OIS @ AAO 2016Barry Cheskin, October 13, 2016

2PowerVision │ FluidVision™ IOL

The FluidVision™ A-IOL Advantage

First true shape changing, fluid-driven IOL

Mimics eye’s natural accommodative process

Creates a continuously variable monofocal

Designed to restore True AccommodationTM

Stable visual outcomes in both Pilot and Multi-Center Studies

3PowerVision │ FluidVision™ IOL

How the FluidVision Lens Works

• When the eye moves to its natural accommodated state, the capsular bag squeezes a tiny amount of fluid (less than a drop) from the haptics at the periphery of the A-IOL into the center

• This inflates the lens, giving near vision

• When the eye attempts to move to its disaccommodated state, the capsular bag squeezes fluid the other way

• This deflates the lens, giving far vision

4PowerVision │ FluidVision™ IOL

Excellent, Stable Outcomes and Proven Accommodative Function

Results presented by Louis D. “Skip” Nichamin, MD and Paul Roux, MD at ESCRS, Copenhagen, September 2016

5PowerVision │ FluidVision™ IOL

Clear Capsular Bag out to 36 Months

Bilaterally implanted subject, M36

Image courtesy of Frik Potgieter, MD, Optimed Eye and Laser Clinic, Pretoria, SA

Monocular implanted subject, M12

6PowerVision │ FluidVision™ IOL

Response Time is Fast

29 yo FluidVision AIOL0

0.1

0.2

0.3

0.4

0.5

0.6

Res

pons

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S.R. Bharadwaj, C.M. Schor / Vision Research 45 (2005) 17–28; S. Kasthurirangan, A. Glasser / Vision Research 46 (2006) 1507–1519 and PowerVIsion Testing & Analysis

Response Time for 2 D of Accommodation

7PowerVision │ FluidVision™ IOL

Evolution of an Accommodating IOL

Conceptual • Non Optical• Non-foldable• Proof of

concept in blind eyes

• Single Center Study

• Non-foldable• Single Center

Study

• Foldable• Superseded

by Gen 4

FluidVision™• Started with

4.0 mm, moved to 3.5 mm incision

• Single Center and Multicenter Studies

FluidVision 20/20™• Twice the

accommodation• Achieve 20/20 across

all distances• Studies to start

shortly

Gen 0 Gen 1 Gen 2 Gen 3 Gen 4 Gen 5

8PowerVision │ FluidVision™ IOL

FluidVision 20/20 Design Complete

• Successful bench testing

• Designed to meet all current ISO/ANSI standards

• Performed rabbit study at Moran Eye Center to confirm surgical procedure and ocular tissue compatibility, also with positive results

FluidVision 20/20

9PowerVision │ FluidVision™ IOL

Exclusive FluidVision 20/20 Performance Preview

Advanced Multifocal Design

FluidVision 20/20

Far Near0.0 D +1.0 D +2.0 D +3.0 D

From PowerVision bench testing

10PowerVision │ FluidVision™ IOL

Product Innovation Plans

3.5 mmincision FluidVision 20/20 3.2 mm

incision ToricPost implantadjustment,

2.8 mm incision

11PowerVision │ FluidVision™ IOL