal Member 7. Dr. R. Sundaram Member

Pharmaceutical Chemistry 8. Dr. A. Rajasekaran Member

Pharmacognosy 9. Dr. D. Chamundeeswari Member 10. Dr. Mamta B. Shah Member

Gunapadam 11. Prof. Dr. M. Rajasekaran Member

Siddha Pharmacy 12. Dr. M. Pitchiah Kumar Member 13. Dr. G. Sivaraman Member

Siddha Industry 14. Dr. L. Sivakumar Member

Bio-technology 15. Dr. M. Ramanathan Member

Parpam / Minerals & Metals 16. Dr. K. Ponsingh Member 17. Dr. M. Ravichandran Member

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Sub committees: Muppu Subcommittee under SAB

S.No Name Designation Position 1. Prof. Dr. A. Kumaravel Former Chairman, Chairman

SAB, CCRS 2. Dr. G. Victor Senior Scientist & Director in Research, Member

Rajamanickam Vel's University, Pallavaram 3. Dr. N. Chandrasekar Professor & Head, Member

Centre for Geo-Technology, Manonmaniam Sundaranar University, Tirunelveli.

4. Dr. C. Eleza Medical Officer (Siddha), Kanyakumari Member 5. Dr. G. Manimaran HOD, School of Tectonics, Member

Dept. of Geology, VO.C. College, Tuticorin.

6. Dr. R. Sudha Asst. Medical Officer (Siddha), Member Denkanikottai, Krishnagiri.

7. Dr. S. Ayyasamy DSMO, Kanchipuram & Thiruvalluvar Member Dist.

8. Dr. B. Michael Jeyaraj Managing Trustee, Member Ulaga Tamil maruthuva kazhagam, Papanasam

9. Mr. A. Asokan Traditional Healer, Vellore Member 10. Prof. Dr. R.S. Ramaswamy Director General, CCRS Member

Secretary

Varmam and Bone Setting Subcommittee under SAB S.No Name Designation Position 1. Prof. Dr. A. Kumaravel Former Chairman, Chairman

SAB, CCRS 2. Dr. K. Gopakumar Former Research Officer, i/ c, S - II, SCRI, Member

Arumbakkam, Chennai 3. Prof. Dr. N. Shunmugom Associate Professor, Member

Dept. of Tamil, SRMV College of Arts & Science, Coimbatore

4. Dr. T. Kannan Rajaram Siddha Physician, Nagercoil Member 5. Dr. R. Ramesh Babu Siddha Physician, Kallakurichi Member 6. Dr. S. Natarajan Research Officer (Siddha), Member

SCRI, Chennai 7. Dr. K.P. Arjunan Traditional Siddha Practitioner, Vellore Member 8. Thiru. Arjunan Asan Traditional Siddha Practitioner, Nagercoil Member 9. Mr. Karuna Traditional Siddha Practioner, Chennai Member

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10. Dr. G. Manimaran, HOD, School of Tectonics, V.O.C. College, Member Tuticorin

11. Prof.Dr.RS. Ramaswamy Director General, Chennai Member Secretary

Kattu and Kalangu Subcommittee under SAB S.No Name Designation Position 1. Prof. Dr. A. Kumaravel Former Chairman, SAB, CCRS Chairman

2. Prof. Dr. I. Sornamariammal Former Joint Director, Member Dept. of Indian Medicine and Homeopathy, Chennai

3. Dr. Ravichandran Reader & HOD, Member Dept. of Udal koorugal (Anatomy), Government Siddha Medical College, Chennai

4. Dr. T. Thirunarayanan Secretary, CTMR, Chennai Member 5. Dr. S. Natarajan Research Officer (Siddha), Member

SCRI, Chennai 6. Dr. K. P. Arjunan Traditional Siddha Practitioner, Member

Vellore 7. Dr. Ravindranathan Traditional Siddha Physician, Member

Mathuranthagam 8. Prof. Dr. R.S. Ramaswamy Director General, Chennai Member

Secretary

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INTRODUCTION Central Council for Research in Siddha is an autonomous body under the Ministry of

AYUSH, Government of India. This autonomous body is registered under the Societies Act in July 2010. The AYUSH ministry was especially created for traditional system of medicines in the year 2014 for effective development and promotion of AYUSH systems. Central Council for Research in Siddha was established as a separate council in the year 2010 after bifurcating from Central Council for Research in Ayurveda and Siddha (CCRAS). It is the apex body for Siddha system of medicine in India. It is the authority for setting standards for Research Methodology and Guidelines in Siddha.

Vision

To promote research activities, contributing towards the globalization of Siddha system of Medicine.

Mission

• Encourage and support ethical research in Siddha system of medicine. • Provide skilled researchers to the community. • Serve the public through world class research in Siddha system of medicine. • Advocate and disseminate knowledge in Siddha research to improve the quality of life.

The activities of the Council are • Clinical Research • Drug Research • Pre-clinical Research / Pharmacological Research • Medicinal Plant Research (Medico-Ethno Botanical Research, Pharmacognosy), • Literary Research & Documentation

Apart from these activities the Council is conducting outreach activities viz. Swasthya Rakshan Programme.

The activities of the Council are carried out through its Institutes/Centres/Units located all over India.

1. Siddha Central Research Institute, Chennai, Tamil Nadu 2. Siddha Regional Research Institute, Puducherry 3. Siddha Regional Research Institute, Thiruvananthapuram, Kerala 4. Siddha Clinical Research Unit, Palayamkottai, Tamil Nadu 5. Siddha Medicinal Plants Garden, Mettur, Tamil Nadu 6. Siddha Clinical Research Unit, Karol Bagh, New Delhi 7. Siddha Clinical Research Unit, Bengaluru, Karnataka 8. Siddha Wing, AYUSH Wellness Clinic, Rashtrapati bhawan, New Delhi 9. Siddha OP Wing at All India Institute of Ayurveda, New Delhi

The Council has also taken up collaborative studies with various Universities, Hospitals and Institutes to widen the research perspectives.

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Peripheral Institutes/Units

After re-organization the Institutes/Units have been classified into 4 categories, of which the CCRS Institutes/Units fall under 'C' and 'D' categories mentioned as under:

CCRS

Category-C Category-D

SCRI, Chennai SRRI, Puducherry

SRRI, Thiruvananthapuram

SCRU, Palayamkottai

SCRU, New Delhi

SCRU, Bengaluru

SMPG, Mettur Dam

OBJECTIVES OF THE COUNCIL The main objectives of the Council are as follows: Development of safe, effective Siddha medicines and therapeutic techniques for diseases of national and global importance. Validation of classical Siddha formulations and therapies. Capacity building programmes on Research methodology and drug development. Research & Development support for academic, research institutes and industry. Dissemination of research outcome through publications and research journals.

ORGANIZATION STRUCTURE The implementation of recommendations of Nityanand Committee was reviewed by Joint

Secretary (AYUSH) in a meeting held on 16-11-2009 under his Chairmanship for the development of the erstwhile CCRAS and notified on 15th December 2009, which included the presently functioning CCRS Institutes/Units also. The organization set up of CCRS is depicted in the flow chart below.

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BUDGET Budget Provision at a glance

Scheme B.E. 2017-18 Funds released in Actual expenditure (in lakhs) 2017-18 (in lacs) 2017-18 (in lacs)

Plan 146.49 Non-Plan 2694.00 2694.00 2291.17 Total 2694.00 2694.00 2437.66

Head-wise Actual Expenditure

S.No Particulars Total Expenditure for 2017-18 (in lacs) Non-Plan Plan Total

1. Pay & Allowances 1212.97 24.72 1237.69 2. Pension 234.24 - 234.24 3. Payment of Gratuity -DCRG 82.36 - 82.36 4. Payment of commutation 42.61 - 42.61 5. NPS (Employer) 135.25 - 135.25 6. Leave travel Concession (ITC) 1.86 - 1.86 7. Travelling allowances 46.65 4.97 51.62 8. Office expenses- Contingencies 322.17 79.89 402.06 9. Other Administrative exp. 84.14 8.71 92.85 10. Research Activities 57.48 13.06 70.54 11. Seminar, Workshop & AROGYA 24.48 14.05 38.53 12. Advertisement and Publicity 21.28 0.95 22.23 13. Machinery & Equipments 25.68 0.14 25.82 14. Capital works (Major Works) - - - 15. Minor works - - -

Total 2291.17 146.49 2437.66

Centre-wise Actual Expenditure

Particulars Total Expenditure for 2017-18 (in lakhs) Non- Plan Plan Total

De - Centralized Units SCRI, Chennai 993.68 55.77 1049.45 SRRI, Pondicherry 263.90 25.06 288.96 SRRI, Thiruvananthapuram 141.81 24.82 166.63 SMPG, Mettur Dam 88.36 33.54 121.9 SCRI, Palayamkottai 84.27 2.63 86.9 SCRU, New Delhi 53.42 - 53.42 SCRU, Bengaluru 17.98 - 17.98 Centralized Unit CCRS, Headquarters 647.75 4.67 652.42

Grand Total 2291.17 146.49 2437.66

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ACTIVITIES OF VARIOUS INSTITUTES/UNIT 1. State-wise distribution of Peripheral Institutes / Units of CCRS

S.No. Name of the State Name of the Institutes/ Units 1. Tamil Nadu i. Siddha Central Research Institute, Chennai.

ii. Siddha Clinical Research Unit, Palayamkottai. iii. Siddha Medicinal Plants Garden, Mettur.

2. Kerala Siddha Regional Research Institute, Thiruvananthapuram. 3. Puducherry (UT.) Siddha Regional Research Institute, Puducherry. 4. New Delhi (UT.) Siddha Clinical Research Unit, Karol Bagh. 5. Bengaluru Siddha Clinical Research Unit, Govt. Sri Jayachamarajendra

Ayurveda Hospital.

2. Co-located units of CCRS

• Siddha wing at A YUSH Wellness Clinic at Rashtrapati Bhavan, New Delhi-Caters to the medical needs of the President, officials of President's Secretariat and residents of the President's Estate.

• A Siddha OP wing at All India Institute of Ayurveda at Saritha Vihar, New Delhi- provides Health care services.

• Apart from this, Siddha Medical Services Unit, Health Centre at Pondicherry university provides Siddha treatment for the staff and students of the university

3. Allocation of Research Activities

S.No Name of Project / Activities Institute

1. Siddha Central 1. Clinical Research Research Institute, 2. Drug Standardization Chennai. 3. Literary Research & Documentation Programme

4. Fundamental Research 5. National Pharmaco-vigilance Programme for Ayurveda, Siddha

and Unani (ASU) Drugs 6. Health care services through Out - Patient Department (OPD)

and In-Patient Departments (IPD) 7. Specialty Clinic for Geriatric Health Care 8. Specialty Clinic for Varmam, Thokkanam and Bone setting 9. Specialty Clinics for Diabetes mellitus 10. Specialty Clinics for reproductive and child health care 11. Pharmacy 12. Intra-mural Research projects. 13. Swasthya Rakshan Programme (SRP) 14. Miscellaneous activities.

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2. Siddha Regional 1. Clinical Research. Research Institute, 2. National Pharmaco - vigilance Programme for Ayurveda, Siddha Puducherry. and Unani (ASU) Drugs.

3. Health care services through Out-Patient Department (OPD) and In-Patient Departments (IPDs).

4. Specialty clinic for Geriatric Health Care. 5. Specialty clinic for Varmam and Thokkanam. 6. Intra-mural Research projects. 7. Swasthya Rakshan Programme (SRP). 8. Miscellaneous activities.

3. Siddha Regional 1. Clinical Research. Research Institute, 2. Drug Standardization. Thiruvanan thapur 3. National Pharmaco - vigilance Programme for Ayurveda, Siddha am. and Unani (ASU) Drugs.

4. Health care services through Out-Patient Department (OPD). 5. Specialty clinic for Geriatric Health Care. 6. Specialty clinic for Varmam &Thokkanam. 7. Intra-mural Research projects. 8. Swasthya Rakshan Programme (SRP). 9. Miscellaneous activities.

4. Siddha Clinical 1. Clinical Research. Research Unit, 2. National Pharmaco-vigilance Programme for Ayurveda, Siddha Palayamkottai. and Unani (ASU) Drugs.

3. Health care services through Out-Patient Department. 4. Specialty clinic for Geriatric Health Care. 5. Intra-mural Research projects. 6. Swasthya Rakshan Programme (SRP). 7. Miscellaneous activities.

5. Siddha Medicinal 1. Medico-Ethno-Botanical Survey. Plants Garden, 2. Cultivation of Medicinal Plants. Mettur. 3. Maintenance and Development of medicinal plants garden.

4. Intra-mural Research projects. 5. Swasthya Rakshan Programme. 6. Miscellaneous activities.

6. Siddha Clinical 1. Clinical Research. Research Unit, 2. National Pharmaco-vigilance Programme for Ayurveda, Siddha Karol Bagh, New and Unani (ASU) Drugs. Delhi 3. Health care services through Out-Patient Department.

4. Specialty clinic for Geriatric Health Care. 5. Specialty clinic for Varmam & Thokkanam 6. Intra-mural Research projects. 7. Swasthya Rakshan Programme. 8. Miscellaneous activities.

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7. Siddha Clinical 1. Clinical Research. Research Unit, 2. Health care services through Out-Patient Department (OPD) and Bengaluru In-patient Department (IPD)

3. Speciality clinic for Varmam & Thokkanam 4. Swasthya Rakshan Programme

1. Siddha Central Research Institute (SCRI), Chennai is identified as a potential centre of excellence for clinical research. This Institute is located in the campus of Anna Government Hospital of Indian systems of Medicine and Homoeopathy at Arumbakkam, Chennai. Central Research Institute for Siddha was established in the year 1971. SCRI, Chennai has got the basic facilities for Clinical research, drug research and literary research. In the department of literary research, palm leaf manuscripts and rare Siddha books collection, preservation, annotation, Cataloguing, transcription and publications are being periodically carried out. The department of Clinical research carries out the clinical trials with 50 bedded hospital facilities. Department of Biochemistry and Pathology laboratories also support the Clinical research. Pharmacovigilance cell functions effectively for the betterment of the society and the system. The department of Pharmacognosy helps in identification of herbal drug, Siddha botanical standardization and Siddha Pharmacopoeia works. Standardization of trial drugs, single drugs and Siddha compound formulations are carried out in the department of Chemistry. Department of Pharmacology carries out the biological evaluation, safety and toxicity studies.

2. Siddha Regional Research Institute (SRRI) Puducherry was established on 22nd August, 1979. This institute started functioning in its own premises at Kuyavarpalayam since 2003 with a well-maintained campus and pleasing herbal garden with more than 150 medicinal plants. This institute has enough infrastructure with various departments -- Out-Patient Department, In Patient Department, Varmam clinic, dispensary, clinical pathology laboratory and a library. An In-Patient Department with 25 beds is being utilized for various clinical research projects. Since inception the institute is engaged in clinical research on Siddha formulations for various ailments.

3. Siddha Regional Research Institute (SRRI) is located in Thiruvananthapuram, Kerala with the Department of Clinical Research and Drug Research (Chemistry and Botany Department). The SRRI Thiruvananthapuram caters to the health needs of general public by providing the free out patient service and performing the research activities in the clinical sector. In drug research single and compound formulations are being standardised.

4. Siddha Clinical Research Unit, Palayamkottai was established on 6th February 1980 in the premises of Government Siddha Medical College campus, Palayamkottai. The Survey of Medicinal Plants Unit (SMPU) located there, to its credit, has surveyed around 300 forest areas, which include both Eastern and Western Ghats of Tamil Nadu. A Herbarium hall with 9000 Herbarium sheets covering 1986 individual species and a Museum with 1000 crude drug materials are maintained. General OPD, Varmam OPD and External therapies are provided at Siddha Clinical Research Unit, Palayamkottai.

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5. The Survey of Medicinal Plants Unit - Siddha and Siddha Medicinal Plants Garden are located at Mettur Dam, Salem, Tamil Nadu. Survey of Medicinal Plants Unit- Siddha undertook 332 Medico Ethno Botanical survey in different parts of Tamil Nadu and recorded 10054 field collections. The unit has documented 7700 herbarium specimens covering 1836 species of medicinal plants with special reference to Siddha and Ayurveda in Tamil Nadu. The objectives of survey of medicinal plants unit is to study the medicinal plants wealth of Tarnilnadu by undertaking Medico Ethno Botanical survey tours, collection and documentation of medicinal plants for herbarium, raw drugs/plant materials for museum, plant materials/raw drugs for effective drug supply, identification and authentication of medicinal plants, documentation of medico ethno botanical claims. The Siddha Medicinal Plants Garden has established and developed an arboretum, poly green house. The garden supply raw drugs to meet the partial requirement of SCRI Pharmacy, SPC related works. Farming activities and maintenance of garden is taken care by this unit.

6. Siddha Clinical Research Unit, New Delhi started its function on 29d' February 2016 in the campus of Ayurveda & Unani Tibbia College, Karol Bagh, New Delhi, in the space provided by the Department of A YUSH, Govt. of NCT of Delhi. At present, Out-patient Department (General and Varmam OPD) services, geriatric OPD and clinical research activities are being carried out at the Unit. The Unit is also running integrated A YUSH OPD at All India Institute of Ayurveda (AIIA), Sarita Vihar, New Delhi on every Fridays and Saturdays. Under the Swasthya Rakshan Programme of Ministry of A YUSH, SCRUND is conducting Swasthya Rakshan OPDs on every Monday in the premises of Ramakrishna Mission Ashram, New Delhi and on every first Sunday in Nanakpura Malayalee Welfare Forum, Moti Bagh, New Delhi.

7. Siddha Clinical Research Unit, Bengaluru started functioning at the campus of Govt. Sri Jayachamarajendra Ayurveda Hospital, Dhanvantri Road, Bengaluru since 25th May, 2017. This unit provides medical aid for various diseases through Siddha System of medicine as an adjunct to research pursuits for patients visiting OPD. Speciality treatments like Varmam and Thokkanam therapies for musculo-skeletal and neurological disorders are available for patients.

8. AYUSH Wellness Clinic was inaugurated by the President of India on 25th July 2016, which has a Siddha wing along with other A YUSH systems. The Clinic is catering to the medical needs of the President, officials of President's Secretariat and residents of the President's estate. Treatment includes both internal medicines and external therapies mentioned in Siddha literature. Varmam therapy is one of the unique therapies offered by this Siddha wing to patients suffering from all types of vali (vatha) disorders. Apart from Varmam therapy, external therapies like fumigation, poultice, bandaging, etc., are also available for patients

16


PROJECTS

AR:2017-18

17


PROJECTS

A. Intramural Research Projects Central Council for Research in Siddha is carrying out various IMR projects in its peripheral

institutes / units. The details of the ongoing and completed projects are illustrated in the following table.

1. Clinical Research Projects

1. Title of the !MR-Project RCT of Two Siddha Drugs in the Management of Urolithiasis (Kalladaippu) - Phase 2

Name of the PI Dr. A. Rajendra Kumar

License for Pre-Natal Diagnostic Technique (PNDT) acquired and USG machine installation process has been completed.

2. Title of the !MR-Project Multi centric single arm prospective open trial to check the safety and efficacy of a classical Siddha formulation Rasagandhi Mezhugu in Karuppai N arthasai Kattigal (Fibroid Uterus) among women (25-45 years) attending CCRS-research institutes/unit (MERRYFUL)

Status

Dr. Shyamala Rajkumar

Dr. A. Rajendra kumar, Dr. S. Bhavani, Dr. G. S. Lekha, Dr. K. Sivaranjani, Dr. Padmalatha, Dr. Benitha Segin, Dr. Nirmala Vijaya kumar

SCRI, Chennai, SRRI, Puducherry, SRRI, Thiruvananthapuram, SCRU, Palayamkottai

• Since the project is a multicentric trial, IHEC approval has been obtained from all the four centres.

• Ultra Sono-gram purchased for all centres. PNDT approval and installation done for two centres and it is in pipeline for other two centres.

• Trial drug prepared at IMPCOPS (GMP certified Pharmacy).

• The stability studies of RGM is in progress as per the recommendation of IHEC, SRRI, Puducherry.

3. Title of the !MR-Project Validation of Siddha Udal Iyal inventory -YI for assessment of body constitution : a descriptive, cross sectional study

Name of the PI

Name of the Co-Pls

Centers

Status

Name of the PI

Name of the Co-PI

Status

Dr. M. Kannan

Dr. P. Sathiyarajeswaran

SAB approved, fund Sanctioned, project is in progress

4. Title of the !MR-Project Assessment of awareness and usage of Siddha medicine among the patients reporting to selected Siddha OPD in Puducherry & Karaikkal region.

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Name of the PI Dr. A. Rajendra Kumar

Project completed and report submitted to CCRS for Project Evaluation and Monitoring Committee (PEMC)

5. Title of the !MR-Project A Randomized Controlled Three arm Clinical Trial on the effectiveness of Mudakku Vatha Ilagam (MVI) and Varmam Therapy in Midlife population afflicted by Azhal Keel Vayu (AKV) (Knee-Osteoarthritis).

Status

Name of the PI

Name of the Co-PI

Status

Dr. S. Shunmugaram

Dr. B. Chitra

IHEC approval obtained. Project initiated.

6. Title of the !MR-Project Evaluation of safety and efficacy of Sivappu Kukkil Thylam and Varmam Therapy among subjects with Osteoarthritis of knee joints.

Name of the PI

Status

Dr. S. Saravanan

IHEC approval obtained. CTR! registration done.

7. Title of the !MR-Project Evaluation of efficacy and safety of two Siddha formulations for the treatment functional constipation -A comparative randomized clinical trial

Name of the PI

Status

Dr. R. Manickavasagam

IHEC approval obtained. CTR! Registration is in process.

2. Pre-Clinical Research Projects

1. Title of the !MR-Project Pre-Clinical Evaluation (Chronic toxrcity ) of Gowri Chinthamani Chenduram - A Siddha Drug

Name of the PI

Name of the Co-PI

Dr. P. Elankani

Dr. R.Ganesan

Study was initiated. Blood was withdrawn for batch A and batch B animals to carryout 30th day biochemical parameters. Study is in progress.

2. Title of the !MR-Project A Siddha polyherbal formulation (Nilappanai Choornam) in the management of Oligospermia (Vindhanu Kuraipadu)

Status

Name of the PI

Name of the Co-Pls

Dr. S. Selvarajan

Dr. V Gayathri Devi, Dr. G. Dayanand Reddy

• Standardization of Nilappanai chooranam completed. • Recruitment of project staff to carry out the

pharmacological study is in progress.

3. Title of the !MR-Project Evaluation of Anti-cancerous activity of Sengathari ennai

Status

in in-vitro

19


Name of the PI

Status

Dr. R. Thilagavathi

Project work initiated

4. Title of the !MR-Project Anti-hyperlipidemic activity of D5 choornam.

Name of the PI Dr. G. Dayanand Reddy

The study is under process, at present the data is being analyzed for statistical significance and awaiting for histopathology report and tissue homogenizer for various parameters.

5. Title of the !MR-Project Nephroprotective Effect of Sphaeranthus amarathoides Burm. f. (Sivakaranthai) against Gentamycin induced nephrotoxicity in Rats.

Status

Name of the PI

Name of the Co-PI

Status

Dr. R. Ganesan

Dr. G. Dayanand Reddy

• IAEC approval obtained. Plant sample collected and authenticated.

• Standardisation completed. Pharmacological study is in progress.

3. Drug Standardization Projects

1. Title of the !MR-Project Qualitative and Quantitative Analysis of Lead in 'Lead containing plants' - A Scientific Validation of Siddha Claim

Name of the PI

Name of the Co-PI

Smt. Anitha John

Dr. M. Padma Soma Subramanian

• Analysis of 3 plant materials: Microscopic Analysis, Powder Microscopic Analysis.

• Physico-chemical analysis HPTLC study- extracts of 10 plant materials.

• Herbarium preparation - 1 plant. • Estimation of lead and other metals - 6 plant materials.

2. Title of the !MR-Project Isolation of chemical marker from selected plants used in Reproductive and Child Health.

Name of the PI Smt. R. Shakila

Status

• Isolated a compound from Cassia fistula and is yet to be identified.

• Early fractions of Myristica fragrans has been sent for GC MS analysis.

• Installation of HPLC is in process.

3. Title of the !MR-Project Qualitative and Quantitative Analysis of Chembu (copper) in 'Chembu containing Plants' - A Scientific validation of Siddha claim.

Status

20


Name of the PI

Name of the Co-PI

Dr. I<:.. Parthasarathy

Dr. M. Padma Soma Subramanian

• Analysis of 3 plant materials: Microscopic Analysis, Powder Microscopic Analysis, Physico-chemical analysis.

• HPTLC study- extracts of 10 plant materials. • Herbarium preparation - 1 plant. • Estimation of lead and other metals - 6 plant materials.

4. Title of the !MR-Project Untargetted approach to the geochemical characterization of Hypothecated Muppu (Marine sediments collected from Bay of Bengal at Rameswaram and white powdery salts collected from Kovanur and Siddha malli)

Status

Name of the PI

Name of the Co-Pls

Dr. K. Parthasarathy

Dr. S. Ayyasamy, Dr. R. Sudha

• Chemical characterization of Sangu parpam prepared from seven different herbs was completed.

• Non-marine evaporite called "Pooneeru" was geo chemically characterised.

• Provisional patent was filed under the title "Process for the preparation of "Pooneeru used in the Siddha medicine".

• Pooneeru was collected from January to June, 2018 on full moon day.

5. Title of the !MR-Project Metabolomic profiling and Identification of Principle Components from herbals used in Siddha System for Cognitive disorders using multivariate statistical analysis

Status

Name of the PI

Name of the Co-Pls

Dr. I<:.. Parthasarathy

Dr. M. Kannan, Dr. VL. Reena

LC-MS instrument was procured and installed. Recruitment of project staff is in progress.

6. Title of the !MR-Project Analysis of inorganic composition of selected plants used in Siddha system.

Status

Name of the PI Smt. R. Shakila

Status • Collected Triticum aestivum Linn. from Mandi, HP.The ash of 5 samples were sent to XRF analysis.

• Procurement of XRD is in progress.

4. Drug Development Projects

1. Title of the !MR-Project Standardisation of Sirukan Nagam Suddhi (Purification) and Physiochemical evaluation of Naga parpam, A Siddha drug- process study.

Name of the PI

Status

Dr. M.Harihara Mahadevan

Raw drugs procurement is in progress.

21


2. Title of the !MR-Project Sarakku Vaippu of a poly herbal formulation with Abini like properties by Siddha Methodology of Konganavar

Name of the PI Dr. V Aarthi

Name of the Co-PI Dr. L. Juliet

Review of literature completed and initiated pilot study of formulation of study drug.

3. Title of the !MR-Project A Comparative study on Quality control parameter of Mathirai/Tablet formulations used in Siddha system of

Status

Name of the PI

Name of the Co-PI

Project supervisor

medicine

Dr. M. S. Shreedevi

Dr. M. Muthutamizh


• Authentication of raw Drugs of the project completed. • Purification process of below listed Raw drugs completed:

Venkaram, Milagu, Nabi, Sukku, Lingam, Rasa K.arpooram, Nervalem, Thipilli, Adhimathuram.

• Analysis of formulations completed for (Swasakudori Mathirai, Bala sanjeevi & Santha Sandrothayam Mathirai).

• Disintegration study of Swasakudori Mathirai, Bala sanjeevi completed. Market survey of Project drugs completed.

• Purchase of surveyed market drugs completed. • Disintegration study of market brands completed Weight

variation study of Market brands completed.

4. Title of the !MR-Project Scientific validation of Serankottai (Semecarpus anacardium) before and after purification in Siddha system of medicine

Status

Name of the PI

Name of the Co-PI

Dr. L. Juliet

Dr. V Aarthi, Dr. VL. Reena

• Purchasing and collection of raw drugs for the purification processes.

• Process II & Process IV purification processes have been completed.

• Processes III & Process V are in progress. • Five samples sent for analysis.

5. Literary Research and Documentation Projects

Status

1. Title of the !MR-Project Development of Siddha Treatment Guidelines for Non Communicable Diseases (DSTGNCD)

Name of the PI

Name of the Co-Pls

Status


Dr. Shyamala Rajkumar, Dr. M. Kannan

Project completed and Zero draft book is submitted to CCRS forPEMC

22


2. Title of the !MR-Project Vernacular Name Encyclopedia of Siddha Drugs Mentioned in Siddha Materia Medica (Gunapadam)

Name of the PI

Name of the Co-Pls


Dr. Shyamala Rajkumar, Dr. M. Kannan

• Vernacular names of 90 medicinal plants and 76 herbo mineral drugs have been analyzed, reasoning identified and decision arrived.

• The etymological root of all animals and its by-products mentioned in Siddha materia medica have been analyzed

3. Title of the !MR-Project Database of Siddha preparations for certain diseases mentioned in the enlisted books of drugs and cosmetics act, 1940

Status

Dr. Shyamala Rajkumar

Completed and project report submitted to CCRS for PEMC

4. Title of the !MR-Project Siddha Encylopaedia & Android Application for Research Community and Health care Institutions (T.V. Sambasivam Pillai Medical Dictionary) - SEARCH;

Name of the PI

Status

Name of the PI

Name of the Co-PI

Dr. M. Kannan


• Creation of soft copy (vl):5320 pages were typed. • Completion of hard copy proof correction (v2): 1740 pages

in Volume I, 150 pages in Volume II. • Completion of soft copy proof correction (v3):600 pages in

Volume I. • Section wise data base was completed. All the 86618 key

words were categorized under 52 sections. • 2310 new keywords were identified. • Derived mobile App Technical specification from App

developer.

5. Title of the !MR-Project Annotation and Translation of the Siddha Classical

Status

Name of the PI

Name of the Co-PI

Book "Agathiyar Aruliya Pin Enbathu"

Dr. P. Thenmozhi

Dr. M. Kannan

Typing work of the book finished and correction is in progress Recruitment of Tamil Scholar is in progress.

6. Medicinal Plant Research Projects

Status

1. Title of the !MR-Project Digitisation and compilation of Herbarium and Folklore claims of Survey of Medicinal Plants Unit-Siddha, Palayamkottai.

Name of the PI Dr. M. Padma Soma Subramanian

23


Name of the Co-PI Dr. A. Kanagarajan

• Digitisation of Raw drugs ( dried form) of the museum sample (481 nos.) is reprocessed and photographed.

• Botanical names with author citations; family names etc. are checked in the website database - 1530 species (mounted herbariurn sheets) representing 3150 collection numbers.

2. Title of the !MR-Project Medico Ethno Botanical Study of Palamalai

Status

Name of the PI Dr.M.Padma Soma Subramanian

• Number of Survey tours undertook: 01. • Number of Field collections made: 55. • Number of Species recorded: 55. • Number of Genus recorded: 51. • Number of Families recorded: 37. • Number of Ferns recorded: 02. • Number of Photographs taken: 85. • Number of Herbarium Sheets prepared: 410. • Number of Raw drug samples added to SMPG Museum:

05. • Number of Folklore claims: 06. • Number of Saplings collected and added to SMPG: 46.

3. Title of the !MR-Project A Survey on Ethno medicinally important plants for common ailments

Status

Name of the PI

Name of the Co-PI

Status

Dr. P. Radha

Dr. K. Sivaranjani

• First Phase survey tour was made and 25 ethno-medicinal folklore claims were documented from 10 informants of Tiruppur block, Tiruppur Distrcit (5 villages) and about 50 plants were collected for herbarium.

• A manuscript based on the medico-botanical survey on Udumalai Block, Tiruppur District is in progress.

7. Collaborative Projects

1. Title of the !MR-Project Status of labeling, drug information and branding in marketed anti-diabetic Siddha formulations: Cross sectional study

Name of the Pls

Status

Dr. P. Sathiyarajeswaran, Dr. P. Manickam

Data under compilation

2. Title of the !MR-Project Pre-clinical safety and efficacy of Nuna kadugu (internal medicine) and N una thailam ( external medicine) in Venpadai (Vitiligo)

Name of the PI Prof. Dr. R. S. Ramaswamy

24


Name of the Co-PI

Status

Dr. G. Dayanand Reddy

• Preparations of NK and NT were done. Testing of Pesticides, Aflatoxin, Microbial load and Heavy metal in unaKadugu (NK) and NunaThailam (NT) were done.

• 90 day Dermal and Oral toxicity studies have been completed.

• Stability Study of NT is in progress.

B. Extramural Research Projects The AYUSH ministry has introduced the scheme of Extra-mural Research for the purpose

of motivating academic and research organizations to pursue research activities in AYUSH along with allied sciences like Botany, Chemistry, Pharmacy, and Pharmacology. The EMR is designed to encourage R&D in key areas based on disease burden in alignment to National Health programme. It also aims to make use of the vast research infrastructure available within the country for standardization and validation of classical drugs.

CCRS is coordinating/ facilitating the research projects related to Siddha under the Extra mural Research Scheme of Department of AYUSH since 2011.

Aim and Objectives

• To produce Research and Development (R & D) based AYUSH drugs for prioritized diseases • To generate data on safety, standardization and quality control for AYUSH products and

practices • To develop evidence based support on the efficacy of AYUSH drugs and therapies • To encourage research on classical texts and investigate fundamental principles of AYUSH

systems • To generate data on heavy metals, pesticide residues, microbial load, Safety /Toxicity etc. in the

raw drugs and finished products • To develop AYUSH products having intellectual property rights (IPR) and potentials for

increasing AYUSH exports • To develop potential Human Resource in AYUSH systems, especially to develop scientific

aptitude and expertise related to AYUSH systems • To develop joint research venture among AYUSH Departments and other Organizations /

Institutes

Extra Mural Research Process Snap Shot

25


Role of Internal Scrutiny Committee in EMR

• Application by a stake holder (University, Researcher, College, NGO).

• Thorough examination by ISC (Internal Scrutiny committee).

• If found fit, EMR projects are recommended to PSC by DG, CCRS, Chairman of ISC.

• If not, will be sent back to the PI for necessary modification/ correction or rejection.

Role of Project Screening Committee in EMR

• Applicants recommended by ISC are called for presentation.

• Thorough examination by PSC (Project Screening Committee)

• If found fit, EMR projects are recommended to PAC by JS, AYUSH, Chairman of PEC.

Role of Project Approval Committee in EMR

• Thoroughly examines the projects referred by PSC. • If approved, recommends for grants.

Current Status of EMR proposals

The current status of EMR projects handled in the year 2017-18 is tabulated below.

Completed Projects of EMR - Siddha

SI.No. Title of the project Name and address of PI 1. Pre-clinical Studies of a Polyherbal and a Dr. D. Chamundeeswari,

Herbomineral formulation ill the Principal, Faculty of Pharmacy, Management of Urolithiasis - A Sri Ramachandra University, Comparative study Porur, Chennai - 600 116

2. Documentation and clinical validation of Dr. S. Sridhar, the efficacy of classical Siddha external Ashram Siddha Yoga Research Institute, therapy "Suttigai" for Azal keelvayu Salem - 636 004

3. Study on the Unique Siddha Dosage form Dr. T. Thirunarayanan Kattu Centre for traditional Medicine &

Research Adambakkam, Chennai - 600 088.

4. Documentation of Visha Vaidhya Practices Dr. V Ganapathy, (Treatment of poison intake and Vivekananda Kendra - NARDEP, poisonous bites) in the southern parts of Kanyakumari- 629 702. Tamil Nadu

26


Ongoing Projects of EMR - Siddha Si.No. Title of the project ame and address of PI 1. Scientific validation of a Siddha - Dr. D. Chamundeeswari,

formulation, Iedi Vallathi (Mezhugu) for Principal, Faculty of Pharmacy, arthritis and to derive its underlying Sri Ramachandra University, mechanisms Porur, Chennai - 600 116.

2. Therapeutic efficacy mezhugu (RGM) in benz[a]anthracene

of 7-12

(DMBA) mammary tumours in rats

Rasaganthi Dr. C. Balachandran, Dimethyl Dean and Professor of Veterinary induced Pathology, Madras Veterinary College,

Vepery, Chennai - 600 007. 3. In vitro and in vivo evaluation of

therapeutic potential of Siddha drugs upon Chikungunya virus infection

Dr. Sujatha Sunil Vector Borne Diseases Group International Center for Genetic Engineering and Biotechnology Aruna Asaf Ali Marg, New Delhi

4. Standardization, validation, toxicity and Dr. M. Ramanathan, efficacy studies on Sangu parpam and Principal cum Professor Arathai Choornam PSG College of Pharmacy

Peelamedu, Coimbatore-641 004. 5. Validation of the Pharmacological Dr. M. R. Srinivasan,

Efficacy of Nandhi Mezhugu, Assistant Professor, Department of pretreatment with Kummati Mezhugu in Veterinary Pharmacology and Toxicology, Preclinical models of anovulation and its Madras Veterinary College, application in Veterinary medicine in Chennai - 600 007. Ovulatory Disorders in Cattle.

6. Elucidation of the mechanism of action Dr. K. Uma Maheswari, of a Siddha formulation against Associate Dean & Professor, Centre for Alzheimer's disease Nanotechnology Advanced Biomaterials,

SASTRA University, Thanjavur. 7. Enumerative and analytical study on Dr. Ernest David,

certain Siddha drugs against enteric and Prof. & Head, Dept. of Biotechnology, superficial skin infective microbial Thiruvalluvar University, Vellore - 632 115. pathogens

8. An Evaluation of Chandamaruta Dr. S. Balarama Kaimal, Cheduram and Ayaveera Cheduram Asst. Professor, Dept. of Biochemistry, through study of Neurotransmitter, Saveetha Medical College and Hospital, Protein and Enzyme level alterations Thandalam, Chennai - 602 105. occurring during their treatment for MCAO Focal Cerebral ischemia (induced brain stroke) in rats

9. Oncological care with Siddha concepts in I Dr. N. Deepa, formulation: A novel scientific approach Asthagiri Herbal Research Foundation,

Perungudi Industrial Estate, Perungudi, Chennai - 600 096.

27


10. Validation of the safety and therapeutic Dr. S.P. Preetha, efficacy of Poorana chandirodayam in Principal Investigator & Dimethylhydrazine dihydrochloride Asst. Professor, induced colon cancer in rats. Dept. of Veterinary Pharmacology &

Toxicology, Madras Veterinary College, Chennai -600 007.

11. Single step extraction of whole plant Dr. M. Meenakshi Sundaram, extract containing phenylpropanoids and Assistant Professor, investigation of their biomedical role in School of Chemical & Biotechnology, treatment of stomach cancer SASTRA University, Tirumalaisamudram,

Thanjavur-613401

28


PUBLICATIONS

29


PUBLICATIONS Publication of the research activities is the need of the hour to march forward towards

globalization of Siddha system of medicine. Publications are the outputs of research activities of the Council. In the reporting year 96 research articles are published in national/international peer reviewed journals.

1. Research Publication in Indexed/ peer viewed journals

SI. Publications No.

1. Deepa Yadav, Mohd Salim Reshi, ChhaviUthra, Sadhana Shrivastava, Nalini Shrivastava, Sunil Kumar Koppala Narayana. Botanical and Chemical Fingerprinting of Medicinal Roots

of JusticiagendarussaBurm f.Phcog Res.2017; 8(2): 26-30. 2. Chaithra S Hebbar, Lalitha BR, Sunil Kumar KN, Krishnamurthy D. HPTLC profiling of

useful parts of fifteen plants in Ayurveda with cold potency. Int J Res Ayurveda Pharm. 2017; 8(2):26-30.

3. Laxmi Bidari, Suma V Mallya, Suchitra Prabhu, Sunil Kumar Koppala Narayana, Pharmacognosy. Nutritional Value and Antioxidant Activity of Aglaia elaeagnoidea (A.Juss.)

Benth. J Ayu Med Sci. 2017; 2(1):104-11. 4. Suchitra Prabhu, Puneeth, Priyadarshini Rao, Sunil Kumar Koppala Narayana, Ravishankar

Basaviah, Suchitra Prabhu, Puneeth, Priyadarshini Rao. Comparative Phytochemical and

Antioxidant Properties of Costuspictus and C. speciosus. J Ayu Med Sci. 2017; 2(1):121-8. 5. RemyaAndalil, BrindhaSundaramoorthy, DivyaKallingilkalathil Gopi, Sunil Kumar Koppala

Narayana, SathiyaRajeswaran P. Atlas of Macro-microscopy of Savuripazham of Siddha - Fruit of Trichosanthestricuspidata Lour. J Ayu Med Sci. 2017; 2(1):153-7.

6. Savin CG, Rajendra H, ShivarajaShannkara YM, Sunil Kumar KN, Ravi M, Goetgh, Simpson DA. Microscopical Evaluation, Phytochemical Analysis and HPTLC Finger

printing of Tuber of Actinoscirpusgrossus (L.f.). PhcogJ. 2017; 9(5): 657-62. 7. Brindha S, Divya KG, Remya A, Sunil Kumar KN, SathiyaRajeshwaran P. A complete

maco-microscopic profile of Capparis Z!Jlanica L. leaf. J Ayu Med Sci. 2017;2(2):174-8. 8. Ravi M, Sivanesan S, Padmaja U, Febin J, SunilKumar KN, Lekshmi R, Alfarhan AH,

Thomas J, Rajakrishnan R, Sameh MH. Quality Standardization and Nephroprotective

Effect of Garcinia peduncuiataRoxb. Fruit rind.IJPER. 2017;51 (4):713-21. 9. Mall ya SV, Kamat M, SunilKumar KN. Ayurvedic pharmacopea if constructed as per

Ayurvedic principles; An observational outlook.] Ayu Herb Med. 2017; 3(2):95-7. 10. Dintu J, Suma VM, Shridhara BT, Vishwanatha U, Suchitra P, Sunil Kumar KN.

Pharmacognostical Evaluation of an Extra-pharmacopoeia! Drug of Ayurveda -Anisochilus carnosus (L.f.) Wall. J Ayu Med Sci.2017;2(2):179-87.

30


11. Dixit SO, Angadi R, Narayana SK. Comparative Physico-chemical Analysis

of ApamargaKshara Samples Prepared in Presence of Jala and Gomutra. J Ayu Med Sci. 2017;2(3):244-6.

12. Mohammed F, Joshi SV, Patgiri B, Bairy ST, Narayana SK Analytical Standards

of Vrukshamla (Garcinia indica Choisy) BeejaTaila - Kokum Butter. J Ayu Med Sci. 2017;2(3):247-50.

13. Gopi DK, AndalilR, Sundaramoorthy B, Narayana SKK, Parameswaran SR. Comparative

Macro-microscopic Atlas of Two Aroids used in Siddha Medicine. J Ayu Med Sci. 2017;

2(4): 256-60. 14. Rai A, Prabhu SN, Udupi V, Basaviah R, Narayana SK.I(. Phytochemical Standardisation

and Antimicrobial Effects of Sidarhombifolia Linn. Aerial Parts. J Ayu Med Sci. 2017; 2(4):

269-73. 15. Hima Sasidharan, Suma Venkatesh Mallya, Prabhu Suchitra, Sunil kumar KN. Identity

parameters on traditionally used Antiurolithiatic herb- Scopariadulcis Linn. J Ayurveda Integr Med Sci. 2017; 2(6): 72-9

16. Narasimha Kumar G V, Deepishka, Chitikela P, Pullaiah, Dayanand Reddy G. Antimicrobial Resistance - its Causes. Effects and Preventive Measures.International Journal of Phar. &

Biol. Arch. 2017; ISSN: 0976-3333, 8(6): 21-4. 17. Godlaveti Vijay Narasimha Kumar, Akkula Jyothi, Chitikela P Pullaiah, Veluri Kishore

Sastha Ram, SandopaDhanunjaya, Gaddam, Dayanand Reddy.Evaluation of Combination of Low Dose Atorvastatin plus Ezetimibe and Aspirin in the Treatment of Atherosclerotic Vascular Disease.Journal of Young Pharmacist. 2017; 9(4): 605-10.

18. Narasimha Kumar G V, Chitikela P Pullaiah, Dhanunjaya S, Dayanand Reddy G.Metabolic Syndrome: A Rising Epidemic: Comprehensive Review.International Journal of Research in Ayurveda and Pharmacy.2017; 8(3): 36 - 41.

19. ChitikelaP Pullaiah, Narasimha Kumar G V, Jyothsna K, Thyagaraju K, Vinod K, Nelson, Dayanand ReddyG.Rosa damascena Mill. L. attenuates myocardial lysosomal membrane destabilizationin isoproterenol induced oxidative stress.Orint. Phar. Exp. Med Springer. 2017; ISSN: 1598-2386, 16(2).

20. ParthasarathyK, Ponpandian T, Praveen C.Gold-catalyzed addition reaction between creatinine and isatin: A sustainable and green chemistry approach for the diastereoselective synthesis of, 3-substituted-3-hydroxyisatins.Chinese Journal of Catalysis.2017; 38: 775-83.

21. Shanmuganathana T, Venugopal M, Parthasarathy K, Dhatchanamoorthya N, Arune Y, Prince AM M.Synthesis of novel bis-allyloxy and hydroxypropoxy derivatives of 4, 5-diaryl thiophene-2-carboxylic acid and their biological evaluation: Journal of Chemical Sciences.: 129(5): 623-36.

22. Shakila R, Ganesan R, Arul Antony S, Duraipandiyan V Analytical and HPTLC studies on ColdeniaprocumbensLinn. Whole plant.Journal of Innovations in Pharmaceutical and Biological Sciences (JIPBS).2017; 4 (2): 28-35.

23. Sathiyarajeswara P, Samraj K, Kanakavalli KThe Siddha Drug V elvangaParpam Intervention In The Management Of Benign Prostatic Hyperplasia (Bph): A Case Series.Indian Journal of Applied Research.2017; ISSN: 2249-55510, 7(7): 74-76.

24. Kalyan Hazra, Achintya Kumar Mandal, Sreya Dutta, Dhirendra Nath Mondal, Jayram Hazra. "Comprehensive Dossieron Ayurvedic Medicinal plant Acacia Catechu Willd.: A Review".Journal of Applied Science and Research.2017; ISSN: 2348-0416, 5(3): 53-87.

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25. Kalyan Hazra, Sreya Dutta, Achintya Kumar Mandal, Dhirendra Nath Mondal, Jayram Hazra.Comprehensive Dossier on Ayurvedic Medicinal plant Aegle marmelos (L.) Correa: A Review The Pharmaceutical and Chemical Journal.2017; ISSN: 2349-7092, 4(3): 55-74.

26. Mary Princess Sulekha S, Aadinaath Reddy G, MuthuvelA. Physiochemical and Phytochemical Standardization of Polyherbal Siddha formulation Karisa!aichoornam.Indian Journal of Traditional Knowledge.2017; 16(2): 263 - 69.

27. Meghana Devulapalli TS, Durga Prasad, Narasimha Kumar G V, Avanthi B, Shabana Banu S K.A Case Report on Methotrexate Induced Pancytopenia.lnternational Journal of Basic and Clinical Pharmacology. 2017; ISSN: 2279-0780, 6(4): 1006-10.

28. Meena R, Natarajan S, Anbarasi C, Muralidass SD.Effect of Varmam therapy in Santhuvatham (Osteo arthritis -knee joint) - A single case study.International Journal of Pharmacy & Pharmaceutical Sciences. 2017; ISSN: 0975-1491, 9(9): 285-287.

29. Bhavani S. Hepato-protective herbs & medicines in Siddha system of medicine. Journal of Pharmacognosy and Phytochernistry. 2017; 6(5): 2246-51.

30. Juliet L. Evaluation of Antioxidant Properties of Poly Herbal Siddha Preparation. Karisalai KarpaChooranam. IJAPR. 2018; 17(6): 51-5.

31. Anbarasi C, Natarajan S, Meena R, MuralidassSD.A hospital based cross sectional study on the prevalence of musculoskeletal diseases in Varmam out-patient department, Siddha Central Research Institute, Chennai. Journal of Indian Medicine and homoeopathy. 2018; 41-48

32. Arunadevi R, Susila R, Murugammal S, Divya S. Preperation and Standardisation of Mathanthailam: A classical Siddha formulation for diabetic ulcerative wound healing. Journal of Ayurveda and Integrative Medicine. 16th March 2018 (available online)

33. Susila R.A review on anti-diabetic herbs of Siddha system withspecial reference to its organoleptic quality (taste) asper tridosam concept. International Journal of Herbal Medicine. 2017; 5(5): 97-101.

34. SathiyarajeswaranP, Shree Devi MS, Siva lakshrniS, Daniyafrancis. U rolithiasis (Kalladaippu)- An Evidence based case study. International journal of Ayurvedic medicine. 2017; 8(1): 35-7.

35. UmamaheswariNC, NeelavathyR, Sasi SK, SaraswathyS, EsaivaniS, Shree DeviMS. A Study on Neikuri in Kalanjagapadai. Bulletin of Trends in Biological Sciences. 2017; 1(1): 34-6.

36. Mohansrinivasan V, JananiSV, ParidaMeghaswani, Naine S. Jemimah, Rajasekaran C, Shree devi MS, Devi C. Subathra. Exploring the Bioactive Potential of Carica papaya. The Natural Products Journal. 2017; 7(4): 291-97.

37. Sai Dhivya S, PorkodiP, PriyankaKT, GuganA, Mohamed AjmalS, KarthikL, Shree DeviMS.Antirnicrobial and anthelrnintic activity of new herbal Siddha formulation. International Journal of Current Research inMedical Sciences. 2017; 3(9): 38-57.

38. Esaivani S.Toxicologial Profiling of Siddha Formulation NaauruviKuzhithylam ill

Experimental rodents.European Journal of Biomedical and Pharmaceutical Sciences.2017; ISSN 2349-8870, 4(9): 457-461.

39. Susila R, Jeeva Gladys R, Arunadevi R, Jothi J, Arunachalam C, Balagurusamy.A review on anti-diabetic herbs of Siddha system with special reference to it's organoleptic quality (taste) as per ridosam concept.International Journal of Herbal Medicine.2017; ISSN: 2321-2187, 5(5): 97-101.

40. KavithaT. Review article on Cucurbitamaxima seeds. IOSR journals. 2017; ISSN: 2349-8870, 4(12): 288-99.

41. Jescelin H, Ganesan R, Shakila R, Sathiyarjeswaran P.HPTLC Study & In - Vitro Antioxidant assay of 'ParutiVitaiCuranam' - A Siddha drug.World Journal of Pharmacy and Pharmaceutical Sciences.2017; 6(10): 790-99

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42. Sri Harini MS, Ganesan R, Murugammal S, Shakila R, Sathiyarajeswaran P.In-Vitro Antioxidant efficacy and HPTLC assay of Alcoholic extract of incithenural.World Journal of Pharmaceutical Research.2017; 6(13), 394-403.

43. Ganesan R, Meenakshi, Reena VL, Shakila R, Sathyarajeswaran P, Chitra S. HPTLC study and In-vitro antioxidant assay of 'NellikkayThenural' ASiddha drug. World Journal of Pharmaceuticaland Medical Research. 2017; 3(10):162-7.

44. Janet Sabina X, Karthikeyan J, Velmurugan Gunasekaran, Muthu TamizhM, Nityananda Shetty A. Design and in vitro biological evaluation of substituted chalcones synthesized from nitrogen mustards as potent microtubule targeted anticancer agents.New Journal of Chemistry. 2017; 41(10): 4096-109.

45. Narasimha Kumar GV, Chitikela P Pullaiah, Dhanujay S, Dayanand reddy. Acute toxicity of aqueous seed extract of Vigna unguiculata in albino rats. Innovative Journal of Ayurveda. Sci.2017; 5(2):58-62

46. Shanmuganathan T, Prince AAM, Dhatchanamoorthy N, Parthasarathy K, Venugopal M. Synthesis, anti-inflammatory activity of picen-13-ylmethylene derivatives. The Free Internet Journalfor Organic Chemistry. 2017; 5: 67-79

47. Narasimha Kumar GV, Chitikela P Pullaiah, Dhanunjaya S, Dayanand Reddy G. Acute Toxicity Studies of Aqueous Seed Extract of Vigna Unguiculata InAlbino Rats.Innovare Journal of Ayurvedic Science. 2017; 5(2): 1-4.

48. Ganesamoorthy S, Muthu Tamizh M, Shanmugasundaram K, Karvembu R.A sustainable heterogenized palladium catalyst for Suzuki-Miyaura cross coupling reaction of azaheteroaryl halides in aqueous media.Journal of Organometallic Chemistry.2018; 76-85.

49. Sathiyarajeswaran P, Dhanaraj K, Shree Devi MS, Muthu Tamizh M, Pattirayan R.Design of solid oral dosage form and its quality control assessment of Uraimathirai - A tablet from Siddha formulation for immuno modulation in pediatric community.World journal of pharmaceutical research.2018; 7(3): 514-22.

50. Chitikela P Pullaiah, Thyagaraju, Vinod K Nelson, Narasimha KumarGV, Bosubabu G, Dayananda Reddy.Phlorotannins and Their Biological Significances.Journal of Global Trends in Pharmaceutical Sciences.2018; ISSN: 2230-7346, 9(1): 4893-904.

51. Sathiyarajeswaran P, Pattarayan R, Dayanand Reddy G, Narasimha Kumar GV, Chitikela P Pullaiah.Experimental Evaluation of Analgesic and Anti-Inflammatory Potential of UraiMathirai - A Siddha Formulation.Journal of Global Trends in Pharmaceutical Science.2018; ISSN: 2230-7346, 9(1): 4839-844.

52. DhanunjayaSandopa, Sree Keerthi Nethi, Sai Charitha Sreeram, Narasimha Kumar Godlaveti Vijay, Vyshnavi Biradavolu, Jagadeesh Vijay Kakimani.Prescribing antibiotics to pediatric dengue: . . risk of bacterial resistance. Paediatr Indones. increasmg Paediatricalndonesiana. 2018; 58(1): 51 - 5.

53. Ganesan R, Nivedha N, Sujith T, Shakila R, Sampath KS, Sathiyarajeswaran P.Antioxidant Activity and HPTLC Analysis of the Siddha Drug Elicevi.kutinircuranam. European Journal of Pharmaceutical and Medical Research.2018; 5(4): 281-85.

54. Sathyarajeswaran P, Devi MSS, Narayana SKK., Manoharn MT, Durairaj K, Patturayan R. Quality standards for UraiMathirai - A Siddha Immunomodulator Formulation for Children. J Phytopharmacol. 2018; 7(1):40-4.

55. Esaivani S.Evaluation of Antihistamic and Bronchodilator activity of a Siddha Drug NaauruviKuzhiThylam.World Journal of Pharmaceutical Research.2018; ISSN: 2277-7105, 7(5): 595-601.

56. Kalaivanan M, LouisJesuddoss L, Saravanaganthi A, Padma Sarna Subramanian M. Preliminary Phytochemical screening and HPTLC fingerprint profile of Tragiaplukenetii. International Journal of Pharmaceutical Sciences and Research, IJPSR, (E-ISSN: 0675- 8232; P-ISSN: 2320-5148.). 2017;.8(3): 1194-8.

57. M. Padma Soma Subramanian , Saravana Ganthi A, Rajabudeen E. Documentation of Ethnomedicinal Plants used by the People of Point Calimere Wildlife and Bird Sanctuary,

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Tamilnadu. European Journal of Biomedical and Pharmaceutical Sciences, (EJBPS) ISSN:2349-8870. 2017;4(8): 759-67.

58. M.Padma Soma Subramanian, Lakshmanan R and Thiruvalluvar.M Selected Folklore Claims of Malayali Tribes of Palamalai Hills, Salem District, Tamil Nadu, India. European Journal of Biomedical And Pharmaceutical Sciences, (EJBPS) ISSN:2349-8870. Vol:5 (3) , 2018.

59. Lakshmanan R, Thiruvalluvar M, Padma Sorna Subramanian M, Saravanaganthi A.: A Study on the Diversity of Medicinal Plants in Palamalai Hills, Salem District, Tamil Nadu.: European Journal of Biomedical and Pharmaceutical Sciences. EJBPS: Vol.5 (4): 294-303

60. Gayathri Devi V, Sreekanth Narayanaru, Natarajan M, Anitha John, Kanagarajan A. Standardisation of Aya chenduram- a nanosized herbo-mineral Siddha formulation using modern techniques. European journal of pharmaceutical and medical research. 2017; 4(09): 405-9.

61. Anitha john, Gayathri Devi V, Sasikala Ethirajulu, Shyamala Rajkumar, Selvarajan S. 'Standardisation of Murukkan vitai mathirai- A Siddha tablet formulation'. World journal of pharmaceutical and life sciences (WTPLS).WJPLS 3(2), 201, 50-5.

62. Lekha GS, Kanagarajan A, Kasirajan N, Mithun, Deepa JP, Subha Sukumar, Surya CS, Ansari A, Abhil Mohan. An Interventional Cohort Study in Dengue prevalent area by Nilavembu Kudineer distribution and Awareness Programme. IOSR Journal of Dental and Medical Sciences. 2018 17(2):19-23.

63. Kumar S, MaanickhaChelvi KS, Farida A, Gayathri Gunalan. Invitro anti oxidant property of Siddha formulation-Irunellikarpam. Journal of Pharmacy Research, 2017;11 (9)., 1135- 9.

64. Maanickha Chelvi KS, Mathipriya T, Kasirajan N. An overview of the Siddha polyherbal formulation - AthimadhuraChoornam for Migrane Headache. Indo American journal of pharmaceutical Research.March 2018; 8(3): 1511-16.

65. MaanickhaChelvi KS, Kasirajan N, Maheswari B. Pivotal role of arusuvai in traditional diet and its compatibility- Siddha concept. WJPPS:.7(4), 2018; 606-614.

66. Senthamil Rajam C, Manickavasagam R. Siddha Varmam Therapy for Shoulder Impingement Syndrome. International Journal of Research in Ayurveda Pharmaceuticals. 2017; 8(2):64-65

67. Janani, Manickavasagam R. Effectiveness of Varma therapy on Hypertension. World Journal of Pharmaceutical Research. Apr 2017; 6 (4): 986 - 91.

68. ManickavasagamR. Siddha literature repositories in and outside Tamil Nadu. European Journal of Biomedical and Pharmaceutical sciences. 2017; 4 (7): 195-7.

69. Manickavasagam R, Senthamil Rajam C. Acute and Sub-Acute Toxicity Studies of Siddha Metallic Preparation "Velvanga Chunnam" in Wistar Albino Rats. World Journal of Pharmaceutical Research. 2017; 6(7), 1122-8.

70. ThiyagasundaramT, Juliet RubyV, ManickavasagamR. Acute and Chronic Toxicity Study on Siddha Single Herbal Medicine "Seenthil Sarkarai". World Journal of Pharmaceutical Research. August, 2017; Spl. issue 6 (9).

71. Tushita Thakur, Izhar Ul-Hassan, Janani, Manickavasagam, Lubna Ahmed, Divya Saraswat et al.Model AYUSH wellness clinic at President Estate, India: Successful Stories. Indo American Journal of Pharmaceutical sciences. Nov 2017; 4(11).

72. Janani, ManickavasagamR. Effectiveness Of Varmam Therapy For the Management of Osteoarthritis. International Journal of Pharmaceutical science and research. December, 2017; Vol. 8, (12): 5286-90.

73. Senthamil Rajam C, ManickavasagamR. Thaarai Vidal - Ozhukku Maruthuvam - An Unique Therapy Of Siddha System. European Journal of Pharmaceutical Research. Mar 2018;.5(3).

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74. AkilaB, Manickavasakam K, Kavitha T.Acute Oral Toxicity Study of Chandrakanthi Chooranam. European Journal of Biomedical and Pharmaceutical Sciences. December, 2017; Volume 4, Issue 12: 652-6.

75. Akila B, Manickavasakam K, Kavitha T. Long Term Toxicity Study of Chandrakanthi Chooranam. International Journal of Scientific Research. December, 2017; 6 (12), 352-6.

76. Akila B, Manickavasakam K, Kavitha T. A Review on Male Infertility. European Journal of Biomedical and Pharmaceutical sciences. December, 2017; Volume 4, Issue 12, 288-99.

77. Akila B, Manickavasakam K, Kavitha T. Siddha Science in Male Infertility - A Review. International Journal of Research in Ayurveda and Pharmacy. 2018; 9(2), 34-40.

78. Pratheep G, Yogeswari C, Elavarasan K, Menaka M. "Efficacy of Siddha Medicine and Varmam therapy on Hemiplegia (Pakkavatham) - A Single case study". World Journal of Pharmaceutical Research.6 (10), 2017; 1253-8.

79. Pratheep G, Kumar S, Elavarasan K. Herbal Remedies for Venpadai (Vitiligo). World Journal of Pharmaceutical Research.6(9), 2017; 721-30.

80. Pratheep G, Rahini M, Elavarasan K, Menaka M.Validation of Siddha Medicine and Varmam therapy on Azhalkeelvayu (Osteo Arthritis) - Case series.World Journal of Pharmaceutical Research. 6(13), 2017; 601-6.

81. Elavarasan K, PratheepG, Harikrishnan M. A review of Anti-cancer drugs in Siddha Medicine for Yoni puttru (Cervical or Vaginal cancer). World Journal of Pharmaceutical Research. 6 (13), 2017; 260-5.

82. Revathi G, Elavarasan K, Santhini G, Shanmugom N. Efficacy of Varmam in case of Traumatic Mydriasis (dilated pupil) -A Single case study. World Journal of Pharmaceutical Research. 6(16), 2017; 667-71.

83. Elavarasan K, Pratheep G, Rahini M, Menaga M. To Evaluate the effectiveness of Ottradam (Fomentation) on Azhal Keel Vaayu (Osteoarthritis). World Journal of Pharmaceutical Research. 6, (16), 2017, 663-666.

84. Sivaranjani K, Meera R. Anti-obesity and hypolipidemic activity of Siddha drugs: A review. World J Pharm Sci. 2017; 5(5): 150-61.

85. SivaranjaniK, Glara AF, Ashm' R, ShyamalaK. Vasambu Kaapu In Prevention Of Common Pediatric Ailments - An Overview.World Journal Of Pharmacy and Pharmaceutical Sciences.2017; 6 (9):360 - 7.

86. Sivaranjani K, Vaniswari DS, ShyamalaK. Adulterants And Substitutes For Herbal Plants In Siddha System Of Medicine. World Journal Of Pharmacy And Pharmaceutical Sciences. 2017; 7(1): 244-68.

87. Skelley P, Xu G, Tang W, Lindstorm A, Marler T, Singh JS, Singh R, Radha P, Rich S. Review of CycadophilaXu, Tang &Skelley (Coleoptera: Erotylidae: Pharaxonothinae) inhabiting <;yeas (Cycadaceae) in Asia with descriptions of a new subgenus and thirteen new species, Zootaxa. 2017; 4267(1): 1-63.

88. Radha P, Manokari M. A checklist of medicinally important weeds grows in the horticulture fields of Palayamkottai, Tirunelvelidistict, Tamil Nadu.lnternational Journal of Herbal Medicine. 2017; 5(6): 108-13.

89. Manokari M, Shekhawat MS.Optimization of in vitro and ex vitroregeneration and micromorphological studies of Micrococcamercurialis (L.) Benth. BotanicaPasifica. 2017; 6(1): 37-44.

90. Manokari M, Shekhawat MS. Phytosynthesis of zinc oxide nanoparticles from Caesalpiniapulcherrima (L.) Sw.Journal of Scientific Achievements. 2017; 2(8): 17-23.

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91. Manokari M, Shekhawat MS. Biosynthesis and characterization of zinc oxide nanoparticles using Thunbergiaerecta (Benth.) T. Anders plant extracts. Archives of Agriculture and Environmental Science. 2017; 2(2): 148-51.

92. Shekhawat MS, Manokari M. Comparative foliar micromorphological studies of in vitroand field transferred plants of Morindacitrifolia, Acta. BotanicaHungarica. 2017; 59(3-4): 427-38.

93. Revathi J, ManokariM, Shekhawat MS.Optimization of factors affection in vitroregeneration, flowering ex vitro rooting and foliar micro-morphological studies of OfdenfandiacorymbosaL. a multi potent herb. Plant cell, Tissue and Organ Culture, doi 10.0007 /S 11240-18-: 2018;1395-8.

94. Janaki RamA, Prabhavathi J, Radha P. A note on the role of Siddha system of Medicine in the treatment of Arthritis. Journal of Medicinal Plant studies. 2018; 6(2): 255-260.

95. Punitha A, Visweswaran, Rajendra Kumar A, Manickavsakam K. Effect of Sarva Noi Linga chenduram for anti urolithiatic activity 10 Ethylene glycol induced animal model.International Journal of Advanced Research in Biological Sciences. 2017;Vol 2(4): 50-9.

96. Faridha A, Gayathri Gunalan, Rajendra Kumar A. Siddha therapeutics for the management of PCOS - A Review.lndo American Journal of Pharmaceutical Research. 2018; Vol 8, Issue 03, 1481-9.

2. Publications of Books

Nine books were published in the reporting year.

s. Title of the Books Version No 1. Monograph on Nila Vembu Kudineer English 2. Monograph on D5 Chooranam English 3. Siddha Maruthuva Eliya Vazhakku Muraigal (Revised 6th Edition) Tamil 4. Siddhar Y ogam Oor Karpam Tamil 5. Guidelines for Practice of Siddha Varmam Therapy - 2017 English 6. A Hand Book of Glossary on Siddha External Therapies. (Excerpts from Bilingual

T.VSambasivam Pillai Dictionary) 7. A Glossary on Siddha External Therapies (Excerpts from T.VSambasivam Bilingual

Pillai Dictionary) 8. Siddha Protocols and Research OUTcomes (SPROUT) for Siddha External English

Therapies 9. Agathiyar Aivu Thoguppu Tamil

3. Patent

Title: Synergistic natural novel usage of Siddha formulation - Thiriphala Chooranam as

pharmaceutical excipient

Abstract:

The present invention and application discloses a pharmaceutical drug excipient / binder / disintegrant prepared through the synergistic effects of Thiriphala Kudineer (decoction) /aqueous

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extract provides an excellent pharmaceutical excipient /binder / disintegrant which can be used in the preparation of tablets which possesses good binding property and having improved compressibility, when utilised in wet granulation method of tablet preparation. Synergistic effects of Thiriphala improves the characteristics and the properties of the tablets when mixed. The present invention also discloses a method for obtaining tablets made into an acceptable pharmaceutical form by weight with respect to the total weight of the tablet. Tests proved that Thiriphala Kudineer (decoction) / aqueous extract is very easy to prepare and has excellent binding and disintegrating properties which is the important function for tablet and simple cost-effective method to compress good tablets. So that, drug preparation cost can be lowered, side effects of the drug are reduced and the drug efficacy can be improved. Similarly, alcoholic extraction is prepared using Thiriphala Chooranam which can be also used as a binding / disintegrant agent. Inventors of the patents are Dr. P. Sathiyarajeswaran, Dr. M. S. Shree Devi, Dr. M. Kannan, Mr. N. Kirubakaran from CCRS - SCRI, Chennai.

PARTICIPATION/ PRESENTATION 1. Seminar / Conference / Workshop organized by the Institute s. Title of the Seminar / Conference / Institutes / Units Date No. Workshop 1. Workshop on general awareness and Siddha Regional Research 21" April 2017

propagation of Extra Mural Research Institute, Puducherry Scheme (EMR) of Ministry of AYUSH

2. National Seminar on "Glory of Siddhar Siddha Central Research 26th& zr- Agathiyar and His Contribution to Siddha Institute, Chennai August 2017 system of Medicine"

3. A National seminar on current trends in Siddha Clinical Research 4ch and 5th Siddha Varmam Therapy Unit, New Delhi November

2017

4. National Conference on "Pura Siddha Regional Research 9th and 10th Maruthuvam - External Therapies in Institute, Puducherry December Siddha system of Medicine" (NCPM-2017) 2017

5. National Workshop on conservation of Siddha Medicinal Plants 16th and 17th medicinal plants Garden, Mettur Dam December

2017 6. National conference on prevention and Central Council for 4th January,

management of lifestyle disorders through Research in Siddha 2018 Siddha system of Medicine

7. One Day Workshop on Official Language Siddha Central Research 12th January, Hindi Institute, Chennai 2018

National Seminar on "Glory of Siddhar Agathiyar and his Contribution to Siddha System of Medicine"

Siddhar Agathiyar, one among the line of Eighteen Siddhars, is called the Father of Siddha Medicine. His contribution to Siddha system of medicine and other related fields is immense. Ministry of AYUSH has approved the proposal to celebrate Agathiyar's birthday as "Siddha Day" every year. The first "Siddha Day" falls on 4th January 2018. It has also been suggested by the Ministry

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of AYUSH to conduct a National Seminar, well in advance, as a preamble to the grand Siddha Day celebration. Based on this National Seminar on "The Glory of Siddhar Agathiyar and his Contribution to Siddha System of Medicine" was organised on 26th & zr: August 2017 by Literary Research & Documentation Department, Siddha Central Research Institute, Central Council for Research in Siddha, Ministry of AYUSH, Govt. of India) Arumbakkam, Chennai - 600106. The enlightenment acquired through the deliberation on these 2 days accentuated the greatness and magnificence of Siddhar Agathiyar.

Twelve resource persons from various field of interest delivered their lecture on Glory of Siddha Agathiyar. One hundred and sixteen delegates participated in the Seminar, 34 poster presentations were displayed related to history and Anthropology on Agathiyar, Agathiyar and his Legacies, Agathiyar and his contributions towards Alchemy, Agathiyar and his contributions to Basic principles in Siddha, Agathiyar and his contributions to Medicine, Agathiyar and his contributions towards Linguistics and Astrology

National Seminar on Current Trends in Siddha Varmam Therapy 4th& 5th November 2017, AYUSH Auditorium, New Delhi

The National seminar was inaugurated by Sh. P.N. Ranjit Kumar, the Joint Secretary, Ministry of AYUSH, New Delhi and inaugural address was also delivered by him. Felicitation addresses were given by Prof. Dr. R.S. Ramaswamy, Director General, CCRS and Prof. Vaidhya. K.S. Dhiman, Director General, Central Council for Research in Ayurvedic Sciences, New Delhi. Eight invited speakers, four from the Council and four from outside the Council, who are experts in the field of Varmam therapy, shared their expertise in the Seminar. Sh. Roshan Jaggi, Joint Secretary, Ministry of AYUSH, New Delhi, Dr. D.C. Katoch, Advisor (Ayurveda), Ministry of AYUSH and Dr. Vanitha Muralikumar, President, Central Council for Indian Medicine, New Delhi graced the valedictory ceremony by their presence.

Various participants from Ayurveda, Siddha and Unani streams participated in the seminar from the following Institutes / Councils,

1. Ayurveda and Unani Tibbia College, Karol Bagh, New Delhi 2. Ch. Brahm Prakash Ayurvedic Charak Sansthan, New Delhi (A postgraduate Ayurveda Institute

of Delhi government) 3. All India Institute of Ayurveda, Sarita Vihar, New Delhi 4. Central Council for Research in Unani Medicine, New Delhi 5. Central Council for Research in Ayurvedic Sciences, New Delhi 6. National Institute of Ayurveda,Jaipur.

Research Officers from the peripheral institutes and units of CCRS actively participated in the senunar

National Conference on Pura Maruthuvam - External Therapies in Siddha System of Medicine (NCPM-2017), December - 9th & 10'\ 2017 At Dr.A.P.J. Abdul Kalam JIPMER Auditorium, Puducherry.

The Siddha Regional Research Institute, under the Central Council for Research in Siddha (CCRS) has organized a two day National Conference on Pura Maruthuvam- External Therapies in Siddha System of Medicine on 9'h& 1 O'h December, 2017 at Dr. APJ Abdul Kalam JIPMER Auditorium, Puducherry for Undergraduate and Postgraduate Scholars of Siddha Medicine, Siddha

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Practitioners, Faculty and Research Officials of Siddha institutions, Research Scholars, Senior Research Fellows, Research Associates, Scientists and others who are involved in interdisciplinary research and also for nominees of AYUSH Pharma Industry or entrepreneurs. The two day National Conference on Pura Maruthuvam has the following scopes,

1. Literature evidences for external therapies in Siddha. 2. Evidence based researches in the field of external therapies. 3. Pros and cons in practicing external therapies. 4. Development of standard operating procedure for external therapies. 5. Emerging trends in external therapies for the management of life style disorders. 6. Effective therapeutic approaches for chronic diseases in external therapy. 7. Exploration of folklore practices in external therapy. 8. Ethical perspectives in the practice of external therapies.

National workshop on Conservation and Cultivation of Medicinal Plants (NWCCMP), 16th& 17th of December, 2017 at Mohan residency, Mettur Dam

The Siddha Medicinal Plants Garden, Mettur Dam under the Central Council for Research in Siddha (CCRS) organized the National workshop on Conservation and Cultivation of Medicinal Plants (NWCCMP), 16th & 17u, December, 2017 at Mohan residency, Mettur Dam. In the National conference, 159 delegates including Researchers/ Academicians/Students and medicinal plants stakeholders from various research and academic institutions participated and presented their research works. Six scientific sessions with 53 oral and 18 poster research papers were presented by delegates from different disciplines related with medicinal plants. The delegates were taken for a field visit to Siddha Medicinal Plants Garden, Mettur Dam and were introduced with the live medicinal plants being grown/ cultivated in the Siddha Medicinal Plants Garden. An exhibit of live medicinal plants and crude raw drugs were also arranged in the temporary shamina erected for the workshop.

2. The first Siddha Day It was decided by the Ministry of AYUSH to observe Siddha Day every year on the birthday

of Siddhar Agathiyar, the father of Siddha Medicine. Accordingly, the first Siddha Day celebration was organised on 4th January 2018, by the Central Council for Research in Siddha in collaboration with the Directorate of Indian Medicine and Homeopathy, Government of Tamil Nadu, The Tamil Nadu Dr. M. G. R Medical University and National Institute of Siddha. The event was held in the Silver Jubilee auditorium of The Tamil Nadu Dr. M.G.R Medical University, Chennai. The National Conference on "Prevention and management of Lifestyle Disorders through Siddha System of Medicine" was organized in the first Siddha Day. Nine hundred and Twenty registered delegates participated in this mega-event apart from several invitees and Siddha experts. Six plenary lecutes were delivered by invited speakers on the theme "Prevention and Management of Life-style disorders through Siddha system of Medicine".

The National Conference on "Prevention and management of Lifestyle Disorders through Siddha System of Medicine" was alson organized on the eve of First Siddya day. the Souvenir comprising 213 abstracts, a monograph on Siddhar Agathiyar and the Hindi version of the book Theraiyar Kudineer were released.

The celebration of the first Siddha Day was marked by many valuable events - Siddha stalls put up by the Council and other Government Siddha institutions displayed informative materials on

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Siddha system of medicine. An exhibition cum sales of medicinal plants had been arranged by Siddha Medicinal Plants Garden, a unit of CCRS located in Mettur. Siddha, Varmam and Yogam outpatient clinics were conducted for providing free consultation and Siddha medicines for the public. Around 650 public were benefited.

Prior to Siddha day, quiz competition, essay competition, elocution competition and short film competition were held to exhibit and hone the talents of students of Siddha Medical colleges. Prizes and certificates were awarded to the winners on the Siddha Day.

3. Third International day of yoga The international yoga day celebration commenced from 9.6.017. As a part of celebration

of IYD and to create awareness towards healthy and long life among the staff through Yogam, a practical session was conducted to all staff members of Central Council for Research in Siddha and Siddha Central Research Institute from 9.6.17 to 20.6.2017. The students from Govt. Siddha Medical college, Chennai, were also trained along with the staff. The Director General, Prof. Dr. R.S. Ramaswamy conducted theory and practical demonstrations of yogasanas. DG, CCRS gave a talk on yoga in the International Yoga Day celebration of All India Radio. The students trained by DG also performed yogasanas and pranayamam on stage. The talk by DG was aired in FM gold and Rainbow FM on 21.6.17. The Director General, CCRS was invited to give a special lecture on 21.6.17 in connection with IDY celebration in National Institute of Epidemiology, ICMR, Chennai. He also made live programme in Podhigai television on 21.6.17. T.Shirts were issued to all the participants.

On 21.6.2017, the International Day of Yoga was celebrated in the playground of Govt. Siddha Medical College, Chennai. 194 staff of CCRS and SCRI and internees of Govt, Siddha Medical College, Chennai participated in the mass yoga performance. The staffs participated in the uniform provided by the Council and followed the instructions of DG. A book on Yoga was released by the Literary Research and Documentation Department of SCRI. The book was released by DG and the first copy was received by our OPD patient Mr. Ramadoss.

4. Science Club Meeting Introduction

The Science club of CCRS - Siddha Central Research Institute, Chennai is conducted with the aim to provide in-house training and the exposure to the recent advances in different areas of different faculties to the research officials of this institute. The chairman of the science club for the reporting year was Dr. P. Sathiyarajeswaran, Asst. Director (Siddha) and i/ c, Secretary Dr. M. Kannan, Research officer (Siddha) and Coordinator Dr. G. Dayanand Reddy, Asst. Director, Scientist-2 (Pharmacology).

Aims & objectives

• To update the knowledge of the members through invited lectures from eminent Scientists. • To reorient, revise, and regulate the ongoing research projects. • To get training for better presentation of our scientific work and to improve the style of

presentation. • To understand the advancement in latest technology, therapies and the methodology followed

in reputed institutions. • To get guidance and professional contact / access for further collaborative research work to

share knowledge through healthy interaction.

40


Members of the club

All the staff starting from Group-C working in this Institute in various departments likes Pharmacognosy, Chemistry, Biochemistry, Pathology, Pharmacology and Clinical Research are the members of the club.

Details of Science Club meeting organized during the reporting period

During the current year five Science Club meetings were held. "Overview of Intellectual Property Rights by Dr. Eugene Wilson, Evaluation of Naadi and its significances in Obstetrics and Gynaecology by Dr. S. K. Sasi, Standardization of ISM drugs - An Integrative Approach by Dr. K. Parthasarathy, Basics of Varmam, contemporary subtle energy theories and its research methodology by Dr. S. Natarajan and Overview of Regulatory Toxicology by Dr. S. Sugin Lal Jabaris are the topics dealt in the Science Club meeting.

5. Training/ Workshop attended by Officers of CCRS -Peripheral Institutes/Units

SI.No. Name of the Name of Seminar/ Name of the Date of participant Conference / Organiser Participation

Workshop/ Training 1. Dr. M. S. Shree Devi Public awareness Doordharshan 1 s' April, 2017

campaign on I yarkai Kendra maruthuvam & Iyarkai unavu thiruvizha

2. Dr. P. Sathiyarajeswaran Structural standards Ministry of 6'11 April, 2017 and quality AYUSH, management system in New Delhi AYUSH hospitals towards NABH accreditation

3. Dr. S. Selvarajan Awareness Programme Ministry of zi- April, Dr. G Dayanand Reddy on EMR Scheme (Min. AYUSH, Govt. of 2017

of AYUSH) India 4. Dr. M. Kannan National workshop on Central Council znd - 4ch May,

e -Granthalaya 4.0 for Research in 2017 software for Unani Medicine Automation and & National Networking of Informatics Government Libraries Centre (Ministry

of Electronics and Information Technology, Govt. of India)

5. Dr.R. Meena A discussion on Apollo Medical zr: May, 2017 Dr.S.Esaivani Neurology and Centre, Annanagar Dr. T. Kavitha Orthopedics

6. Dr. M. S. Shree Devi NABH-AYUSH QCI, India S'h to 9'hJune, Assessor training 2017 programme

7. Smt. S. Gajalakshmi CME on Specialized Kokila Siddha 22nd to 27'h Smt. E. Shanthi Hands-on training for Hospital and June,2017 Smt. R. K. Sathya AYUSH Therapists.

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Research Centre, Madurai.

8. D. Satheesh Dr. M. Muthu Tamizh

One Day I Madras University Chromatography Work shop

30'h 2017

June,

9. Dr. M. Kannan Dr. M. Muthu Tamizh

Training programmes I QCI, India, Kochi on Capacity Building Initiative for Trade Development in India (CITD)

3rd & 4th July, 2017

10. Dr. S. Selvarajan Dr. A. Rajendra Kumar Dr. Eugene Wilson Dr. A Kanagarajan Sh. George Joseph

Training Programme on "Training-cum Workshop for implementation of Public Financial Management System (PFMS)"

CCRS, Chennai 7th & 8th July, 2017

11. Dr. A. Rajendra Kumar

Dr. Eugene Wilson

Capacity Building Initiative for Trade Development in India (CITD) herbal products for the EU market - Traditional herbal products directive and good manufacturing practice

Quality Council of India

1 O" to 11 °1 July 2017

12. Dr. L. Mugunthan Dr. K. Samraj

Affordable Health Care Confederation of I 19th July, 2017 for All-way forward for Indian Industry TamilNadu (CII) Chennai,

Hilton Hotel 13. Dr.P. Sathiyarajeswaran

Dr. A. Rajendra Kumar Dr. R. Meena Dr. S. Shunmugaram Dr.K.Samraj

CME programme on Kokila Siddha 16th August, structural standards and Hospital and 2017 quality management Research Centre, system in AYUSH Madurai hospitals towards NABH accreditation

14. Dr. M. Kannan Training programme on Communication and Presentation Skills (CAPS)

Institute of Management Training and Research International Centre Goa

29th August to znd

September, 2017

15. I Dr. S. Selvarajan Training programme on Government e Marketplace (GeM) and GFRs 2017

National Institute of Financial Management (NIFM) campus in Faridabad

4th & 5th September, 2017

16. I Dr. R. Rathinamala A Half-a-day workshop_/ awareness

The National Informatics

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Dr. Gayathri Gunalan Sh. G. Vijaya Kumar, UDC

session for the Central Government departments to provide an overview of the e procurement process.

Centre, Chief Secretariat Complex, Puducherry.

September, 2017

17. I Dr. A. Rajendra Kumar I Forum for Ethical I ICMR-NIE, review committees in Chennai. the Asian and Western Pacific region SIDCER-FERCAP.

18'h to 20'" September, 2017

18. I Dr. G. S. Lekha Dr. B. Chitra

Training Workshop to initiate centralized collection of AYUSH Morbidity statistics through NAMSTP by dual coding system

CCRAS, New Delhi

6th October, 2017

19. Dr. Shyamala Rajkumar

Dr. Eugene Wilson

INDO-USP Workshop on Pharmacopoeia! Monographs of Ayurvedic/Herbal Medicines

PCIM&H, Ministry of AYUSH, Govt. of India and USP, Rockville, Mar_yland, USA

6'" November, 2017

20. Dr. B. Chitra 5 days workshop on ''Applied Psychometrics in research - principles of scale development and validation organized by school of public health.

SRM University Kattankulathur, Chennai.

13th to 17'11 November, 2017

21. Dr. M. Kannan Distinguished Lecture & Symposium on Pharmacovigilance for H Products By Indian Pharmacopoe Commission, Ghaziabad

Indian Pharmacopoeia Commission, Ghaziabad.

20th

November, 2017

22. Dr. S. Selvarajan Training programme on Advance Public Procurement

ational Institute of Finance Management (NIFM), Farid a bad

4'h to 8th December, 2017

23. Dr. C. Anbarasi Workshop on Access to Technology for Innovation and Establishing a Technology and Innovation Support centre (TISC) Network

Centre for Intellectual Property Rights, Anna University, Guindy, WIPO, Geneva and D IPP, Ministry of Commerce and Industry, Government of India

7'h& 8'h December, 2017

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24. Dr. Shyamala Rajkumar Dr. VAarthi Dr. G.S. Lekha Dr. L. Juliet Dr. R. Rathinamala Dr. P. Thenmozhi

A National workshop on "Conservation & Cultivation of Medicinal plants"

Siddha Medicinal Plants Garden, Mettur.

16th & 17th December, 2017

25. Dr. M. Muthu Tarnizh Training programme on Computational Chemistry (Introduction to Gaussian: Theory and Practice) in New Delhi

Gaussian Inc. USA.

8'" to 12th

January, 2018

26. Dr. S. Natarajan Dr. M. Harihara Mahadevan Dr. Eugene Wilson Dr. R. Rathinamala Dr. B. Akila

Two days training cum exposure programme on "Social media content development." - Level I

AYUSH Auditorium, Janakpuri, New Delhi

15th & 16'" January, 2018

27. Dr .. G.Dayanand Reddy GST-Training Programme

IFM, Faridabad 17th to 19th

January , 2018

28. Dr. B. Akila Cancer Events, AIIA, New Delhi

Center of Integrative Oncology (CIO) of AIIA, New Delhi

5th& 6th February, 2018

29. Dr P.Elankani Training Programme on Public Procurement

ational Institute of Financial Management, Faridabad

5th to 10th February, 2018

30. Dr. A. Rajendra Kumar Dr..G. S. Lekha

Training programme on Public Procurement.

National Institute of Financial Management, Faridabad

19th to 24th February, 2018

31. Dr. Eugene Wilson Dr. R. Rathinamala Dr. B. Akila

Two days training cum exposure programme on "Social media content development." - Level II

AYUSH Auditorium, Janakpuri, New Delhi

16th & 17th February, 2018

32. Dr. P. Sathiyarajeswaran State Level workshop on National Biodiversity action plan

Tamil Nadu I 20th February, 2018 Biodiversity

conservation and greerung project (TBGP), Chennai

33. Dr. P. Sathiyarajeswaran I Inception workshop Tamil Nadu and launch of Indo- Biodiversity German Technical co- conservation and operation project- greening project access and benefit (TBGP), Chennai sharing partnership project (TBGP)

zr: February, 2018

44


34. Dr. M. Muthu Tamizh National workshop on SAIF, IIT-M, 5th to 8th Nuclear Magnetic Chennai March, 2018 Resonance

35. Dr. M. Muthu Tamizh Participated ill Madras University 15th to 17th

Sh. D. Satheesh international March, 2018 conference (ICORTAC)

36. Dr. A Kanagarajan Induction Program on All India Institute o 19'h March, Dr. R. Rathinamala Pharmacovigilance for Ayurveda(Ministry 2018 Dr. M. Kannan Coordinators of ASU&l AYUSH, Govt. of

Dr. R. Rathinamala drugs New Delhi

37. Mr. Chitikela, P Pullaiah ICMR Sponsored Sathyabama 19th to 23rd

and Mrs.K..Bhavani Workshop On Lab Institute of March, 2018 Animal Techniques Science and And Ethics Technology,

Chennai 38. Mr. N. Kirubakaran Conference and ASIALABEX 20th March,

Workshop on lab 2018 2018 Instruments, Chemicals Trade Centre - & Machineries Chennai

6. Expo S.No Name of the Title Organization Date

Officer

1. Dr. B. Akila Wellness India Expo Pragati Maidan, New 29th to 318t

Delhi August, 2017

2. Dr. V Aarthi III Indian International Ministry for 13th to 16d' Dr. T. Kavitha Science Festival (IISF) - Environment and October, 2017 Dr. A. Usha 2017 forest and vijana

Bharati and IIT Madras, Anna University

3. Sh. M. Natarajan 27th Swadeshi Science Swadeshi Science 7rh to 9rh Congress Movement - Kerala November,

and Amrita Viswa 2017 Vidyapeetham, Amrita University, K.ollam

4. Dr. S. Saravanan Ayurveda Conclave: Ministry of AYUSH 16th October, Vision 2022: Widening and Confederation 2017 Horizon of Ayurveda for of Indian Industries three fold growth of market size, India Habitat Centre, New Delhi

5. Dr. R. Meena World Congress on The Tamilnadu 9th to io- Dr. L. Juliet Holistic Health 2018 Dr.MGR medical December, 17 Dr. P. Thenmozhi university, Chenni. Dr. R. Susila Dr. T. K.avitha

45


6. Dr.Harihara Ayurveda Parv during All Bangaluru 16th to 18'h Mahadevan India Ayurvedic Congress February, 18. Dr.R.Meena at International Ashram Dr.S.Esaivani RubeenaM Sujith T

7. Dr. T. Kavitha Nalam expo- 2018 Govt. Siddha 15th to 18th Dr. K. Samraj Medical College, February, 2018 Dr. R. Susila Chennai.

7. Presentation in Seminars/Conferences s. No

Name of the Officer Presented Title Venue Date

1. Dr. M. Kannan Inspection visit for National Raw Drug Repository by Committee from Ministry of AYUSH, Govt. of India Digital Imaging at SCRI for NRDR

Siddha Central Research Institute Chennai

30th June, 2017

2. Dr. P. Sathiyarajeswaran Dissertation and Paper I Lecture - Sarada Publication on Research Krishna

Homeopathic Medical College, Kulasekharam, Kanyakumari Dist.

17°1 August, 2017

3. Dr. P. Sathiyarajeswaran Dr. M. Kannan

Special event - ICD - 11 Definitions related to development of National ASU Morbidity codes in the line of TM - ICD-11 format - Review and Finalization meeting

CCRS, Chennai

3rd October, 2017

4. Dr. M. Kannan THERAN - THE Research Application Nexus (Electroni Capturing System) - presentat and software demo National Seminar on Current Trends ir Siddha Varmam Therapy

AYUSH Auditorium, 61- 65, Institutional Area Janakpuri, New Delhi

4th & 5th November, 2017

5. Dr.K.Samraj Effectiveness of Siddha Topical Applications for Chronic Non-Healing Lower Extremity Ulcers- Case Series

Siddha Regional Research Institute, Puduchery

9rh & io December, 2017

6. Dr. P. Sathiyarajeswaran ational Workshop on Mohan Residency, Conservation and cultivation Square Market, of Medicinal Plants Mettur dam

16'h & 17th December, 17

7. Sh. V Chelladurai, "Export Potential of Medicinal Plants and Value additions" in National Workshop on Conservation

SMPG Mettur

16th & 17th December, 2017

46


and Cultivation of Medicinal Plants.

8. Dr. K.G. Divya "IUCN red listed medicinal plants in Siddha" at National Workshop on Conservation and Cultivation of Medicinal Plants

9. Rubeena. M "Bioactive entities from I SMPG Mettur ingredients of Nilavembu kutineer" at National Workshop on Conservation and Cultivation of Medicinal Plants

17th December, 2017

10. I Dr. M. Kannan THERAN - THE Research I Central Council Application Nexus (Electronic Data Capturing System) - presentation and software demo All Council (Ministry of Meeting A YUSH exclusive for THERAN Govt. of India) software demonstration and

61_65 '

for Research in Ayurvedic Sciences

Presentation Institutional Area Janakpuri, New Delhi

13th

December, 2017

11. Dr. M. Kannan Multi Centric Clinical Trial Experiences in N eerizhivu (Diabetes mellitus) The First Siddha Day Celebration By Central Council for Research in Siddha (Ministry of AYUSH Govt. of India) Chennai

Auditorium The Tamil Nadu Dr. MGR. Medical University, Chennai

4th January, 2018

12. Dr. K.N Sunil Kumar "Development of Monograph on Quality Standard of Viscum angulatum B. Heyne ex DC. (Pulluruvi) by Macro-microscopy, phytochernical, HPTLC and NMR techniques"

International Conference Challenges Global

znci to 4th

on I February, for 2018.

Competitiveness of AYUSH and Natural Products organized by Delhi

13. Dr. K. Parthasarathy "Structural Characterization Abdul Hakeem of Drug substances by College, spectroscopic techniques" in Melvisharam. state level conference on Vellore. "Chemistry and Environment pollution".

13th February, 2018

14. Dr. P. Sathiyarajeswaran Integration AYUSH into I AIIMS, palliative care: IAPON 2018 Delhi preconference workshop

New I 22nd February, 2018

47


8. Participation in Seminars/Conferences

S.No Name of the Name of the Event Name of the Organizer Date Officer

1. Dr. V Gayathri ''Analytical solutions Fortune Hotel The South 4th Devi for today's science" Park, MG Road, Palayam, October,

Thiruvananthapuram 2017 conducted by Agilent Technologies India Pvt. Ltd

2. Dr.R. Update Proctology - A yurved proctology 24'h to 26'h Manickavasagam National Conference Association and November,

on Ano-Rectal Maharashtra Council for 2017 Disorder, Malvan, Indian Medicine, Mumbai Maharastra

3. Mr. Edukondalu Laboratory Animal NIN, Hyderabad 12'h to 16'h

Mr. K. Dhanaraj Science and December, Techniques training 2017 course

4. Dr. G. S. Lekha, National Conference Avinasalingam University, 18th& 19'h Dr. Anitha John, on Medicinal plant Coimbatore, DST - December, M Natarajan, research and CURIE 2017 Neethu Kannan B. Translational Trends Tirupathi B (MPRTT 2017)

5. Dr. S. Saravanan I" edition of National Department of 22nd Biotechnology Biotechnology, December, Conclave, Hotel Sangri Government of India and 2017 La, New Delhi Confederation of Indian

Industry 6. Dr. P. Participation in the 22nd Prashanti Kudeeram, S- 9th January,

Sathiyarajeswaran INCOFYRA VYASA University 2018 Bengaluru.

7. Dr. P. National Seminar on University of Madras, at 19'h March, Sathiyarajeswaran "life style disease with Venugopal Auditorium 2018

focus on Diabetes (NSLSD-2018)

9. Events

S.N Name of the Officer Event Venue/ Date Activities 0

1. Dr. S. Selvarajan 11th Common Review Nagaland, 4th to Review the Mission (CRM) of 10th November, deliverables National Health Mission 2017 with regard to (NHM) all the health

care facilities including the AYUSH systems of the state of Nagaland

48


2. Dr. M. Kannan Dr. G.S. Lekha Dr. M. Harihara Mahadevan Dr. B. Chitra Dr. Eugene Wilson

Training workshop to initiate centralized collection of AYUSH morbidity statistics through national AYUSH morbidity and standardized terminologies portal (NAMSTP)

AYUSH Auditorium, Janakpuri, New Delhi 6th October, 2017

Review and finalization meeting for definitions related to the development of Siddha Morbidity codes in the lines of TM ICD-11

3. Dr. S. Saravanan International Yoga Fest, A Curtain raiser for International Yoga Day 2018

Zl " to 23rd March, 2018

Displaying and Distributing IEC materials, Sale of CCRS Publication

4. I Dr. M. S. Shree Devi Live program - Siddha questions

Doordharshan Kendra 25th April 2017

5. I Dr. R. Meena International Day of Yoga program

All India Radio, Chennai. 15d' lune 2017

Speech about Therapeutic Yo_g_a

6. Dr. P. Sathiyarajeswaran Monitoring committee for central sector scheme with promotion of AYUSH intervention in Public Health Initiatives

National of Tambaram Sanatorium 1st & 2nd November

Institute Siddha,

2017

49

10. Research papers and Presentation of Guest lecturers

S.No. Name of the Title of the presentation Conference / Seminar / Workshop / other Date presenter

1. Dr. M.S. Shree Devi Women care in Siddha medicine National Arogya fair -at Indore 7th April, 2017 2. Dr. Eugene Wilson IPR/Translational values of Extra Mural One-day workshop on creating effective 21st April, 2017

Research Proposals" utilization of EMR scheme entitled "General awareness and Propagation of EMR scheme of Ministry of AYUSH, SRRI, Puducherry

3. Dr. B. Chitra Mother and Child care and Mitigation of The field publicity office, Vanur Block, 27'h April, 2017 effects of Summer Heat. Puducherry.

4. Dr. A. Faridha Mother and Child care and Mitigation of The field publicity office, Morattaandi 28'h April, 2017 effects of Summer Heat. Puducherry.

5. Dr. K. Parthasarathy Project proposal presentation of AYUSH Bhawan, New Delhi 1st May, 2017 "Development of National Raw Drug Repository" (NMPB project)

6. Dr. A. Faridha Awareness about Siddha medicinal plants. The field publicity office, Youth Educational 5th May, 2017 Center, Auroville, Puducherry

7. Dr. T.Kavitha Siddha management for womens health Arogya mela -Chennai 5th May, 2017 8. Dr. S. Natarajan Innovative Global Program for Scientific Transdisciplinary university, Bangalore. 25'h July, 2017

training of Barbers based on the Siddha Varmam Points which are located in head and neck

9. Dr.S.Saravanan Introduction to the basic principles of Seminar on Introduction to the basic principles 5th August, Siddha and its relevance in the light of of Unani, Siddha, Homoeopathy 2017 basic principles of A yurvedic medicine

10. Dr. L.J uliet Role of Siddha in Female Reproductive 9th September, Health care National Arogya fair -at Vishakapatinam 2017

11. Dr. P. Thenmozhi Geriatric Health Care Through Siddha 11 'h September, System of Medicine 2017

12. Dr. A. Rajendra Kumar Scope for research in Siddha in conditions Temple of consciousness, Aliyar, Coimbatore. 7th October, of Infertility. 2017

so

ANNUAL REPORT 2017-18 I CCRS

13. Dr. V. Gayathri Devi Invited lecture on "Phytochemical 'Recent Approaches in Biochemical Research' 13th October, techniques: Extraction and Isolation" 2017

14. Dr. K. Elavarasan Study on the Efficacy ofVarmam therapy and Siddha Medicines in Pediatric National Workshop on Marmachikitsa

27u1 & 23u, Neurological Disorders-Cerebral Palsy and October, 2017 Erbs palsy

15. Dr.R.Manickavasagam Management of Pakka Vatham and Migraine through Siddha Varmam Therapy

16. Dr. S. Natarajan Basics of Varmam and contemporary subtle energy theories 4th & 5th

17. Dr. R. Meena Management of ceganavatham and azhal National Seminar on Current trends in Siddha November, keel vayu through Siddha Varmam Varmam Therapy, AYUSH auditorium, 2017 Therapy Janakpuri, New Delhi 18. Dr.K.Elavarasan A study on effectiveness of Siddha

Varmam therapy and Siddha Medicine in paediatric neurological problems (Cerebral palsy and Erb's palsy)

19. Sh. M. Natarajan, A review on nanoparticles synthesis from biological resources

20. Sh. Tirupathi B A Review on Therapeutic actions of Piper nigrum L. (Black Pepper). 27th Swadeshi Science Congress Amrita 7th to 9th

21. Ms. Neethu Kannan B An insight to ethno-medicinal plants of Vishwavidyapeetham, Amrita University, November, Apocynaceae used in Siddha medicine Amritapuri Campus, K.ollam 2017

22. Dr. Gayathri Devi V Characterisation Of Ayakantha Chenduram, A Nanosized Herbo-Mineral Formulation Using Modern Techniques

23. Dr. C. Anbarasi Preclinical safety and efficacy studies on Siddha Polyherbal formulation 1st International AYUSH conference &

9th & u- Madhumega chooranam in the Exhibition 2017, Dubai, UAE November, management of Neerizhivu (Diabetes 2017 mellitus)

51


24. Dr. G. S. Lekha 1st International AROGYA Fair in Management of Lifestyle Disorders through 5th December, collaboration with FICCI Siddha System at Vigyan Bhavan New Delhi 2017

25. Dr.R.Manickavasagam Kudori -An Unexplored Siddha External Therapy for Handling of Emergency Clinical Conditions

26. Dr. C. Anbarasi Case series - Management of Thandagavatham with Siddha Varmam therapy and Podithimirthal therapy

27. Dr. S. Natarajan Management of Ankle injuries with Siddha Varmam Therapy and Traditional bone setting method (Kattu)

28. Dr. R.Susila, Diversification of external therapeutics a National conference on Puramaruthuvam - 9th & 10'h current need in field of baalar External therapies in Siddha system of medicine, vagadam(Siddha paediatrics) by Siddha Regional Research Institute, December,

29. Dr. R.Meena Evidence based conduct of Varmam Puducherry 2017

clinical trials-An overview. 30. Dr. S.Esaivani The efficacy of katrazhai thiripala kattu in

the management of karuppai adithallal (uterine prolapse) A case study

31. Dr. G. S. Lekha Emergency medical care and external therapy in Siddha

32. Dr. K.Samraj Effectiveness of Siddha Topical Applications for Chronic Non-Healing Lower Extremity Ulcers- Case Series

33. Dr.K.Samraj Siddha Management of High altitude 15th December, Disorders and External therapies in Siddha 2017 System of Medicine Arogya Mela -Nagaland 34. Dr. Eugene Wilson Overview of Siddha system of Medicine 14th December,

2017

52


35. Sh. V. Chelladurai Presented an invited lecture on the "Export Potential of Medicinal Plants and Value additions".

36. Dr. Radha P Anticancer activity of Vinca alkaloids from madagaskar periwinkle ( Catharanthusroseus (L.) G. Don) - A review.

37. Dr. M.Padma soma Ex-situ conservation of RET plant species Subramanian in Siddha Medicinal Garden

38. Dr. M.Padma soma Herbal Wealth of Marunthumalai 16th & 17th Subramanian National Workshop on Conservation and December, Cultivation of Medicinal Plants. Siddha

39. Sh. R. Lakshmanan Prominent Plant Species of Palamalai Hills Medicinal Plants Garden, Mettur Dam 2017 of Salem dt. Tamilnadu, India

40. Dr. M. Thiruvalluvar Ethno Botanical Study of Medicinal Plants Used for the Poisonous (Vishskkadi) Ailments of Palamalai in Salem dt. Tamilnadu, India

41. Dr. Padma Soma Phytochernical Analysis of Flueggea Subramanian M leucotrvrus Willd.

42. Dr. Padma Soma In vitro Anti - diabetic activity of Subramanian M Orthosiphon comosus Wight ex Ben th.

(Lamiaceae) 43. Dr. G. S. Lekha IPR and patenting issues on Medicinal

plants National Conference on Medicinal Plant

44. Dr. Kasirajan N Management of Skin diseases in Siddha Research and Translational Trends (MPRTT 18t!'& 19th system of Medicine - A Review 2017) Avinasalingam University, Coimbatore, December 2017

45. Dr. Anitha John Chemical standardisation of Pavetta indica Tamil Nadu

Linn. (Leaf)

53


46. Sh. B. Tirupathi Chemical Standardisation And An Overview Of Wrightia Tinctoria R. Br. -A Potent Herbal Drug

47. Sh. M. Natarajan Chromatographic Techniques In Quality Assessment Of Herbal Drugs

48. Ms. Neethu Kannan Plant assisted synthesis of metallic nanomaterials: A green chemistry perspective

49. Dr. V. Gayathri Devi Invited lecture on "Methods of Standardization for Medicinal Plant Materials"

50. Dr. Padma Soma Special lecture on "Utilization of medicinal Farmer's meeting in Aththanoor, Namakkal dt., 20th December Subramanian M plants and its Cultivation" Tamilnadu organised by ''Biodiversity 2017.

conservation and greenness scheme under Dept. of Forest, Salem.

51. Dr. G. S. Lekha Traditional concept of Cancer First Siddha Day 2018; Central Council for 4th January 2018 management in Siddha System. Research in Siddha, Chennai

52. Dr. M. Muthu Tamizh Computational Chemistry Training Gaussian Inc. USA 8th to 12th

programme (Introduction to Gaussian: New Delhi January, 2018 Theory and Practice)

53. Dr. S. Selvarajan Over view of Siddha system of medicine 2ot1, January, in the one-day training program for the 2018 officers of Ministry of AYUSH Training Hall, NASC Complex, PUSA, New

54. Dr. P. Sathiyarajeswaran Research in Siddha system of Medicine Delhi. zo- January, 2018

55. Dr. B. Akila "Siddha in Cancer" Cancer Events 5th February, 2018

56. Sh. R. Nagaraj Documentation of ethno-medicinal plants 3rd National Conference on Frontiers in Eco- 7th to 9'h from folk healers of Padmanabamangalam, biological Sciences and its Applications February, 2018 Tuticorin District, Tamil Nadu

54


57. Dr. L. Juliet Evaluation of Antioxidant Properties of Siddha Unit, Jaffna university, Srilanka 23rd to 27'" Poly Herbal Siddha Preparation. Karisalai February, 18 KarpaChooranam

58. Dr. T. Kavitha Acute and repeated oral toxicity studies on 1 st International conference and Exhibition on 27u, February, Siddha drug Lavanga choornam Siddha Medicine -2018\ Sri Lanka 18

59. Dr. M. Muthu Tamizh National Workshop on Nuclear Magnetic SAIF, IIT-M, Chennai 5th to 8th March, Resonance Spectroscopy 2018

60. Dr. T. Kavitha Magalir Nalanil Siddha Maruthuvam On the occasion of women's day celebration 8th March, 2018 61. Dr. T. Kavitha Stress Management 62. Dr. R. Susila Beauty mania and the devastating factors

behind 63. Dr S Natarajan Multicentric Clinical Trial Experiences on Life style diseases with focus on Diabetes, 19th March,

Diabetes University of Madras, Taramani, Campus 2018

64. Dr. P. Sathiyarajeswaran Research Methodology GSMC, Arumbakkam, Chennai 22nd March, 2018

65. Dr. K. Sivaranjani Varmam for Geriatric care 1 "International Conference & Exhibition on 2018 Siddha Medicine 2018 organized by Unit of Siddha Medicine, University of Jaffna, Kaithadi, SRILANKA.

55

11. Participation in Arogya fairs

S.N Name of Mela/ Participation Duration & Activities o. Exhibition / Camp place

1. National level Arogya Dr .. S.Natarajan 7'h to 10th Medical camp, awareness Fair - Indore, Madhya Dr .. M.S.Shreedevi April, 2017 through translates exhibited Pradesh Dr. C. Anbarasi in the CCRS stall, sale of Organized by FICCCI, Dr .. B.Akila Siddha books AYUSH

2. National level Arogya Dr.M.Harihara S'h & 8'h May, OPD for public and Siddha mela in Chennai Mahadevan 2017 books sales and pamphlets

Dr.R.Thilagavathi Chennai distribution to the public. Dr. T. Kavitha Dr. A. Usha

3. The MADITSSIA- Dr. S. Bhavani 11th to 15th Distribution of OPD and AYUSH-2017. Dr. R. Rathinamala August, 2017 issued free Siddha medicines.

MADITSSI Publications of CCRS were A Hall, sold. Charts were exhibited. Madurai.

Pamphlets about the Siddha system of medicine and remedy for different diseases were distributed.

4. National level Dr.L.Juliet 8'h to 11 Special OPD and issue of AROGYA Expo 2017 Dr.P.Thenmozhi September, free Siddha medicines. &The International Dr. S. 2017 Publications of CCRS were conference on Shunrnugaram Andhra sold. Charts were exhibited. "convergence of University

Pamphlets about the Siddha health traditions in Grounds, Bharatavarsha." Vishakhapat system of medicine and

nam, remedy for different diseases Andhra were distributed. Pradesh.

5. India International Dr. S. Saravanan 14'h to 27'h Siddha Consultation Trade Fair 2017 Dr. B. Akila November, including Varmam therapy

2017, Pragati and advice about NCD Maidan, Awareness and Screening New Delhi Camps

6. Arogya 2017: First Dr. G. S. Lekha 4th to 7'h Distribution of pamphlets international exhibition Dr.R.Manickavasaga December, regarding Siddha medicine, and conference on m 2017 display of books on Siddha A YUSH and wellness Dr. K. G. Divya New Delhi medicines, OPD sector Dr.Natarajan M consultation.

7. State Arogya Dr.Eugene Wilson 12th to 15th Display and distribution of Dr. K. Samraj December, publicity materials, Stall Sh. A.K. Mandal, 2017 management and Sh. A. Rajesh Mokokchung Consultation

, Nagaland

56

Memorandum of Understanding (MOU) 1. Central Council of Research in Siddha (CCRS), Ministry of A YUSH, Government of India and

Rajiv Gandhi Centre for Bio Technology, Thiruvananthapuram entered into Memorandum

of Understanding on 11th April, 2017 to undertake collaborative research and training activities for

establishing evidence based Siddha system. The MoU focuses on developing new collaborative

research and teaching programmes in the areas of fundamental research, clinical research, health

care research, drug discovery, literary research, training of faculty members and sharing of faculty

members' expertise etc.

CCRS was represented by its Director General Prof. Dr. R. S. Ramaswamy and Rajiv

Gandhi Centre for Bio Technology (RGCB), Thiruvananthapuram was represented by its Director

Prof. Dr. M. Radhakrishna Pillai. The signing of MoU took place at the Raj iv Gandhi Centre for

Bio Technology, Thiruvananthapuram in the presence of Dr. S. Selvarajan, Research Officer

(Siddha), Incharge of Siddha Regional Research Institute, Thiruvananthapuram, Dr. V. Gayathri

Devi, Research Officer (Chemistry), Dr. G. S. Lekha, Research Officer (Siddha), Siddha Regional

Research Institute, Thiruvananthapuram, Dr. T. R. Santhosh Kumar, Scientist - F, Dr. K.

Santhosh Kumar, Scientist - F from Rajiv Gandhi Centre for Biotechnology and Dr. K. B.

Harikumar, Scientist - C, Dr. E.V. Sonya, Scientist - G and Dr. E. Sreekumar, Scientist - F from

Rajiv Gandhi Centre for Bio Technology.

2. Central Council for Research in Siddha (CCRS), Ministry of AYUSH, Government of India and

Santhigiri Health Care and Research Organization, Thiruvananthapuram entered into

Memorandum of Understanding on n- April, 2017 to undertake collaborative research and training activities for establishing evidence based Siddha system. The MoU is focussed on

developing new collaborative research and teaching programmes in the areas of fundamental

research, clinical research, health care research, drug discovery, literary research, training of faculty

members and sharing of faculty members' expertise etc.

CCRS was represented by its Director General Prof. Dr. R. S. Ramaswamy and Santhigiri

Health Care and Research Organization, Thiruvananthapuram was represented by Dr. Janani

Nishchitha J nana Thapaswini, Head, Administration. The signing of Mo U took place at the Rajiv

Gandhi Centre for Bio Technology, Thiruvananthapuram in the presence of Dr. S. Selvarajan,

Research Officer (Siddha), Incharge of Siddha Regional Research Institute, Dr. G. S. Lekha,

Research Officer (Siddha), Dr. V. Gayathri Devi, Research Officer (Chemistry) SRRI,

Thiruvananthapuram, Shri. Vijayan, Manager, Santhigiri Health Care and Research Organization

and Dr. V. Pushpaja, Santhigiri Health Care and Research Organization.

pg. 57

CLINICAL RESEARCH

AR:2017-18

58

CLINICAL RESEARCH Clinical research in Siddha system of medicine helps in generating, authenticating,

consolidating scientific evidences pertaining to Siddha system of medicine. To prove the efficacy of the Siddha drugs / to establish clinical safety of Siddha Drugs adopting AYUSH GCP Guidelines either to establish the claim stated in the literature or to test a newer combination for varied health problems is the mandate of clinical research. Various Randomized Controlled Clinical trials, observational studies, open clinical trials, comparative trials are carried out by the Council. During the reporting year, eleven clinical trials are being conducted by the council's peripheral institutes / units.

1. Health Care Services through OPD and IPD

OPDs Gende SCRI SRRI SRRI SCRU SCRU SCRU Total r C p p p B ND

General M 23025 23407 1777 4759 1388 3830 58186 OPD F 19318 25256 3039 4393 774 3417 56197

T.G 13 0 0 0 0 0 13 Flu Like M 10 97 27 0 0 0 134 Illness F 6 86 14 0 0 0 106 programme Special M 3940 0 0 0 0 0 3940 OPD for Neerizhivu (Diabetes F 2864 0 0 0 0 0 2864 mellitus) Geriatric M 6530 5827 727 475 0 8 13567 Health F 3015 4090 803 478 0 50 8436 Care Special OPD Special M 6013 477 187 0 604 2181 9462 OPD for F 7547 846 443 0 204 2096 11136 Varmam and Thokkana m RCH M 1016 0 0 0 0 0 1016 Special F 2663 0 0 0 0 0 2663 OPD Special M 427 0 0 0 0 0 427 OPD for F 0 0 0 0 0 0 349 Traditional T.G 1 0 0 0 0 0 1 Bone Setting (TBS)

Total 76737 60086 7017 10105 2970 8189 168497

59

OPD Censes:

No. of Out patients 90000

80000

70000

60000

50000

40000

30000

20000

10000

0 - SCRlC SRRIP SRRlT SCRUP

2970

SCRUB SCRUND

2. Special OPDs

Flu like Illnesses programme

As per the instruction of the Council, the patients with the clinical features of flu like illness were treated in the OPD level, since October 2009. In this reporting year a total number of 240 cases were treated with the recommended drugs.

Geriatric Health Care Special OPD

The geriatric population in India is increasing in recent decades due to various reasons like good and adequate nutrition and health delivery system. The Government of India and the Ministry of AYUSH has taken keen interest to promote health care to the older population through AYUSH. Siddha system of medicine has health promotive and rejuvenative approach for geriatric health care under the specialized branch called Kaya Karpam. The geriatric health care special OPD started functioning every Tuesday. In this reporting year, a total number of 22,003 cases were treated with the recommended drugs.

Special OPD for Neerizhivu (Diabetes mellitus)

Special OPD for Neerizhivu (Diabetes mellitus) is conducted in Siddha Central Research Institute, Chennai. India is the hub of diabetes mellitus. Among the NCDs diabetic population in India especially Tamil Nadu is increasing in recent decades due to various reasons like sedentary life style, improper diet, etc.

Based on the burden of DM and national importance of NCDs, CCRS took the research on DM. After successful completion of the multicentric clinical trial with D5 chooranam which has given promising results, it has been launched in diabetic special OPD for the betterment of the society. The special OPD for Neerizhivu (DM) started functioning every Monday. In this reporting year, a total number of 6804 diabetic patients were treated with the D5 Chooranam.

60

Varmam, Thokkanam and Bone setting Special OPD

Varmam and Thokkanam are unique and special therapeutic entities in Siddha, which are useful in treating several neurological and musculo - skeletal diseases mostly without the intervention of internal drugs. This Special OPDs is functioning in SCRI, Chennai, SRRI, Puducherry and Thiruvananthapuram, SCRU, Bengaluru and New Delhi. In this reporting year a total number of 20598 patients were treated with Varmam and Thokkanam therapy.

3. Swasthya Rakshan Programme Swasthya Rakshan Programme of Ministry of A YUSH is effectively implemented at

Siddha Central Research Institute, Chennai (3 locations), Siddha Regional Research Institute, Puducherry (1 location), Siddha Regional Research Institute, Thiruvananthapuram (2 locations), Siddha Clinical Research Unit, Palayamkottai (2 locations), Siddha Clinical Research Unit, New Delhi (2 locations) and Palamalai hill (Tribal), Siddha medicinal plants garden, Mettur (1 location)

SL Name of System (AYUSH) - No. of Villages/ No. Siddha Colonies covered State-wise 1. Siddha Central Research Institute, PSBB Matriculation Higher Secondary School,

Chennai Maangadu Vanagaram Panchayat Office, Vanagaram National Institute of Epidermiology (NIE) -

Indian Council of Medical Research (ICMR), Ayapakkam

2. Siddha Regional Research Institute, Bahour Village, Commune Panchayat Puducherry Puducherry

3. Siddha Regional Research Institute, AK.G Sports and Arts Club, Pangappara (Rural), Thiruvanan thapuram Thiruvanan thapuram

Primary Health Centre, Karode (Rural), Thiruvananthapuram

4. Siddha Clinical Research Unit, Keelanatham Melur Village Palayamkottai Mela Thiruvengadanathapuram Village

Institutes / Units Total SCRIC 10230 SRRIP 1618 SRRIT 2317 SCRUP 2425 SCRUND 2589 SMPGMD 622 TOTAL 19801

4. Department of Pathology

Pathology Male Female Total

No. of Investigations Carried out 2672 3163 5835

61

5. Department of Biochemistry

s. OPD/IPD Biochemical Investigations Number of No investigation

s done 1 General Investigation Male Femal

OPD 1. Blood Glucose(Fasting) e 2. Blood Glucose (OGTI and PP), Blood Urea, Serum 7388 7093 Creatinine, Lipid Profile, Liver Function Test, Uric Acid, Calcium, Thyroid Function Test, HbAlc, RA, Total: 14481 CRP, ASO, Insulin, Urine Microalbumin, Irnmunoglobin A, Immunoglobin E, Immunoglobin G.

2 IPD Investigation 756 813 1. Blood Glucose(Fasting) 2. Blood Glucose (OGTI and PP), Blood Urea, Serum Total: 1803 Creatinine, Lipid Profile, Liver Function Test, Uric Acid, Calcium, Thyroid Function Test, HbAlc, RA, CRP, ASO, Insulin, Urine Microalbumin, Immunoglobin A, Immunoglobin E, Immunoglobin G.

6. Pharmaco-Vigilance Programme Siddha Central Research Institute, Chennai, Siddha Regional Research Institute,

Puducherry and Siddha Regional Research Institute, Thiruvananthapuram are the peripheral Pharmacovigilance centres functioning under CCRS. No adverse drug reactions have been observed in Out-Patient Department and In-Patient Department patients in the any of the Institute/Units under CCRS.

Pharmacovigilance App SiddAR

Pharmacovigilance ADR reporting system is very essential to each and every health care system. As per the ethical guidelines it is mandate to all the Research Councils and National Institutes to document the ADR. This reporting system started in the year 2009 and is actively and effectively carried out in SCRI. There is a tall claim that traditional medicines are safe and have no side effects. As per National Pharmacovigilance Resource Centre of India (NPRC) - Institute of PG Teaching and Research in Ayurveda (IPGTRA), Jamnagar, Gujarat and initiatives from AYUSH, this Institute has given contribution to the Pharmacovigilance system to emphasize more on the documentation of ADRs and creating awareness. Through Pharmacovigilance, quality of drugs can be improved and medication errors can be reduced for the betterment of the public.

In continuation of the above monitoring of the ADR, the Institute has developed the New Pharmacovigilance ADR reporting app (SiddAR) for the easy and convenience reporting system at any time & anywhere through e- filing system. The mobile app is designed in such a manner for usage in mobile app at patient convenience and the document to be reached to the ADR monitoring officer and the SMS alert system to be inbuilt to convey the information. The mobile android app was launched at National Conference on Pura Maruthuvam-2018 (NCPM), at Puducherry by the Prof. Dr. R.S. Ramaswamy, Director General, CCRS.

62

<1 0 CJ

::: D ~ .,1w!681'll 19 53

About us

Confidentiality The patient's identity is held in strict confidence and protected to the fullest extent. Programme staff Is not expected to and will not disclose the reporters identity in response to a request from the public.

This app is developed by Siddha team however.it can be used by any AY\JSH practitioner.

Disclaimer This app has been developed to document the observed and reported side effects for the benefit of the public in near future. This information cannot be used legally. This app do not offer any medical advice or any insurance or any reimbursement.

Idea and Content develooment Dr. P. Sathlyarajeswaran Dr. M. S. Shree Devi

Verification and Testing Dr. M. Kannan Dr. S. Natarajan

ADoroval authority Prof. Dr.RS.Ramaswamy Director General

PvPI ADR (Sidd.AR) is an adverse drug reporting android application.

Using PvPI adverse reporting android application, healthcare

professional or consumers can instantly report any suspected Adverse

Drug Reaction to PvPI from any part of India.The Pharmacovigilance

Program of India (PvPI) was launched with a broad objective to safe

guard the health of 1.27 billion people of India. Adverse drug

Reactions (ADRs) are reported from all over the country to PvPI,

which also work in collaboration with the global ADR monitoring

centre (WHO-UMC), Sweden to contribute in the global ADRs data

base. PvPI monitors the ADRs among Indian population and helps

the regulatory authority of India (CDSCO) in taking decision for safe

use of medicines

Copyright@2017,CCRS

63

DRUG RESEARCH

AR:2017-18

64

DRUG RESEARCH

1. Drug Development

Drug development part was undertaken by the Pharmacy of Siddha Central Research Institute. The Pharmacy functioning has three main divisions like production unit, quality control unit and research unit. Production unit will have the roles and responsibilities of procuring of raw materials, processing of raw materials, purification (suthi) process, drug preparations, drug licensing & regulatory aspects, packaging, labelling & dispensing to hospital for patients as per the requirement. Quality control will support the production unit with respect to quality control estimation of raw materials and in process quality control analysis, analysis of finished drugs to ensure the quality of drugs before reaching the hospital unit.

2. Pharmacy

The Pharmacy is functioning since 1972. The main objectives for establishing the Pharmacy is to procure quality drugs, to prepare general medicines for running OPD & IPD and to prepare research drugs for screening. After the year 1979 the Pharmacy also started preparing certain general medicines for other Siddha units and special drugs for their research projects. So far, the Pharmacy has prepared about 15 types of research medicines and 18 types of general medicines.

To increase the production and to make the Pharmacy self-sufficient and to cater to the needs of all the Siddha units under the council, the same is being mechanised. The machineries have been installed and the operation initiated successfully. The cost of preparation after mechanisation will be cheaper than the open market. The quality of medicine can also be maintained.

3. Licensing & Certification

Good Manufacturing Practice (GMP) is a system for ensuring that products are consistently produced and controlled according to quality standards. It is designed to minimize the risks involved in any pharmaceutical production that cannot be eliminated through testing the final product. Based on this, to maintain the manufacturing standards and to improve the quality of drugs to the patients, Siddha Central Research Institute successfully completed the GMP audit and the Institute received the GMP certification for the quality manufacturing of drugs.

65

• F,orm 26 ... E-l (Ee:!!s Rule 155 • BJ

eER.TJ'FIC.A.TE OF GOOO· MANUP-ACW.RIItG PRA.C'nCES !.GMP~ -TO .MANUFACTURER or AYURVEDA, swl>HA OR UiN\Mr[ DIR'llGs.

O!;F!Tlfl!;l:!''IIIJ!i ffl;)!'.IJ!l51Ctt:J riln!il 1111lt~it=il;.-., r»m,c,b' l-Ns-,.r,f...,.J:..!.l..#t.C'?,!-_?,~);:f..J..~~i:;.f 7"'~,,_~,_,,.J:,L ~ - .• , _,;.,, .i~,...,,, ~; '.r f.J..Jc,,r;,L,.. J; rn ,·,- . .CJ-.. !-,l,.,. .,,_,' . ,.r17r.:-;,.-:-,;r. ...•• ....,,..r;t.rJ.. /J,.t;::;.1.,.E:~:...r...:.~-~~~-tt..-J.•K11f-~,1~1~,-=i-.-,.. :~:":!,,r.__ __ ,,.,_:;.lh:u....iiu~ V ll!ll):t __

- /".~-a-,", ;, - 1 J:k, ? r.t~. • /,~tr;;{, "" • -rc,....,"'l,'-.l<!-.,-1' .. <M.lm:1,-,;,,...,.i;,..x >';;'~- .• ~,,...~=,?,~.~ _, .,lll'UI .., ••• t..~J •• 1rr,--m.=,: J fllr~rt -- ••• -

1,,;eii,n~o· No, ~L:!?..Jf.tr.-:,,. . ..ll.i..~ .. !ii.?.:fl .3 '~z~ .. {'p __ ,,., .... _ •. 1,;,Qmpiy .,,,1mi 1:ti,;,, r11qUln:i1M1i.c,...~ ~iMI ..,,.. . IMnm,rn(lfllrl'-0 Pr.it-1li,i,~.o•A:,,w-.-ed;;..:Sld!IN--\IIJl3'1l r;lrrr,gr. B f:dd dll'Wll inSclw.d'!UID T-,Ttllc a111g,.~l'IIII

~gnx.111:1~ RuJ.x;. t945.

ll•ill Cfflllii:«fxlo Iii v-Blrcl '" ;!:l!isriodl l!-flFJ'ie \!WI~ ,11,<11r,,,;, G~ !,1rimurM'L\lrl119 P,.u:ne.i~ (Gl.1PI - ••. ~ :'<,rfl1g,r.,jfocn, dor.;;,i_g<>foemi.ol"i!t..-..all'Sh;n:lhri;.,.;ic; fn>ilD.WJ., (.,,J• IE!" p .;;l(J. !!J']-.;;u,n

List of New Drugs Licensing

The Institute applied licence for new product and received the licence grant for manufacturing of below listed products:

Sastric Medicine

s. Product Name Reference Book Page No No.

Kudineer Chooranam 1. Kabasura Kudineer chooranam The Siddha Formulary of India, Part - I 160 2. Pitha Sura Kudineer Chooranam The Siddha FormuJary of India, Part - I 162 3. Vatha Sura Kudineer Chooranam The Siddha FormuJary of India, Part - I 162 4. Adathodai Kudineer chooranam The Siddha FormuJary of India, Part - I 160 Chooranam 5. Amukkara Kizhangu Chooranam The Siddha Pharmacopeia of India, Part - 1

I, Vol- I 6. Atimatura Chooranam The Siddha Pharmacopoeia of India, Part 12

-I,Vol-I 7. Gunma Uppu Chooranam Pulippaani V aidhyam - 500 5 8. Maruthampattai Chooranam The Siddha Pharmacopoeia of India, Part 104

- I, Vol - I 9. Nannari Ver Chooranam The Siddha Pharmacopoeia of India, Part 115

- I, Vol - I 10. Naaval Pattai Chooranam The Siddha Pharmacopoeia of India, Part 81

-I,Vol-I 11. Nelli Vatral Chooranam The Siddha Pharmacopoeia of India, Part 122

-I,Vol-I 12. Seenthil thandu Chooranam The Siddha Pharmacopoeia of India, Part 35

-I,Vol-I

66

13. V aividaga Chooranam The Siddha Pharmacopoeia of India, Part 163 -1, Vol-I

14. Pirandai Uppu The Siddha Formulary of India, Part - II 30 15. Pungampoo Chooranam The Siddha Formulary of India, Part - II 31 16. Seeraga Chooranam Siddha Vaidhiya Thirattu 211 Thailam 17. Kulir Thamarai Thailam The Siddha Formulary oflndia, Part-II 115 18. Mayana Thailam Theraiyar Thaila Vargam 137 19. Ulundhu Thailam Siddha Vaidhiya Thirattu 263 20. V etpalai Thailam Siddha Formulary of India, Part - II 343 21. Lagu Vishamushti Thailam Siddha Formulary of India, Part - I 105 22. Valamburi Kai Thailam Siddha Formulary of India, Part - II 139 23. Siddhathi Ennai Siddha Vaithiya Thirattu 271 Theeneer 24. Oma Theeneer Siddha Vaithiya Thirattu 297 25. Sombu Theeneer Siddha Vaithiya Thirattu 297 Manapagu 26. Nannari Manapagu Siddha Vaidhiya Thirattu 259 Parpam 27. Padikara Parpam Siddha Vaidhiya Thirattu 127 Kulambu 28. Agasthiyar K.ulambu Siddha Formulary of India, Part - I 60 Mathirai 29. K.orosanai Mathirai Siddha Formulary of India, part - I 90 Melugu 30. K.ilinjil Melugu Siddha Formulary of India, Part - I 166 31. Vellai Melugu Siddha Formulary of India, Part - I 167 32. Milagu Melugu Siddha Vaithiya Thirattu 307 Podi 33. Padai Sankaran Siddha Vadhiya Thirattu 310 Vadagam 34. lnji Vadagam Siddha Vaidhiya Thirattu 229

The Institute is working to fulfil various regulatory requirements as per the drugs & cosmetics rules 1945 - schedule T such as manufacturing, labelling, quality control aspects, regulatory auditing regarding the manufacturing & storage aspects of prepared drugs, stock maintenance and stock auditing of raw medicinal drugs, prepared drugs etc.

The Pharmacy additionally focusses on updating various regulatory requirements, manufacturing aspects of quality drug preparations, record maintenance, etc.

Pharmacy instruments

The following list of instruments are available in SCRI Pharmacy

S.No Name of Equipment Year of Cost of the Condition of Purchase Equipment the

Equipment 1. Disintegrator 17-01-1980 9550.00 Working 2. Mixer 50 kzs, 06-04-1980 26280.00 Working 3. Oscillating Granulator 06-04-1980 18480.00 Not Working

67

4. 16 Stations Rotary Tablet 06-04-1980 47340.00 Working 5. Coating Pan 06-04-1980 32280.00 Working 6. 24 Tray Drier 200° C 29-03-1994 17625.00 Working 7. Chaff Cutting 11-01-1990 9395.00 Working 8. Capsules 31-03-1992 25600.00 Working 9. Kalvam Assembly (6 no's) 31-03-1992 46500.00 Working 10. Sealing Machine 31-03-1995 1600.00 Working 11. Refrigerator 10-03-2006 12740.00 Working 12. DPM mini pact pulveriser 15-05-2006 160875.00 Working 13. Automatic Sieving 31-03-1992 31800.00 Working 14. Muffle Furnace 18-01-2010 144562.00 Working 15. Pills Tablets cutting machine and 20-03-2010 12800.00 Working

dies 100 mg size pills 16. Pills making tube Machine 20-05-2010 14900.00 Working 17. Wet grinder 5 lits cap. 29.04-2015 14900.00 Working 18. Weighing Balance 19-08-2015 3000.00 Working

4. Department of Chemistry

• Standardisation of three single drugs and 13 compound formulations were carried out. Establishment of sophisticated analytical instrumentation facility such as Triple quadrupole LC-MS, Inductively Coupled Plasma - Optical Emission Spectrophotometer (ICP-OES), UV-Visible Spectrophotometer and Microwave digester. JASCO V 750 UV-Visible spectrophotometer was procured in the project funds and installed in the laboratory of SCRI, Chennai.

• Standardisation of 37 single drugs and 8 compound formulations were done. Chromatogram for 57 single drugs have been developed for Siddha Pharmacopoeia! work at SRRI, Thiruvananthapuram.

5. Drug Standardization

Department of Quality control

Details of analysis carried out

S.No. Sample Name/Code Analysis Details 1. U rai Ma thirai (UM 1 to UM 10) Loss on drying, Total Ash, Water soluble Ash, Acid 2. Thiriphala Chooranam (TPC) insoluble ash, Water-soluble extractive, Alcohol- 3. Thanrikkai (THK) soluble extractive, pH and High Performance Thin 4. Kadukkai (KAD) Layer Chromatography analysis and its 5. Nelli Vathal (NEL) documentation 6. Unpeeled raw vasambu (URVP) 7. Skin peeled raw vasambu

(SPRVP) Loss on drying, Total Ash, Water soluble Ash, and Acid insoluble ash

8. Charred vasambu (CV) 9. Skin Peal of Vasambu(SPV)

68

PRE-CLINICAL RESEARCH

69

PRE-CLINICAL RESEARCH Preclinical studies include safety and efficacy studies. The aim of a preclinical study is to collect

data in support of the safety of the new treatment. These studies are conducted on the predetermined experimental models in the laboratory attached to the SCRI, Chennai. These studies are based on experimental models in different species of animals. This provides vital information for pursuing clinical studies in human beings.

1. Department of Pharmacology

Reapproved Project list by IAEC as follows

SL Drug allotted Target Studies carried out Remarks No. fixed 1. Urai mathirai Toxicity, Acute toxicity in rats Completed

Efficacy Sub-acute toxicity in rats Completed Chronic toxicity in rats Completed Anti-inflammatory study in rats Completed Analgesic activity in rats Completed Immunomodulatory activity Completed

2 Thetran vidhai kudineer Toxicity, Acute toxicity in rats Completed Efficacy Sub-acute toxicity in rats Completed

Chronic toxicity in rats Completed Anti-diabetic study Under

progress 4 IMR - project: Pre-clinical Toxicity, Toxicity study Under

safety and efficacy study of efficacy progress Nuna K.adugu (Internal Medicine) and Nuna Thailam (External Medicine) m Venpadai (Vitilizo)

6 Venthamarai choornam Toxicity Acute toxicity in rats Yet to start

Pharmacology / Pre-Clinical Animal Studies

1. Urai mathirai

Acute toxicity study of Urai mathirai was completed. There was no mortality in the drug treated groups which indicates that Urai mathirai is safe up to 100 mg/kg, which is ten times of therapeutic dose. The results of sub-acute toxicity study (28 days), chronic toxicity study (90 days), Analgesic activity, Anti-inflammatory activity, lmmunomodulatory activity were completed statistical evaluation is in progress.

2. Thetran vidhai kudineer

Acute toxicity of Thetran vidhai kudineer was completed. There was no mortality in the drug treated groups which indicates that Thetran Vidhai (Kottai kudineer is safe up to 3600 mg/kg, which is ten times of therapeutic dose. The results of sub-acute toxicity study (28 days), chronic toxicity study (90 days), Anti-diabetic activity were completed statistical evaluation is in progress.

3. Anti-hyperlipedemic activity of D5 choornam (IMR Project) is in progress.

70

MEDICINAL PLANT RESEARCH

AR:2017-18

71

MEDICINIAL PLANT RESEARCH Medicinal plants research is primarily carried out at Siddha Medicinal Plants Garden,

Mettur

1. Medico-ethno Botanical Research

Eight survey tours to various places like Palar, Kombaikadu, Moolakompai, Kodiveri dam, Pannavadi, Kathrimalai, Yercaud, were carried out to study the medicinal plants wealth of the forest area and to facilitate raw drug supply to CCRS institutes for research purpose and healthcare. Also seedlings/ saplings were collected to introduce in SMPG, Mettur dam.

• No. of plants collected at present: 217 • Herbarium specimen: 209 • Specimen collected for museum: 205 • Stem cuts/ saplings/ seedlings collected: 408 • Medicinal plants photographs taken: 160 • Folklore claims: 6 • An arboretum with 638 plants covering 211 species is being maintained in 3.7 acres

One hundred and forty seven new plants are introduced to the existing plants. Also 34 Red Endangered and Threatened (RET) species are conserved in SMPG.

2. Cultivation of Medicinal Plants

In the year 2017-2018, nine medicinal plants are under major cultivation. Five plants are under trail cultivation. The harvest of the plant materials are supplied to SCRI pharmacy.

3. Digitization and Compilation of Herbarium and folklore claims

Digitization is the process of converting information into digital format. During the period under report 2273 mounted herbarium sheets were checked and reprocessed and kept them free from infestations and other deterioration. Two thousand five hundred and fourteen mounted herbarium sheets were photographed for the purpose of digitizations. Thousand two hundred and six mounted herbarium sheets were re-photographed for bringing out perfection. Photographs of 5386 herbarium sheets including those of previous year were edited and appended scale along with the sheets. A herbarium with collection of dried plant specimens used in Siddha medicines are preserved in the SMPU-S Herbarium. Two hundred and forty four herbarium sheets covering 124 species were added to the existing herbarium. SMPU-S herbarium has 7700 herbarium sheets covering 1836 species under 248 families covering Angiosperms, Gymnosperms, Pteridophytes, Algae and fungi. In the catalogue the species were arranged on family wise starting from A-Z (say Acanthaceae the first family and Zygophyllaceae the last) following Bentham and Hooker's classification. The genera and species in a family were arranged alphabetically with author citation. The Flora of Tamil Nadu Analysis I to III was used as reference book. Tamil/Siddha/Local/ folk names were added according to the availability.

72

4. 365 Days National Campaign on Medicinal Plant Awareness

ational Medicinal Plants Board (NMPB) - Project: 365 Days National campaign on Medicinal plants Awareness: Campaign on awareness on Medicinal plants was carried out by providing news in dailies and weeklies from time to time and also by providing medicinal plants to the educational institutions for establishing herbal gardens in their premises and also promoting home herbal gardens. IEC pamphlets about the home herbal garden was issued as a promotion scheme for the visitors.

5. Pharmacognosy

The department of Pharmacognosy helps in identification of herbal drugs, Siddha Botanical Standardization and Pharmacopoeia! works. Eight compound formulations and seventeen single drugs were standardized. Thirty plant specimens were included in herbarium and fifty raw drug specimens were included in the museum. Two hundred and eleven single drugs were authenticated during the year 2017-2018. They were authenticated by micro-microscopy including powder microscopy and quantitative microscopy. Two samples were authenticated by powder microscopy.

73

LITERARY RESEARCH

AR:2017-18

74

LITERARY RESEARCH AND DOCUMENTATION

Literary Research lays platform to any research in Siddha System as they are scientific reflections of the Intuitions of Siddhars. Palm leaves and paper manuscripts still hold with them many unfolded scientific details which are to be unearthed.

A Literary Research Unit was started by the Government of India, at Saraswathi Mahal Library Campus, Thanjavur in the year 1964 for the enlightment of the Siddha system. In 1971, one more Literary Research Unit was started at Govt. Siddha Medical College, Palayamkottai. They have made wonderful collections of traditional manuscripts and very old Siddha printed books dealing with treatment of ailments from the traditional physicians all over Tamilnadu. In 1979 the Units were merged and formed as Literary Research & Documentation Department at CRIS, Chennai. In April 2007, the LR&DD was merged with CRIS, Chennai-106. The mandate of this department is to carry out Literary Research.

The wealth of traditional medicines is available both in a coded and non-coded document. This traditional knowledge should be properly documented, digitized, preserved and published to the public domain. Both virtual and real manuscripts are made available as a ready beckoner for students, research scholars and the public. Literary Research and Documentation Department of Siddha Central Research Institute, CCRS is carrying out the above said activities in a stipulated manner.

New books purchased in the year 2017-18: 1004 books.

1. Key activities of LR & DD

• Collection of manuscripts and other old rare printed books and hand written copies. • Cleaning and preservation of collected materials. • Preparing, cataloguing and classification. • Transcription of palm leaf manuscripts. • Annotation of poems. • Typing of transcribed poems along with annotations. • Correction of typed copies. • Comparison with original. • Submission for approval. • Publications. • Translation of books published in Siddha into English, Hindi and other south Indian

language. • Publication of translated Siddha Text in English, Hindi and other south Indian language. • Sale of publications.

75

2. Activities in the Current Year

S.No Title of the Books version Status Remarks 1. Siddhar Kaya Karpam English Proof correction Will be published in due

is being carried course out

2. Materials collection for - Collection Will be launched in due course launching the Museum process 1s m

nrno-rP<:<: 3. Library Management - 3688- Completed and back volume

Software (THERAN) Individual book journals are in progress id has been generated through THERAN.

4. Collection of e-books - Collected pdf/ e- 2344 no of e- books / pdf for e-library books from added in thee-library

vanous resources 5. Monograph on Nila English Completed Published and released on

Vembu Kudineer 26.08.2017 6. Monograph on D 5 English Completed Published and released on

Chooranam 26.08.2017 7. Siddhar Kaya Karpam Tamil Completed Published and released on

(Reprint) 26.08.2017 8. Siddha maruthtuva eliya Tamil Completed Published and released on

vazhakku muraigal 26.08.2017 (Revised Edition 6'h)

9. Siddhar Y ogam Oor Tamil Completed Published and released on June Karpam 21,2017

10. Guidelines for Practice English Completed Published and released on of Siddha Varmam 09.12.2017 Therapy

11. A Hand Book of Bilingual Completed Published and released on Glossary on Siddha 09.12.2017 External Therapies. (Excerpts from T.VSambasivam Pillai Dictionary)

12. A Glossary on Siddha Bilingual Completed Published and released on External Therapies 09.12.2017 (Excerpts from T.VSambasivam Pillai Dictionary)

13. Siddha Protocols and English Completed Published and released on Research OUTcomes 09.12.2017 (SPROUT) for Siddha External Therapies

14. Agathiyar Aivu Tamil Completed Published and released on Thoguppu 04.01.2018

76

Title wise books sold out in the year 2017-18

_ ~ 76

39

89

, n,," I 335

I 25 5 I 105

I 84

I 163

0

44 34

50 100 150 200 250 300 350 400

Siddha Formulary of India (Part-II)-Tamil Version CD-Rom

Siddha Pharmacopoeia of India (Part-I, Vol. II) CD-Rom

Siddha Formulary of India (Part-II)-Tamil Version

Siddha Pharmacopoeia of India (Part-I, Vol. II)

Siddha Pharmacopoeia of India (Part-I, Vol. I)

ti Monograph on Nilavanbu Kudineer Chooranam

Agathiyar Vaidya Pooranam - 205(Hindi)

Guideline for Practice of Siddha Varmam Therapy

Kalndu Soothiram-16

A-Z Know your alphabets through Siddha Medicinal Plants

Siddha research Review in Cancer

A Hand Book of Common in Siddha System of Medicene

Siddha Kaya Kalpa Mooligai

Pulippaani Vaidhyam - 500

Monograph ofThamira Cehnduram (Peptic Ulcer)

Sangamuni Visha Vaidhyam- 100 (Eng.)

Glossary on Siddha External Therapies

• Agathiyar Vaidya Pooranam - 205(Eng.)

Uyir mei mooligaigal

77

LIBRARY USERS' PERCENTAGE (2017-2018)

MONTH WISE LR&DD LIBRARY USER 2017-18

February 5%

March 3%

April 8%

July 9%

November 9%

Month wise sale of Publications 2017-18

•April May •June • July • August • September

October November js December • January • February • March

19%

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3. A YUSH Research Portal

In order to make research findings of A YUSH systems and the other allied faculties accessible through web, the Department of AYUSH started AYUSH Research Portal. Central Council for Research in Ayurvedic Sciences (CCRAS) and the National Institute of Indian Medical Heritage (NIIMH), Hyderabad are coordinating and maintaining this freely accessible web portal in collaboration with National Informatics Centre. All the research findings of Central Council for Research in Siddha are made available in this portal.

AYUSH RESEARCH PORTAL

ADVANCED SEARCH

Medical System Select Medical System .., Category l Selecl Category ·I[ Select a Search Field T j Search j

5fa!rll with AVUSH Jeanlnofoo't

CUNICAL RESEARCJI l'RE-CLlrilCAt RF.SEARCH llRUG RFSF.ARCH

FUNDAMENTAi. Rr.Sl'.ARCII

- Seleu Body Syttem -

~Tt,mon,o&oov,

A YUSH Research Portal http: / / ayushportal.nic.in.

4. Digitization

In India most of the manuscripts composed by our Siddhars in ancient period are written on palm leaves. Digitization is one of the means of preservation of manuscripts. The Literary Research and Documentation Department has taken up the task of preservation of our treasure - palm leaf manuscript and digitization of the palm leaves.

S.No. Name of the Books Digitization

1. The Pharmacopoeia Siddha Research Medicine Completed 2. Agathiyar 12000 Ennum Perunool Kaaviyam Completed 3. Ramadevar Sivayogam 200 Completed 4. Agathiyar Antharnga Dhitchavithi Completed 5. Agathiyar Aarezhuththunthathi Antharnga Dhitchavithi Completed 6. Agathiyar pallu 200 Completed 7. Agathiyar Aruliya Anuboga Vaithiya kazhanjiyam Completed 8. Agathiyar Muppu Soothirangal Completed 9. Agathiar vagara soothiram 200 Completed 10. Akkalathu Siddha Vaithiya Anubava Muraigal Completed 11. Agathiar Karppa Muppu Kurnool 100 Completed 12. Anubava Siddha Maruthuva Muraigal Completed

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Siddha Pharmacopoeia Committee (SPC) Objectives and Achievements of Siddha Pharmacopoeia Committee (SPC)

The Siddha Pharmacopoeia Committee with the mandate of establishing quality parameters for Siddha drugs and formulations is working under the auspices of the Ministry of AYUSH. It is currently functioning at CCRS Headquarters, Chennai. "The Siddha Pharmacopoeia of India, Part I, Vol. III" and "The Siddha Formulary of India, Part I, 1st revised Edition (Tamil)" which have been approved by the SPC have been modified as per the new format and it have been sent to PCIM for printing. Again the format has been changed by PCIM and the works are in progress. 150 Siddha classical formulations have been identified for the Siddha Formulary of India, Part - III and the work is in progress. Translation of "The Siddha formulary of India, Part-II-English" is in progress. Preparation of the Siddha Pharmacopoeia of India, Part I, Vol. IV has also been initiated during the reporting period.

HUMAN RESOURSE DEVELOPMENT 1. IEC Materials/ Pamphlets

Brochures and Pamphlets were reprinted and were distributed / displayed in the National level Arogya fairs (Comprehensive Health Mela on AYUSH) and other campaigns. IEC materials have been published on several disease conditions and their management through Siddha System of Medicine. Eight pamphlets in English were translated to Hindi, Malayalam, Telugu and Kannada for distribution in the National level Arogya fairs.

2. Other Tools The Clinical Research Programme under the Council focuses mainly on clinical evaluation

of selected therapies in clinical conditions. The activities in the following areas have been carried out and recently two new applications have been developed and implemented to aid in the health care services:

• THERAN - THE Research Application Network (Electronic Data Capturing System (Registration upto Receiving Medicine).

• SiddAR - Siddha initiative for documentation of drug Adverse Reaction App - Pharmacovigilance.

• In addition to this SLING- Duty Scheduling App is also implemented.

3. The Research Application Network (THERAN) It is an Electronic Data Capturing System, a kind of software which has been developed by

the Central Council for Research in Siddha with the calibre software technologies and it was launched by Shri. P N. Ranjith Kumar, Joint Secretary, Ministry of AYUSH, Govt. of India, during the inauguration of the two day National Seminar on "Current Trends in Siddha Varmam Therapy" held on 4th and S'h November, 2017 at AYUSH auditorium, Janakpuri, New Delhi.

Siddha Central Research Institute, Chennai successfully completed the trial and error execution and troubleshooting also. With the THERAN software, SCRI is successfully documenting the hospital information. Now CCRS is planning to extend the THERAN software to all its peripheral institutes and units.

80

Key features of THERAN

• Conduct a full range of OPD consultation with excellent data recording • Similarly, IPD can also be subjected to data capturing for day to day treatment and procedures • Boon for getting the NABH and NABL accreditation • Centralized patient registration system to create and maintain patients' record • Routing of patients to respective department for consultation through Centralized Out-patient

queue management system • Serve the patients with system generated prescriptions - no pen and paper required • In-built inventory system for better accountability • Generate dynamic reports • Work quantification of human resources can be measured • Enhances transparency in cash transactions and eco-friendly

INAUGURATION OF NEW WING AT SRRI, THIRUVANANTHAPURAM

The new wing i.e, the 3rd floor of SRRI, Thiruvananthapuram was inaugurated on 21-10- 2017 by Shri Shripad Yesso Naik, the Hon'ble Minister of state (independent charge) Ministry of AYUSH, Govt. of India and presided over by Prof. Dr. R.S. Ramaswamy, Director General of CCRS in this annual year 2017-18.

MISCELLANEOUSE ACTIVITIES 1. Institutional Human Ethics Committee (IHEC)

Siddha Central Research Institute, Chennai, Siddha Regional Research Institutes, Thiruvananthapuram and Puducherry and Siddha Clinical Research Unit, New Delhi had convened Institutional Human Ethical Committee meetings at regular intervals.

The Second Institutional Ethical Committee Meeting of Siddha Clinical Research Unit, New Delhi was held on 4th October 2017 at the PG Library Hall of A & U Tibbia College, Karol Bagh for the evaluation six IMR projects.

Administrative training during the reporting year

Shri. P. Prakasam, Retd. Deputy Director (Admin.), National Institute of Siddha, Chennai gave a talk on "Budget and its relations to establishment" on 18-07-2016.

2. ICD 11-TM-Siddha

International Code of Diseases 11- Traditional Medicine- Siddha (ICD11-TM-SIDDHA)

The World Health Organization presents its compliments to member states and Associate members and has the honour to present major milestones towards the finalization of the 11th

Revision of the International Classification of Diseases (ICD-11) as WHO seeks comments on the 2016 version of the ICD-11.

As enlisted under the heading "ICD-11 Advances and Data Priorities (New Data Options)" the move to include the new chapter for traditional medicine diagnosis is a welcome measure, which ensures tangible reporting of the services of Nationally recognized traditional medicine

81

practitioners, which is by and large under reported all these years due to lack of an organized system. Though the chapter included currently covers Traditional Chinese Medicine practiced in China, Japan and Korea, this measure has created space for inclusion of other recognized traditional medical systems viz., Ayurveda, Siddha, Unani etc., which are widely practiced in South, South East Asia and South-West Asian Countries and further making inroads into Europe, Africa, America and Australia and New Zealand.

Further as noted at "Data Priorities" enlisted at No. 3, there is even stronger demand for quality country mortality and morbidity statistics at national level as reported at the recent WHO World Health Statistics Report and at the Tokyo ICD-11 Revision Conference

Keeping in view of the above, Ministry of A YUSH, Government of India has initiated a process to develop National Morbidity Codes for Ayurveda, Siddha and Unani Systems of Medicine through wide National Consultation Process. Hence, an expert committee has been formed to develop National Morbidity Codes - Siddha by Ministry of AYUSH, Government of India. A working group was constituted at the organization level to carry out the works related to NAMSTP and the codes are uploaded in portal.

Based on the importance of ICD 11 (TM)-Siddha, SCRI, Chennai has constituted a working group to develop ontology frame work for ICD 11 (TM)-Siddha. The team has worked tirelessly and developed ontology frame work for Siddha. It has been evaluated by the ICD expert committee constituted by the Ministry of AYUSH, Govt. of India. The team has completed the task within stipulated time of 10 days. So far 927 Siddha ICD morbidity codes have been completed and it has been published in ASU morbidity website.

3. Promotion of Official Language

Official language implementation programme has been carried out in CCRS and its peripheral institutes / unit. Hindi fortnight has observed and competitions for the staff of CCRS and its units were conducted. OLIC - Official Language Implementation Committee meetings were periodically convened.

4. Internal Complaints Committee constituted under sexual harassment of women at work place (Prevention, Prohibition and Redressal)

The first meeting of the internal complaints committee constituted under sexual harassment of woman at work place (Prevention, Prohibition and Redressal) Act, 2013 was convened on 27th March, 2018. No case related to the issue was reported in the meeting. Sensitizing programme on sexual harassment for women working at Central Council for Research in Siddha and Siddha Central Research Institute was held on 28th March, 2018.

5. Website

The official website of Central Council for Research in Siddha was launched on 18th February. By the constant support from the peripheral institutes/ units the website is functioning as the 'facade of the Council' depicting the information and important research activities carried out by the Council.

Link: http://www.siddhacouncil.in

82

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Title wise books sold out in the year 2017-18

40 ._ __ ..,38

1

0 50 100 150 200 250 300 350 400

IJ Siddha Formulary of India (Part-11)-Tamil Version CD-Rom

IJ Siddha Pharmacopoeia of India (Part-I, Vol. II) CD-Rom

Siddha Formulary of India (Part-I I) - Tamil Version

Siddha Pharmacopoeia of India (Part-I, Vol. II)

Siddha Pharmacopoeia of India (Part-I, Vol. I)

Monograph on Nilavanbu Kudineer Chooranam

AgathiyarVaidya Pooranam- 205(Hindi)

Guideline for Practice of Siddha Varmam Therapy

Kalndu Soothiram - 16

A-Z Know your alphabets through Siddha Medicinal Plants

D Siddha research Review in Cancer

a A Hand Book of Common in Siddha System of Medicene

Siddha Kaya Kalpa Mooligai

a Pulippaani Vaidhyam - 500

IJ Monograph ofThamira Cehnduram (Peptic Ulcer)

Sangamuni Vis ha Vaidhyam- 100 (Eng.)

Glossary on Siddha External Therapies

a AgathiyarVaidya Pooranam- 205(Eng.)

Uyir mei mooligaigal

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October Nm-ember December .JJanuary February U March

6°~, 8°/o

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AYUSH RESEARCH PORTAL [videnLe 8ds.ed Re-.o.uch D.il..d of AV~lt Sy,.tems. .itGk>bitl Levd

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~: http://www.siddhacouncil.com/

Shri Shripad Yesso Naik, Minister of State (independent charge) -AYUSH during the Inauguration of 3rd Floor of SRRI, Thiruvananthapuram on 21st October, 2017

Shri Shripad Yesso Naik, Minister of State (independent charge) -AYUSH visiting CCRS stall at National Level Arogya Fair from flth to 11th September 2017 at Andhra University Grounds, Vishakhapatnam

Vaidya Rajesh Kotecha, Secretary, Ministry of AYUSH during the inauguration of LCMS equipment

on f)h February, 2018

Vaidya Rajesh Kotecha, Secretary & Shri P.N. Ranjit Kumar, Joint Secretary, Ministry of AYUSH during the inauguration of Ramp on f)h

February, 2018

SCRI, Chennai Pharmacy Visit by Dr. J.P. Venthamarai Selvi, Drug Inspector, Chennai

SPC meeting on 2.Jrd May, 2017 at CCRS, Chennai

International Day of Yofa ~6l)ffi IBlUlllI>IT ~(j)f(D

o .

Visit of Dignitaries from Malaysia on 8'" January, 2018

RRDR inspection on 13'" July, 2017

Demonstration of Yoga by Prof. Dr. R.S. Ramaswamy, oDicials ofCCRS and SCRI, Chennai and students of GSMC, Chennai during the .Jrd International Yoga day on 21st fune, 2017

Cit

National Level Comprehensive Health F on Ayurveda, Yoga & Naturopathy, U Sowa4Rtgpa, Siddha & Homoeopathy

5-8 MAY 2017 CHfN

Inaugural ceremony of the National Level Arogya on 5th & 8'" May, 2017 at Chennai

MoU between CCRS and Rajiv Gandhi Centre for Bio Technology, Thiruvananthapuram

MoU between CCRS and Santhigiri Health Care and Research Organization, Thiruvananthapuram

CCRS stall at National Level Arogya on 5th & 9'h May, 2017 at Chennai

"National Conference on Pura Maruthuvam - External Therapies in Siddha system of Medicine" (NCPM-2017) on f>h &l(}h December, 2017 at Dr.

AP] Abdul Kalam]IPMER Auditorium, Puducherry.

Shri P.N. Ranjit Kumar,Joint Secretary visit to SRRI, Thiruvananthapuram

PFMS workshop on 'J'h July, 2017

Workshop on General Awareness and Propagation of Extra Mural Research Scheme (EMR) at

Pondicherry Central University on 21st April 2017

Inauguration ofSRP at SCRUND, New Delhi

Swasthya Rakshan - Kabasura kudineer camp conducted at Dr. APJ Abdul Kalam nagar,

Government Housing Board Society, Mudaliarpet, Puducherry on S,h April 2017

Hindi Fortnight celebration from 14th to 28th September, 2017 at SRRI, Puducherry

MADITSSIA-AYUSH-2017 from 11'11 to is« August at MADITSSIA Hall, Madurai

Nilavembu Kudineer distribution in Nemom Block, Thiruvananthapuram

Hindi Fortnight activity in SRRI, Thiruvanenthepuram

Swasthya Rakshan Programme at SRRI, Thiruvananthapuram

Vigilance Awareness Week at SRRI, Thiruvananthapuram

National Seminar on Current trends in Siddha Varmam Therapy, AYUSH auditorium, Janakpuri, New Delhi on 4th & 5th November, 2017

Release ofHerbarium catalogue ofSMPU, Palayamkottai

SRP Camp at Ramanpatti in the tribal hamlets of Palamalai

Inauguration SCRU, Bengaluru on 25th May, 2017 Free Siddha Medical Camp in Seshadripuram, Bengaluru

Jrd International Yoga Day at SCRU, Palayamkottai

annual report of ccrs 17-18(2) - siddhacouncil.com

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