anthony k. c. chan publications as of june 16, 2013 - taari

Anthony K. C. Chan Publications as of June 16, 2013.

PUBLICATIONS (Peer-Reviewed): * corresponding author/Principal investigator # trainee under my supervision

1. Bingham WT, Chan A, Rennie R, Williams KE, Sankaran K. Neonatal campylobacter fetus meningitis: a report of an unusual case (letter). Clinical Pediatrics 31(4):255-256, 1992.

2. Wong V, Cheng CH, Chan KC. Fetal and neonatal outcome of exposure to

anticoagulants during pregnancy. American Journal of Medical Genetics 45(1):17-21, 1993.

3. Chan AKC, Leaker M, Burrows FA, Williams WG, Gruenwald CE, Whyte L, Adams

M, Brooker LA, Adams H, Mitchell L, Andrew M. Coagulation and fibrinolytic profile of paediatric patients undergoing cardiopulmonary bypass. Thrombosis and Haemostasis 77(2):270-277, 1997.

4. Chan A, Berry L, O’Brodovich H, Klement P, Mitchell L, Baranowski B, Monagle P,

Andrew M. Covalent antithrombin-heparin complexes with high anticoagulant activity: Intravenous, subcutaneous and intratracheal administration. Journal of Biological Chemistry 272(35):22111-22117, 1997.

5. Chan AKC, Berry L, Mitchell L, Baranowski B, O'Brodovich H, Andrew M. Effect of

a novel covalent antithrombin-heparin complex on thrombin generation on fetal distal lung epithelium. American Journal of Physiology-Lung Cellular and Molecular Physiology 274:L914-L921, 1998.

6. Nitschmann E, Berry L, Bridge S, Dereske M, Richardson M, Monagle P, Chan A,

Andrew M. Morphological and biochemical features affecting the antithrombotic properties of the inferior vena cava of rabbit pups and adult rabbits. Pediatric Research 43(1):62-67, 1998.

7. Nitschmann E, Berry L, Bridge S, Hatton MWC, Richardson M, Monagle P, Chan

AKC, Andrew M. Morphological and biochemical features affecting the antithrombotic properties of the aorta in adult rabbits and rabbit pups. Thrombosis and Haemostasis 79(5):1034-1040, 1998.

8. Berry L, Chan AKC, Andrew M. Polypeptide-polysaccharide conjugates produced

by spontaneous non-enzymatic glycation. Journal of Biochemistry 124(2):434-439, 1998.

9. Chan AKC, Baranowski B, Berry L, Liu M, Rafii B, Post M, O'Brodovich H, Monagle

P, Andrew M. Influence of mechanical stretch on thrombin regulation by fetal mixed lung cells. American Journal of Respiratory and Cellular and Molecular Biology 19(3):419-425, 1998.

Dr. Anthony Chan

10. Chan AKC, Berry L, Klement P, Julian J, Mitchell L, Weitz J, Hirsh J, Andrew M. A

novel antithrombin-heparin covalent complex: Antithrombotic and bleeding studies in rabbits. Blood Coagulation and Fibrinolysis 9(7):587-595, 1998.

11. Monagle P, Berry L, O’Brodovich H, Andrew M, and Chan A*. Covalent heparin

cofactor II-heparin and heparin cofactor II-dermatan sulfate complexes: Characterization of novel anticoagulants. Journal of Biological Chemistry 273(50):33566-33571, 1998.

12. Berry L, Stafford A, Fredenburgh J, O’Brodovich H, Mitchell L, Weitz J, Andrew M,

Chan AKC*. Investigation of the anticoagulant mechanisms of a covalent antithrombin-heparin complex. Journal of Biological Chemistry 273(52):34730-34736, 1998.

13. deVeber G, Monagle P, Chan A, MacGregor D, Curtis R, Lee S, Vegh P, Adams M,

Marzinotto V, Leaker M, Massicotte MP, Lillicrap D, Andrew M. Prothrombotic disorders in infants and children with cerebral thromboembolism. Archives of Neurology 55(12):1539-1543, 1998.

14. deVeber G, Chan A, Monagle P, Marzinotto V, Armstrong D, Massicotte P, Leaker M,

Andrew M. Anticoagulation therapy in pediatric patients with sinovenous thrombosis: A cohort study. Archives of Neurology 55(12):1533-1537, 1998.

15. Streif W#, Andrew M, Marzinotto V, Massicotte MP, Chan AKC, Julian J, Mitchell L.

Analysis of warfarin therapy in pediatric patients: A prospective cohort study of 319 patients. Blood 94 (9):3007-3014, 1999.

16. Dix D, Andrew M, Marzinotto V, Charpentier K, Bridge S, Monagle P, deVeber G,

Leaker M, Chan AKC, Massicotte MP. The use of low molecular weight heparin in pediatric patients: a prospective cohort study. Journal of Pediatrics 136(4):439-445, 2000.

17. Marzinotto V, Monagle P, Chan A, Adams M, Massicotte P, Leaker M, Andrew M.

Capillary whole blood monitoring of oral anticoagulants in children in outpatient clinics and home setting. Pediatric Cardiology 21(4):347-352, 2000.

18. Gruenwald C, deSouza V, Chan AKC, Andrew M. Whole blood heparin

concentrations do not correlate with plasma antifactor Xa heparin concentrations in pediatric patients undergoing cardiopulmonary bypass. Perfusion 15(3):203-209, 2000.

19. Streif W#, Paes B, Berry L, Andrew M, Andreasen RB, Chan AKC*. Influence of

exogenous factor VIIa on thrombin generation in cord plasma of full-term and pre-term newborns. Blood Coagulation and Fibrinolysis 11(4):349-357, 2000.

20. Streif W#, Borum Andreasen R, Paes B, Berry LR, Xu L, Andrew M, Chan AKC. Influence of activated factor VII concentrates on thrombin generation in full-term

Dr. Anthony Chan

and preterm neonates. Blood Coagulation and Fibrinolysis 11(Suppl1):S133-S134. 21. Wiernikowski J, Crowther M, Clase C, Ingram A, Andrew M, Chan AKC*. Stability

and sterility of recombinant tissue plasminogen activator at -30ºC. (Letter) Lancet 355(9222):2221-2222, 2000.

22. Choi M, Massicotte MP, Marzinotto V, Chan AKC, Holmes JL, Andrew M. The use of

alteplase to restore patency of central venous lines in pediatric patients: A cohort study. Journal of Pediatrics 139(1):152-156, 2001.

23. Askalan R, Laughlin S, Mayank S, Chan A, MacGregor D, Andrew M, Curtis R,

Meaney B, deVeber G. Chickenpox and stroke in childhood: A study of frequency and causation. Stroke 32(6):1257-1262, 2001.

24. deVeber G, Chan A. Aspirin versus low-molecular-weight heparin for ischemic

stroke in children: an unanswered question. (Letter) Stroke 33(8):1947-8, 2002. 25. Klement P, Du YJ#, Berry L, Andrew M, Chan AKC*. Blood-compatible biomaterials

by surface coating with a novel antithrombin-heparin covalent complex. Biomaterials 23(2):527-535, 2002.

26. Crowther MA, Berry LR, Monagle PT, Chan AKC*. Mechanisms responsible for the

failure of protamine to inactivate low-molecular-weight heparin. British Journal of Haematology 116(1):178-186, 2002.

27. Cornelius RM, Archambault JG, Berry L, Chan AKC, Brash JL. Adsorption of

proteins from infant and adult plasma to biomaterial surfaces. Journal of Biomedical Materials Research 60(4):622-632, 2002.

28. Chan AKC, Berry LR, Monagle PT, Andrew M. Decreased concentrations of

heparinoids are required to inhibit thrombin generation in plasma from newborns and children compared to plasma from adults due to reduced thrombin potential. Thrombosis and Haemostasis 87(4):606-613, 2002.

29. Chan AKC, Rak J, Berry L, Liao P, Vlasin M, Weitz J, Klement P. Antithrombin-

heparin covalent complex: A possible alternative to heparin for arterial thrombosis prevention. Circulation 106(2):261-265, 2002

30. Berry LR, Becker DL, Chan AKC*. Inhibition of fibrin-bound thrombin by a

covalent antithrombin-heparin complex. Journal of Biochemistry 132(2):167-176, 2002.

31. Paredes N, Xu L, Berry LR, Chan AKC*. The effects of chemotherapeutic agents on

the regulation of thrombin on cell surfaces. British Journal of Haematology 120(2):315-324, 2003.

32. Berry LR, Klement P, Andrew M, Chan AKC*. Effect of covalent serpin-heparinoid

complexes on plasma thrombin generation on fetal distal lung epithelium.

Dr. Anthony Chan

American Journal of Respiratory Cell and Molecular Biology 28(2):150-158, 2003. 33. Monagle P, Chan AKC, Albisetti M, Vegh P, Andrew M, Mitchell L. Fibrinolytic

system in adolescents: Response to venous occlusion stress tests. Pediatric Research 53(2):333-337, 2003.

34. Albisetti M#, Chan AKC, McCrindle BW, Wong D, Vegh P, Adams M, Dinyari M,

Monagle P, Andrew M. Fibrinolytic response to venous occlusion is decreased in patients after Kawasaki disease. Blood Coagulation and Fibrinolysis 14(2):181-186, 2003.

35. Streif W, Goebel G, Chan AKC, Massicotte MP. Use of low molecular mass heparin

(enoxaparin) in newborn infants: A prospective cohort study of 62 patients. Archives of Disease in Childhood, Fetal Neonatal Edition 88(5):F365-F370, 2003.

36. Revel-Vilk S#, Chan A*, Bauman M, Massicotte P. Prothrombotic conditions in an

unselected cohort of children with venous thromboembolic disease. Journal of Thrombosis and Haemostasis 1(5):915-921, 2003.

37. Walker IR, Sek JT, Almonte TM, Carruthers JB, Chan AKC, Pai MK, Thibault AA,

Heddle NM. Developing a tracking system for coagulation factor concentrates in southern Ontario. Transfusion 43(5):556-562, 2003.

38. Massicotte MP, Julian JA, Marzinotto V, Gent M, Shields K, Chan AK, Szechtman B,

Kohne S, Shepherd S, Bacher P, Andrew M. Dose-finding and pharmacokinetic profiles of prophylactic doses of a low molecular weight heparin (reviparin-sodium) in pediatric patients. Thrombosis Research 109(2-3):93-99, 2003.

39. Massicotte P, Julian JA, Gent M, Shields K, Marzinotto V, Szechtman B, Chan AK,

Andrew M: the PROTEKT Study Group. An open-label randomized controlled trial of low molecular weight heparin for the prevention of the central venous line-related thrombotic complications in children: the PROTEKT trial. Thrombosis Research 109(2-3):101-108, 2003.

40. Watson LM, Chan AKC, Berry LR, Li J, Sood SK, Dickhout JG, Xu L, Werstuck GH,

Bajzar L, Klamut HJ, Austin RC. Overexpression of the 78-kDa glucose-regulated protein/immunoglobulin-binding protein (GRP78/BiP) inhibits tissue factor procoagulant activity. Journal of Biological Chemistry 278(19):17438-17447, 2003.

41. Paredes N, Wang A, Berry LR, Smith LJ, Stafford AR, Weitz JI, and Chan AKC*.

Mechanisms responsible for catalysis of the inhibition of factor Xa or thrombin by antithrombin using a covalent antithrombin-heparin complex. Journal of Biological Chemistry 278(26):23398-23409, 2003.

42. Chan AKC *, Berry LR, Paredes N, Parmar N. Isoform composition of antithrombin

in a covalent antithrombin-heparin complex. Biochemical and Biophysical Research Communication 309(4):986-991, 2003.

Dr. Anthony Chan

43. Kuhle S, Koloshuk B, Marzinotto V, Bauman M, Massicotte P, Andrew M, Chan A, Abdolell M, Mitchell L. A cross-sectional study evaluating post-thrombotic syndrome in children. Thrombosis Research 111(4-5):227-233, 2003.

44. Lanthier S, Kirkham FJ, Mitchell LG, Laxer RM, Atenafu E, Male C, Prengler M, Domi

T, Chan AKC, Liesner R, deVeber G. Increased anticardiolipin antibody IgG titers do not predict recurrent stroke or TIA in children. Neurology 62(2):194-200, 2004.

45. Revel-Vilk S#, Sharathkumar A, Massicotte P, Marzinotto V, Daneman A, Dix D, Chan

A*. Natural history of arterial and venous thrombosis in children treated with low molecular weight heparin: A longitudinal study by ultrasound. Journal of Thrombosis and Haemostasis 2(1):42-46, 2004.

46. Albisetti M#, Chan AKC, McCrindle BW, Wong D, Monagle P, Andrew M. Impaired

fibrinolytic activity is present in children with dyslipidemias. Pediatric Research 55(4):576-580, 2004.

47. Chan AKC*, Patel S, Male C, Berry LR, Mitchell LG. Activated protein C generation

is greatly decreased in plasma from newborns compared to adults in the presence or absence of endothelium. Thrombosis and Haemostasis 91(2):238-247, 2004.

48. Parvez B, Parmar N, Chan AKC*. Trimming of peripherally inserted central venous

catheters may increase the risk of thrombosis. (Letter) Thrombosis Research 113(2):175-177, 2004.

49. Chan AKC*, Paredes N, Thong B, Chindemi P, Paes B, Berry LR, Monagle P. Binding

of heparin to plasma proteins and endothelial surfaces is inhibited by covalent linkage to antithrombin. Thrombosis and Haemostasis 91(5):1009-1018, 2004.

50. Kuhle S, Massicotte P, Andrew M, Chan A, Mitchell L. A case series of 72 neonates

with renal vein thrombosis: Data from the 1-800-NO-CLOTS registry. Thrombosis and Haemostasis 92(4):929-933, 2004.

51. Kuhle S, Massicotte P, Chan A, Adams M, Abdolell M, deVeber G, Mitchell L.

Systemic thromboembolism in children: Data from the 1-800-NO-CLOTS Consultation Service. Thrombosis and Haemostasis 92(4):722-728, 2004.

52. Walker I, Sigouin CS, Sek J, Almonte T, Carruthers J, Chan A, Heddle N. Comparing

handheld computers and paper diaries for hemophilia home therapy: A randomized trial. Haemophilia 10(6):698-704, 2004.

53. Monagle P, Chan A, Massicotte P, Chalmers E, Michelson AD. Antithrombotic therapy in children: The seventh ACCP conference on antithrombotic and thrombolytic therapy. Chest 126(3 Suppl):645S-687S, 2004.

54. Parmar N, Berry LR, Paredes N, Chan AKC*. Effect of heparins on thrombin

generation in hemophilic plasma supplemented with FVIII, FVIIa, or FEIBA. Clinical Laboratory 51(3-4):157-166, 2005.

Dr. Anthony Chan

55. Athale UH, Siciliano SA, Crowther M, Barr RD, Chan AKC. Thromboembolism in

children with acute lymphoblastic leukemia treated on Dana-Farber Cancer Institute protocols: Effect of age and risk stratification of disease. British Journal of Haematology 129(6):803-810, 2005.

56. Du YJ#, Klement P, Berry LR, Tressel P, Chan AKC*. In vivo rabbit acute model

tests of polyurethane catheters coated with a novel antithrombin-heparin covalent complex. Thrombosis and Haemostasis 94(2):366-372, 2005.

57. Kuhle S, Massicotte P, Dinyari M, Vegh P, Mitchell D, Marzinotto V, Chan A,

Pieniaszek H, Mitchell LG. Dose-finding and pharmacokinetics of therapeutic doses of tinzaparin in pediatric patients with thromboembolic events. Thrombosis and Haemostasis 94(6):1164-1171, 2005.

58. Ignjatovic V, Furmedge J, Newall F, Chan A, Berry L, Fong C, Cheng K, Monagle P.

Age-related differences in heparin response. Thrombosis Research 118(6):741-745, 2006.

59. Rafay MF, Armstrong D, deVeber G, Domi T, Chan A, MacGregor DL.

Craniocervical arterial dissection in children: clinical and radiographic presentation and outcome. Journal of Child Neurology 21(1):8-16, 2006.

60. Kuhle S, Mitchell L, Andrew M, Chan AKC, Massicotte MP, Adams M, deVeber G.

Urgent clinical challenges in children with ischemic stroke: Analysis of 1065 patients from the 1-800-NOCLOTS pediatric stroke telephone consultation service. Stroke 37(1):116-122, 2006.

61. Monagle P, Barnes C, Ignjatovic V, Furmedge J, Newall F, Chan A, De Rosa L,

Hamilton S, Ragg P, Robinson S, Auldist A, Crock C, Roy N, Rowlands S. Developmental haemostasis. Impact for clinical haemostasis laboratories. Thrombosis and Haemostasis 95(2):362-372, 2006.

62. Arnold DM, Fergusson DA, Chan AKC, Cook RJ, Fraser GA, Lim W, Blajchman MA,

Cook DJ. Avoiding transfusions in children undergoing cardiac surgery: A meta-analysis of randomized trials of aprotinin. Anesthesia and Analgesia 102(3):731-737, 2006.

63. Chan A, Jayasuriya K, Berry L, Roth-Kleiner M, Post M, Belik J. Volutrauma

activates the clotting cascade in the newborn but not adult rat. American Journal of Physiology: Lung Cellular and Molecular Physiology 290(4):L754-L760, 2006.

64. Parmar N, Mitchell LG, Berry LR, Andrew M, Chan AKC*. The influence of age on

in vitro plasmin generation in the presence of fibrin monomer. Acta Haematologica 115(3-4):141-51, 2006.

65. Brandao LR, Williams S, Kahr WHA, Clodagh R, Temple M, Chan AKC. Exercise-

induced deep vein thrombosis of upper extremity. 2. Case series in children. Acta

Dr. Anthony Chan

Haematologica 115(3-4):221-229, 2006. 66. Chindemi PA, Klement P, Konecny P, Berry LR, Chan AKC*. Biodistribution of

covalent antithrombin-heparin complexes. Thrombosis and Haemostasis 95(4):629-636, 2006.

67. Klement P, Du YJ, Berry LR, Tressel P, Chan AKC*. Chronic performance of

polyurethane catheters covalently coated with ATH complex: A rabbit jugular vein model. Biomaterials 27(29):5107-5117, 2006.

68. Mewhort-Buist TA, Junop M, Berry LR, Chindemi P, Chan AKC*. Structural effects

of a covalent linkage between antithrombin and heparin: Covalent N-terminus attachment of heparin enhances the maintenance of antithrombin’s activated state. Journal of Biochemistry (Tokyo) 140:175-184, 2006.

69. Berry LR, Parmar N, Hatton MWC, Chan AKC*. Selective cleavage of heparin using

aqueous 2-hydroxypyridine: Production of an aldose-terminating fragment with high anticoagulant activity. Biophysical Biochemical Research Communications 346(3):946-957, 2006.

70. Athale U, Cox S, Siciliano S, Chan AKC. Thromboembolism in children with

sarcoma. Pediatric Blood and Cancer, 49(2):171-176, 2007. 71. Ignjatovic V, Summerhayes R, Gan A, Than J, Chan A, Cochrane A, Bennett M,

Horton S, Shann F, Lane G, Ross-Smith M, Monagle P. Monitoring unfractionated heparin (UFH) therapy: Which anti factor Xa assay is appropriate? Thrombosis Research, 120(3):347-351, 2007.

72. Wiernikowski JT, Chan A*, Lo G. Reversal of anti-thrombin activity using

protamine sulfate. Experience in a neonate with a 10-fold overdose of enoxaparin. Thrombosis Research, 120(2):303-305, 2007.

73. Lau A, Berry LR, Mitchell LG, Chan AKC*. Effect of substrate and fibrin

polymerization inhibitor on determination of plasma thrombin generation in vitro. Thrombosis Research 119(6):667-677, 2007.

74. Belletrutti M, Ali K, Barnard D, Blanchette V, Chan A, David M, Luke B, Price V,

Ritchie B, Wu J, on behalf of the Canadian Pediatric Thrombosis and Hemostasis Network. Chronic immune thrombocytopenic purpura in children. A survey of the Canadian experience. Journal of Pediatric Hematology/Oncology 29(2):95-100, 2007.

75. Du YJ, Brash JL, McClung G, Berry LR, Klement P, Chan AKC*. Protein adsorption

on polyurethane catheters modified with a novel antithrombin-heparin covalent complex. Journal of Biomedical Materials Research - Part A 80(1):216-225, 2007.

76. Patel S#, Berry LR, Chan AKC*. Analysis of inhibition rate enhancement by

covalent linkage of antithrombin to heparin as a potential predictor of reaction mechanism. Journal of Biochemistry (Tokyo) 141(1):25-35, 2007.

Dr. Anthony Chan

77. Klaassen RJ, Blanchette VS, Barnard D, Wakefield CD, Curtis C, Bradley CS, Neufeld

EJ, Buchanan GR, Silva MP, Chan AKC, Young NL. Validity, reliability, and responsiveness of a new measure of health-related quality of life in children with immune thrombocytopenic purpura: The kids’ ITP tools. Journal of Pediatrics 150(5):510-515, 2007.

78. Gupta A, Wiernikowski JT, Chan AKC. The use of low molecular weight heparins in

pediatrics: Two cases that highlight potential risks to patient safety. (Letter) Thrombosis Research, 121(2):281-282, 2007.

79. Arnold DM, Webert KE, Carruthers J, Almonte T, Decker K, Seroski W, Reed J, Chan

AKC, Pai M, Walker I. Trends in the utilization and wastage of coagulation factor concentrates: The application of a regional tracking programme. Haemophilia 13(3):271-278, 2007.

80. Malowany JI, Knoppert DC, Chan AKC, Pepelassis D, Lee DSC. Enoxaparin use in

the neonatal intensive care unit: Experience over 8 years. Pharmacotherapy, 27(9):1263-1271, 2007.

81. Webert KE, Arnold DM, Carruthers J, Molnar L, Almonte T, Decker K, Seroski W,

Reed J, Chan AK, Pai M, Walker IR. Utilization of recombinant activated factor VII in southern Ontario in 85 patients with and without haemophilia. Haemophilia, 13(5):518-526, 2007.

82. Jegatheeswaran A, Parmar N, Walton JM, Yip C, Chan AKC*. Quantitative analysis

of catheter roughness induced by cutting and manipulation: A potential prothrombotic risk. Blood Coagulation and Fibrinolysis, 18(6):531-536, 2007.

83. Chan AKC, Black L, Ing C, Brandão LR, Williams S. Utility of aPTT monitoring

unfractionated heparin in children. (Letter) Thrombosis Research, 122(1):135-136, 2008.

84. Bassler D, Greinacher A, Okascharoen C, Klenner A, Ditomasso J, Kiefel V, Chan A,

Paes B. A systematic review of the management of unexpected neonatal alloimmune thrombocytopenia. Transfusion, 48(1):92-98, 2008.

85. Mewhort-Buist TA, Liaw PC, Patel S, Atkinson HM, Berry LR, Chan AKC*.

Treatment of endothelium with the chemotherapy agent vincristine affects activated protein C generation to a greater degree in newborn plasma than in adult plasma. Thrombosis Research, 122(3):418-426, 2008.

86. Athale UH, Nagel K, Khan AA, Chan AKC. Thromboembolism in children with

lymphoma. Thrombosis Research, 122(4):459-465, 2008. 87. Whelan HT, Cook JD, Amlie-Lefond CM, Hovinga CA, Chan AK, Ichord RN, deVeber

GA, Thall PF. Practical model-based dose-finding in early phase clinical trials: Optimizing tPA dose for treatment of ischemic stroke in children. Stroke,

Dr. Anthony Chan

39(9):2627-2636, 2008. 88. Domi T, Edgell DS, McCrindle BW, Williams WG, Chan AK, MacGregor DL, Kirton

A, deVeber GA. Frequency, predictors, and neurological outcome of vaso-occlusive strokes associated with cardiac surgery in children. Pediatrics, 122(6):1292-1298, 2008.

89. Biss TT, Brandao LR, Kahr WH, Chan AK, Williams S. Clinical features and

outcome of pulmonary embolism in children. British Journal of Haematology, 142(5):808-818, 2008.

90. Smith LJ, Mewhort-Buist TA, Berry LR, Chan AKC*. An antithrombin-heparin

complex increases the anticoagulant activity of fibrin clots. Research Letters in Biochemistry, 2008, Article ID 639829, 4 pages (doi:10.1155/2008/639829).

91. Robertson JD, Brandao L, Williams S, Ing C, Chan AKC. Use of single anti-Xa

calibration curve is adequate for monitoring enoxaparin and tinzaparin levels in children. (Letter) Thrombosis Research, 122(6):867-869, 2008.

92. Kirton A, Chan AKC, Amlie-Lefond C. Arterial ischemic stroke: Experience in

Chinese children. (Letter). Pediatric Neurology, 39(2):142-143, 2008. 93. Biss TT, Chan AK, Blanchette VS, Iwenofu LN, McLimont M, Carcao MD,

Association of Hemophilia Clinic Directors of Canada (AHCDC), Canadian Association of Nurses in Hemophilia Care (CANHC). The use of prophylaxis in 2,663 children and adults with haemophilia: Results of the 2006 Canadian National Haemophilia prophylaxis survey. Haemophilia, 14(5):923-930, 2008.

94. Athale U, Siciliano S, Thabane L, Pai N, Cox S, Lathia A, Khan A, Armstrong A, Chan

AKC. Epidemiology and clinical risk factors predisposing to thromboembolism in children with cancer. Pediatric Blood & Cancer, 51(6):792-797, 2008.

95. Monagle P, Chalmers E, Chan A, deVeber G, Kirkham F, Massicotte P, Michelson AD.

Antithrombotic therapy in neonates and children: ACCP evidence-based clinical practice guidelines (8th edition). Chest 133(6 Suppl):887S-968S, 2008.

96. Young G, Albisetti M, Bonduel M, Brandao L, Chan A, Friedrichs F, Goldenberg N,

Grabowski E, Heller C, Journeycake J, Kenet G, Krümpel A, Kurnik K, Lubetsky A, Male C, Manco-Johnson M, Mathew P, Monagle P, van Ommen H, Simioni P, Svirin P, Tormene D, Nowak-Göttl U. Impact of inherited thrombophilia on venous thrombo-embolism in children: a systematic review & meta-analysis of observational studies. Circulation, 118(13):1373-1382, 2008.

97. Amlie-Lefond C, Chan AKC, Kirton A, deVeber G, Hovinga CA, Ichord R, Stephens

D, Zaidat OO. Thrombolysis in acute childhood stroke: Design and challenges of Thrombolysis in Pediatric Stroke clinical trial. Neuroepidemiology, 32(4):279-286, 2009.

Dr. Anthony Chan

98. Parmar N, Berry LR, Post M, Chan AKC*. Effect of covalent antithrombin-heparin complex on developmental mechanisms in the lung. American Journal of Physiology: Lung Cellular and Molecular Physiology, 296(3):L394-L403, 2009.

99. Atkinson HM, Mewhort-Buist TA, Berry LR, Chan AKC*. Anticoagulant

mechanisms of covalent antithrombin-heparin investigated by thromboelastography - comparison with unfractionated heparin and low molecular weight heparin. Thrombosis and Haemostasis, 102(1):62-68, 2009.

100. Biss TT, Kahr WH, Brandão LR, Chan AKC, Williams S. The use of elastic

compression stockings for post-thrombotic syndrome in a child. Pediatric Blood and Cancer, 53(3):462-463, 2009.

101. Amlie-Lefond C, deVeber G, Chan AK, Benedict S, Bernard T, Carpenter J, Dowling

M, Fullerton H, Hovinga C, Kirton A, Lo W, Zamel K, Ichord R, on behalf of members of the International Pediatric Stroke Study. Use of alteplase in childhood arterial ischemic stroke: A multicenter observational cohort study. Lancet Neurology, 8(6):530-536, 2009.

102. Yee DL, Chan AKC, Williams S, Goldenberg NA, Massicotte MP, Raffini LJ. Varied

opinions on thrombolysis for venous thromboembolism in infants and children: Findings from a survey of pediatric hematology-oncology specialists. Pediatric Blood and Cancer, 53(6):960-966, 2009.

103. Muwakkit SA, Saab R, Sanjad SA, Bhar SI, Ishak RS, Samad ZA, Chan AK, Abboud

MR. Renal venous thrombosis in a newborn with prothrombotic risk factors. Blood Coagulation and Fibrinolysis, 20(6):458-460, 2009.

104. Berry LR, Thong B, Chan AKC*. Comparison of recombinant and plasma-derived

antithrombin biodistribution in a rabbit model. Thrombosis and Haemostasis, 102(2):302-308, 2009.

105. Kassam A, Chan AKC, Dzolganovski B, Constantin J, Ramphal R, Grant R, Sung L.

No association between protein C levels and bacteremia in children with febrile neutropenia. Journal of Pediatric Hematology/Oncology, 31(9):647-650, 2009.

106. Biss TT, Brandão LR, Kahr WHA, Chan AKC, Williams S. Clinical probability score

and D-dimer estimation lack utility in the diagnosis of childhood pulmonary embolism. Journal of Thrombosis and Haemostasis, 7(10):1633-1638, 2009.

107. Mullah-Ali AM, Chan AK, Lillicrap D, Decker K, Seroski W, Moffat K, Walker I, Pai

MK. Undetected factor VIII in a patient with type 3 von Willebrands disease mistaken as severe haemophilia A. Haemophilia, 15(6):1258-1261, 2009.

108. Chan VHT, Monagle P, Massicotte P, Chan AKC*. Novel paediatric anticoagulants:

A review of the current literature. Blood Coagulation and Fibrinolysis, 21(2):144-151, 2010.

Dr. Anthony Chan

109. Yang JYK, Chan AKC*. Anti-prothrombin antibodies and other acquired antibodies associated with thrombosis in children. (Editorial). Thrombosis Research, 125:2-3, 2010.

110. Moharir MD, Shroff M, Stephens D, Pontigon A, Chan A, MacGregor D, Mikulis D,

Adams M, deVeber G. Anticoagulants in pediatric cerebral sinovenous thrombosis: A safety and outcome study. Annals of Neurology, 67(5):590-599, 2010.

111. Athale U, Moghrabi A, Nayiger T, Delva YL, Thabane L, Chan AKC. von Willebrand

factor and thrombin activation in children with newly diagnosed acute lymphoblastic leukemia: An impact of peripheral blasts. Pediatric Blood and Cancer, 54(7):963-969, 2010.

112. van Walderveen M, Berry LR, Atkinson HM, Chan AKC*. Covalent antithrombin-

heparin effect on thrombin-thrombomodulin and activated protein C reaction with factor V/Va. Thrombosis and Haemostasis, 103(5):910-919, 2010.

113. Sask KN, Berry LR, Zhitomirsky I, Chan AK, Brash JL. Surface modification with

an antithrombin-heparin complex for anticoagulation: Studies on a model surface with gold as substrate. Acta Biomaterialia,6(8):2911-2919, 2010.

114. Kenet G, Lütkhoff LK, Albisetti M, Bernard T, Bonduel M, Brandao L, Chabrier S,

Chan A, deVeber G, Fiedler B, Fullerton HJ, Goldenberg NA, Grabowski E, Günther G, Heller C, Holzhauer S, Iorio A, Journeycake J, Junker R, Kirkham FJ, Kurnik K, Lynch JK, Male C, Manco-Johnson M, Mesters R, Monagle P, van Ommen CH, Raffini L, Rostásy K, Simioni P, Sträter RD, Young G, Nowak-Göttl U. Impact of thrombophilia on risk of arterial ischemic stroke or cerebral sinovenous thrombosis in neonates and children: a systematic review and meta-analysis of observational studies. Circulation, 121(16):1838-1847, 2010.

115. van Walderveen MC, Berry LR, Chan AKC*. Effect of covalent antithrombin-

heparin on activated protein C inactivation by protein C inhibitor. Journal of Biochemistry, 148(2):255-260, 2010.

116. Ghanny S, Ross C, Chan A, Chan H. Coagulopathy in a patient with nephrotic

syndrome. American Journal of Hematology, 85(9):708-710, 2010. 117. Chan HH, Brimble KS, Lau KK, Chan AK. Scurvy: an old disease in modern

society. The Internet Journal of Internal Medicine, Volume 9, Number 1, 2010. 118. Gruenwald CE, Manlhiot C, Chan AK, Crawford-Lean L, Foreman C, Holtby HM, Van

Arsdell GS, Richards R, Moriarty H, McCrindle BW. Randomized controlled trial of individualized heparin and protamine management in infants undergoing cardiac surgery with cardiopulmonary bypass. Journal of the American College of Cardiology, 56(22):1794-1802, 2010.

119. Klement P, Berry LR, Liao P, Wood H, Tressel P, Smith LJ, Haque N, Weitz JI, Hirsh

J, Paredes N, Chan AKC*. Antithrombin-heparin covalent complex reduces

Dr. Anthony Chan

microemboli during cardiopulmonary bypass in a pig model. Blood 116(25):5716-5723, 2010.

120. Stevic I, Parmar N, Paredes N, Berry LR, Chan AKC*. Binding of heparin to metals.

Cell Biochemistry and Biophysics, 59(3):171-178, 2011. 121. Nagel K, Laudenbach L, Rivard GE, Jardine L, Chan AK, Pai M. Immune tolerance

induction for a patient with factor IX inhibitors: A case report. (Letter). Haemophilia 17(2):315, 2011.

122. Sask KN, McClung G, Berry LR, Chan AK, Brash JL. Immobilization of

antithrombin-heparin complex on gold: Anticoagulant properties and platelet interactions. Acta Biomaterialia, 7(5):2029-2034, 2011.

123. Rajpurkar M, Monagle P, Massicotte P, Chan A. Need for a new pediatric post-

thrombotic sequelae outcome measure for non-extremity thrombosis. (Letter). Thrombosis and Haemostasis, 105(6):1105-1106, 2011.

124. Muwakkit SA, Majdalani M, Hourani R, Mahfouz RA, Otrock ZK, Bilalian C, Chan

AK, Abboud M, Mikati MA. Inherited thrombophilia in childhood stroke: Data from Lebanon. Pediatric Neurology, 45(3):155-158, 2011.

125. Chan AKC, Decker K, Warner M. Adherence with hemophilia treatments: A survey

of hemophilia healthcare professionals in Canada. (Letter). Haemophilia, 17(5):816-7, 2011.

126. Du YJ, Berry LR, Chan AKC*. Chemical-physical characterization of polyurethane

catheters modified with a novel antithrombin-heparin covalent complex. Journal of Biomaterial Science - Polymer Edition, 22(17):2277-2294, 2011.

127. Manlhiot C, Menjak IB, Brandão LR, Gruenwald CE, Schwartz SM, Sivarajan VB,

Yoon H, Maratta R, Carew CL, McMullen JA, Clarizia NA, Holtby HM, Williams S, Caldarone CA, Van Arsdell GS, Chan AK, McCrindle BW. Risk, clinical features and outcomes of thrombosis associated with pediatric cardiac surgery. Circulation, 124(14):1511-1519, 2011.

128. Al-Aridi C, Abboud MR,Saab R, Eid D, Jeha S, Chan AKC, Muwakkit SA.

Thrombosis in children with acute lymphoblastic leukemia treated at a tertiary care center in Lebanon: Revisiting the role of predictive models. Pediatric Hematology and Oncology, 28(8):676-681, 2011.

129. Nagel K, Walker I, Decker K, Chan AK, Pai MK. Comparing bleed frequency and

factor concentrate use between hemophilia A and hemophilia B patients. Haemophilia, 17(6):872-874, 2011.

130. Lau KK, Giglia L, Chan H, Chan AK. Management of children after renal

transplantation: Highlights for general prediatricians. [Article in Chinese] Zhongguo Dan Dai Er Ke Za Zhi [Chinese Journal of Contemporary Pediatrics],

Dr. Anthony Chan

14(2):81-88, 2012.

131. Gruenwald CE, Manlhiot C, Abadilla AA, Kwok J, Maxwell S, Holtby HM, Brandão LR, Chan AK, Crawford-Lean L, Foreman C, Caldarone CA, Van Arsdell GS, McCrindle BW. Heparin brand is associated with postsurgical outcomes in children undergoing cardiac surgery. Annals of Thoracic Surgery, 93(3):878-883, 2012.

132. Schechter T, Finkelstein Y, Ali M, Kahr WH, Williams S, Chan AK, deVeber G,

Brandão LR. Unfractionated heparin dosing in young infants: Clinical outcomes in a cohort monitored by anti-Xa levels. Journal of Thrombosis and Haemostasis, 10(3):368-74, 2012.

133. Monagle P, Chan AK, Goldenberg NA, Ichord RN, Journeycake JM, Nowak-Göttl U,

Vesely SK; American College of Chest Physicians. Antithrombotic therapy in neonate and children: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-based Clinical Practice Guidelines. Chest, 141(2 Suppl):e737S-e801S, 2012.

134. Atkinson HM, Parmar N, Berry LR, Chan AKC*. Determination of alpha-2-

macroglobulin complexes by a new immuno-activity assay. Thrombosis Research, 129(5):635-640, 2012.

135. Manlhiot C, McCrindle BW, Menjak IB, Yoon H, Holtby HM, Brandão LR, Chan AK,

Schwartz SM, Sivarajan BV, Crawford-Lean L, Foreman C, Caldarone CA, Van Arsdell GS, Gruenwald CE. Longer blood storage is associated with suboptimal outcomes in high-risk pediatric cardiac surgery. Annals of Thoracic Surgery, 93(5):1563-1569, 2012.

136. Athale U, Siciliano S, Cheng E, Thabane L, Chan AKC. Central venous line

dysfunction is an independent predictor of poor survival in children with cancer. Journal of Pediatric Hematology/Oncology, 34(3):188-193, 2012.

137. Newall F, Chan AK, Ignjatovic V, Monagle P; on behalf of the Perinatal and Paediatric

Haemostasis Subcommittee of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis. Recommendations for developing uniform laboratory monitoring of heparinoid anticoagulants in children. Journal of Thrombosis and Haemostasis, 10(1):145-147, 2012.

138. Schechter T, Kirton A, Laughlin S, Pontigon AM, Finkelstein Y, MacGregor D, Chan

A, deVeber G, Brandão LR. Safety of anticoagulants in children with arterial ischemic stroke. Blood, 119(4):949-956, 2012.

139. Sask KN, Berry LR, Chan AKC, Brash JL. Modification of polyurethane surface

with an antithrombin-heparin complex for blood contact: Influence of molecular weight of polyethylene oxide used as linker/spacer. Langmuir, 28(4):2099-2106, 2012.

Dr. Anthony Chan

140. Goldenberg NA, Brandão LR, Journeycake J, Kahn SR, Monagle P, Revel-Vilk S, Sharathkumar A, Chan AKC; on behalf of the Perinatal and Paediatric Haemostasis Subcommittee of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis. Definition of post-thrombotic syndrome (PTS) and standardization outcome measurement following lower extremity deep vein thrombosis in paediatric clinical investigations. Journal of Thrombosis and Haemostasis, 10(3):477-480, 2012.

141. Kaatz S, Kouides PA, Garcia DA, Spyropolous AC, Crowther M, Douketis JD, Chan AKC, James A, Moll S, Ortel TL, Van Cott EM, Ansell J. Guidance on the emergent reversal of oral thrombin and factor Xa inhibitors. American Journal of Hematology, 87(Suppl 1):S141-S145, 2012.

142. Tuckuviene R, Christensen AL, Chan AKC, Athale U. Body mass index and thromboembolism in children with hematological malignancies. Pediatric Blood and Cancer, 59(2):320-322, 2012.

143. Lau KK, Giglia L, Chan H, Chan AK. Management of children after renal transplantation: Highlights for general prediatricians. Translational Pediatrics, 1(1):35-46, 2012.

144. Stevic I, Berry LR, Chan AKC. Mechanism of inhibition of the prothrombinase

complex by a covalent antithrombin-heparin complex. Journal of Biochemistry, 152(2):139-148, 2012.

145. Almonte T, Decker K, Seroski W, Walker I, Webert K, Bos C, Strike K, Waterhouse L, Goldsmith R, Chan AKC. The importance of haemophilia treatment centre administrators in patient care. (Letter) Haemophilia, 18(5):e366-e367, 2012.

146. Manlhiot C, Brandao LR, Kwok J, Kegel S, Menjak IB, Carew CL, Chan AK, Schwartz SM, Sivarajan VB, Caldarone CA, Van Arsdell GS, McCrindle BW. Thrombotic complications and thromboprophylaxis across all three stages of single ventricle heart palliation. Journal of Pediatrics, 161(3):513-519, 2012.

147. Halton J, Nagel K, Brandão L, Silva M, Gibson P, Chan A, Blyth K, Hicks K, Parmar N, Paddock L, Willing S, Thabane L, Athale U. Do children with central venous line (CVL) dysfunction have increased risk of symptomatic thromboembolism compared to those without CVL-dysfunction, while on cancer therapy? BMC Cancer, 12(1):314-324, 2012.

148. Teitel J, Belliveau D, Blanchette V, Chan A, Klaassen R, Price V, Ritchie B, Wu J. A Canadian survey of self-infusion practices in persons with hemophilia A. (Letter) Haemophilia, 18(6):e403-5, 2012.

149. Revel-Vilk S, Brandão LR, Journeycake J, Goldenberg A, Monagle P, Sharathkumar A, Chan AKC; on behalf of the Perinatal and Paediatric Haemostasis Subcommittee of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis. Standardization of post-thrombotic syndrome definition and

Dr. Anthony Chan

outcome assessment following upper venous system thrombosis in pediatric practice. Journal of Thrombosis and Haemostasis, 10(10):2182-2185, 2012.

150. Paes B, Nagel K, Sunak I, Rashish G, Chan AK; Thrombosis and Hemostasis in Newborns (THiN) Group. Neonatal and infant pulmonary thromboembolism: A literature review. Blood Coagulation and Fibrinolysis, 23(7):653-662, 2012.

151. Sask KN, Berry LR, Chan AKC, Brash JL. Polyurethane modified with an antithrombin-heparin complex via polyethylene oxide linker/spacer: Influence of PEO molecular weight and PEO-ATH bond on catalytic and direct anticoagulant functions. Journal of Biomedical Materials Research: Part A, 100(10):2821-8, 2012.

152. Berry LR, van Walderveen MC, Atkinson HM, Chan AKC. Comparison of N-linked glycosylation of protein C in newborns and adults. Carbohydrate Research, 365(1):32-37, 2013.

153. Nagel K, Pai MK, Paes BA, Chan AK. Diagnosis and treatment of intracranial hemorrhage in children with hemophilia. Blood Coagulation and Fibrinolysis, 24(1):23-27, 2013.

154. Stevic I, Chan HHW, Berry LR, Chan AKC. Inhibition of the prothrombinase complex on red blood cells by heparin and covalent antithrombin-heparin complex. Journal of Biochemistry, 153(1):103-110, 2013.

155. Hilliard P, Zourikian N, Blanchette V, Chan A, Elliot B, Israels SJ, Nilson J, Poon MC, Van Neste C, Jarock C, McLimont M, Feldman BM. Musculoskeletal health of subjects with hemophilia A treated with tailored prophylaxis: Canadian Hemophilia Primary Prophylaxis (CHPS) Study. Journal of Thombosis and Haemostasis, 11(3):460-466, 2013.

156. Yang JYK, Williams S, Brandão LR, Chan AKC, Mondal T. Neonatal and childhood right atrial thrombosis: Critical clot size. (Letter) Blood Coagulation and Fibrinolysis, 24(4):458, 2013.

157. Stevic I, Chan HHW, Chander A, Berry LR, Chan AKC. Covalently linking heparin to antithrombin enhances prothrombinase inhibition on activated platelets. Thrombosis and Haemostasis, 109(6):1016-1024, 2013.

158. Rochow N, Chan E, Wu WI, Selvaganapathy PR, Fusch G, Berry L, Brash J, Chan A, Fusch C. Artificial placenta - Lung assist devices for term and preterm newborns with respiratory failure. The International Journal of Artificial Organs, (accepted, 2012).

159. Chander A, Nagel K, Wiernikowski J, Bosco P, Chan A, and the Thrombosis and Hemostasis in Newborns (THiN) Group. Evaluation of the use of low molecular weight heparin in neonates: A retrospective, single-center study. Clinical and Applied Thrombosis/Hemostasis, (accepted, 2013).

Dr. Anthony Chan

160. Lane S, Arnold E, Webert K, Chan A, Walker I, Heddle N. What should men living with severe hemophilia need to know? The perspectives of Canadian hemophilia healthcare providers. Haemophilia (accepted, 2013).

161. Rashish G, Nagel K, Thomas S, Chan AK. Spontaneous neonatal arterial thromboembolism: At risk infants, diagnosis, treatment and outcomes. Blood Coagulation and Fibrinolysis, (accepted, 2013).

REVIEW ARTICLES (Peer-Reviewed)

1. Chan AKC, deVeber G. Prothrombotic disorders and ischemic stroke in children. Seminars in Pediatric Neurology 7(4):301-308, 2000.

2. Andrew ME, Monagle P, deVeber G, Chan AKC. Thromboembolic disease and

antithrombotic therapy in newborns. Hematology (American Society of Hematology Education Program) 358-374, 2001.

3. Kuhne S, Chan AKC. Neonatal thrombosis. ADVANCE for Medical Laboratory

Professionals 14(16), 2002. 4. Chan AK, deVeber G, Monagle P, Brooker LA, Massicotte PM. Venous thrombosis in

children. Journal of Thrombosis and Haemostasis 1(7):1443-1455, 2003. 5. Revel-Vilk S, Chan AKC*. Anticoagulation therapy in children. Seminars in

Thrombosis and Hemostasis 29(4):425-432, 2003. 6. Athale UH, Chan AKC. Thrombosis in children with acute lymphoblastic leukemia.

Part I. Epidemiology of thrombosis in children with acute lymphoblastic leukemia. Thrombosis Research 111(3):125-131, 2003.

7. Athale UH, Chan AKC. Thrombosis in children with acute lymphoblastic leukemia.

Part II. Pathogenesis of thrombosis in children with acute lymphoblastic leukemia: Effects of the disease and therapy. Thrombosis Research. 111(4-5):199-212, 2003.

8. Athale UH, Chan AKC. Thrombosis in children with acute lymphoblastic leukemia.

Part III. Pathogenesis of thrombosis in children with acute lymphoblastic leukemia: Effects of host environment. Thrombosis Research. 111(6):321-327, 2003.

9. Berry L, Chan AKC*. Development of antithrombin-heparin covalent complexes.

Current Topics in Biochemical Research 5:121-131, 2003. 10. Sutor AH, Chan AKC, Massicotte P. Low-molecular-weight heparin in pediatric

patients. Seminars in Thrombosis Hemostasis 30(Suppl 1):31-39, 2004. 11. Lequier L, Chan AKC. Anticoagulation during extracorporeal life support. Progress

in Pediatric Cardiology 21(1): 81-85, 2005.

Dr. Anthony Chan

12. Chan AK, deVeber G, Gruenwald C, Yager J, Massicotte MP. Cardiopulmonary bypass and arterial ischemic stroke in infants and children. Progress in Pediatric Cardiology 21(1):117-121, 2005.

13. Bajzar L, Chan AK, Massicotte MP, Mitchell LG. Thrombosis in children with

malignancy. Current Opinion in Pediatrics 18(1):1-9, 2006. 14. Brandao LR, Williams S, Kahr WHA, Clodagh R, Temple M, Chan AKC. Exercise-

induced deep vein thrombosis of the upper extremity. 1. Literature review. Acta Haematologica 115(3-4):214-220, 2006.

15. Parmar N, Albisetti M, Berry L, Chan AKC*. The fibrinolytic system in newborns

and children. Clinical Laboratory 52(3-4):115-24, 2006. 16. Lau K, Liu G, Chan AKC. Management of asymptomatic proteinuria in children:

Role of general practitioner. The Hong Kong Practitioner 28:383-387, 2006. 17. Patel S, Berry LR, Chan AKC*. Covalent antithrombin-heparin complexes.

Thrombosis Research, 120(2):151-160, 2007. 18. Athale UH, Chan AKC. Thromboembolic complications in pediatric hematologic

malignancies. Seminars in Thrombosis and Hemostasis 33(4):416-426, 2007. 19. Athale UH, Chan AKC. Hemorrhagic complications in pediatric hematologic

malignancies. Seminars in Thrombosis and Hemostasis 33(4):408-415, 2007. 20. Price VE, Hawes SA, Chan AKC. A practical approach to hemophilia care in

children. Paediatrics & Child Health 12(5):381-383, 2007.

21. Lau KK, Stoffman JM, Williams S, McCusker P, Brandao L, Patel S#, Chan AKC*; for the Canadian Pediatric Thrombosis and Hemostasis Network. Neonatal renal vein thrombosis: Review of the English-language literature between 1992 to 2006. Pediatrics, 120(5):e1278-e1284, 2007.

22. Kakzanov V, Monagle P, Chan AKC*. Thromboembolism in infants and children

with gastrointestinal failure receiving long-term Total Parenteral Nutrition. Journal of Parenteral and Enteral Nutrition 32(1):88-93, 2008.

23. Price VE, Chan AKC. Arterial thrombosis in children. Expert Review of

Cardiovascular Therapy 6(3):419-428, 2008. 24. Price VE, Chan AKC. Venous thrombosis in children. Expert Review of

Cardiovascular Therapy 6(3):411-418, 2008. 25. Berry LR, Chan AKC*. Review on patents for potent anticoagulant antithrombin-

heparin covalent complexes that control thrombosis in vivo. (Invited Review) Recent Patents on Biomedical Engineering, 1(2):82-91, 2008.

Dr. Anthony Chan

26. Malowany JI, Monagle P, Knoppert DC, Lee DSC, Wu J, McCusker P, Massicotte MP, Williams S, Chan AKC, for the Canadian Paediatric Thrombosis and Hemostasis Network. Enoxaparin for neonatal thrombosis: A call for higher dose for neonates. Thrombosis Research, 122(6):826-830, 2008.

27. Yang J, Paredes N, Chan AKC*. Antithrombotic therapy in children with venous

thromboembolism. Hämostaseologie, 29(1):80-87, 2009. 28. van Walderveen MC, Berry LR, Chan AKC*. Intravascular targeting of a new

anticoagulant heparin compound. Cardiovascular & Hematological Disorders - Drug Targets, 9(2):149-158, 2009.

29. Gruenwald CE, Manlhiot C, Crawford-Lean L, Foreman C, Brandão LR, McCrindle

BW, Holtby H, Richards R, Moriarty H, Van Arsdell G, Chan AK. Management and monitoring of anticoagulation for children undergoing cardiopulmonary bypass in cardiac surgery. The Journal of Extracorporeal Technology, 42(1):9-19, 2010.

30. Nagel K, Tuckuviene R, Paes B, Chan AK*. Neonatal aortic thrombosis: A

comprehensive review. Klinische Pädiatrie, 222(1):134-139, 2010. 31. Yang JY, Williams S, Brandão LR, Chan AKC*. Neonatal and childhood right atrial

thrombosis: Recognition and risk-stratified treatment approach. Blood Coagulation and Fibrinolysis, 21(4):301-307, 2010.

32. Yang JYK, Chan AKC, Callen DJA, Paes B. Neonatal cerebral sinovenous

thrombosis: Sifting the evidence for a diagnostic plan and treatment strategy. Pediatrics, 126(3):e693-e700, 2010.

33. Kenet G, Chan AKC, Soucie MJ, Kulkarni R. Bleeding disorders in neonates.

Haemophilia, 16(Suppl 5):168-174, 2010. 34. Yang YK, Chan AKC*. Neonatal systemic venous thrombosis. Thrombosis

Research, 126(6):471-476, 2010. 35. Paredes N, Mondal T, Brandão LR, Chan AKC*. Management of myocardial

infarction in children with Kawasaki disease. Blood Coagulation and Fibrinolysis, 21(7):620-631, 2010.

36. Iorio A, Marchesini E, Marcucci M, Stobart K, Chan AKC. Clotting factor

concentrates given to prevent bleeding and bleeding-related complications in people with hemophilia A or B. (Intervention Review) Cochrane Database of Systematic Reviews, (9):CD003429, 2011.

37. Stevic I, Chan HH, Chan AKC*. Carotid artery dissections: Thrombosis of the

false lumen. Thrombosis Research, 128(4):317-324, 2011. 38. Price VE, Ledingham DL, Krümpel A, Chan AK. Diagnosis and management of

neonatal purpura fulminans. Seminars in Fetal and Neonatal Medicine, 16(6):318-

Dr. Anthony Chan

322, 2011. 39. Williams S, Chan AKC. Neonatal portal vein thrombosis: Diagnosis and

management. Seminars in Fetal and Neonatal Medicine, 16(6):329-339, 2011.

40. Macartney CA, Chan AKC*. Thrombosis in children. Seminars in Thrombosis and Hemostasis, 37(7):763-771, 2011.

41. Kenet G, Aronis S, Berkun Y, Bonduel M, Chan A, Goldenberg NA, Holzhauer S, Iorio A, Journeycake J, Junker R, Male C, Manco-Johnson M, Massicotte P, Mesters R, Monagle P, van Ommen H, Raffini L, Simioni P, Young G, Nowak-Göttl U. Impact of persistent antiphospholipid antibodies on risk of incident symptomatic thromboembolism in children: A systematic review and meta-analysis. Seminars in Thrombosis and Hemostasis, 37(7):802-809, 2011.

42. Steele M, Chen HHW, Steele J, Chan AKC, Lau KK. Thrombotic thrombocytopenic purpura in pediatric patients. [Article in Chinese] Zhongguo Dan Dai Er Ke Za Zhi [Chinese Journal of Contemporary Pediatrics], 14(11):803-810, 2012.

43. Chan AKC, Monagle P. Updates in thrombosis in pediatrics: Where are we after 20 years? Hematology: ASH Education Book, 2012(1):439-443, 2012.

44. Chen K, Williams S, Chan AKC, Mondal TK. Thrombosis and embolism in pediatric cardiomyopathy. Blood Coagulation and Fibrinolysis, 24(3):221-230, 2013.

45. Chan HHW, Chan AKC, Alexopoulou I, Lau KK. Thrombotic thrombocytopenic

purpura, from the prospective of a pediatrician. Current Pediatric Reviews, (accepted, 2013).

PUBLICATIONS (Non Peer-Reviewed):

1. Jamieson MA, Douketis J, Chan AK, Massicotte P. Opinions in pediatric and adolescent gynecology. Does oral contraceptive therapy do more harm than good in adolescents who are receiving chemotherapy? Journal of Pediatric and Adolescent Gynecology 16(6):377-9, 2003.

2. Monagle P, Chan AK. Pediatric edition thrombosis research. (Editorial) Thrombosis

Research 118(1):1-2, 2006.

3. Chan HH, Chan AK, Lau KK. A surfacing problem. Ibnosina Journal of Medicine and Biomedical Sciences 4(3):103-105, 2012.

CONTRIBUTIONS TO A COLLECTIVE WORK

Published Peer-Reviewed Articles

Dr. Anthony Chan

1. deVeber G, Andrew M, Adams C, Bjornson B, Booth F, Buckley DJ, Camfield CS, David M, Humphreys P, Langevin P, MacDonald EA, Gillett J; for the Canadian Pediatric Ischemic Stroke Study Group. Cerebral sinovenous thrombosis in children. New England Journal of Medicine 345(6):417-423, 2001.

2. Massicotte P, Julian JA, Gent M, Shields K, Marzinotto V, Szechtman B, Andrew M:

REVIVE Study Group. An open-label randomized controlled trial of low molecular weight heparin compared to heparin and coumadin for the treatment of venous thromboembolic events in children: the REVIVE trial. Thrombosis Research 109(2-3):85-92, 2003.

3. O'Brien LA, James PD, Othman M, Berber E, Cameron C, Notley CRP, Hegadorn CA,

Sutherland JJ, Hough C, Rivard GE, O'Shaunessey D, Lillicrap D: Association of Hemophilia Clinic Directors of Canada. Founder von Willebrand factor haplotype associated with type 1 von Willebrand disease. Blood 102(2):549-557, 2003.

4. Arnold DM, Julian JA, Walker IR: for the Association of Hemophilia Clinic Directors

of Canada. Mortality rates and causes of death among all HIV-positive individuals with hemophilia in Canada over 21 years of follow-up. Blood 108(2):460-464, 2006.

5. James PD, Paterson AD, Notley C, Cameron C, Hegadorn C, Tinlin S, Brown C,

O'Brien L, Leggo J, Lillicrap D; Association of Hemophilia Clinic Directors of Canada. Genetic linkage and association analysis in type 1 von Willebrand disease: Results from the Canadian Type 1 VWD study. Journal of Thrombosis and Haemostasis 4(4):783-92, 2006.

6. Feldman BM, Pai M, Rivard GE, Israels S, Poon MC, Demers C, Robinson S, Luke

KH, Wu JKM, gill K, Lillicrap D, Babyn P, McLimont M, Blanchette BS: on behalf of the Association of Hemophilia Clinic Directors of Canada Prophylaxis Study Group. Tailored prophylaxis in severe hemophilia A: interim results for the first 5 years of the Canadian Hemophilia Primary Prophylaxis Study. Journal of Thrombosis and Haemostasis 4(6):1228-1236, 2006.

7. James PD, Notley C, Hegadorn C, Poon MC, Walker I, Rapson D; Association of

Hemophilia Clinic Directors of Canada. Challenges in defining type 2M von Willebrand disease: results from a Canadian cohort study. Journal of Thrombosis and Haemostasis, 5(9):1914-1922, 2007.

8. Golomb MR, Fullerton HJ, Nowak-Göttl U, deVeber G, and for the International

Pediatric Stroke Study Group. Male predominance in childhood ischemic stroke. Findings from the International Pediatric Stroke Study. Stroke, 40(1):52-57, 2009.

9. Amlie-Lefond C, Bernard TJ, Sébire G, Friedman NR, Heyer GL, Lerner NB, deVeber

G, Fullerton HJ, on behalf of the International Pediatric Stroke Study Group. Predictors of cerebral arteriopathy in children with arterial ischemic stroke: Results of the International Pediatric Stroke Study. Circulation, 119(10):1417-1423, 2009.

Dr. Anthony Chan

10. Goldenberg NA, Bernard TJ, Fullerton HJ, Gordon A, deVeber G, for the International Pediatric Stroke Study Group. Antithrombotic treatments, outcomes, and prognostic factors in acute childhood-onset arterial ischaemic stroke: A multicentre, observational, cohort study. Lancet Neurology, 8(12):1120-1127, 2009.

11. Jordan LC, Rafay MF, Smith SE, Askalan R, Zamel K, deVeber G, Ashwal S, for the

International Pediatric Stroke Study Group. Antithrombotic treatment in neonatal cerebral sinovenous thrombosis: Results of the International Pediatric Stroke Study. Journal of Pediatrics, 156(5):704-710, 2010.

12. Kirton A, Armstrong-Wells J, Chang T, deVeber G, Rivkin MJ, Hernandez M,

Carpenter J, Yager JY, Lynch JK, Ferriero DM, and for the International Pediatric Stroke Study Investigators. Symptomatic neonatal arterial ischemic stroke: The International Pediatric Stroke Study. Pediatrics, 128(6):e1402-e1410, 2011.

13. Mackay MT, Wiznitzer M, Benedict SL, Lee KJ, deVeber GA, Ganesan V, on behalf of

the International Pediatric Stroke Study Group. Arterial ischemic stroke risk factors: The International Pediatric Stroke Study. Annals of Neurology, 69(1):130-140, 2011.

14. Lo WD, ichord RN, Dowling MM, Rafay M, Templeton J, Halperin A, Smith SE, Licht DJ, Moharir M, Askalan R, deVeber G; International Pediatric Stroke Study (IPSS) Investigators. The Pediatric Stroke Recurrence and Recovery Questionnaire: validation in a prospective cohort. Neurology, 79(9):864-870, 2012.

Abstracts (Oral Presentation)

1. deVeber G for the Canadian Pediatric Ischemic Stroke Study Group. Canadian

Pediatric Ischemic Stroke Registry: Analysis of children with arterial ischemic stroke. Child Neurology Society 29th Annual Meeting, 2000, St Louis, MO.

2. deVeber G for the Canadian Pediatric Ischemic Stroke Study Group. Canadian

Pediatric Ischemic Stroke Registry: Analysis of children with sinovenous thrombosis. Canadian Congress of Neurological Sciences Meeting, 2000, Ottawa, ON.

3. Massicotte P, Julian JA , Gent M, Shields K, Marzinotto V, Szechtman B, Andrew M:

on behalf of the REVIVE Study Group (Canada). An open-label randomized controlled trial of low molecular weight heparin compared to heparin and coumadin for the treatment of venous thromboembolic events in children: The REVIVE trial. XVIII Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2001, Paris, France.

4. deVeber G, Kirton A, The Canadian Pediatric Ischemic Stroke Study Group. Arterial

ischemic stroke in infants and children: A prospective epidemiological study. 35th Annual Meeting of the Child Neurology Society, 2006, Pittsburgh, PA.

5. deVeber G, Kirton A, The Canadian Pediatric Ischemic Stroke Study Group. Neonatal

Dr. Anthony Chan

stroke in the Canadian Pediatric Ischemic Stroke Registry. 49th Pediatric Academic Societies’ Annual Meeting, 2007, Toronto, ON.

6. Amlie-Lefond C, Bernard T, Sébire G, Friedman N, Heyer G, Lerner N, deVeber G,

Fullerton H, on behalf of the International Pediatric Stroke Study Group. Predictors of cerebral arteriopathy in children with arterial ischemic stroke: Results of the International Pediatric Stroke Study. 2009 International Stroke Conference, American Heart Association, 2009, San Diego, CA (Stroke 2009; 40:e105-e276; Abstract #71).

7. Jordan L, Smith S, Rafay M, Zamel K, Askalon R, Ashwal S and Members of the

International Pediatric Stroke Study Group. Predictors of antithrombotic treatment in neonatal cerebral sinovenous thrombosis: Results of the International Pediatric Stroke Study. 2009 International Stroke Conference, American Heart Association, 2009, San Diego, CA (Stroke 2009; 40:e105-e276; Abstract #75).

Abstracts (Posters)

1. MacGregor D for the Canadian Paediatric Ischemic Stroke Study Group. Craniocervical arterial dissection in a paediatric population. Canadian Congress of the Neurological Sciences Meeting, 2000, Ottawa, ON.

2. deVeber G for the Canadian Paediatric Ischemic Stroke Study Group. Canadian

Paediatric Ischemic Stroke Registry. Canadian Paediatric Society Annual Meeting, 2000, Ottawa, ON.

3. International Paediatric Stroke Study Group. Establishing a multinational research

network in paediatric stroke: The International Paediatric Stroke Study Group. 35th Annual Meeting of the Child Neurology Society, 2006, Pittsburgh, PA.

4. International Paediatric Stroke Study Group. The importance of arteriopathy in

arterial ischemic stroke in children: Results from the International Paediatric Stroke Study. 35th Annual Meeting of the Child Neurology Society, 2006, Pittsburgh, PA.

5. Billinghurst LL, deVeber G, The Canadian Pediatric Ischemic Stroke Study Group.

Cerebral venous sinus thrombosis and common childhood illness. 36th Annual Meeting of the Child Neurology Society, 2008, Santa Clara, CA.

WEB PUBLICATION

1. Chan A, David M, Massicotte P. Warfarin therapy in children. (http://www.tigc.org/clinical-guides/Warfarin-in-Children.aspx), 2009.

2. Massicotte P, David M, Chan A. Thrombolytic therapy in children.

Dr. Anthony Chan

(http://www.tigc.org/clinical-guides/Thrombolytic-Therapy-in-Children.aspx), 2009. 3. Chan A, David M, Massicotte P. Heparin and LMWH in children.

(http://www.tigc.org/clinical-guides/Heparin-and-LMWH-in-Children.aspx), 2009. 4. Chan AKC, Chan HHW, Berry LR. Chapter 24 - Vitamin K. In: Mechanisms in

Hematology. Israels S (Ed), Concord, ON, Canada, 2010. (http://www.mechanismsinhematology.ca/contents.aspx)

5. Chan AKC, Chan HHW, Berry LR. Chapter 25 - Fibrinogen, Factor XIII and

Fibrinolysis. In: Mechanisms in Hematology. Israels S (Ed), Concord, ON, Canada, 2010. (http://www.mechanismsinhematology.ca/contents.aspx)

ABSTRACTS: ORAL PRESENTATION

1. Chan AKC, Coppes M, Adams M, Andrew M, Directors of Canadian Children's Thrombophilia Program. Right atrial thrombosis in pediatric patients: Analysis of the Canadian Registry of venous thromboembolic complications. Joint Meeting of the American Pediatric Societies and the Society for Pediatric Research, 1996, Washington, DC (Pediatric Research 39(4):907a, 1996).

2. Chan AKC, Berry L, Mitchell L, Andrew M, Klement P. Evaluation of antithrombin-

heparin covalent complex coated endoluminal grafts in rabbits. Society for Biomaterials 25th Annual Meeting, 1999, Providence, RI.

3. Gruenwald C, DeSouza V, Chan A, Andrew M. Whole blood heparin concentrations

do not correlate with plasma anti-factor Xa heparin concentrations in pediatric patients undergoing cardiopulmonary bypass. The American Academy of Cardiovascular Perfusion Annual Meeting, 1999, San Antonio, TX.

4. Chan AKC, Berry L, Andrew M, Klement P. Antithrombin-heparin covalent

complex: A novel approach for improving thromboresistance of cardiovascular devices. The 6th World Biomaterials Congress, 2000, Kamuela, Hawaii. (Accepted but withdrew for family reasons).

5. Monagle P, Cheung A, Chan A, Dinyari M, Charpentier K, Massicotte MP. Decreased

bone density in children on long-term warfarin therapy: A cross-sectional study. Joint Meeting of the American Pediatric Society and the Society for Pediatric Research Annual Meeting, 2000, Boston, MA. (Pediatric Research 47(4):251a, 2000).

6. Lanthier S, Lindsay, Mitchell L, Male C, Domi T, Chan AKC, deVeber G.

Anticardiolipin antibodies are associated with cardioembolic stroke but do not predict recurrent cerebral ischemia in children. American Academy of Neurology 53rd Annual Meeting, 2001, Philadelphia, PA. (Neurology 56:(8 Supplement 3), A11, 2001).

7. Marzinotto V, Choi M, Massicotte P, Chan AKC, Andrew M. Post-thrombotic

Dr. Anthony Chan

syndrome in children with previous deep vein thrombosis. XVIII Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2001, Paris, France.

8. Adams M, Chan AKC, Massicotte P, deVeber G, Dunn C, Andrew M. A quaternary

care solution to a new tertiary care disease: Childhood thrombophilia. XVIII Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2001, Paris, France.

9. Cheung AM, Halton J, Dinyari M, Chan A, Shaughnessy S, Webber C, Massicotte P.

Bone mineral density (BMD) in a cohort of children on long term warfarin therapy (>1 year). XVIII Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2001, Paris, France.

10. Chan AKC, Du YL, Berry LR, Tressel P, Vlasin M, Benetka M, Miszczak P, Klement

P. Evaluation of covalent antithrombin-heparin complex coated polyurethane central venous catheters in acute and chronic rabbit models. Society for Biomaterials 28th Annual Meeting, 2002, Tampa, FL.

11. Sharathkumar A, Revel-Vilk S, Chan AKC, Marzinotto V, Andrew M, Massicotte P.

Outcome of children with thromboembolic events treated with low molecular weight heparin. Pediatric Academic Societies’ Annual Meeting, 2002, Baltimore, MD. (Pediatric Research 51 (4): 231A-232A, #1348 Part 2 Supplement S, 2002).

12. Hung R, Chan AKC, deVeber G. Aspirin therapy for the prevention of recurrent

cerebral thrombo-embolic events in children: A prospective cohort. Canadian Congress of Neurological Sciences Meeting, 2002, Vancouver, BC.

13. deVeber G, Shroff M, Atre A, Chan AKC, Adams M, Sofronas M. Recanalization of

neonatal cerebral sinovenous thrombosis: A follow-up study. Pediatric Academic Societies’ Annual Meeting, 2003, Seattle, WA. (Pediatric Research 53 (4 Supplement, Part 2): 537A, #3039, 2003).

14. deVeber G, MacGregor D, Curtis R, Friefeld S, Anderson P, Chan A, Meaney B, Domi

T. Neurological outcome in survivors of neonatal arterial ischemic stroke. Pediatric Academic Societies’ Annual Meeting, 2003, Seattle, WA. (Pediatric Research 53 (4 Supplement, Part 2): 537A, #3037, 2003).

15. Chan AK, deVeber G, Monagle P, Brooker LA, Massicotte PM. Venous thrombosis in

children. (Symposium). XIX Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2003, Birmingham, England.

16. Kuhle S, Massicotte MP, Andrew M, Chan AKC, Mitchell L. A case series of 72

neonates with renal vein thrombosis: Data from 1-800-NO-CLOTS registry. XIX Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2003, Birmingham, England.

17. Williams S, Chait P, Temple M, Connolly B, Chan AK, Bauman M, Ashe M,

Massicotte MP. Vena cava filters in children: Review of a single centre clinical

Dr. Anthony Chan

experience over 7 years. XIX Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2003, Birmingham, England.

18. Massicotte P, Andrew M, Dinyari M, Marzinotto V, Vegh P, Lau A, Mitchell L, Kuhle

S, Chan A. Ex vivo thrombin generation capacity in pediatric patients receiving Tinzaparin. XIX Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2003, Birmingham, England.

19. Kirkham FJ, deVeber G, Chan AK, Straeter R, Ganesan V, Prengler M, Nowak-Gottl U.

Recurrent stroke: The role of prothrombotic disorders. 32nd Annual Meeting of the Child Neurology Society, 2003, Miami Beach, FL. (Annals of Neurology 54 (Supplement 7): S110, 2003).

20. Chan AKC. Thrombosis in paediatric cancer patients. (Symposium). XX Congress

of the International Society on Thrombosis and Haemostasis (ISTH), 2005, Sydney, Australia.

21. Chan AKC, Black L, Ing C, Williams S, Brandao L, Walter K, Abdelhaleem M. Utility

of aPTT in monitoring unfractionated heparin in children. XX Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2005, Sydney, Australia.

22. Chan AKC, Berry LR, Thong B. Analysis of plasma proteins bound to catheter

surfaces. XX Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2005, Sydney, Australia.

23. Monagle P, Ignjatovic V, Newall F, Furmedge J, Gan A, Summerhayes R, DeRosa L,

Shann, F, Butt, W, Chan AKC. Developmental haemostasis and response to heparin therapy in children. XX Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2005, Sydney, Australia.

24. Kirkham F, deVeber G, Chan AKC, Sträter R, Ganesan V, Prengler M, Nowak-Göttl U.

Recurrent stroke: The role of prothrombotic disorder. XX Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2005, Sydney, Australia.

25. Schechter T, Finkelstein Y, Williams S, Chan AK, Ali M, Brandao LR. Dosing and

safety of unfractionated heparin in infants with thrombotic complications. Pediatric Academic Societies’ Annual Meeting, 2007, Toronto, ON.

26. Parmar N, Berry LR, Post M, Chan AKC. Impact of covalent antithrombin-heparin

on vascularization in the developing lung. Pediatric Academic Societies’ Annual Meeting, 2007, Toronto, ON.

27. Athale U, Lathia A, Cox S, Khan A, Pai N, Armstrong A, Odame I, Chan AKC.

Epidemiology of thromboembolism (TE) in children with cancer. XXI Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2007, Geneva, Switzerland.

28. Price V, Chan AKC. Management of venous and arterial thrombosis in children.

Dr. Anthony Chan

(Symposium). XXI Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2007, Geneva, Switzerland.

29. Gupta A, Seroski W, Wiernikowski J, Chan AKC. The use of low molecular weight

heparins in pediatrics: Cases that highlight potential risks to patient safety. Hamilton Health Sciences’ 4th Annual Patient Safety Symposium, 2007, Hamilton, ON.

30. Mullah-Ali A, Chan A, Lillicrap D, Decker K, Seroski W, Moffat k, Walker I, Pai M.

Undetected factor VIII level in a type 3 von Willebrand disease patient masquerading as severe hemophilia A. Association of Hemophilia Centre Directors of Canada (AHCDC) Scientific & Educational Meeting, 2008, Saskatoon, SK.

31. Almonte T, Decker K, Seroski W, Chan A, Walker I, Webert K. Launch of toll free

telephone line. XXVIIIth International Congress of the World Federation of Hemophilia, 2008, Istanbul, Turkey. (Haemophilia 14 (Supplement 2): 132).

32. Gruenwald C, Manlhiot C, Chan AK, Crawford-Lean L, Forman C, Holtby H, Van

Arsdell G, Richards, R, Moriarty H, McCrindle BW. Response to heparin in infants undergoing cardiopulmonary bypass is associated with preoperative antithrombin level: Implications of unbound heparin for clinical outcomes. Canadian Cardiovascular Congress (CCC), 2008, Toronto, ON.


Arsdell G, Richards, R, Moriarty H, McCrindle BW. Individualized heparin and protamine management protocol in infants undergoing cardiopulmonary bypass for cardiac surgery should consider the immaturity of the coagulation system. Canadian Cardiovascular Congress (CCC), 2008, Toronto, ON.


Arsdell G, Richards R, Moriarty H, McCrindle BW. Individualized heparin and protamine management protocol in infants undergoing cardiopulmonary bypass for cardiac surgery improves immediate post-operative clinical outcomes. American Heart Association Scientific Session, 2008, New Orleans, LA.

35. Mewhort-Buist TA, Berry LR, Chan AKC. Selective detection of free plasmin using

a chromogenic substrate bound to agarose beads. XXII Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2009, Boston, MA.

36. Bungay SD, Chan AK. Modelling thrombin generation in developmental

hemostasis. XXII Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2009, Boston, MA.

37. Sinclair GD, Blanchette V, Card RT, Chan AKC, Israels S, Lillicrap D, Rivard G,

Robinson S, Vickars L, Williams Z, Wu JKM, Poon MC. Does heterogeneity in measured calibrated thrombin generation assay or FVIII activity (<1%) explain clinical heterogeneity in severe hemophilia A? XXII Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2009, Boston, MA.

Dr. Anthony Chan

38. Stevic I, Berry LR, Chan A. Investigation into mechanisms of prothrombinase complex inhibition by a covalent antithrombin-heparin complex. 51st Annual Meeting of American Society of Hematology, 2009, New Orleans, LA. (Blood [ASH Annual Meeting Abstracts] 114(22):Abstract 2136; Winner of the 2009 TIGC Bayer Thrombosis Research Award).

39. Berry LR, Chan AKC. Developmental variation in glycosylation of anticoagulant

protein C. Pediatric Academic Societies’ Annual Meeting, 2010, Vancouver, BC. 40. Sask KN, Berry LR, Chan AKC, Brash JL. Influence of polyethylene oxide spacer on

anticoagulant properties of immobilized antithrombin-heparin complex. 28th Canadian Biomaterials Society Meeting, 2010, Kingston, ON. (Winner of the 2010 CBS Student Travel Award)

41. Chan A. Evaluation of neonatal hemostasis. XXIX International Congress of the

World Federation of Hemophilia (WFH), 2010, Buenos Aires, Argentina. (Haemophilia 16(Supplement 4):1-158; Abstract 05S01)

42. Sask KN, Berry LR, Chan AKC, Brash JL. Polyurethane modified with an

antithrombin-heparin complex (ATH) via PEO: Effect of PEO end group on ATH immobilization and subsequent protein interactions. Society for Biomaterials 2011 Annual Meeting & Exposition, 2011, Orlando, FL.

43. Bos C, Wright M, Chan A, Almonte T, Decker K, Goldsmith R, Strike K, Walker I,

Waterhouse L, Webert K. Measuring balance in individuals with hemophilia using the Community and Mobility Scale: A pilot study. World Federation of Hemophilia (WFH) Musculoskeletal Congress, 2011, Dubai, UAE.

44. Traore AN, Chan AKC, Webert KE, Heddle N, Ritchie B, St.-Louis J, Walker I. First

analysis of 10-year trend in national factor concentrates usage in Hemophilia: Data from the Canadian Hemophilia Assessment and Resource Management System. XXIII Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2011, Kyoto, Japan.

45. Brandao LR, Manlhiot C, Kwok J, Kegel S, Menjak IB, Carew CL, Chan AK,

Calderone CA, Van Arsdell GS, McCrindle BW. Thrombotic complications and thromboprophylaxis in single ventricle heart palliation in children. XXIII Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2011, Kyoto, Japan.

46. Stevic I, Berry LR, Chan AKC. Mechanism of inhibition of the prothrombinase

complex by a covalent antithrombin-heparin conjugate. XXIII Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2011, Kyoto, Japan. (Journal of Thrombosis and Haemostasis, 9(Suppl 2):277, 2011)

47. Nowak-Gottl U, Kenet G, Bonduel M, Chan A, Goldenberg NA, Holzhauer S, Iorio A,

Journeycake J, Junker R, Male C, Massicotte P, Monagle P, Van Ommen HC, Raffini L, Simioni P, Young G. Impact of persistent antiphospholipid antibodies on

Dr. Anthony Chan

symptomatic thromboembolism in children: A systematic review & meta-analysis (observational studies). XXIII Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2011, Kyoto, Japan.

48. Manlhiot C, Brandão LR, Williams S, Chan AK, Menjak IB, McCrindle BW.

Definition, characterization, and clinical sequelae of post-thrombotic syndrome in children with congenital heart disease. Canadian Cardiovascular Congress (CCC), 2011, Vancouver, BC.

49. Manlhiot C, Brandão LR, McMullen JA, Chan AK, Williams S, Sivarajan VB,

Schwartz SM, McCrindle BW. Thrombus persistence and embolization after paediatric cardiac surgery. Canadian Cardiovascular Congress (CCC), 2011, Vancouver, BC.

50. Stevic I, Chan HWW, Berry LR, Chan AKC. Inhibition of red blood cell-

prothrombinase by heparin and a covalent antithrombin-heparin complex. 53rd Annual Meeting of American Society of Hematology (ASH), 2011, San Diego, CA. (Blood [ASH Annual Meeting Abstracts] 118:Abstract 1179)

51. Chan AKC, Berry LR. Application of a novel heparinoid to prevent surface-induced thrombosis. Canadian Cardiovascular Congress (CCC), 2012, Toronto, ON.

ABSTRACTS: POSTER

1. Berry L, Chan AKC, Andrew M. A novel antithrombin-heparin covalent complex with high specific anti-factor Xa and antithrombin activities. XVI Congress of the International Society of Thrombosis and Haemostasis (ISTH), 1997, Florence, Italy. (Thrombosis and Haemostasis (Supplement): 299, PS-1223 1997).

2. Chan AKC, Berry L, Klement P, Weitz J, Hirsh J, Andrew M. A novel antithrombin-

heparin covalent complex: Efficacy and safety in rabbits. XVI Congress of the International Society of Thrombosis and Haemostasis (ISTH), 1997, Florence, Italy. (Thrombosis and Haemostasis (Supplement): 689, PS-2812, 1997).

3. Andrew M, Massicotte P, deVeber G, Leaker M, David M, Brown A, Adams M, Chan

A. 1-800-NO-CLOTS: A quaternary care solution to a new tertiary care disease: Childhood thrombophilia. XVI Congress of the International Society of Thrombosis and Haemostasis (ISTH), 1997, Florence, Italy. (Thrombosis and Haemostasis (Supplement): 727, PS-2964, 1997).

4. Berry L, Stafford A, Fredenburgh J, O’Brodovich H, Mitchell L, Weitz J, Andrew M,

Chan AKC. Investigation of the anticoagulant mechanisms of a covalent antithrombin-heparin complex. 40th Annual Meeting of the American Society of Hematology, 1998, Miami Beach, FL. (Blood 92(10, Supp1ement 1, Part 1):358, #1475, 1998).

5. Monagle P, Berry L, O’Brodovich H, Andrew M, Chan AKC. Covalent heparin

Dr. Anthony Chan

cofactor II-heparin and heparin cofactor II-dermatan sulfate complexes: Characterization of novel anticoagulants. 40th Annual Meeting of the American Society of Hematology, 1998, Miami Beach, FL. (Blood 92(10, Supp1ement 1, Part 1):358, #1476, 1998).

6. Streif W, Paes B, Berry L, Xu L, Andrew M, Chan AKC. Influence of factor VIIa

concentrates on thrombin generation in full term and preterm neonates. XVII Congress of the International Society of Thrombosis and Haemostasis (ISTH), 1999, Washington, DC. (Thrombosis and Haemostasis (Supplement):759-760, #2400, 1999).

7. Xu L, Berry L, Chan AKC. Effect of chemotherapeutic agents on the regulation of

thrombin by endothelial cells. XVII Congress of the International Society of Thrombosis and Haemostasis (ISTH), 1999, Washington, DC. (Thrombosis and Haemostasis (Supplement):811, #2566, 1999).

8. Chan AKC, Berry L, Baranowski B, Shah B, Andrew M. Comparison of inhibition of

thrombin generation in newborn, child or adult plasmas by different heparinoids. XVII Congress of the International Society of Thrombosis and Haemostasis (ISTH), 1999, Washington, DC. (Thrombosis and Haemostasis (Supplement):451, #1426, 1999).

9. Berry L, Crowther M, Pawlowski E, Chan AKC. Incomplete neutralization of low

molecular weight heparin by protamine results from decreased binding affinity. XVII Congress of the International Society of Thrombosis and Haemostasis (ISTH), 1999, Washington, DC. (Thrombosis and Haemostasis (Supplement):451, #1427, 1999).

10. Wiernikowski J, Crowther M, Andrew M, Clase C, Ingram A, Chan AKC. Stability

and sterility of recombinant tissue plasminogen activator under –30oC. 41st Annual Meeting of the American Society of Hematology, 1999, New Orleans, LA. (Blood 94 (10, Supplement 1, Part 1): 24 , #94, 1999).

11. Albisetti M, Chan AKC, Wong D, Vegh P, Adams M, McCrindle B, Monagle P,

Andrew M. Fibrinolytic response to venous occlusion is reduced in children with Kawasaki disease or hyperlipidemia. 41st Annual Meeting of the American Society of Hematology, 1999, New Orleans, LA. (Blood 94 (10, Supplement 1, Part 1):235, #1039, 1999).

12. Massicotte MP, Marzinotto V, Julian J, Gent M, Shields K, Szechtman B, Chan AKC,

Andrew M. Dose finding and pharmacokinetics of prophylactic doses of a low molecular weight heparin (Reviparin) in pediatric patients. 41st Annual Meeting of the American Society of Hematology, 1999, New Orleans, LA. (Blood 94 (10 Supplement 1, Part 1):27A, #105, 1999).

13. Choi M, Massicotte MP, Marzinotto V, Chan AKC, Andrew M. Use of tissue

plasminogen activator to clear blocked central venous lines in pediatric patients: A prospective cohort study. 41st Annual Meeting of the American Society of Hematology, 1999, New Orleans, LA. (Blood 94 (10, Supplement 1, Part 1):25, #96, 1999).

Dr. Anthony Chan

14. Cornelius RM, Berry L, Chan AKC, Archambault JG, Brash JL. Comparison of the

response of neonate and adult plasma to biomaterial surfaces. The 6th World Biomaterials Congress, 2000, Kamuela, Hawaii.

15. Chan AKC, Berry L, Pawlowski E, Crowther M. Incomplete neutralization of low

molecular weight heparin by protamine is due to decreased binding affinity. Joint Meeting of the Pediatric Academic Societies and the American Academy of Pediatrics, 2000, Boston, MA. (Pediatric Research 47 (4 Supplement, Part 2):248A-248A, #1460, 2000).

16. Albisetti M, Chan AKC, Vegh PA, Adams M, McCrindle B, Monagle P, Andrew M.

Fibrinolytic response to venous occlusion is reduced in children with Kawasaki disease or hyperlipidemia. Joint Meeting of the Pediatric Academic Societies and the American Academy of Pediatrics, 2000, Boston, MA.

17. Chan AKC, Crowther MA, deVeber G. Factor V Leiden and arterial ischemic stroke

in children: A meta-analysis. 42nd Annual Meeting of the American Society of Hematology, 2000, San Francisco, CA. (Blood 96 (11, Supplement 1, Part 1):645a, #2772, 2000).

18. Crowther M, Berry M, Powers J, Chan AKC. Sulfate density of the low molecular

weight heparins determine their protamine neutralizability. 42nd Annual Meeting of the American Society of Hematology, 2000, San Francisco, CA. Blood 96 (11, Supplement 1, Part 1):649a-649a, #2790, 2000).

19. Lanthier S, Lindsay S, Mitchell L, Male C, Domi T, Chan AKC, deVeber G. IgG

anticardiolipin antibodies are associated with cardioembolic stroke but do not predict recurrent cerebral ischemia in children. European Stroke Conference, 2001, Lisbon, Portugal. (Cerebrovascular Disease 11(Supplement 4):99, 2001).

20. Chan AKC, Du YJ, Berry L, Tressel P, Klement P. Evaluation of antithrombin-

heparin covalent complex coated polyurethane central venous catheter. Society for Biomaterials 27th Annual Meeting, 2001, St. Paul, MN.

21. Dinyari PM, Marzinotto V, Chan AKC, Vegh P, Massicotte P, Andrew M. Evaluation

of the AvosureTM INR (PROTHROMBIN TIME) system in the pediatric population. XVIII Congress of the International Society of Thrombosis and Haemostasis (ISTH), 2001, Paris, France.

22. Chan AKC, Du YJ, Berry LR, Tressel P, Vlasin M, Benetka M, Miszczak P, Klement P.

Covalent antithrombin-heparin complex coated catheter prevents thrombosis in a rabbit central venous catheter model. XVIII Congress of the International Society of Thrombosis and Haemostasis (ISTH), 2001, Paris, France.

23. Berry LR, Andrew M, O’Brodovich H, Chan AKC. Effect of covalent serpin-

heparinoid complexes on plasma thrombin generation on fetal lung epithelium. XVIII Congress of the International Society of Thrombosis and Haemostasis (ISTH),

Dr. Anthony Chan

2001, Paris, France. 24. Anton N, Chait P, Chan A, Marzinotto V, Massicotte P. Vena caval filters in children:

Preliminary safety and efficacy data. XVIII Congress of the International Society of Thrombosis and Haemostasis (ISTH), 2001, Paris, France.

25. Halton J, Dinyari M, Chan A, Shaughnessy S, Webber C, Massicotte P. Bone mineral

density in children with congenital heart disease requiring the Fontan procedure. XVIII Congress of the International Society of Thrombosis and Haemostasis (ISTH), 2001, Paris, France.

26. Paredes N, Berry L, Chan AKC. Mechanisms responsible for catalysis of the

inhibition of factor Xa or thrombin by antithrombin using a covalent antithrombin-heparin complex. XVIII Congress of the International Society of Thrombosis and Haemostasis (ISTH), 2001, Paris, France.

27. Paredes N, Berry LR, Chan AKC. Increased requirement for heparin in children is

due to increased non-specific protein binding. XVIII Congress of the International Society of Thrombosis and Haemostasis (ISTH), 2001, Paris, France.

28. Marzinotto V, Choi M, Massicotte P, Chan AKC, Andrew M. Post-thrombotic

syndrome in children with previous deep vein thrombosis. XVIII Congress of the International Society of Thrombosis and Haemostasis (ISTH), 2001, Paris, France.

29. Adams M, Chan AKC, Massicotte P, deVeber G, Dunn C, Andrew M. 1-800-NO-

CLOTS: A quaternary care solution to a new tertiary care disease: Childhood thrombophilia. XVIII Congress of the International Society of Thrombosis and Haemostasis (ISTH), 2001, Paris, France.

30. McCrindle BW, Albisetti M, Chan AKC, Wong D, Vegh P, Adams M, Dinyari M,

Monagle P, Andrew M. Impairment of the fibrinolytic system is present and is a marker for endothelial dysfunction in adolescents after Kawasaki disease. 7th International Kawasaki Disease Symposium, 2001, Hakone, Japan. (Pediatric Research 53(1):185-185, 163, 2003).

31. Chan AKC, Rak J, Berry LR, Liao P, Vlasin M, Weitz JI, Klement P. Covalent

antithrombin-heparin complex (ATH): An alternative to heparin for arterial thrombosis prevention. 43rd Annual Meeting of the American Society of Hematology, 2001, Orlando, FL.

32. Revel-Vilk S, Chan AKC, Knapp C, Koloshuk B, Carosons R, Massicotte P. Incidence

of congenital prothrombotic disorders in children with venous thrombo-embolic disease: A prospective cohort study. 43rd Annual Meeting of the American Society of Hematology, 2001, Orlando, FL.

33. Anton N, Chait P, Chan A, Marzinotto V, Massicotte P. Vena caval filters in children:

Preliminary safety and efficacy data. Pediatric Academic Societies’ Annual Meeting, 2001, Baltimore, MD.

Dr. Anthony Chan

34. Du YL, Brash JL, McClung G, Klement P, Berry LR, Tressel P, Cornelius R, Chan

AKC. Antithrombin adsorption onto polyurethane central venous catheter surfaces modified with antithrombin-heparin covalent complex: In vitro and rabbit model studies using radiolabelling and immunoblotting. Society for Biomaterials 28th Annual Meeting, 2002, Tampa, FL.

35. Hung R, Chan AKC, deVeber G. Aspirin therapy for prevention of recurrent

cerebral thromboembolic events in children: A prospective cohort study. 31st Annual Meeting of the Child Neurology Society, 2002, Washington, DC. (Annals of Neurology 52(3):S123-S124, Supplement 1, 2002).

36. Ng W, Chan AKC, Massicotte P, Curtis R, MacGregor D, Sofronas M, Domi T, Hung

R, deVeber G. Safety and feasibility of warfarin in pediatric patients with arterial ischemic stroke: A consecutive cohort study. 31st Annual Meeting of the Child Neurology Society, 2002, Washington, DC. (Annals of Neurology 52(3): S131-S131, Supplement 1, 2002).

37. Ng W, Chan AKC, Curtis R, MacGregor D, Massicotte P, Sofronas M, Domi T,

deVeber G. Safety of low molecular weight heparin at treatment doses in children with arterial ischemic stroke: A consecutive cohort study. 31st Annual Meeting of the Child Neurology Society, 2002, Washington, DC. (Annals of Neurology 52(3):S132 Supplement 1, 2002).

38. Walker I, Almonte T, Chan A, Heddle N, Sek J, Carruthers J, Pai M, Stiles C, Thibault

A. Managing a regional concentrate tracking system with CHARMSTM. XXV International Congress of the World Federation of Hemophilia (WFH), 2002, Seville, Spain.

39. Thomas SS, Lanthier S, Clark D, Chan AKC, Rand M, deVeber G. Efficacy of aspirin

treatment in pediatric stroke patients as measured with the PFA-100. 44th Annual Meeting of the American Society of Hematology, 2002, Philadelphia, PA. (Blood 100 (11, Supplement 1, Part 1):279a-280a, #1071, 2002).

40. Chan AKC, Berry LR. Control of plasma thrombin generation on fetal distal lung

epithelium by covalent serpin-heparinoid complexes. 44th Annual Meeting of the American Society of Hematology, 2002, Philadelphia, PA. (Blood 100(11, Supplement 1, Part 1): 499a, #1945, 2002).

41. Revel-Vilk S, Sheratkumar A, Massicotte P, Marzinotto V, Denman A, Dix D, Chan

AKC. Natural history of arterial and venous thrombosis in children treated with low molecular weight heparin: A longitudinal study by Doppler ultrasound. 44th Annual Meeting of the American Society of Hematology, 2002, Philadelphia, PA. (Blood 100(11, Supplement 1, Part 1): 278a, #1065, 2002).

42. Parvez B, Parmar N, Chan AKC. Trimming of peripherally inserted central venous

catheters may increase the risk of thrombosis. Pediatric Academic Societies’ Annual Meeting, 2003, Seattle, WA. (Pediatric Research 53 (4 Part 2):454A-455A, #2569,

Dr. Anthony Chan

2003). 43. Bauman M, Mitchell L, Chan A, deVeber G, Massicotte MP. Very low dose warfarin

for primary and secondary prophylaxis in children: A prospective cohort study of 20 children. Pediatric Academic Societies’ Annual Meeting, 2003, Seattle, WA.

44. Bauman M, Chan A, Mitchell L, deVeber G, Massicotte MP. Reversal of warfarin or

low molecular weight heparin (LMWH) using subcutaneous unfractionated heparin (UFH) in pediatric outpatients with an ongoing high risk for thrombosis and requiring invasive procedures: A prospective cohort study of 146 children. Pediatric Academic Societies’ Annual Meeting, 2003, Seattle, WA.

45. Kuhle S, Massicotte P, Andrew M, Chan A, Dinyari M, Marzzinitto V, Vegh P,

Mitchell M. Ex-vivo endogenous thrombin generation capacity in pediatric patients receiving tinzaparin. Pediatric Academic Societies’ Annual Meeting, 2003, Seattle, WA.

46. Chan AKC, Berry L, Klement P, Cornelius RM, Brash JL. A novel antithrombin-

heparin covalent complex for modification of intravascular catheters: Comparison of protein interactions on the inside and outside surfaces in a rabbit model. Society for Biomaterials 29th Annual Meeting, 2003, Reno, NV.

47. Berry LR, Patel S, Chan AKC. Activated protein C generation is greatly decreased

in plasma from newborns compared to adults in the presence or absence of endothelium. XIX Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2003, Birmingham, England. (Journal of Thrombosis and Haemostasis 1 [Supplement 1]:Abstract P0005, 2003).

48. Parmar N, Mitchell LG, Berry LR, Chan AKC. The effect of age on plasmin

generation in the presence of fibrin monomer on endothelium. XIX Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2003, Birmingham, England. (Journal of Thrombosis and Haemostasis 1 [Supplement 1]:Abstract P1833, 2003).

49. Parmar N, Berry LR, Chan AKC. Isoform composition of antithrombin (-AT vs. -

AT) in a covalent antithrombin-heparin complex. XIX Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2003, Birmingham, England. (Journal of Thrombosis and Haemostasis 1 [Supplement 1]:Abstract P1565, 2003).

50. Parmar N, Paredes N, Berry LR, Kim E, Chan AKC. Binding of heparin to alkaline

earth and transition metals. XIX Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2003, Birmingham, England. (Journal of Thrombosis and Haemostasis 1 [Supplement 1]:Abstract P1105, 2003).

51. Parmar N, Berry LR, Chan AKC. Effect of heparin on thrombin generation in factor

VIII depleted plasma supplemented with FEIBA or FVIII. XIX Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2003, Birmingham, England. (Journal of Thrombosis and Haemostasis 1 [Supplement 1]:Abstract P1630,

Dr. Anthony Chan

2003). 52. Paredes N, Berry LR, Paes B, Chan AKC. Effect of protein binding on the anti-FXa

activity of different heparinoids in either adult or newborn plasma. XIX Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2003, Birmingham, England. (Journal of Thrombosis and Haemostasis 1 [Supplement 1]:Abstract P2031, 2003).

53. Paredes N, Berry LR, Thong B, Chindemi P, Chan AKC. Binding of covalent

antithrombin-heparin complex to endothelial cells. XIX Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2003, Birmingham, England. (Journal of Thrombosis and Haemostasis 1 [Supplement 1]:Abstract P0143, 2003).

54. Bauman M, Chan AK, Mitchell L, deVeber G, Massicotte P. Reversal of warfarin or

low molecular weight heparin (LMWH) using subcutaneous unfractionated heparin (UFH) in paediatric outpatients with an ongoing high risk for thrombosis and requiring invasive procedures: A prospective cohort study of 146 children. XIX Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2003, Birmingham, England. (Journal of Thrombosis and Haemostasis 1 [Supplement 1]:Abstract P0048, 2003).

55. Bauman M, Mitchell L, Chan AK, deVeber G, Massicotte P. Very low dose warfarin

for primary and secondary prophylaxis in children: A prospective cohort study of 20 children. XIX Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2003, Birmingham, England. (Journal of Thrombosis and Haemostasis 1 [Supplement 1]:Abstract P0063, 2003).

56. Bauman M, Chan AK, Mitchell L, Massicotte P. Reversal of low molecular weight

heparin (LMWH) prior to invasive procedures using subcutaneous unfractionated heparin in children with ongoing high risk for thrombosis. XIX Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2003, Birmingham, England. (Journal of Thrombosis and Haemostasis 1 [Supplement 1]:Abstract P0067, 2003).

57. Revel-Vilk S, Sharathkumar A, Chan AKC, Marzinotto V, Massicotte P. Use of low

molecular weight heparin in children with thrombo-embolic events: Predictors for bleeding and recurrence on therapy. XIX Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2003, Birmingham, England. (Journal of Thrombosis and Haemostasis 1 [Supplement 1]:Abstract P0044, 2003).

58. deVeber G, Chan AK, Shroff M, MacGregor DL, Massicotte MP, Curtis RM, Adams M.

Low molecular weight heparin therapy in neonatal cerebral sinovenous thrombosis: A consecutive cohort study. XIX Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2003, Birmingham, England. (Journal of Thrombosis and Haemostasis 1 [Supplement 1]:Abstract P1890, 2003).

59. deVeber G, Chan AK, Sofronas M, The Canadian Pediatric Ischemic Stroke Study

Dr. Anthony Chan

Group. Predictors of recurrent thrombo-embolic events in 153 infants and children with cerebral sinovenous thrombosis: A national population based study. XIX Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2003, Birmingham, England. (Journal of Thrombosis and Haemostasis 1 [Supplement 1]:Abstract P1376, 2003).

60. Kuhle S, Massicotte MP, Dinyari M, Marzinotto V, Mitchell D, Pieniaszek H, Andrew

M, Chan AKC, Vegh P, Mitchell L. A pharmacokinetic study of Tinzaparin in pediatric patients. XIX Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2003, Birmingham, England. (Journal of Thrombosis and Haemostasis 1 [Supplement 1]:Abstract P1886, 2003).

61. Kuhle S, Massicotte MP, Dinyari M, Andrew M, Chan AKC, Mitchell D, Vegh P,

Mitchell L. A dose-finding study of Tinzaparin in pediatric patients. XIX Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2003, Birmingham, England. (Journal of Thrombosis and Haemostasis 1 [Supplement 1]:Abstract P1887, 2003).

62. Athale UH, Mah D, Davidson A, Nagel K, Odame I, Chan AKC. Thromboembolism

(TE) in children with acute lymphoblastic leukemia (ALL) treated on Dana Farber Cancer Institute (DFCI) protocols: Effect of age and risk stratification of ALL. 35th Annual Meeting of the International Society of Paediatric Oncology (SIOP), 2003, Cairo, Egypt.

63. Domi T, MacGregor D, Curtis R, Friefeld S, Anderson P, Chan AKC, Meaney B,

deVeber G. Neurological outcome in survivors of neonatal arterial ischemic stroke and cerebral sinovenous thrombosis: A prospective longitudinal study. 32nd Annual Meeting of the Child Neurology Society, 2003, Miami Beach, FL. (Annals Of Neurology 54(Supplement 7): S138, 2003).

64. Chan AKC, Tressel P, Weitz J, Hirsh J, Liao P, Klement P. Novel antithrombotic drug

reduces arterial Doppler high intensity transient signals during and after hypothermic cardiopulmonary bypass in pigs. 76th Annual Scientific Session of the American Heart Association, 2003, Orlando, FL. (Circulation 108(17):433-433, #1996, Supplement, 2003).

65. Parvez B, Parmar N, Chan AKC. Heparin for prevention of central line thrombosis:

How much and how? Pediatric Academic Societies’ Annual Meeting, 2004, San Francisco, CA.

66. Hune S, Rafay M, Domi T, Chan A, Allen A, deVeber G. Plavix (clopidogrel) in

pediatric stroke: Monitoring of side effects and parent education strategies. 29th International Stroke Conference, 2004, San Diego, CA. (Stroke 35(1):284, 2004).

67. Domi T, Thomas SS, Rand ML, Chan AK, Lanthier S, Clarke D, deVeber G. A study

of platelet response to aspirin in children with arterial ischemic stroke utilizing the PFA-100 analyzer. 29th International Stroke Conference, 2004, San Diego, CA. (Stroke 35(1):308, 2004).

Dr. Anthony Chan

68. Rafey M, Armstrong D, deVeber G, Chan AK, MacGregor D. Long term outcome of

angiographic abnormalities in children with cranio-cervical arterial dissection. 5th World Stroke Congress, 2004, Vancouver, BC. (Stroke 35(6):E277, 2004).

69. deVeber G, Sofronas M, Chan AK, the Canadian Pediatric Stroke Study Group.

Predictors of recurrent thrombo-embolic events in 174 infants and children with cerebral sinovenous thrombosis: Results from the Canadian Registry. 5th World Stroke Congress, 2004, Vancouver, BC. (Stroke 35(6):E234, 2004.

70. Athale UH, Siciliano SA, Barr RD, Chan AK. Thromboembolism in children with

acute lymphoblastic leukemia (ALL) treated on Dana Farber Cancer Institute (DFCI) protocols: effect of dose and type (prednisone versus dexamethasone) of steroids used. Annual Meeting of the America Society of Clinical Oncology, 2004, New Orleans, LO.

71. Kuhle S, Mitchell L, Massicotte P, Adams M, Andrew M, Chan AKC, deVeber G.

Pediatric ischemic stroke: Data on over 1000 children with stroke from the 1-800-NO-CLOTS consultation service. 33rd Annual Meeting of the Child Neurology Society, 2004, Ottawa, ON.

72. Crowther M, Klement P, Liao P, Chen F, Berry Leslie, Chan AKC. Significant

differences in neutralization of heparin and its low molecular fragments by protamine sulfate: An in vivo study. 46th Annual Meeting of American Society of Hematology, 2004, San Diego, CA. (Blood [ASH Annual Meeting Abstracts] 104:Abstract 1850).

73. Smith LJ, Berry LR, Chan AKC. Reaction of fibrin-bound thrombin with a covalent

antithrombin-heparin complex results in an anticoagulant surface. 46th Annual Meeting of American Society of Hematology, 2004, San Diego, CA. (Blood [ASH Annual Meeting Abstracts] 104:Abstract 1848).

74. Mewhort TA, Berry LR, Chan AKC. Effect of covalently-bound heparin on insertion

of the reactive centre loop in antithrombin. 46th Annual Meeting of American Society of Hematology, 2004, San Diego, CA. (Blood [ASH Annual Meeting Abstracts] 104:Abstract 1783).

75. Kentner TA, Berry LR, Chan AKC. Inhibition of factor–Xa in prothrombinase is

enhanced by covalent linkage of antithrombin to heparin. 46th Annual Meeting of American Society of Hematology, 2004, San Diego, CA. (Blood [ASH Annual Meeting Abstracts] 104:Abstract 1051).

76. Arnold D, Fergusson D, Chan A, Cook R, Fraser R, Lim W, Heddle N, Blajchman M,

Cook D. The use of aprotinin to reduce transfusion requirements in children undergoing cardiac surgery: A meta-analysis. 46th Annual Meeting of American Society of Hematology, 2004, San Diego, CA. (Blood [ASH Annual Meeting Abstracts] 104:Abstract 2718).

Dr. Anthony Chan

77. Chan AKC. Dosing regimen of rFVIIa for orthopedic surgery in hemophilia with inhibitor – what is the right dose? XX Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2005, Sydney, Australia. (Journal of Thrombosis and Haemostasis 3 [Supplement 1]:Abstract P1437A, 2005).

78. Pai KM, Walker I, Almonte T, Chan AKC, Sek J, Decker K. Comparing bleed

frequency and factor concentrate use between Haemophilia A and Haemophilia B. XX Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2005, Sydney, Australia. (Journal of Thrombosis and Haemostasis 3 [Supplement 1]:Abstract P0807, 2005).

79. Pai KM, Chan AKC, Laudenbach L, McCusker PJ, Rivard GE, Jardine L, Walker.

Immune tolerance to factor IX inhibitor. XX Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2005, Sydney, Australia. (Journal of Thrombosis and Haemostasis 3 [Supplement 1]:Abstract P0654, 2005).

80. Walker I, Arnold D, Carruthers J, Almonte T, Chan AKC, Pai M, Goldsmith R, Seroski

W, Decker K, Stiles C. A system to track coagulation factor concentrates can decrease waste. XX Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2005, Sydney, Australia. (Journal of Thrombosis and Haemostasis 3 [Supplement 1]:Abstract P0228, 2005).

81. Seroski W, Goldsmith R, Decker K, Almonte T, Walker I, Pai M, Chan AKC.

Telephone consultation provided by the Hemophilia Treatment Centre - A significant part of the service. XX Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2005, Sydney, Australia. (Journal of Thrombosis and Haemostasis 3 [Supplement 1]:Abstract P1997, 2005).

82. Chan AKC, Berry LR, Lau A, Parmar N, Jayasuriya K, Roth M, Post M, Belik J. Effect

of mechanical ventilation on the hemostatic state of the newborn. XX Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2005, Sydney, Australia. (Journal of Thrombosis and Haemostasis 3 [Supplement 1]:Abstract P1456, 2005).

83. Chindemi PA, Konecny F, Berry LR, Smith LJ, Klement P, Chan AKC.

Biodistribution of a covalent antithrombin-heparin complex. XX Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2005, Sydney, Australia. (Journal of Thrombosis and Haemostasis 3 [Supplement 1]:Abstract P1201, 2005).

84. Smith, LJ, Berry, LR, Chan AKC. Reaction of clot-bound thrombin with a covalent

antithrombin-heparin complex results in an anticoagulant surface. XX Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2005, Sydney, Australia. (Journal of Thrombosis and Haemostasis 3 [Supplement 1]:Abstract P1969, 2005).

85. Lau A, Berry LR, Mitchell LG, Chan AKC. Comparison of continuous and

subsampling methods for analysis of thrombin generation. XX Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2005, Sydney, Australia.

Dr. Anthony Chan

(Journal of Thrombosis and Haemostasis 3 [Supplement 1]:Abstract P0094, 2005). 86. Williams S, Chan AKC. Umbilical vein catheterization and portal vein thrombosis

in neonates and children: A systematic review with meta-analysis. XX Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2005, Sydney, Australia. (Journal of Thrombosis and Haemostasis 3 [Supplement 1]:Abstract P0442, 2005).

87. Lau A, Berry LR, Chan AKC. Comparison of continuous and subsampling

determination of thrombin generation in the presence of anticoagulants. XX Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2005, Sydney, Australia. (Journal of Thrombosis and Haemostasis 3 [Supplement 1]:Abstract P0693, 2005).

88. Patel S, Berry LR, Chan AKC. Inhibition of coagulation cascade enzymes by a

covalent antithrombin-heparin complex. XX Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2005, Sydney, Australia. (Journal of Thrombosis and Haemostasis 3 [Supplement 1]:Abstract P0600, 2005).

89. Ignjatovic V, Monagle P, Newall F, Furmedge J, Summerhayes R, Gan A, Jones C,

Ross-Smith M, Ellis A, Chan AKC. Heparin monitoring during haemodialysis in children. XX Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2005, Sydney, Australia. (Journal of Thrombosis and Haemostasis 3 [Supplement 1]:Abstract P0858, 2005).

90. Ignjatovic V, Monagle P, Newall F, Furmedge J, Summerhayes R, Gan A, Jones C,

Ross-Smith M, Ellis A, Chan AKC. Tissue factor pathway inhibitor (TFPI) contributes to the early anticoagulant effect of unfractionated heparin (UFH) during haemodialysis. XX Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2005, Sydney, Australia. (Journal of Thrombosis and Haemostasis 3 [Supplement 1]:Abstract P1342, 2005).

91. Monagle P, Ignjatovic V, Newall F, Furmedge J, Gan A, Summerhayes R, DeRosa L,

Shann F, Butt W, Chan AKC. Tissue factor pathway inhibitor (TFPI) during heparin therapy in the paediatric intensive care unit (PICU). XX Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2005, Sydney, Australia. (Journal of Thrombosis and Haemostasis 3 [Supplement 1]:Abstract P0742, 2005).

92. Komvilaisak P, Brandão L, Massicotte P, Chan AKC, Castle D, Williams S.

Antiphospholipid antibody syndrome (APS) experience in the Hospital for Sick Children. XX Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2005, Sydney, Australia. (Journal of Thrombosis and Haemostasis 3 [Supplement 1]:Abstract P1214, 2005).

93. Ryan C, Williams S, Kahr W, Chan AKC, Castle D, Floros G, Brandão LR. Exercise-

induced deep vein thrombosis of the upper extremity in children: Management and outcome in a small series. XX Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2005, Sydney, Australia. (Journal of Thrombosis

Dr. Anthony Chan

and Haemostasis 3 [Supplement 1]:Abstract P1132, 2005). 94. Chan A, Parmar N, Jegal A, Yip C, Farrokhyar F, Walton MJ. Quantitative analysis of

roughness of catheters by scanning electron microscopy (SEM) and atomic force microscopy (AFM). 47th Annual Meeting of American Society of Hematology, 2005, Atlanta, GA. (Blood [ASH Annual Meeting Abstracts] 106:Abstract 3218).

95. Rand M, Lanthier S, Domi T, Clark D, Chan AKC, deVeber G. Incidence of aspirin

resistance as determined using the PFA-100 in pediatric patients with arterial ischemic stroke. 47th Annual Meeting of American Society of Hematology, 2005, Atlanta, GA. (Blood [ASH Annual Meeting Abstracts] 106:Abstract 1882).

96. Rand M, Le Breton G, Paton T, Pai MK, Chan AKC, Blanchette VS, Kahr WH. A

novel inherited platelet function disorder involving the thromboxane A2 pathway of platelet activation. 47th Annual Meeting of American Society of Hematology, 2005, Atlanta, GA. (Blood [ASH Annual Meeting Abstracts] 106:Abstract 2175).

97. Athale U, Cox S, Siciliano S, Chan A. Thromboembolism in children with sarcoma.

Pediatric Academic Societies’ Annual Meeting, 2005, Washington, DC. 98. Jayasuriya K, Berry L, Chan A, Roth M, Post M, Belik J. Mechanical ventilation

activates the clotting cascade in newborn rat. Pediatric Academic Societies’ Annual Meeting, 2005, Washington, DC.

99. Komwilaisak P, Brandão L, Blaser S, deVeber G, Dirks P, Kulkarni A, Williams S,

Chan AKC. Cerebral sinovenous thrombosis post head injury-10-year experience in children. American Society of Pediatric Hematology and Oncology 19th Annual Meeting, 2006, San Francisco, CA.

100. Traivaree C, Brandao L, Kahr W, Lau W, Massicotte P, Chan AKC, Williams S.

Antithrombin concentrate use in children on heparin infusion. American Society of Pediatric Hematology and Oncology 19th Annual Meeting, 2006, San Francisco, CA.

101. Schechter T, Brandao L, Chan A, Williams S, MacGregor D, Finkelstein Y, Kirton A,

Adams M, Pontigon A, deVeber G. The safety of anticoagulants in pediatric arterial ischemic stroke: Preliminary results. Child Neurology Society Annual Meeting, 2006, Montreal, QC.

102. Mullah-Ali A, Chan AKC, Decker K, Seroski W, Moffat K, Walker I, Pai MK.

Undetected factor VIII level in a type III von Willebrand disease (vWD) patient masquerading as severe hemophilia A. Hemophilia World Congress, 2006, Vancouver, BC.

103. Malowany J, Knoppert D, Chan AKC, Pepelassis D, Lee DSC. Enoxaparin use in the

neonatal intensive care unit (NICU): Experience over 7 years. American College of Clinical Pharmacy Annual Meeting, 2006, St. Louis, MO.

104. Patel S, Berry LR, Smith L, Chan AKC. Inhibition of factor Xa in prothrombinase is

Dr. Anthony Chan

enhanced by covalent linkage of antithrombin to heparin. 48th Annual Meeting of American Society of Hematology, 2006, Orlando, FL. (Blood [ASH Annual Meeting Abstracts] 108:Abstract 1613).

105. Patel S, Berry LR, Hatton MWC, Chan A. Implications of heparinoid-induced

inactivation of coagulation cascade factors and in vivo proenzyme concentration. 48th Annual Meeting of American Society of Hematology, 2006, Orlando, FL. (Blood [ASH Annual Meeting Abstracts] 108:Abstract 1621).

106. Klaassen RJ, Young NL, Barnard D, Wakefield CP, Chan AKC, Silva MP, Curtis C,

Bradley CS, Neufeld E, Buchanan GR, David M, Blanchette VS. The Kids’ ITP Tools (KIT): Validity, reliability and responsiveness of a new measure of quality of life in children with ITP. Pediatric Academic Societies’ Annual Meeting, 2006, San Francisco, CA.

107. Lefond K, Benedict S, Benard T, Carpenter J, Chan AKC, deVeber G, Dowling M,

Hovinga C, Ichord R, Kirton A, Lo W, Tsuchida T, Whelan H, Zamel K, The International Pediatric Stroke Study. Thrombolysis in children with arterial ischemic stroke: Initial results from the International Pediatric Stroke Study. International Stroke Conference, 2007, San Francisco, CA.

108. Kirton A, Schechter T, Brandao L, Laughlin S, Chan AKC, Williams S, MacGregor D,

Pontigon A, deVeber G. Hemorrhagic transformation of arterial ischemic stroke in children. International Stroke Conference, 2007, San Francisco, CA.

109. Malowany JI, Knoppert DC, Chan AKC, Lee DSC. Suboptimal dosing of enoxaparin

in preterm infants. Pediatric Academic Societies’ Annual Meeting, 2007, Toronto, ON.

110. Khan A, Nagel K, Chan AKC, Athale UH. Does mediastinal lymphadenopathy

increase the risk of thromboembolism in children with lymphoma? Pediatric Academic Societies’ Annual Meeting, 2007, Toronto, ON.

111. Traivaree C, Brandão L, Chan A, Williams S. Outcomes of thrombolysis for repeated

courses of systemic tissue plasminogen activator for intravascular thrombosis in children. Pediatric Academic Societies’ Annual Meeting, 2007, Toronto, ON.

112. Parmar N, Berry LR, Post M, Chan AKC. Impact of a novel covalent antithrombin-

heparin (ATH) on gene expression during epithelial branching of the developing mouse lung. Pediatric Academic Societies’ Annual Meeting, 2007, Toronto, ON.

113. Lau K, Stoffman J, David M, Brandão, Chan AKC. Neonatal renal vein thrombosis –

15 years of literature. XXI Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2007, Geneva, Switzerland. (Journal of Thrombosis and Haemostasis 5 [Supplement 1]:Abstract P-S-591, 2007).

114. Chan AKC, Jayasuriya K, Parmar N, Berry LR, Belik J. Covalent antithrombin-

heparin complex neutralizes procoagulant activity induced by ventilation in

Dr. Anthony Chan

newborns. XXI Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2007, Geneva, Switzerland. (Journal of Thrombosis and Haemostasis 5 [Supplement 1]:Abstract P-S-656, 2007).

115. Chan AKC, Berry LR, Tressel P, Weitz JI, Hirsh J, Liao P, Klement P. Covalent

antithrombin-heparin complex reduces brain emboli during hypothermic cardiopulmonary bypass in pigs. XXI Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2007, Geneva, Switzerland. (Journal of Thrombosis and Haemostasis 5 [Supplement 1]:Abstract P-S-657, 2007).

116. Mewhort-Buist T, Patel S, Berry LR, Chan AKC. Chemotherapy affects activated

protein C generation to a greater degree in newborn than in adult plasma. XXI Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2007, Geneva, Switzerland. (Journal of Thrombosis and Haemostasis 5 [Supplement 1]:Abstract P-M-084, 2007).

117. Parmar N, Berry LR, Chan AKC. Influence of covalent antithrombin-heparin

complex on fibroblast growth factor expression and lung angiogenesis. XXI Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2007, Geneva, Switzerland. (Journal of Thrombosis and Haemostasis 5 [Supplement 1]:Abstract P-S-436, 2007).

118. Berry LR, Parmar N, Chan AKC. Determination of thrombin-alpha2macroglobulin

complexes by a new immuno-activity assay. XXI Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2007, Geneva, Switzerland. (Journal of Thrombosis and Haemostasis 5 [Supplement 1]:Abstract P-S-119, 2007).

119. Berry LR, Patel S, Chan AKC. Effect of age on the relationship between rate of

heparin-catalyzed inhibition of coagulation factors by antithrombin and in vivo plasma concentration. XXI Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2007, Geneva, Switzerland. (Journal of Thrombosis and Haemostasis 5 [Supplement 1]:Abstract P-W-052, 2007).

120. Chan AKC, Black L, Ing C, Williams S, Brandão L. Do we need different standard

curves for measuring different low molecular weight heparins? XXI Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2007, Geneva, Switzerland. (Journal of Thrombosis and Haemostasis 5 [Supplement 1]:Abstract P-S-128, 2007).

121. Chan AKC, Siciliano S. 1800NOCLOTS – What have we learned from this free

consultative service? XXI Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2007, Geneva, Switzerland. (Journal of Thrombosis and Haemostasis 5 [Supplement 1]:Abstract P-M-491, 2007).

122. Levinson A, Garside S, Chan A, Pai M, Webert K, Walker IR. Efficacy of teaching

clinical clerks and residents about management of bleeding and coagulation disorders using e-learning. XXI Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2007, Geneva, Switzerland. (Journal of Thrombosis and

Dr. Anthony Chan

Haemostasis 5 [Supplement 1]:Abstract P-S-218, 2007). 123. Malowany JI, Knoppert DC, Lee DS,Wu J, McCusker P, Massicotte P, Williams S,

Chan AKC. Differential dosing of enoxaparin (Enox) in term and preterm neonates. XXI Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2007, Geneva, Switzerland. (Journal of Thrombosis and Haemostasis 5 [Supplement 1]:Abstract P-M-675, 2007).

124. Traivaree C, Brandão L, Chan A, Williams S. The efficacy and safety of fresh frozen

plasma (FFP) and systemic tissue plasminogen activator for treatment of intravascular thrombosis in infants. XXI Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2007, Geneva, Switzerland. (Journal of Thrombosis and Haemostasis 5 [Supplement 1]:Abstract P-W-415, 2007).

125. Traivaree C, Brandão L, Chan A, Williams S. Comparison of systemic tissue

plasminogen activator for venous thrombi and arterial thrombi in children. XXI Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2007, Geneva, Switzerland. (Journal of Thrombosis and Haemostasis 5 [Supplement 1]:Abstract P-W-413, 2007).

126. Traivaree C, Brandao L, Chan A, Williams S. Outcomes of thrombolysis for repeated

courses of systemic tissue plasminogen activator for intravascular thrombosis in children. XXI Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2007, Geneva, Switzerland. (Journal of Thrombosis and Haemostasis 5 [Supplement 1]:Abstract P-W-414, 2007).

127. Biss TT, Brandão LR, Chan AK, Williams S. Clinical characteristics of pulmonary

embolism in childhood-experience from a single centre. XXI Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2007, Geneva, Switzerland. (Journal of Thrombosis and Haemostasis 5 [Supplement 1]:Abstract P-S-583, 2007).

128. Traivaree C, Brandão L, Kahr W, Lau W, Chan A, Williams S. The efficacy and safety

of antithrombin concentrate in children receiving heparin infusions. XXI Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2007, Geneva, Switzerland. (Journal of Thrombosis and Haemostasis 5 [Supplement 1]:Abstract P-W-655, 2007).

129. Kirton A, Schechter T, Brandão L, Laughlin S, Chan A, Williams S, MacGregor D,

Pontigon A, deVeber G. Hemorrhagic transformation of arterial ischemic stroke in children. XXI Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2007, Geneva, Switzerland. (Journal of Thrombosis and Haemostasis 5 [Supplement 1]:Abstract P-T-592, 2007).

130. Damme AV, Williams S, Caldarone CA, Chan AK, Brandão LR. Evaluation of

thrombolytic therapy with tissue-type plasminogen activator (t-PA) for prosthetic valve thrombosis in children: A single institution experience. XXI Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2007, Geneva,

Dr. Anthony Chan

Switzerland. (Journal of Thrombosis and Haemostasis 5 [Supplement 1]:Abstract P-T-388, 2007).

131. Finkelstein TS, Williams S, Ali M, Finkelstein Y, Kahr WH, Chan AK, Brandão LR.

Dosing efficacy and safety of unfractionated heparin in infants with thrombotic complications. XXI Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2007, Geneva, Switzerland. (Journal of Thrombosis and Haemostasis 5 [Supplement 1]:Abstract P-S-613, 2007).

132. Finkelstein TS, Brandão LR, Kirton A, Chan AK, Williams S, MacGregor D,

Finkelstein Y, Pontigon A, Adams M, deVeber G. The safety of anticoagulants in pediatric arterial ischemic stroke: Preliminary results. XXI Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2007, Geneva, Switzerland. (Journal of Thrombosis and Haemostasis 5 [Supplement 1]:Abstract P-T-584, 2007).

133. Amlie-Lefond A, Chan A, Ichord R, deVeber G. tPA in children with arterial

ischemic stroke: Cases from the IPSS compared with literature-based cases. XXI Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2007, Geneva, Switzerland. (Journal of Thrombosis and Haemostasis 5 [Supplement 1]:Abstract P-T-579, 2007).

134. Athale U, Siciliano S, Cox S, Lathia A, Khan A, Pai N, Armstrong A, Odame I, Chan

AKC. Risk factors predisposing to thromboembolism in children with cancer. 49th Annual Meeting of American Society of Hematology, 2007, Atlanta, GA. (Blood [ASH Annual Meeting Abstracts] 110:Abstract 1633).

135. Van Walderveen M, Berry L, Chan A. Inhibition of the thrombin-thrombomodulin

by a covalent antithrombin-heparin. 49th Annual Meeting of American Society of Hematology, 2007, Atlanta, GA. (Blood [ASH Annual Meeting Abstracts] 110:Abstract 2693).

136. Young G, Friedrichs F, Chan A, Kenet G, Simioni P, van Ommen H, Krümpel A,

Bonduel M, Goldenberg N, Male C, Albisetti M, Manco-Johnson M, Brandão, Nowak-Göttl U. Impact of inherited thrombophilia on symptomatic venous thromboembolism (VTE) in children: A systematic review & meta-analysis of 37 studies including 2470 pediatric patients. 49th Annual Meeting of American Society of Hematology, 2007, Atlanta, GA. (Blood [ASH Annual Meeting Abstracts] 110:Abstract 3189).

137. Thomas K, Chan AKC, Athale U. The safety and efficacy of anticoagulation therapy

in children with cancer: A systematic review of the literature. Annual Pediatric Oncology Group of Ontario (POGO) Symposium – “Childhood Cancer in the Age of Genomics”, 2007, Toronto, ON. (Winner of “The Most Outstanding Abstract” in the Clinical Category)

138. Sask KN, Brash JL, Chan AKC, Berry LR, McClung WG, Zhitomirsky I. Surface

modification with an antithrombin-heparin covalent complex. 8th World

Dr. Anthony Chan

Biomaterials Congress, 2008, Amsterdam RAI, The Netherlands. 139. Biss TT, Chan AK, Blanchette VS, Iwenofu LN, McLimont M, Carcao MD for the

Association of Hemophilia Centre Directors of Canada (AHCDC) and the Canadian Association of Nurses in Hemophilia Care (CANHC). A survey of factor prophylaxis in Canadian patients with hemophilia. Hemophilia 2008 World Congress, the XXVIII International Congress of the World Federation of Hemophilia (WFH), 2008, Istanbul, Turkey. (Haemophilia 14 [Supplement 2]: 100).

140. Malowany JI, Jardine L, Chan AKC. Contribution of genetic thrombophilic risk

factors to clinical heterogeneity of severe hemophilia. Hemophilia 2008 World Congress, the XXVIII International Congress of the World Federation of Hemophilia (WFH), 2008, Istanbul, Turkey. (Haemophilia 14 [Supplement 2]: 60).

141. Berry LR, Chan AKC. Age-related differences in the glycoslylation of anticoagulant

protein C. 50th Annual Meeting of American Society of Hematology, 2008, San Francisco, CA. (Blood [ASH Annual Meeting Abstracts], 112:Abstract 2031).

142. Athale U, Moghrabi A, Nayiager T, Yves-Line D, Thabane, Chan A. Circulating

blasts are associated with high levels of vWF and thrombin activation in children with newly diagnosed ALL. 50th Annual Meeting of American Society of Hematology, 2008, San Francisco, CA. (Blood [ASH Annual Meeting Abstracts], 112:Abstract 1824).

143. Van Walderveen MC, Berry LR, Chan AK. The effects of a covalent antithrombin-

heparin on components of the protein C pathway. Canadian Cardiovascular Congress (CCC), 2008, Toronto, ON.

144. Sask KN, Chan AKC, Berry LR, Zhitomirsky I, Brash JL. Surface modification of

model gold substrates with an antithrombin-heparin anticoagulant complex. Society for Biomaterials Annual Meeting and Exposition, 2009, San Antonio, TX.

145. Sask KN, Chan AKC, Berry LR, Zhitomirsky I, Brash JL. Surface modification of

model gold substrates with an antithrombin-heparin anticoagulant complex. The 27th Canadian Biomaterials Society Meeting, 2009, Quebec City, QC.

146. Athale U, Siciliano S, Cheng J, Thabane L, Chan AKC. Decreased overall survival

and increased risk of thrombosis in children with cancer and central venous line (CVL) dysfunction. 41st Congress of the International Society of Paediatric Oncology (SIOP), 2009, Sao Paulo, Brazil.

147. Van Walderveen MC, Berry LR, Chan AKC. Covalent antithrombin-heparin and

the protein C pathway. XXII Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2009, Boston, MA. (Journal of Thrombosis and Haemostasis 7 [Supplement 2]:Abstract PP-TH-135, 2009)

148. Berry LR, Thong B, Atkinson HM, Chan AKC. Comparison of recombinant and

plasma-derived antithrombin biodistribution in vivo. XXII Congress of the

Dr. Anthony Chan

International Society on Thrombosis and Haemostasis (ISTH), 2009, Boston, MA. (Journal of Thrombosis and Haemostasis 7 [Supplement 2]:Abstract PP-MO-197, 2009)

149. Atkinson HM, Mewhort-Buist TA, Berry LR, Chan AKC. Anticoagulant mechanisms of antithrombin-heparin studied by TEG. XXII Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2009, Boston, MA. (Journal of Thrombosis and Haemostasis 7 [Supplement 2]:Abstract PP-WE-173, 2009)

150. Chan HHW, French DL, Berry LR, Chan ACK. Novel heparin cofactor II-dermatan

sulfate covalent complex formation selects for dermatan sulfate with higher molecular weight. XXII Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2009, Boston, MA. (Journal of Thrombosis and Haemostasis 7 [Supplement 2]:Abstract PP-WE-174, 2009)

151. Stevic I, Kentner TA, Berry LR, Chan AKC. Covalently linking antithrombin to

heparin enhances the inhibition of FXa in the prothrombinase complex. XXII Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2009, Boston, MA. (Journal of Thrombosis and Haemostasis 7 [Supplement 2]:Abstract PP-WE-177, 2009)

152. Berry LR, Tseu I, Post M, Chan AKC. Covalent linkage of heparin to antithrombin

increases lung cell proliferation. XXII Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2009, Boston, MA. (Journal of Thrombosis and Haemostasis 7 [Supplement 2]:Abstract PP-WE-193, 2009)

153. Yang JYK, Williams S, Brandao LR, Chan AKC. Right atrial thrombosis in infants

and children: Literature review from 1981 to 2008. XXII Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2009, Boston, MA. (Journal of Thrombosis and Haemostasis 7 [Supplement 2]:Abstract PP-WE-288, 2009)

154. Yang JYK, Chan AKC, Brandao LR, Williams S. Filter fracture and migration of a

gunther tulip retrievable inferior vena cava filter 22 days after in a pediatric patient: A case report. XXII Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2009, Boston, MA. (Journal of Thrombosis and Haemostasis 7 [Supplement 2]:Abstract PP-MO-426, 2009)

155. Sask KN, Brash JL, Chan AKC, Berry LR, McClung WG. Biomaterial surface

modification with an antithrombin-heparin covalent complex for improved intravascular devices. XXII Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2009, Boston, MA. (Journal of Thrombosis and Haemostasis 7 [Supplement 2]:Abstract PP-TH-435, 2009)

156. Goldsmith RE, Chan AKC, Seroski WM, Wizowski L. Development of Factor V

Leiden brochure. XXII Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2009, Boston, MA. (Journal of Thrombosis and Haemostasis 7 [Supplement 2]:Abstract PP-WE-431, 2009)

Dr. Anthony Chan

157. Yang JYK, Wong MLG, Chan AKC, Li RCH, Lee ACW. Experience of treating pediatric venous thromboembolism with low molecular weight heparin (LMWH) in an institute lack of anti-Xa monitoring support. XXII Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2009, Boston, MA. (Journal of Thrombosis and Haemostasis 7 [Supplement 2]:Abstract PP-TH-441, 2009)

158. Al-Zahrani A, Komwilaisak P, Brandao L, Kahr WHA, Chan AKC, Williams S.

Equivalency of tinzaparin and enoxaparin children: A single centre report on efficacy and safety. XXII Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2009, Boston, MA. (Journal of Thrombosis and Haemostasis 7 [Supplement 2]:Abstract PP-TH-459, 2009)

159. Tam BHL, Chan AKC, Williams S, Brandao L. Systematic literature review of iliac

vein compression syndrome in pediatric patients. XXII Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2009, Boston, MA. (Journal of Thrombosis and Haemostasis 7 [Supplement 2]:Abstract PP-WE-445, 2009)

160. Athale U, Nayiager T, McGrath J, Moghrabi A, Chan A. Elevated levels of FVIIa-AT

following prednisone monotherapy in children with newly diagnosed acute lymphoblastic leukemia. XXII Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2009, Boston, MA. (Journal of Thrombosis and Haemostasis 7 [Supplement 2]:Abstract PP-MO-494, 2009)

161. Athale U, Siciliano S, Cheng J, Thabane L, Chan AKC. Decreased overall survival

and increased risk of thrombosis in children with cancer and central venous line (CVL) dysfunction. XXII Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2009, Boston, MA. (Journal of Thrombosis and Haemostasis 7 [Supplement 2]:Abstract PP-TH-503, 2009)

162. Athale UH, Moghrabi A, Nayiger T, Yves-Line D, Thabane L, Chan A. Production of

vWF may mediate lymphoblast induced thrombin activation in children with newly diagnosed ALL. XXII Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2009, Boston, MA. (Journal of Thrombosis and Haemostasis 7 [Supplement 2]:Abstract PP-WE-507, 2009)

163. Strike KL, Chan AKC, Almonte TM, Decker KP, Goldsmith RE, Walker I, Wright MJ.

Long-term bleeding history as a tool for hemophilia management. XXII Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2009, Boston, MA. (Journal of Thrombosis and Haemostasis 7 [Supplement 2]:Abstract PP-WE-541, 2009)

164. Hang MX, Blanchette VS, Pullenayegum E, Babyn P, Card R, Chan A, Demers C, Gill

K, Israels S, Klaassen R, Laferriere N, Lillicrap D, Luke K, McLimont M, Pai M, Poon M, Price V, Rivard GE, Robinson S, Steele M, Wu JKM, Feldman B. Risk factors of bleeding severity in young boys with severe hemophilia A on tailored prophylaxis: Long term (10-year) results from the Canadian Hemophilia Primary Prophylaxis Study. XXII Congress of the International Society on Thrombosis and Haemostasis

Dr. Anthony Chan

(ISTH), 2009, Boston, MA. (Journal of Thrombosis and Haemostasis 7 [Supplement 2]:Abstract PP-WE-553, 2009)

165. Yenson P, Chan AKC, Williams S, Brandao LR. The utility of PF4-dependent

enzyme immunoassay to diagnose heparin-induced thrombocytopenia in children. XXII Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2009, Boston, MA. (Journal of Thrombosis and Haemostasis 7 [Supplement 2]:Abstract PP-WE-719, 2009)

166. Gruenwald CE, Manlhiot C, Crawford L, Foreman C, Maxwell S, Chan AK, Brandao

LR, Van Arsdell G, Caldarone CA, Holtby H, Schwartz S, Sivarajan VB, McCrindle BW. Enhanced coagulation profile monitoring minimizes the risk of thrombotic and hemorrhagic complications in pediatric cardiac patients supported on extracorporeal membrane oxygenation. Canadian Cardiovascular Congress (CCC), 2009, Edmonton, AB.

167. Manlhiot C, Menjak IB, Brandao LR, Gruenwald CE, Chan AK, Yoon HM, Millar K,

Maratta R, Schwartz S, Sivarajan VB, Holtby H, Van Arsdell G, Caldarone CA, Clarizia NA, Crawford LE, Foreman C, McCrindle BW. Incidence and risk of thromboembolic complications associated with pediatric cardiac surgery. Canadian Cardiovascular Congress (CCC), 2009, Edmonton, AB.

168. Menjak IB, Manlhiot C, Brandão LR, Carew C, Millar K, Van Arsdell G, Caldarone

CA, Chan AK, Gruenwald CE, McCrindle BW. Thromboprophylaxis and thrombotic complications in long-term survivors of the Fontan operation. Canadian Cardiovascular Congress (CCC), 2009, Edmonton, AB.

169. Gruenwald CE, Manlhiot C, Chan AK, Brandao LR, Foreman C, Crawford LE, Kwok J,

Van Arsdell GS, Caldarone CA, Holtby HM, McCrindle BW. Influence of heparin brand on immediate postoperative outcomes in children undergoing cardiac surgery. American Heart Association Scientific Sessions, 2009, Orlando, FL. (Abstract 1798, Circulation 2009; 120:S557)

170. Menjak IB, Manlhiot C, McCrindle BW, Brandao LR, Chan AK, Yoon HM, Van

Arsdell GS, Caldarone CA, Crawford LE, Foreman C, Holtby HM, Gruenwald CE. Association between longer blood conservation and worse post-operative outcomes in pediatric cardiac surgery. American Heart Association Scientific Sessions, 2009, Orlando, FL. (Abstract 1906, Circulation 2009; 120:S568)

171. Manlhiot C, Brandao LR, Manjak IB, Chan AK, Carew C, Schwartz SM, Sivarajan VB,

Caldarone C, Gruenwald CE, McCrindle BW. Association between thromboembolic complications and increased mortality after pediatric cardiac surgery. American Heart Association Scientific Sessions, 2009, Orlando, FL. (Abstract 1796, Circulation 2009; 120:S557)

172. Van Walderveen MC, Berry LR, Chan A. Covalent antithrombin-heparin complex

catalysis of activated protein C inhibition by protein C inhibitor. 51st Annual

Dr. Anthony Chan

Meeting of American Society of Hematology, 2009, New Orleans, LA. (Blood [ASH Annual Meeting Abstracts] 114:Abstract 3167, 2009).

173. Brandao LR, Manlhiot C, Menjak IB, Chan A, Carew C, Gruenwald CE, Schwartz SM,

Sivarajan BV, McCrindle BW. Distribution and clinical signs of venous, arterial and intracardiac clots after pediatric cardiac surgery. 51st Annual Meeting of American Society of Hematology, 2009, New Orleans, LA. (Blood [ASH Annual Meeting Abstracts] 114:Abstract 3992, 2009).

174. Lütkhoff LK, Albisetti M, Bernard TJ, Bonduel M, Brandao LR, Chabrier S, Chan A,

Fiedler B, Fullerton HJ, Ganesan V, Goldenberg NA, Golomb M, Grabowski EF, Heller C, Holzhauer S, Iorio A, Journeycake J, Kenet G, Kirkham FJ, Kurnik K, Lynch JK, Male C, Manco-Johnson MJ, Mesters R, Monagle P, van Ommen HC, Raffini L, Simioni P, Straeter R, Young G, Nowak-Gottl U. Impact of thrombophilia on arterial ischemic stroke or cerebral venous sinus thromboses in children: A systematic review & meta-analysis of observational studies. 51st Annual Meeting of American Society of Hematology, 2009, New Orleans, LA. (Blood [ASH Annual Meeting Abstracts] 114:Abstract 3993, 2009).

175. Sask KN, Berry LR, Chan AKC, Brash JL. Influence of polyethylene oxide spacer on

anticoagulant properties of immobilized antithrombin-heparin complex. Society for Biomaterials Annual Meeting and Exposition, 2010, Seattle, WA.

176. Tuckuviene R, Atkinson H, Berry L, Chan AK. Differences in thromboelastography

parameters for cord and adult plasmas treated with unfractionated heparin and covalent antithrombin-heparin complex. 21st International Congress on Thrombosis, Milan, Italy, 2010. (Abstract P353)

177. Chan A, Decker K, Warner M. Adherence with hemophilia treatments in Canada:

A survey of hemophilia healthcare professionals. XXIX International Congress of the World Federation of Hemophilia (WFH), 2010, Buenos Aires, Argentina. (Haemophilia 16(Suppl 4):1-158; Abstract 04P12, 2010)

178. Moffat KA, Leonard BJN, Chan AK. Mixing studies: Use of specific factor-deficient

plasma allows for confirmation of a single factor deficiency is the cause of an elevated APTT. XXIX International Congress of the World Federation of Hemophilia (WFH), 2010, Buenos Aires, Argentina. (Haemophilia 16(Suppl 4):1-158; Abstract 18P21, 2010)

179. Bos C, Walker I, Chan AK, Almonte T, Decker K, Goldsmith R, Nagel K, Webert K,

Wright M. Change in bone density in patients with severe Hemophilia A and B between the ages of 20 and 50: A pilot study. XXIX International Congress of the World Federation of Hemophilia (WFH), 2010, Buenos Aires, Argentina. (Haemophilia 16(Suppl 4):1-158; Abstract 06P13, 2010)

180. Bos C, Chan AK, Webert K, Almonte T, Decker K, Goldsmith R, Walker I, Waterhouse

L. The year in review: Describing prophylaxis and adherence in children with severe hemophilia A using patient infusion diaries. XXIX International Congress of

Dr. Anthony Chan

the World Federation of Hemophilia (WFH), 2010, Buenos Aires, Argentina. (Haemophilia 16(Suppl 4):1-158; Abstract 29P10, 2010)

181. Almonte T, Chan AK, Decker K, Walker I, Webert K, Goldsmith R, Bos C, Waterhouse

L. Comprehensive care team approach to bleeding disorder patient care: Benefits of team meeting. XXIX International Congress of the World Federation of Hemophilia (WFH), 2010, Buenos Aires, Argentina. (Haemophilia 16(Suppl 4):1-158; Abstract 04P09, 2010)

182. Decker K, Chan AK, Seroski W, Bissonnette D, Floros G, Lacasse L, Laudenbach L,

Paradis E, Purcell S, Stain A. All about hemophilia, a guide for families: Instructor’s manual for health professionals in hemophilia care. XXIX International Congress of the World Federation of Hemophilia (WFH), 2010, Buenos Aires, Argentina. (Haemophilia 16(Suppl 4):1-158; Abstract 12P08, 2010)

183. Menjak IB, Manlhiot C, Brandão LR, Chan AK, Schwartz SM, Sivarajan BV, Holtby

HM, Van Arsdell GS, Caldarone CA, McCrindle BW. Hemorrhagic complications following pediatric cardiac surgery. Canadian Cardiovascular Congress (CCC), 2010, Montreal, QC.

184. Kenet G, Bonduel M, Chan A, Goldenberg NA, Holzhauer S, Iorio A, Journeycake J,

Junker R, Male C, Massicotte P, Mesters R, Monagle P, van Ommen CH, Raffini L, Simioni P, Young G, Nowak-Göttl U. Impact of persistent antiphospholipid antibodies on symptomatic thromboembolism in children: A systematic review & cumulative meta-analysis [observational studies]. 52nd Annual Meeting of American Society of Hematology (ASH), 2010, Orlando, FL. (Blood [ASH Annual Meeting Abstracts] 116:Abstract 3169, 2010)

185. Bos C, Wright M, Chan A, Almonte T, Decker K, Goldsmith R, Strike K, Walker I,

Waterhouse L, Webert K. Measuring dynamic balance and mobility in individuals with hemophilia. Balance, Mobility and Fitness - Accelerating Research into Clinical Practice (Toronto Rehab Conference), 2011, Toronto, ON.

186. Pukulakatt M, Nagel K, Decker K, Chan A. Factor replacement therapy for

hemophilia patients having a central venous line inserted: A local experience. 4th Annual Child Health Pediatric Celebration for Undergraduate Research Trainees, McMaster University, 2011, Hamilton, ON.

187. Stevic I, Chan HHW, Berry LR, Chan AKC. Enhanced inhibition of platelet-

prothrombinase by covalent antithrombin-heparin complex. McMaster Innovation Showcase, McMaster University Campus, 2011, Hamilton, ON.

188. Van Walderveen MC, Berry LR, Chan AKC. Developmental effects on the

glycosylation of anticoagulant protein C. XXIII Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2011, Kyoto, Japan. (Journal of Thrombosis and Haemostasis 9 [Supplement s2]:Abstract P-MO-149, 2011)

Dr. Anthony Chan

189. Atkinson HM, Parmar N, Berry LR, Chan AKC. Development of a new immuno-activity assay for quantification of alpha-2-macroglobulin complexes. XXIII Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2011, Kyoto, Japan. (Journal of Thrombosis and Haemostasis 9 [Supplement s2]:Abstract P-MO-160, 2011)

190. Sask KN, Berry LR, Chan AKC, Brashh JL. Polyurethane immobilized with a

covalent antithrombin-heparin complex for reducing thrombosis on blood contacting devices. XXIII Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2011, Kyoto, Japan. (Journal of Thrombosis and Haemostasis 9 [Supplement s2]:Abstract P-MO-426, 2011)

191. Van Walderveen MC, Berry LR, Chan AKC. Comparison of glycosylation profiles in

various recombinant FVIII products and the effect of B-domain deletion. XXIII Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2011, Kyoto, Japan. (Journal of Thrombosis and Haemostasis 9 [Supplement s2]:Abstract P-TU-152, 2011)

192. Stevic I, Chan HH, Berry LR, Chan AKC. Enhanced inhibition of platelet-

prothrombinase by covalent antithrombin-heparin complex. XXIII Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2011, Kyoto, Japan. (Journal of Thrombosis and Haemostasis 9 [Supplement s2]:Abstract P-TU-180, 2011)

193. Atkinson HM, Berry LR, Chan AKC. Inhibition of coagulation factors by covalent

antithrombin-heparin in the presence of endothelium. XXIII Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2011, Kyoto, Japan. (Journal of Thrombosis and Haemostasis 9 [Supplement s2]:Abstract P-WE-175, 2011)

194. Chan HHW, Atkinson HM, Goncharenko M, Berry LR, Chan AKC. Reversal of

dabigatran using recombinant activated factor VII and activated prothrombin complex concentrates in thromboelastography assay. XXIII Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2011, Kyoto, Japan. (Journal of Thrombosis and Haemostasis 9 [Supplement s2]:Abstract P-WE-180, 2011)

195. Tan LY, Almakadi MS, Chan AKC, Chan HHW. A thromboelastography study to

evaluate the effect of thrombocytopenia on clot formation in the presence of unfractionated heparin. XXIII Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2011, Kyoto, Japan. (Journal of Thrombosis and Haemostasis 9 [Supplement s2]:Abstract P-WE-370, 2011)

196. Almakadi MS, Chan AKC, Chan HHW. Anticoagulant therapy in patients with

thrombocytopenia: A systematic review of case series in medical literature. XXIII Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2011, Kyoto, Japan. (Journal of Thrombosis and Haemostasis 9 [Supplement s2]:Abstract P-WE-372, 2011)

197. Tuckuviene R, Nayiager T, Chan AK, Athale U. Body mass index and

thromboembolism in children with hematological malignancies. XXIII Congress of

Dr. Anthony Chan

the International Society on Thrombosis and Haemostasis (ISTH), 2011, Kyoto, Japan. (Journal of Thrombosis and Haemostasis 9 [Supplement s2]:Abstract P-WE-392, 2011)

198. Bos C, Chan AK, Walker I, Webert K, Almonte T, Decker K, Goldsmith R, Strike K,

Waterhouse L. Dosing decisions in severe hemophilia A: Can we aim lower? FVIII use in a cohort of Canadian patients in 2009. XXIII Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2011, Kyoto, Japan. (Journal of Thrombosis and Haemostasis 9 [Supplement s2]:Abstract P-WE-512, 2011)

199. Brandao LR, Manlhiot C, McMullen JA, Chan AK, Williams S, Sivarajan B, Schwartz

SM, McCrindle BW. Thrombus persistence and thrombotic-related complications after pediatric cardiac surgery. XXIII Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2011, Kyoto, Japan. (Journal of Thrombosis and Haemostasis 9 [Supplement s2]:Abstract P-TH-390, 2011)

200. Chan DCH, Atkinson HM, Berry LR, Athale UH, Chan AKC. Induction of

endothelial von Willebrand’s factor expression by precursor B lymphoblasts. XXIII Congress of the International Society on Thrombosis and Haemostasis (ISTH), 2011, Kyoto, Japan. (Journal of Thrombosis and Haemostasis 9 [Supplement s2]:Abstract P-TH-448, 2011)

201. Stevic I, Chan HHW, Berry LR, Chan AKC. Inhibition of red blood cell-

prothrombinase by heparin and a covalent antithrombin-heparin complex. 53rd Annual Meeting of American Society of Hematology (ASH), 2011, San Diego, CA. (Blood [ASH Annual Meeting Abstracts] 118:Abstract 1179, 2011)

202. Hortelano G, Wen J, Chan AKC. Co-administration therapy modulates immunity in

FVIII in hemophilia mice. 53rd Annual Meeting of American Society of Hematology (ASH), 2011, San Diego, CA. (Blood [ASH Annual Meeting Abstracts] 118:Abstract 1219, 2011)

203. Saldanha LJ, Chan AKC, Gross PL. Exploring the impact of clinical anticoagulants

on venous thrombosis stability using a novel intravital murine model. 53rd Annual Meeting of American Society of Hematology (ASH), 2011, San Diego, CA. (Blood [ASH Annual Meeting Abstracts] 118:Abstract 1246)

204. Chan AK, deVeber GA, Gill JC, Hovinga CA, Kirton A, Ichord RN, Rivkin M, Szabo

A, Zaidat OO, Amlie-Lefond C. Thrombolysis in Pediatric Stroke (TIPs). American Heart Association (AHA) International Stroke Conference, 2012, New Orleans, LA.

205. Manlhiot C, Brandão LR, Williams S, Chan AK, Menjak IB, McCrindle BW. Post-

thrombotic syndrome in children with congenital heart disease is prevalent and associated with important clinical consequences. American Heart Association (AHA) International Stroke Conference, 2012, New Orleans, LA.

206. Almakadi MS, Khan A, Lau KK, Chan AKC, Chan HHW. Antithrombotic therapy in patients with thrombocytopenia: A 30-year systematic review of case series in

Dr. Anthony Chan

medical literature. 16th Annual International Congress on Hematologic Malignancies: Focus on Leukemias, Lymphomas, and Myeloma, 2012, Snowbird, UT.

207. Gantioqui J, Tan LY, Stevic I, Chan AKC, Chan HHW. An in vitro model to study the effect of anticoagulants on clot formation in platelet-enriched plasma. 16th Annual International Congress on Hematologic Malignancies: Focus on Leukemias, Lymphomas, and Myeloma, 2012, Snowbird, UT.

208. deVeber G, Chan A for the International Pediatric Stroke Study Group. The International Pediatric Stroke Study (IPSS): Power in numbers. Thrombosis and Hemostasis Summit of North America (THSNA), 2012, Chicago, IL.

209. Gantioqui J, Tan LY, Stevic I, Chan AKC, Chan HHW. An in vitro model to study the effect of anticoagulants on clot formation in platelet-enriched plasma. Thrombosis and Hemostasis Summit of North America (THSNA), 2012, Chicago, IL. (American Journal of Hematology 2012; 87:S170-S171)

210. Leung JM, Berry LR, Chan AKC, Brash JL. Surface modification of polydimethylsiloxane with an antithrombin-heparin complex for blood-contacting applications. 9th World Biomaterials Congress, 2012, Chengdu, China.

211. Steele M, Nagel K, Chan A. Pharmacokinetics (PK) of recombinant and plasma-derived factor VIII (FVIII) products in pediatric patients with severe hemophilia A. World Federation of Hemophilia (WFH) World Congress, 2012, Paris, France. (Haemophilia 18 [Supplement 3]:Abstract PO-TU-040, 2012)

212. Fonseca A, Nagel K, Decker K, Pukulakatt M, Pai M, Chan AK. Central venous line insertion and factor replacement therapy in patients with haemophilia A: A local experience. World Federation of Hemophilia (WFH) World Congress, 2012, Paris, France. (Haemophilia 18 [Supplement 3]:Abstract PO-TU-159, 2012)

213. Goodyear MD, Wu J, Webert K, Chan A, Dower N, Ritchie B, Poon M-C. The Canadian experience: Severe factor V deficiency. World Federation of Hemophilia (WFH) World Congress, 2012, Paris, France. (Haemophilia 18 [Supplement 3]:Abstract PO-TU-250, 2012)

214. Bos C, Chan A, Atkinson S, Bandosz K, Nagel K, Strike K, Webber C, Webert K, Iorio A, Walker I. Nutritional intake and bone mineral density in boys with severe hemophilia. World Federation of Hemophilia (WFH) World Congress, 2012, Paris, France. (Haemophilia 18 [Supplement 3]:Abstract PO-WE-047, 2012)

215. Arnold E, Walker I, Chan A, Webert K, Lane S, Tufts J, Poon M-C, Rubin S, Belliveau D, Heddle N. What do Canadian men with hemophilia need to know to facilitate optimal disease self-management? A mixed method approach. World Federation of Hemophilia (WFH) World Congress, 2012, Paris, France. (Haemophilia 18 [Supplement 3]:Abstract PO-TU-206, 2012)

Dr. Anthony Chan

216. Bos C, Chan AKC, Webber C, Almonte T, Decker K, Goldsmith R, Iorio A, Nagel K, Strike K, Walker I, Webert K. Low bone mineral density and increased fat mass in boys with severe hemophilia. World Federation of Hemophilia (WFH) World Congress, 2012, Paris, France. (Haemophilia 18 [Supplement 3]:Abstract PO-WE-048, 2012)

217. Strike KL, Ross K, Bos C, Chan AKC, Almonte TM, Decker KP, Goldsmith RE, Iorio A, Walker I, Webert KE, Waterhouse L. Osteochondral lesions of the ankle joint in patients with hemophilia A. A retrospective case series. World Federation of Hemophilia (WFH) World Congress, 2012, Paris, France. (Haemophilia 18 [Supplement 3]:Abstract PO-WE-212, 2012)

218. Lane S, Walker I, Chan A, Heddle N, Arnold E, Poon M-C, Minuk L, Jardine L, Chin-Yee I, Webert K. Understanding health and treatment decision-making among youth with hemophilia: A qualitative approach. World Federation of Hemophilia (WFH) World Congress, 2012, Paris, France. (Haemophilia 18 [Supplement 3]:Abstract PO-WE-274, 2012)

219. Bos C, Walker R, Proudfoot NA, Stike K, Nagel K, Chan AKC, Timmons B. Physical activity measured by high-frequency accelerometry in boys with hemophilia. World Federation of Hemophilia (WFH) World Congress, 2012, Paris, France. (Haemophilia 18 [Supplement 3]:Abstract FP-TU-01.2-1, 2012)

220. Chander A, Atkinson HM, Berry LR, Chan AKC. Inhibition of plasmin by heparin and a covalent antithrombin-heparin complex. Institute of Circulatory and Respiratory Health (ICHR) Young Investigator Forum, 2012, Montreal, QC.

221. Robertson J, Brandão L, Chan A, Wiliams S, Athale U. Cerebral sino-venous thrombosis in children receiving antileukemic therapy. 44th Congress of the Internaltional Society of Paediatric Oncology (SIOP), 2012, London, UK.

222. Chan N, Li C, Lau KK, Chan AKC, Chan HHW. A systematic review evaluating the effects of treatment duration on bleeding due to factor-specific or anticoagulant therapy. 54th Annual Meeting of the American Society of Hematology, 2012, Atlanta, GA. (Abstract #3417-Recipient of the 2012 Abstract Achievement Award)

223. Gantioqui J, Stevic I, Kim P, Lau KK, Chan AKC, Chan HHW. An in vitro model using thromboelastography to evaluate the effects of anticoagulants on clot formation in plasma enriched with autologous platelets. 54th Annual Meeting of the American Society of Hematology, 2012, Atlanta, GA. (Abstract #1091)

224. Stevic I, Chan HHW, Chander A, Berry LR, Chan AKCC. Inhibition of platelet-prothrombinase by a covalent antithrombin-heparin complex. 54th Annual Meeting of the American Society of Hematology, 2012, Atlanta, GA. (Abstract #2212)

225. Walker I, Traore AN, Iorio A, Ritchie B, Heddle N, Webert KE, St. Louis J, Lillicrap D, Teitel J, Chan AKC. Ten-year Canadian national prospective data on utilization of

Dr. Anthony Chan

anti-hemophilic concentrates: Indications and trends. 54th Annual Meeting of the American Society of Hematology, 2012, Atlanta, GA. (Abstract #1186)

226. Chander A, Atkinson HM, Berry LR, Chan AKC. Interactions of heparin and a covalently linked antithrombin-heparin complex with the components of the fibrinolytic pathway. 54th Annual Meeting of the American Society of Hematology (ASH), 2012, Atlanta, GA. (Abstract 2211)

227. Nayiager T, Chan AKC, Athale U. Combination of dexamethasone and asparaginase induces prothrombotic state in children receiving multiagent chemotherapy for acute lymphoblastic leukemia. 54th Annual Meeting of the American Society of Hematology, 2012, Atlanta, GA. (Abstract 3536)

228. Ding Z, Midia M, Chan A, Terry J, Avitzur Y, Brill H. Budd-Chiari syndrome managed with portocaval shunting. Canadian Digestive Diseases Week (CDDW) & the Annual CASL Winter Meeting, 2013, Victoria, BC. (Abstract #A293)

229. Strike K, Almonte T, Chan A, Decker K, Goldsmith R, Iorio A, Matsui N, Smith F, Walker I. Interdisciplinary musculoskeletal clinic for persons with inherited bleeding disorders (PWBD). 13th International Musculoskeletal Congress, World Federation of Hemophilia (WFH), 2013, Chicago, IL. (Abstract P1.23)

ABSTRACTS: PUBLISHED (not presented)

1. Chan A, Rolland-Grinton M, Doyle J, Freedman MH, Saunders EF, Calderwood S. Effect of GMCSF on pediatric bone marrow transplant: Retrospective analysis. 36th Annual Meeting of the American Society of Hematology, 1994, Memphis, TN. (Blood 84 [11, Supplement 1, Part 2]:Abstract 2805, 1994).

2. Chan A, Portwine C, Lees J, Lorenzana A, Malkin D. p16INK4 and p53 mutations in

anaplastic large cell lymphoma (CD30+) cell lines. 37th Annual Meeting of the American Society of Hematology, 1995, Seattle, WA. (Blood 86 [10, Supplement 1, Part 2]:Abstract 2893, 1995).

3. Bajzar L, Chan AKC, Monagle P, Mitchell L, Andrew M. Analysis of plasma thrombin

activatable fibrinolysis inhibitor in a young population pre- and post- venous occlusion. 41st Annual Meeting of the American Society of Hematology, 1999, New Orleans, LA. (Blood 94 [10, Supplement 1, Part 2]: Abstract 3544, 1999).

4. Crowther M, Stevens L, Ingram A, Clase C, Chan AKC. Effectiveness of reconstituted

and then frozen tPA for dysfunctional percutaneous dialysis catheters. 42nd Annual Meeting of the American Society of Hematology, 2000, San Francisco, CA. (Blood 96 [11, Supplement 1, Part 2]:Abstract 4080, 2000).

5. Monagle PT, Barnes C, Newall F, Chan AKC. MTHFR mutation and childhood

stroke. 43rd Annual Meeting of the American Society of Hematology, 2001, Orlando, FL. (Blood 98 [11, Supplement 1, Part 2]:Abstract 4017, 2001).

Dr. Anthony Chan

6. Monagle P, Barnes C, Newall F, Chan AKC. Prothrombin gene mutation and

childhood stroke. 43rd Annual Meeting of the American Society of Hematology, 2001, Orlando, FL. (Blood 98 [11, Supplement 1, Part 2]:Abstract 4018, 2001).

7. Parmar N, Berry LR, Mitchell L, Andrew M, Chan AKC. The influence of age on in

vitro plasmin generation in the presence of fibrin monomer. 44th Annual Meeting of the American Society of Hematology, 2002, Philadelphia, PA. (Blood 100 [11, Supplement 1, Part 2]:Abstract 3850, 2002).

8. Chan AKC, Parmar N. Does low molecular weight heparin give a high aluminum

load? 45th Annual Meeting of the American Society of Hematology, 2003, San Diego, CA. (Blood 102 [11, Supplement 1, Part 2]:Abstract 4220, 2003).

9. Lau A, Berry L, Chan AKC. Continuous versus subsampling analysis of thrombin

generation. 46th Annual Meeting of American Society of Hematology, 2004, San Diego, CA. (Blood [ASH Annual Meeting Abstracts] 104:Abstract 3886, 2004).

10. Ali K, Belletruti M, Blanchette V, Barnard D, Chan A, David M, Luke B, Ritchie B, Wu

J. A ten year survey of chronic immune thrombocytopenic purpura in Canadian children, 1984 – 2003: Report of the Canadian Chronic ITP Working Group. 46th Annual Meeting of American Society of Hematology, 2004, San Diego, CA. (Blood [ASH Annual Meeting Abstracts] 104:Abstract 3935, 2004).

11. Brandão LR, Dix D, David M, Israels S, Massicotte P, Williams S, Chan AKC. An

attempt to reach consensus regarding management of neonatal renal vein thrombosis: The Canadian Pediatric Hemostasis and Thrombosis Network experience. 46th Annual Meeting of American Society of Hematology, 2004, San Diego, CA. (Blood [ASH Annual Meeting Abstracts] 104:Abstract 4026, 2004).

12. Mullah-Ali AM, Chan A, Pai MK, Decker K, Moffat KA, Walker I. Undetected factor

VIII level in a type III von Willebrand disease (vWD) patient masquerading as severe hemophilia A. 47th Annual Meeting of American Society of Hematology, 2005, Atlanta, GA. (Blood [ASH Annual Meeting Abstracts] 106:Abstract 4095, 2005).

13. Athale U, Cox S, Siciliano S, Chan AKC. Thromboembolism in children with

sarcoma. 47th Annual Meeting of American Society of Hematology, 2005, Atlanta, GA. (Blood [ASH Annual Meeting Abstracts] 106:Abstract 4109, 2005).

14. Komwilaisak P, Brandão L, Blaser S, Dirks P, deVeber G, Williams S, Chan AKC,

Ahbaya K. Cerebral sinovenous thrombosis post head injury - 10 year experience in children. 47th Annual Meeting of American Society of Hematology, 2005, Atlanta, GA. (Blood [ASH Annual Meeting Abstracts] 106:Abstract 4132, 2005).

15. Malowany JI, Knoppert DC, Chan AKC, Lee DSC. Risk factors for symptomatic

vascular thrombosis in the neonatal intensive care unit (NICU). Pediatric Academic Societies’ Annual Meeting, 2007, Toronto, ON.

Dr. Anthony Chan

16. Athale UH, Lathia A, Nagel K, Chan AKC. Central venous line dysfunction is associated with increased prevalence of thromboembolism in children with acute lymphoblastic leukemia. Pediatric Academic Societies’ Annual Meeting, 2007, Toronto, ON.

17. Vincent AM, Chan A, Israels SJ, Poon MC, Wu JK, Rivard GE. Use of factor VIII/ von

Willebrand factor complex for inducing immune tolerance in hemophilia A patients who have failed with recombinant FVIII: Recent Canadian experience. 50th Annual Meeting of American Society of Hematology, 2008, San Francisco, CA. (Blood [ASH Annual Meeting Abstracts], 112:Abstract 4520, 2008).

BOOKS

1. Monagle P, Chan AKC, deVeber G, Massicotte M. Andrew's Pediatric Thromboembolism and Stroke. (Third Edition ) BC Decker, Hamilton 2006.

BOOK CHAPTERS

1. Bagnall-Reeb H, Chan AKC, Darouiche R, Jones G, Ryder M. Managing patients with venous access device-related venous thrombosis. IN: Apha Guide to Drug Treatment Protocols: A Resource for Creating and Using Disease-Specific Pathways. Manolakis PG, Albrant DH (Eds) American Pharmaceutical Association, 1998.

2. Monagle P, Chan A. Management of VTE in Paediatric Patients. In: Critical

Decisions in Thrombosis and Hemostasis. Ginsberg J, Kearon C, Hirsh J (Eds), B.C. Decker Inc., Hamilton, 1998.

3. Berry L, Andrew M, Chan AKC. Antithrombin-Heparin Complexes (Chapter 25). In:

Polymeric Biomaterials. Part II: Medical and Pharmaceutical Applications of Polymers. (Second Edition). Dumitriu S (Ed), Marcel Dekker Inc., New York, NY, 2002.

4. Chan A. Pathogenesis, Clinical Manifestations, and Diagnosis of Thrombosis in the

Newborn. In: UpToDate. Rose BD (Ed), UpToDate, Wellesley, MA, 2002 (Annual Review).

5. Chan A. Management of Thrombosis in the Newborn. In: UpToDate. Rose BD (Ed),

UpToDate, Wellesley, MA, 2002 (Annual Review).

6. Albisetti M, Chan AKC. Pathogenesis and Clinical Manifestations of Venous Thromboembolism in Infants and Children. In: UpToDate. Rose BD (Ed), UpToDate, Wellesley, MA, 2004 (Annual Review).

7. Albisetti M, Chan AKC. Diagnosis and Treatment of Venous Thromboembolism in

Infants and Children. In: UpToDate. Rose BD (Ed), UpToDate, Wellesley, MA, 2004 (Annual Review).

Dr. Anthony Chan

8. Blanchette VS, Dror Y, Chan AKC. Hematology. In: Avery’s Neonatology: Pathophysiology and Management of the Newborn. (6th Edition). MacDonald M, Seshia MMK, Mullett MD (Eds), Lippincott Williams & Wilkins, Philadelphia PA, 2005.

9. Massicotte P, Monagle P, Chan AKC. Systemic Thrombosis in Children. In:

Thrombosis in Clinical Practice. Blann A, Lip GYH, Turpie AGG (Eds), Taylor & Francis, New York, NY, 2005.

10. Berry LR, Chan AKC. Improving Blood Compatibility of Biomaterials Using a Novel

Antithrombin-Heparin Covalent Complex. In: Biomaterials Fabrication and Processing Handbook. Chu PK, Lui X (Eds), CRC Press/Taylor and Francis Group, New York, 2008.

11. Chan AKC, Monagle P. Pediatric Thrombosis. In: Evidence-based Hematology.

Crowther M, Ginsberg J, Schünemann H, Meyer RM, Lottenberg R (Eds), Wiley-Blackwell BMJ Books, Malden, MA, 2008.

12. Monagle P, Chan AKC. Anticoagulation in Children. In: New Therapeutic Agents in

Thrombosis and Thrombolysis. (Third Edition). Freedman J, Loscalzo J (Eds), Informa Healthcare, New York, NY, 2009.

13. Chan AKC, Odame I. Coagulation Disorders. In: Manual of Pediatric Intensive Care.

Kirpalani H, Huang L, Duffett M, Michenko M (Eds), PHMP/BC Decker, Hamilton, 2009.

14. Athale UH, Yang JYK, Chan AKC. Thromboembolism in Children with Cancer. In:

UpToDate. Rose BD, Basow DS (Eds), UpToDate, Waltham, MA, 2010 (Annual Review).

15. Chan AKC, Paredes N, Monagle P, deVeber G. Chapter 4 - Prothrombotic Disorders

and Ischemic Stroke in Children. In: Ischemic Stroke in Childhood. González G, Arroyo H, Crosa R, Russi ME (Eds), pp. 113-134, Panamericana, Argentina, 2011. (Translated into Spanish: Trastornos protrombóticos y accidente cerbrovascular isquémico. In: Accidente certrobascular en la infancia y adolescencia.)

16. Journeycake J, Yang J, Chan AKC. Normal and Abnormal Hemostasis. In: Rudolph’s

Pediatrics. (22nd Edition). Rudolph CD, Rudolph AM, Lister GE, First LR, Gershon AA (Eds), McGraw-Hill, New York, 2011.

17. Journeycake J, Chan AKC. Diagnosis and Management of Thrombosis. In: Rudolph’s

Pediatrics. (22nd Edition). Rudolph CD, Rudolph AM, Lister GE, First LR, Gershon AA (Eds), McGraw-Hill, New York, 2011.

18. Macartney CA, Paredes N, Chan AKC. Disorders of Coagulation in the Neonate.

Chapter 152. In: Hematology, Basic Principles and Practice, Sixth Edition. Hoffman R, Weitz JI, Heslop H (Eds). Elsevier (accepted, 2012).

19. Chan HHW, Chan AKC, Alexopoulou I, Lau KK. Thrombotic Thrombocytopenic

Dr. Anthony Chan

Purpura. Current Pediatric Reviews, (accepted, 2011).

20. Chan HHW, Chan AKC, Blatny J, Lau KK. Current Guidelines and Strategies in Management of Renal Vein Thrombosis. Current Pediatric Reviews, (accepted, 2011).

21. Massicotte MP, Bauman ME, Chan V, Chan AKC. Unique Challenges with Hemostatic Testing in Children. Chapter 8. In: Quality in Laboratory Hemostasis and Thrombosis. Kitchen S, Olson JD, Preston FE (Eds), Wiley-Blackwell, (accepted, 2012).

INVITED PRESENTATIONS May 2013 Taiwan Society of Thrombosis and Hemostasis Annual Meeting, Taipei, Taiwan “Optimizing Prophylaxis in Hemophilia B” “B-Domain Deletion: The Clinical Perspective in Hemophilia A

Management” Apr 2013 Lebanese Pediatric Society Meeting, Beirut, Lebanon

“Management of Bleeding and Thrombosis in Neonatal Patients” “Differential Diagnosis of a Prolonged PT and aPTT: Approach to

Prolonged Coagulopathy Test” “New Advance to Approach to Hemophilia in Pediatrics” “Rare Bleeding Disorders in Children”

Apr 2013 Hemostasis and Thrombosis Research Society (HTRS) Scientific Symposium,

Charlotte, NC “Pediatric Stroke and tPA Study Design” (Co-Presenter: C. Amlie-Lefond) Dec 2012 American Society of Hematology (ASH) Annual Meeting and Exposition,

Atlanta, GA “L-asparaginase-associated Thrombosis” Oct 2012 Canadian Society of Atherosclerosis, Thrombosis and Vascular Biology

(CSATVB) Annual Meeting, Toronto, ON “Application of a Novel Heparinoid to Prevent Surface-Induced Thrombosis”

Jun 2012 58th Meeting of the Scientific & Standardization Committee of the International

Society on Thrombosis and Haemostasis (ISTH), Liverpool, UK “Establishment of a Registry of Homozygous Protein C” Jun 2012 Canadian Hemophilia Physician Update (CHPU), Halifax, NS “Gaps in Hemophilia Patients’ Knowledge” Jun 2012 Clinical Rounds, Niagara Health System, St. Catharines, ON “Childhood ITP” “Thrombosis in Children”

Dr. Anthony Chan

May 2012 McMaster Neuroscience Half Day Symposium, Medical and Surgical

Management of Pediatric and Adult Stroke, Hamilton, ON “Anticoagulation in Neonatal CSVT” Apr 2012 1st Kuwait Pediatric Conference: Holistic View into the Future, Kuwait “Pediatric Thromboembolism” “ITP Practical Issues” Jan 2012 The Children’s Hospital of Philadelphia, Hematology Seminar Series,

Philadelphia, PA “Development of a Novel Anticoagulant” Dec 2011 McMaster University, Hematology Rounds, Hamilton, ON “Development of a Novel Anticoagulant - A 15 Year Journey” Nov 2011 Aalborg Hospital, Aarhus University Hospital, Pediatric Seminar, Denmark

“Pediatric Thromboses - Are They Different From Adult Thromboses?”

Jun 2011 2011 Translational Cardiac Research Conference (Nemours Cardiac Center and

Nemours Biomedical Research), Wilmington, DE “Anticoagulation Therapy” Jun 2011 Thomas Jefferson University, A. I. duPont Hospital for Children, Pediatric

Hematology/Oncology Round, Wilmington, DE “Thromboembolism in Pediatric ALL” Jun 2011 Canadian Hemophilia Physician Update (CHPU), Toronto, ON “Bone Health in Children with Hemophilia” May 2011 Middle East Medical Assembly (MEMA), Beirut. Lebanon “Thrombosis and Hemostasis in Children with Cancer” “Pediatric Thromboembolism: An Overview” May 2011 Middle East Medical Assembly (MEMA) in Collaboration with the Middle East

Childhood Cancer Alliance (MECCA), Beirut. Lebanon “Thrombosis in Childhood Acute Lymphoblastic Leukemia” Apr 2011 Buffalo General Hospital, Neurology Grand Rounds, Buffalo, NY “Neonatal Cerebral Sinovenous Thrombosis: Where Do We Stand?” Oct 2010 6th Congress of the Asia Pacific Society on Thrombosis and Haemostasis

(APSTH), Bali, Indonesia “The Benefit of Early Prophylaxis in Inhibitor Prevention” “Pathogenesis, Risk Factor and Diagnosis of Thrombosis in

Pediatrics”

Dr. Anthony Chan

Oct 2010 Baxter Roundtable Meeting, Bali, Indonesia “Canadian Hemophilia Registry” Oct 2010 6th Annual McMaster Update in Thromboembolism and 41st Hematology

Reunion, Hamilton, ON “Hemophilia, 40 Year Perspective” Jul 2010 XXIX International Congress of the World Federation of Hemophilia (WFH),

Buenos Aires, Argentina. “Evaluation of Neonatal Hemostasis” Jun 2010 3rd Canadian Hemophilia Physicians Update, Vancouver, BC “Dose Escalation is the Optimal Approach to Prophylactic Therapy

for Severe Hemophilia A (Disagree)” (Debate) Nov 2009 NRBDO (Network of Rare Blood Disorder Organizations) Progress in

Comprehensive Care for Rare Blood Disorders Conference, Toronto, ON “Models and Examples of Current Registries: Canadian Hemophilia Registry”

Oct 2009 Pediatric Hematology Update, Toronto, ON “Inflammation and Thrombosis: Partners in Crime” Oct 2009 3rd Regional Meeting of the Lebanese Society of Hematology and Blood

Transfusion, Beirut, Lebanon “Pediatric Thrombosis” “Importance of Keeping Accurate and Updated Registry” Jun 2009 Canadian Hemophilia Physician Update (CHPU), Montebello, QC

“What Do You Know About Compliance in Hemophiia?” May 2009 Pediatric Academic Societies Annual Meeting, Boston, MA “Anticoagulation Therapy in Neonate” Feb 2009 53rd Annual Meeting Society of Thrombosis and Haemostasis Research, Vienna,

Austria. “Antithrombotic Therapy for Venous Thromboembolism - How and How Long?”

Oct 2008 Canadian Cardiovascular Congress (CCC), President’s Symposium in

Anticoagulant and Antithrombotics, Toronto, ON “Development of a Novel Anticoagulant, Antithrombin-Heparin Complex - A 10 Year Journey” Sep 2008 5th Congress of Asian-Pacific Society on Thrombosis and Hemostasis (APSTH),

Singapore (Symposium on Paediatrics and Neonatal Issues) “Thrombosis in Children/Neonates”

Dr. Anthony Chan

Jul 2008 54th Annual Meeting of the Scientific and Standardization Committee (SSC) of the Congress of the International Society on Thrombosis and Haemostasis (ISTH), Vienna, Austria (Perinatal/Pediatric Hemostasis: Heparin Therapy, Bleeding Risk)

“Stratification of Therapy Risk with Anticoagulants/Thrombolytics in Children”

Apr 2008 2nd Biennual Conference for Canadian Pediatric Hematology/Oncology Program

Directors and Residents, Montebello, QC. “Career and Family – A Personal Perspective” Jan 2008 Research Seminar Series, Texas Children’s Centre, Houston, TX “Thrombosis in Neonate – What Do We Know?” “Development of a Novel Anticoagulant” “A Balanced Life – A Personal Journey” Dec 2007 Pediatric Grand Rounds, Queen’s University, Kingston, ON “What Does a Clotter Learn from Treating Hemophiliacs?” Nov 2007 Pediatric Grand Rounds, Janeway Children’s Hospital, St. John’s, NL “Prophylaxis in Hemophilia” Jul 2007 XXI Congress of the International Society on Thrombosis and Haemostasis

(ISTH), Geneva, Switzerland “Management of Arterial and Venous Thrombosis in Pediatric Patients”

Jul 2007 XXI Congress of the International Society on Thrombosis and Haemostasis

(ISTH), Scientific Subcommittee Session-Perinatal/Pediatric Hemostasis, Geneva, Switzerland

“Recurrence of DVT in Children” Apr 2007 Pediatric Grand Rounds, Grand River Hospital, Kitchener, ON “Update on Venous Thromboembolism in Children” Nov 2006 Shokeir Lecture, Royal University Hospital, Saskatoon, SK “Thrombosis in Pediatric Oncology” Oct 2006 Inaugural Conference for the Canadian Pediatric Hematology/Oncology Program

Directors and Residents, Calgary, AB “Achieving Balance Between Work and Family” Oct 2006 Grand Rounds, Alberta Children’s Hospital, Calgary, AB “Thrombosis in Pediatric Oncology” Jun 2006 Pediatric Round, Prince of Wales Hospital, Hong Kong Chinese University, Hong

Kong “Pediatric Thrombosis”

Dr. Anthony Chan

Jun 2006 Pediatric Hematology/Oncology Study Group Annual Symposium, Hong Kong “Advances in Management of Hemophilia” “Pediatric Thrombosis” May 2006 Challenges in Neonatal Care: Coagulation Disturbances and IVH Symposium,

San Francisco, CA “Developmental Hemostasis” Nov 2005 Pediatric Oncology Group of Ontario (POGO) Supportive Care Symposium,

Toronto, ON “Thrombosis in Pediatric Oncology” (Chan AKC and Massicotte P) Nov 2005 Third Annual Stroke Conference, Kitchener, ON “All You Need to Know About Pediatric Stroke” Oct 2005 Balkan Coagulation Laboratory Workshop, Belgrade “Concepts in Hemostasis” Oct 2005 World Federation of Hemophilia Twinning Program, Belgrade “Primary Prophylaxis in Hemophilia A” Oct 2005 Miami Children’s Hospital Symposium in Pediatric Hemostasis, Miami, FL “Prothrombotic Disorder in Children” “Update on Hemophilia Care” Aug 2005 XX Congress of the International Society on Thrombosis and Haemostasis

(ISTH), Sydney, Australia “Thrombosis in Pediatric Cancer” Aug 2005 51st SSC Scientific Subcommittees on Perinatal/Pediatric Haemostasis of the

International Society on Thrombosis and Haemostasis (ISTH), Sydney, Australia “Cardiopulmonary Bypass and Stroke-Update” May 2005 Bleeding Disorders Workshop, American Society of Pediatric

Hematology/Oncology Annual Meeting, Washington, DC “Thrombin Generations” May 2005 Neonatology Round, St Joseph's Hospital, London, ON “Neonatal Thrombosis” May 2005 Research Seminar, Lawson Health Research Institute, London, ON “Development of a Novel Anticoagulant” Oct 2004 Pediatric Rounds, The University of Hong Kong, Hong Kong

“Cardiopulmonary Bypass and Stroke” “Development of a Novel Anticoagulant”

Dr. Anthony Chan

Jun 2004 50th SSC Scientific Subcommittees on Perinatal/Pediatric Haemostasis of the International Society on Thrombosis and Haemostasis (ISTH), Venice, Italy

“Cardiopulmonary Bypass and Stroke” Oct 2003 III Congress of the Inter-American Division of the International Society of

Hematology, Santiago, Chile “Developmental Hemostasis” “Neonatal Thrombosis”

Oct 2003 Asociacion Espanola Primera de Socorros Mutuos, Montevideo, Uruguay

“Pediatric Thrombophilia” Oct 2003 Visiting Professor, Hospital Pereira Rossell, Montevideo, Uruguay

“Pediatric Thrombophilia” “Neonatal Thrombosis”

Jul 2003 49th SSC Scientific Subcommittee on Perinatal/Pediatric Haemostasis of the

International Society on Thrombosis and Haemostasis (ISTH), Birmingham, England

“Novel anticoagulant - Solution to CVL-related DVT?” Dec 2002 Visiting Professor, Jinan Central Hospital, China

“Development of a Novel Anticoagulant” “Neonatal Thrombosis”

Dec 2002 Visiting Professor, Institute of Basic Medicine, Shangdon, China

“Development of a Novel Anticoagulant” and “Neonatal Thrombosis”

Dec 2001 43rd Annual Meeting of American Society of Hematology Education Session,

Orlando, FL “Therapeutics for Neonatal Thrombosis”

Oct 2001 XVII Congreso Internacional de Hemostasis y Trombosis del Grupo CLAHT,

Mexico City, Mexico “Neonatal Thrombosis”

Jul 2001 47th SSC Scientific Subcommittee on Perinatal/Pediatric Haemostasis of the

International Society on Thrombosis and Haemostasis (ISTH), Paris, France “Thrombin Generation in the Presence of rFVIIa”

Nov 2000 Novo Nordisk Meeting, Atlanta, GA

“Use of Factor VIIa in Intracranial Hemorrhage: Developmental Hemostasis”

Sep 1999 National Institute of Health Workshop on Fibrin Turnover in the Lung,

Washington, DC “A Novel Antithrombin-Heparin Covalent Complex for

Dr. Anthony Chan

Intrapulmonary Use” Aug 1999 45th SSC Scientific Subcommittee on Fibrinogen and Fibrinolysis of the

International Society on Thrombosis and Haemostasis (ISTH), Washington, DC “Plasma Concentrations of TAFI in the Young” May 1999 The 5th Novo Nordisk Symposium on the Treatment of Bleeding and Thrombotic

Disorders, Copenhagen, Denmark “Thrombin Generation in Premature Infants” CME PRESENTATIONS Dec 2008 CME Grand Rounds (Baxter Canada), Oakville, ON “Managing Hemophilia: What You Need to Know” Nov 2007 Pediatric Practice Hematology Update, Niagara Health System, Niagara Region,

ON “Hemophilia in Children” “Use of LMWH in Children” WORKSHOPS/CHAIR OF SCIENTIFIC SESSIONS Dec 2012 American Society of Hematology (ASH) Annual Meeting and Exposition,

Atlanta, GA “Not So ‘Benign’ Hematologic Issues in Children” (Chair) “Updates in Thrombosis in Pediatrics: Where Are We After 20

Years?” (Guest Speaker) Oct 2012 Canadian Cardiovascular Congress (CCC), Toronto, ON

“Anticoagulant Coating and Applications Symposium” (Co-Chair) Jun 2012 58th Meeting of the Scientific & Standardization Committee of the International

Society on Thrombosis and Haemostasis (ISTH), Liverpool, UK “Thrombosis & Haemostasis Issues in Child Health” (Chair) “Perinatal/Pediatric Session” (Co-chair)

Jul 2011 XXIII Congress of the International Society on Thrombosis and Haemostasis

(ISTH), SSC Session, Kyoto, Japan “Perinatal/Paediatric Haemostasis Session” (Co-chair)

May 2010 American Thoracic Society (ATS) International Conference, Pediatric Clinical

Chest Round, New Orleans, LA “Case 3: A 16 Year Old Male With Dyspnea And Fatigue”

(Discussant) May 2010 XXII Congress of the International Society on Thrombosis and Haemostasis

Dr. Anthony Chan

(ISTH), SSC Session, Cairo, Egypt “PTS as an Outcome Measure of Paediatric Thrombosis Therapy:

Can We Develop Standardised Criteria” (Guest Speaker and Co-Chair) May 2010 Meet the Professor Breakfast Session, Pediatric Academic Societies’ Annual

Meeting, 2010, Vancouver, BC. “Pediatric Thrombosis” (Guest Speaker) Jul 2009 XXII Congress of the International Society on Thrombosis and Haemostasis

(ISTH), Boston, MA “Neonatal and Pediatric Hemostasis” (Chair, Abstract Symposium) “Neonatal Thrombosis” (Co-Chair, SSC Session)

Jul 2009 XXII Congress of the International Society on Thrombosis and Haemostasis

(ISTH), Boston, MA “Neonates: Are They More Prone to Clotting or Bleeding?” (Guest Speaker and Session Chair).

May 2009 Pediatric Academic Societies Annual Meeting, Boston, MA “Topic Symposium: Neonatal Venous Thrombosis Overview” (Chair) Apr 2009 The American Society of Pediatric Hematology/Oncology (ASPHO) Meeting,

San Diego, CA “Below the Neck: Venous and Arterial Thrombosis in the NICU” (Guest Speaker - Thrombotic Complications in the NICU: Controversies and a Multidisciplinary Perspective Workshop)

Feb 2009 53rd Annual Meeting Society of Thrombosis and Haemostasis Research, Vienna,

Austria. “Symposium/Free Communication: Pediatric Session” (Co-Chair) Oct 2008 Pediatric Hemostasis & Thrombosis Update, Toronto, ON

“Congenital and Acquired Prothrombotic States: Diagnostic Challenges” (Guest Speaker - Thrombosis Workshop Session)

Sep 2008 5th Congress of Asian-Pacific Society on Thrombosis and Haemostasis (APSTH),

Singapore “Management of Anticoagulant Therapy in Children”

(Guest Speaker - Anticoagulant Management Workshop) May 2008 The American Society of Pediatric Hematology/Oncology (ASPHO) Meeting,

Cincinnati, OH “Thrombosis for Venous Thromboembolism in Infants and Children:

Thrombolytic Therapy "High," "Low," or "NO!"” (Guest Speaker - Preview of Up-to-Date Guidelines from 8th ACCP

Conference on Antithrombotic and Thrombolytic Therapy)

Dr. Anthony Chan

Apr 2008 Hemophilia and Thrombosis Research Society (HTRS) Meeting, Northwestern University, Chicago, IL

“Neonatal Thrombosis” (Chair) Jul 2007 XXI Congress of the Interantional Society on Thrombosis and Haemostasis

(ISTH), Geneva, Switzerland “Thrombosis and Haemostasis in Children” (Co-chair)

Oct 2006 Second Hemostasis and Thrombosis Update, Toronto, ON “Evaluation of the Child with a Suspected Bleeding Disorder”

(Co-chair) “Interpretation of a Prolonged PTT/INR” (Guest Speaker)

Sep 2006 The Canadian Hemophilia and Thrombosis Summit, Toronto, ON

“Novel Anticoagulants” (Co-chair) Sep 2006 Pediatric Hemostasis and Thrombosis Update, Toronto, ON

“Workshop I: Evaluation of the Child with a Suspected Bleeding Disorder” (Guest Speaker)

Sept 2006 Eastern Canadian Hemostasis Symposium, Montreal, QC

“Update on Evidence Based Use of VIIa” (Chair) “Prophylaxis in Hemophilia” (Chair) “Emerging Problem in Hemophilia” (Chair) Nov 2005 Pediatric Oncology Group of Ontario (POGO) Supportive Care Symposium,

Toronto, ON “Primary Thromboprophylaxis: Is It Ready for Prime Time?” (Guest Speaker)

Aug 2005 XX Congress of the International Society on Thrombosis and Haemostasis

(ISTH), Sydney, Australia “Perinatal/Pediatric Thrombosis and Hemostasis” (Chair) Oct 2004 Pediatric Hemostasis Update, Toronto, ON “Laboratory Aspect of Pediatric Hemostasis” (Chair) Dec 2003 American Society of Hematology Annual Meeting, San Diego, CA “Career Development – Mentor – Trainee Session” (Guest Speaker)

Case Conferences Jun 2011 Nemours Cardiac Center, Wilmington, DE “Anticoagulation for Patient on ECMO” Apr 2011 Hemophilia Center of Western New York, Buffalo, NY Case conference: Three Difficult Cases in Pediatric Stroke

Dr. Anthony Chan

Jun 2006 Tuen Mun Hospital, Hong Kong Case conference: SLE and Thrombocytopenia Nephrotic Syndrome and CSVT Prince of Wales Hospital, Hong Kong Case conference: Neonatal SVC Syndrome Queen Mary Hospital, Hong Kong Case conference: Hemophilia Arthropathy SLE and Thrombosis Oct 2003 Hospital Pereira Rossell, Uruguay Case conference: Neonatal Thrombosis Pediatric Arterial Ischemic Stroke Prothrombotic State

anthony k. c. chan publications as of june 16, 2013 - taari

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