PHARMANEX LifePak®

Anti-Aging LifePak®

Technical Training This material has been prepared by Pharmanex to be used in conjunction with general educational events and activities only. Alterations or modifications of this presentation without the express approval of Pharmanex are prohibited.

PHARMANEX LifePak®

What is LifePak®?

A comprehensive supplementation program for a long and healthy life.*

*This statement has not been evaluated the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

PHARMANEX LifePak®

¨  Ensures meeting all nutrient recommendations (RDAs)

¨  Considers typical dietary intakes ¨  Provides optimum nutrient levels for long-term

health* ¨  Includes “semi-essential” nutrients

The LifePak® Concept: Optimum Supplementation

*This statement has not been evaluated the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

PHARMANEX LifePak®

LifePak® Health Benefits Optimum supplementation for general well-being*

1. Addresses nutrient deficiencies* 2. Has cardiovascular benefits* 3. Provides complete bone nutrition 4. Promotes healthy immune function* 5. Maintains blood sugar levels

already within the normal range* 6. Protects against the symptoms of aging*

*These statements have not been evaluated the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

PHARMANEX LifePak®

Percent of Adults Not Meeting RDA

0

10

20

30

40

50

60

70

80

90

Vitamin A

Vitamin E

Vitamin C

Thiamin

Riboflavin

Niacin

Vitamin B6

Folate

Vitamin B12

Calcium

Magnes

iumIro

nZinc

MalesFemales

Source: USDA 1994-96 CSFII

1. Nutrient Deficiencies

PHARMANEX LifePak®

Percent of LifePak Users Not Meeting RDA

0

10

20

30

40

50

60

70

80

90

Vitamin A

Vitamin E

Vitamin C

Thiamin

Riboflavin

Niacin

Vitamin B6

Folate

Vitamin B12

Calcium

Magnesium Iro

nZinc

Males

Females

1. Nutrient Deficiencies

PHARMANEX LifePak®

♥ Over 20 Antioxidants: protect blood lipids (LDL) from oxidation by free radicals*

2. Cardiovascular Benefits

(means +/- SD)

42.1 4243.4

50.9

30

35

40

45

50

55

60

65

Start After 6 Weeks

PlaceboLifePak

The Silent Benefits of LifePak®: You don’t feel them at first, but you will appreciate them years later!

*This statement has not been evaluated by the Food &Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

PHARMANEX LifePak®

© Calcium & Magnesium: maintain normal blood pressure and heart function*

© B Vitamins: maintain normal blood homocysteine*

© Flavonoids: promote blood circulation*

2. Cardiovascular Benefits © Over 20 Antioxidants: protect blood lipids

(LDL) from oxidation by free radicals*

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

PHARMANEX LifePak®

3. Bone Nutrients ¨  Calcium (500 mg): Major bone mineral; RDA:

1000 to 1300 mg/day; typical intake: 800 mg/day ¨  Magnesium (250 mg): Major bone mineral; RDA:

280 to 320 mg/day ¨  Vitamin D (400 IU): Regulates Ca and Mg bone

metabolism; deficiencies in Northern countries ¨  Vitamin K (40 mcg): Ca transport into bone ¨  Silicon (3 mg): Bone calcification and collagen ¨  Boron (3 mg): Regulates bone cell function ¨  Soy Isoflavones (10 mg): Regulate Ca metabolism ¨  Phosphorus (0 mg): Do not supplement with P! *T

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PHARMANEX LifePak®

* These statements have not been evaluated the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

4. Immune Function LifePak supports normal immune function*

¨  Vitamins C & E

¨  Multi-Carotenoid Blend

¨  Vitamin A, Vitamin B6 & Zinc

Percent of Adults Not Meeting RDA

0

10

20

30

40

50

60

70

80

90

Vitamin A

Vitamin E

Vitamin C

Thiamin

Riboflavin

Niacin

Vitamin B6

Folate

Vitamin B12

Calcium

Magnes

iumIro

nZinc

MalesFemales

LifePak® provides long-term immune system support;* Immune Formula promotes short-term immune response.*

Percent of Adults Not Meeting RDA

0

10

20

30

40

50

60

70

80

90

Vitamin A

Vitamin E

Vitamin C

Thiamin

Riboflavin

Niacin

Vitamin B6

Folate

Vitamin B12

Calcium

Magnes

iumIro

nZinc

MalesFemales

PHARMANEX LifePak®

LifePak® maintains blood sugar levels already within the normal range.*

Chromium, 200 mcg: ¨  essential for normal insulin function ¨  most diets are low in chromium (<50 mcg/day)

5. Blood Sugar & Insulin

Vitamin C, 500 mg Vitamin E, 300 IU Alpha-Lipoic Acid, 30 mg Magnesium, 250 mg Zinc, 15 mg

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure of prevent any disease.

PHARMANEX LifePak®

LifePak® Addresses the Root Cause of Aging:

DNA Damage ¨  DNA (DeoxyriboNucleic Acid) is your genetic

blueprint ¨  DNA enables healthy cell renewal into old age

6. Aging Symptoms

PHARMANEX LifePak®

Cell Old Cell

Days to Months

Cell Division

New Cells

Background Information

Programmed Cell Death (Apoptosis)

Old Cell

PHARMANEX LifePak®

Nucleus

Cell

DNA

G

T

C

A Mitochondria

PHARMANEX LifePak®

DNA is damaged by free radicals:

A Antioxidants “catch” free radicals before they can hurt us

PHARMANEX LifePak®

Extent of DNA Damage 73,000 DNA damage events

per cell every day!

DNA repair enzymes fix

most of the damage

PHARMANEX LifePak®

Mitochondria: “The Perpetrators of Aging”

2 to 5% of the oxygen used by mitochondria is diverted to produce

free radicals!

PHARMANEX LifePak®

Mitochondria produce free radicals

PHARMANEX LifePak®

Body Cell

Summary: How Do We Age?

Weak Antioxidant Defense

DNA Damage

Free Radical Production

DNA Damage

Impaired Cellular Function and Cell Regeneration

Impaired Energy Production

Aging Symptoms

Mitochondria Cell Nucleus

PHARMANEX LifePak®

What Causes DNA Damage?

♦  Free radicals from environmental pollution (Ozone)

♦  Radiation exposure: ♦  sunlight (UV-light), X-rays, cosmic radiation (airline

travel), radioactivity ♦  Smoking:

♦  10,000,000,000,000,000 free radicals/cigarette!

♦  Free radicals from your mitochondria

PHARMANEX LifePak®

Reduce DNA Damage 1. Reduce your exposure to free radicals!

♦  don’t smoke

♦  avoid excessive sun exposure (use sunscreens)

♦  avoid polluted areas

2. Improve your antioxidant defense! ♦  eat more fruits and vegetables

♦  take LifePak®

PHARMANEX LifePak®

LifePak® provides an arsenal of nutrients that

fight DNA damage, protect DNA, and

enhance DNA repair.*

*This statement has not been evaluated the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

PHARMANEX LifePak®

LifePak® & DNA Damage LifePak® Nutrient Function

500 mg Vitamin C300 IU Vitamin E

↓ DNA damage↑ DNA repair

10 mg Vitamin B6600 mcg Folic Acid30 mcg Vitamin B12

Essential for DNAsynthesis, replicationand repair

15 mg Zinc Stabilizes DNA

PHARMANEX LifePak®

LifePak® Nutrient Function

15 mg Multi-Carotenoids6 mg beta carotene2 mg alpha carotene5 mg lycopene2 mg lutein

↓ DNA damage

175 mg Multi-Flavonoids90 mg green tea catechins25 mg quercetin25 mg grape seed OPC25 mg citrus bioflavonoids10 mg soy isoflavones

↓ DNA damage↑ DNA repair

30 mg α-Lipoic Acid ↓ DNA damage

PHARMANEX LifePak®

Green Tea and Longevity

PHARMANEX LifePak®

Green Tea

¨  Green Tea => Oolong Tea => Black Tea

¨  Contains CATECHINS (flavonoids) ¨  C, EC, ECG, EGC, EGCG

¨  very potent antioxidants

¨  green tea catechins reduce DNA damage

PHARMANEX LifePak®

Green Tea and Longevity

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Mea

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Men Women

3 or less4 to 9over 10

Green Tea Consumption (Cups/Day)

Prospective, 11-year cohort study of 8,552 subjects in Yoshimi, Japan, 1986-1997. From: H. Fujiki et al., Ann. N.Y.Acad.Sci., 928:274, 2001; used with author’s permission.

PHARMANEX LifePak®

LifePak® Nutrient Function

15 mg Multi-Carotenoids6 mg beta carotene2 mg alpha carotene5 mg lycopene2 mg lutein

↓ DNA damage

175 mg Multi-Flavonoids90 mg green tea catechins25 mg quercetin25 mg grape seed OPC25 mg citrus bioflavonoids10 mg soy isoflavones

↓ DNA damage↑ DNA repair

30 mg αα--LLiippooiicc AAcciidd ↓ DNA damage

PHARMANEX LifePak®

Alpha-Lipoic Acid “The Universal Antioxidant”

¨  augments the body’s entire antioxidant network, including glutathione and coenzyme Q10*

¨  has ability to neutralize many different free radicals* ¨  crosses blood-brain barrier (protects nervous system)* ¨  directly and indirectly reduces DNA damage* ¨  best mitochondrial antioxidant*

New LifePak®: 30 to 50 mg alpha-lipoic acid *These statements have not been evaluated the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

PHARMANEX LifePak®

LifePak® addresses the root causes of aging symptoms at the molecular level: DNA damage in cells and mitochondria*

6. Aging Symptoms

*This statement has not been evaluated the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

PHARMANEX LifePak®

LifePak® Health Benefits Optimum supplementation for general well-being*

1. Addresses nutrient deficiencies* 2. Provides cardiovascular benefits* 3. Contains complete bone nutrition 4. Promotes healthy immune function* 5. Maintains blood sugar levels

already within the normal range* 6. Protects against the symptoms of aging*

*These statements have not been evaluated the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

PHARMANEX LifePak®

Always the Right Program!

LifePak®:

¨  all adults, 18 years and up

¨  men, 18 to 40 years

PHARMANEX LifePak®

Always the Right Program!

LifePak Women®: ¨  pre-menopausal

women, 18 to 45 years

PHARMANEX LifePak®

LifePak Women® All of the benefits of regular LifePak®, plus: ¨  Extra bone nutrition

¨  more calcium, magnesium, and soy isoflavones

¨  More iron for blood formation and energy* ¨  Added nutrients for female hormone balance*

¨  Evening Primrose and Borage seed oils, ¨  Phytoestrogens

¨  Cranberry Concentrate ¨  promotes healthy urinary tract* ¨  same as in one glass of cranberry cocktail

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure of prevent any disease.

PHARMANEX LifePak®

LifePak Prime®:

¨  post-menopausal women

¨  men over 40 years

Always the Right Program!

PHARMANEX LifePak®

LifePak Prime® All of the benefits of regular LifePak®, plus: ¨  Extra bone nutrition

¨  more Calcium and Magnesium

¨  Extra Anti-Aging Nutrients and Antioxidants ¨  more alpha-lipoic acid and grape seed extract (50 mg) ¨  added Coenzyme Q10 and L-Glutathione

¨  Glucosamine for flexible, healthy joints* ¨  BioGinkgo® 27/7 for brain circulation/memory* ¨  Extra Zinc and Vitamin B12 for immune function*

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure of prevent any disease.

PHARMANEX LifePak®

Always the Right Formula!

LifePak PreNatal®

LifePak® Teen

Jungamals®

LifePak Trim®

PHARMANEX LifePak®

LifePak® Safety ♦  All vitamin and mineral levels are below the

NOAEL (No Observed Adverse Effect Level) established by the CRN (Council for Responsible Nutrition, 1998)

♦  Phytonutrients are added at food levels that are documented safe

♦  Clinical LifePak® studies showed no adverse effects

PHARMANEX LifePak®

LifePak® Directions One packet, twice daily with meals

¨  meals enhance absorption (vitamins) and improve tolerance (minerals)

¨  twice daily promotes steady nutrient delivery, e.g., plasma levels of vitamin B6

7:30 a.m. 6:30 p.m.

PHARMANEX LifePak®

Question: “On the following scale please rate how well you believe LifePak works.” (n=234, Dec. 2001)

LifePak Market Research

68%

23%

7%

2%

0%

0% 20% 40% 60% 80%

5

4

3

2

1

91% of the participants feel LifePak works in the ‘well’ and ‘extremely well’ ranges!

Mean = 4.57

1=Not at all and 5=Extremely well

PHARMANEX LifePak®

Question: “Do you believe LifePak makes a difference in the way you feel?” (n=234, Dec.2001)

LifePak Market Research

5%

95%

0% 20% 40% 60% 80% 100%

No

Yes

95% of the participants believe LifePak makes a difference in how they feel.

PHARMANEX LifePak®

LifePak Market Research Top three reasons LifePak makes a difference in the way people feel:

¨  Increased energy

¨  Healthier immune system ¨  Better sleeping habits

PHARMANEX LifePak®

Conclusion

LifePak® is unique, because it is a

comprehensive wellness program

that gives all the nutrients you need for a long, healthy and productive life.*

*These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, treat, cure of prevent any disease.

PHARMANEX LifePak®

Copyright 2002 by Pharmanex LLC

The copyright owner grants permission to Pharmanex employees, distributors, and other representatives to use this presentation IN ITS ENTIRETY for educational purposes only. It

cannot be changed or modified in any way without prior written permission of the

copyright owner.