Anti Aging Report

2 03/09

Prof. Klaus Jung

Skin Regeneration through Skin Care An indication for inhaling energised air

At the beginning of 2008 the American Society of Plastic Surgeons (ASPS) publisheda study on 186 monozygotic twins with the predictable result that lifestyle shows clearsigns in people’s faces. Worries and stress and divorce or illness accelerate the agingprocesses of an organism and especially the skin.

"It is true that genes also determine how aperson ages, but life circumstances will dictatehow quickly". This is the comment from thestudy director.

The results were obtained using independentassessors who looked at suitable photos andthen estimated the ages of the peopleconcerned then made a comparison with theiractual life circumstances and the differencewas two years on average.

How young or healthy we look depends to a great extent on our skin and in particularon the exposed areas such as the face andhands. The skin is not only a protective barrieragainst external hazards (bacteria, harmfulsubstances, heat and cold) or internal hazards(dehydration), it also says a great deal aboutour age and health (mental and physical). It isno coincidence that the skin plays such animportant role when it comes to anti-aging,wellness and beauty.

There is a desire to delay the natural aging process.

Topical (local) treatments and costly surgicalprocedures are used quite often withunsatisfactory results.

Our skin ages from birth onwards. Early on inlife it appears elastic, fresh and firm but withincreasing age it becomes rather thin, lackingin oil and collagen and "exsiccated" (driedout).

Besides the "time aging" factors of the skin,environmental and behavioural aspects havea strong effect on skin aging such as nicotineabuse, UV exposure and exposure to radicals.Effective combative measures are thought tobe a healthy diet, regular physical exercise,sufficient sleep, limited alcohol, ongoingde-stressing and avoidance of intense solarradiation.

Can the inhalation of energised air also bedefined as a protective measure or even as away of "rejuvenating" the skin, as claimed bymany end users based on their personalexperience?

BeautyBeauty is an abstract concept and it relatesto all aspects of human existence. Its positiveemotional effect has been proven and how itis perceived depends on different criteria andpurposes, as determined by particularconventions within society.

In everyday usage "beautiful" usually describessomething which leaves a particularly pleasantimpression behind, whether it be the body, a piece of music, a movement or evenexperiences. Beauty overlaps with theconcepts "harmony" and "symmetry" and ademarcation in respect of what is "sensuallyoverpowering" or "merely" pretty is sometimesdifficult.

While psychology and sociology base theirevaluation of what is "beautiful" on the idealsformulated by society, and philosophy defines"beauty" as a property of an object (in medievaltimes) or as a judgment based on reason (inthe modern era), the natural sciences tendwhen defining "beauty" to focus solely onstating the "ideal proportions" for that whichis generally considered beautiful. Yet thedebate continues as to whether such "idealproportions" are applicable in a general sense

or merely the particular expression of changingfashions and ideals of beauty.

Aging

During a person’s lifetime his/her appearanceundergoes the type of changes we are allfamiliar with. Posture, proportions andespecially the skin and its adnexae, the hairand nails, are all affected.

Young people are naturally affected far less(though sometimes by acne). (Premature)aging of the skin tends to occur in the primeyears of life. It can cause concern during themenopause and becomes even morepronounced during a person’s declining years,from which time it can have seriouspsychological implications.

There are countless comments about theaging process, which as a rule mainly concernpsychosocial and cognitive aspects but alsorelate to external appearance - at least whereconcrete questions are asked - it plays asignificant role when it comes to increasinglynegative feelings of self-worth and how othersregard us.

The most striking feature of aperson is their face and this is

because it can hardly be coveredup like other parts of the body,and its perceived or "actual"

deficits are mercilessly exposed.

Fig. 2: Leonardo da Vinci (Self-portrait, ca. 1516)

Fig. 1: Beauty

Anti Aging Report

303/09

Fig. 3: Albrecht Dürer’s “Portrait of Dürer’sMother” (Charcoal drawing, 1514).

Even though the aging process may differgreatly from one person to another there arecertain principles which are inescapable andundeniable.

Amongst these are horizontal wrinkles or linesin the region of the forehead, nose and cornersof the mouth and furthermore fine lines runningoutwards at the lateral corners of the eyes(crow’s feet) and then, later, wrinkles runningfrom the lower region of the chin to the frontareas of the neck.

Facial features become coarser and the noseand earlobes appear to grow. Age spotsincrease considerably. As a result of theadditional loss of subcutaneous fatty tissue,wrinkles and lines deepen further, giving thefamiliar appearance of an "old bat".

In addition, a change in facial appearance canbe caused by changes in skin turgor(plumpness) triggered by a decrease in thesupply of fluids to the connective tissuetogether with uneven distribution of fat (a change of fat density downwards in thecheeks resulting in ”drooping jowls”) as a result

of connective tissue weakness orloss of elasticity in the connectivetissue.

Because of localised loss of fat(subcutaneous fatty tissue) the facebecomes thinner. The eyes sink backinto the eye sockets. Increasinglythere is the impression of frailty andeven cachexia.

Depending on the propensity of theindividual, sooner or later there is areduction in elasticity of the cutisand subcutis, leading later to thedevelopment of "aged skin".

Thinning, white head hair is usuallylank and dry, with a tendency towardsbrittleness. Lips appear thin, dry andcracked.

The visual impression of age isreinforced by any loss of teeth andjaw atrophy (recession) due to boneloss.

Influence of the Mind

Intra and interpersonal problems play a key rolewhen it comes to the trigger mechanism of skinaffections and how they progress.

This is thought to be the case especially inacne, allergies, eczema, neurodermatitis,pruritis, psoriaris, urticaria and warts.

Theoretical ideas under discussion aboutpsychosomatic-guided dermatology involvedeep psychological, and biological responseaspects and psycho-neuro-immunologicalfactors.

Anxiety and depression often accompany skindisease. Those affected undergo appropriatepsychotherapy generally only if the anticipatedsuccess of their treatment fails to materialise.It is by no means rare for referrals to apsychotherapy practice which are made toolate or even possibly with undertones ofaggressive frustration to lead to feelings ofguilt, blame and denial. In such circumstancesthe entire treatment programme is virtuallydestined to fail.

The evaluation of psychological factors in theoccurrence of skin affections today comparedwith previous times shows that psychosomaticfactors are thought to be more significant thanever.

Anatomical PhysiologicalFoundationsThe skin is a vitally important organ making upthe body’s external surface and so forming theboundary between the environment and thebody’s internal milieu.

The role of the skin is:

• To protect the organism from mechanical,chemical and physical damage and from thepenetration of micro organisms

• To prevent dehydration by guaranteeingphysiological water evaporation (from thebody)

• To allow blood vessels to contract or dilatefor the purposes of heat regulation

• To support the elimination of metabolic endproducts through perspiration

• To help the body react to pressure, traction,vibration, temperature and pain sensations/ stimuli.

The skin consists of the outer layer of skin(epidermis), its adnexae (glands, hair and nails)as well as a connective tissue portion, thedermis (corium). Both parts together form thecutis under which is found the bottom layer ofconnective tissue, (the subcutis) which mergeswithout any sharp demarcation into the dermisand attaches it to the bottom layer.

The outer layer (epidermis) has a thickness of0.5 to 5 mm and is at its thickest at those pointsmost exposed to mechanical stress (palms ofthe hand and soles of the feet). It contains noblood vessels, its nutrition comes from thedermis. It consists of several definable portions(the corneal layer right on the surface downto the deep base layer, from where it alsoregenerates itself and where the synthesisand storage of the skin’s main pigment, melanintakes place).

The dermis located underneath is rich instabilising fibrils and immune-competent cells,in capillaries and nerve endings, its deeperportion in strong interwoven bundles ofcollagen fibres and elastic fibres guaranteeing

Prof. Klaus Jungis a Doctor of internal medicine, sportsmedicine and naturopathic treatmentand was in charge of the Departmentof Sports Medicine at the JohannesGutenberg University in Mainz from1982 to 2007. In addition he is also a

member of numerous scientific advisory boards andcommittees and is a member of the board of theInternational Society for Prevention (InternationaleGesellschaft für Prävention). His main areas of work are:preventative and rehabilitative sport and enduranceperformance, sport nutrition, lactate metabolism andperformance physiology. He has given more than 1,100lectures, written / contributed to 108 books, has had morethan 600 publications, predominantly in the area of sportsmedicine and endurance sports, sport therapy andnutrition.

Contact:Im Altengarten 17, D-76889 Gleishorbach

Tel .: 0049 / 2242 / 93300

Fig. 4: Typical Acne Vulgaris

Anti Aging Report

4 03/09

the stability and elasticity required in equalmeasure.

The subcutis consists of loose connectivetissue which houses more or less abundantfatty tissue (protection against the cold, energystore and padding). Bursae are also foundhere especially in places where the skin pressesagainst hard underlayers (elbows and kneecaps).

The sebaceous glands, sweat glands, apocrinesweat glands, hair and nails form the adnexae(appendages) of the skin.

The sebaceous glands produce sebum fromfat droplets. The sebum covers the surface ofthe skin and hair to form a protective fatty layer.If there is over-production this leads toseborrhoea and if it is too low, sebostasis.

Around 2 million sweat glands produce an acidsecretion - sweat, which besides water alsocontains different electrolytes and amino acids,urea, lactic acid, pyruvic acid and histamine.Disorders in terms of over or underproductionas well as variations in composition can occur.

Apocrine sweat glands occur in humans in thearmpits, external auditory canal, in the nippleregion, in the eyelids and genital region. Theyproduce a fatty alkaline secretion which isincreased in women.

Hairs are flexible, high tensile protein filaments,5 – 200 µm thick, which grow approx. 0.4 mma day and which are nourished from the hairroot from where they also obtain their colour.Hair loss can have many causes and atrophyof hair papillae with loss of its nutrition is themost decisive factor. Greying of the hair resultsfrom a lack of pigment formation or from airbubbles (in the hair shaft).

The nails are protective organs and also serveto counteract pressure exerted on the tactileelevations (small areas in the palms and solesespecially rich in sensory nerve endings). Thenails start growing from the nail matrix in the

depths of the nail pocket and from the whitearea at the lower end of the nail edge.

Some basic data about the skin may helpexplain its importance for the organism as awhole (cf. Tab. 1).

Barrier Function Example

The skin, alongside the mucosa of therespiratory, gastrointestinal and urogenitaltracts, also offers effective protection againstinfections. Intact skin protects against the penetration of pathogens and at the same time its symbiotic bacteria living on the skin potentially prevent pathogenic bacteria taking over. Changes to the naturalflora (through the administration of antibiotics,too frequent washing with aggressivesubstances, weaknesses in the immunesystem and contact with harmful substances)can lead to colonisation with pathogenicbacteria.

Damage to the barrier function is frequentlythe starting point for infections, mainly bacterialbut occasionally of the viral type.

Temperature RegulationExampleHomoiothermic (constantly warm) livingorganisms such as man are capable of keepingtheir body temperature virtually constant withina wide range of different ambient temperatures.The important requirements for this arepotentially high energy conversion withincreased heat formation and the possibility ofincreased heat release. Both mechanismsmust be fine tuned to one another and balancedso that humans feel comfortable.

Factors which increase heat generation areprimarily an increase in muscle tension(emotion and/or cold) and the conversion ofenergy especially though the completion ofmechanical work while the heat given off canbe regulated by and large via the ambientatmosphere, by clothing and the circulation ofblood in the skin.

General

SurfaceWeight (cutis)Weight (cutis and subcutis)Proportion of the total weightTotal cell countCell count/cm2

Vessel length/cm2

1.5-1.8m2

Approx. 3 kg11-15 kg7-20%Approx. 110 billion6 millionApprox. 1 m

Metabolism

CirculationO2 requirementAmount of ‘flakes’ a dayCell formation to shedding

500-1500 ml/min5 ml/min10g20-30 days

Glands Sebaceous glandsSweat glands

Approx. 250 000Approx 2 million (55-750/cm2)

Receptors Length of nerve fibres/cm2

Number of nerve fibres/cm2

4 m500

Tab. 1: Important Key Data about the Skin

To do this, heat must be transported from thecentre of the body mainly through the mediumof blood to the body’s periphery where it canbe released through the skin or mucousmembrane surface into the environment. Thebody’s regulating mechanism works accordingto the constriction or dilation of the skin’svessels and the functionality of the sweatglands, whereby the corresponding receptors(cold and warmth receptors) ensure feedbackto the temperature regulating centre of thebrain (hypothalamus), from where thenecessary readjustment of the desired valueis made.

Somatovisceral SensorySystem Example The subjective perception of our body – bodyimage / body perception – dependspredominantly on the activity of thesomatovisceral sensory system. Besides theinternal organs and the musculoskeletalsystem this mostly incorporates the sensoryfunctions of the skin. The skin with its sensoryinnervation acquires its functional efficiencyas the first sensory organ as early as theembryonic stage, which is an indicator of justhow important it is for the ontogeneticdevelopment of each individual. The sensoriumaround the mouth contributes to the newborninfant finding its mother’s breast. The firstimpressions of the environment are gainedthrough the mouth and hands. The sense oftouch from the hand that moves allows thesmallest details to be recognised. Blind peopleread with the help of their moving fingers.Palpation using their hands helps doctors tomake a diagnosis.

UV Radiation Example

UV radiation produces reactive oxygen species(oxygen radicals) from whose action brokenstrands of DNA are produced (destruction ofthe carrier of genetic information), whichtogether with toxic photo products lead topremature aging of the skin and in the worstcase scenario to skin cancer.

Fig. 5: Anatomical Structure of the Human Skin

Anti Aging Report

503/09

The longer the wavelength of the radiation, thedeeper into the layers of the skin it canpenetrate. In particular the upper tissue layersof the skin are affected by the damaging raysfor which the shorter wavelengths areresponsible at between 210 and 305 nm.

More than 80 percent of the externally visible and histologicallyprovable changes in "aging skin"

can be ascribed to the effects of UV radiation.

It causes a breakdown in collagen by dissolvingproteins and the "metabolic slags" therebyproduced trigger chronic inflammation withensuing disorganisation, incomplete repair andthe formation of scars. Visible signs of this canbe seen in characteristic changes in the skinsurface.

From an anatomical analysis of the structureof the skin and especially its physiologicaltasks it becomes clear just how complex anorgan it is, how keenly it affects our health,biological age and well being, how susceptibleto disease it is, how many functional processesit coordinates and how closely it is interlinkedwith other organ systems (cardiovascularsystem, metabolism, immune system,hormone system, the mind, sensory system,nervous system and the urogenital system).

In this context an anatomical structure(connective tissue) and a physiological function(oxygen supply) should be portrayed by wayof example to show their particular way ofpositively as well as negatively affecting thehealth of the skin and how they play a leadingrole in all deviations from the norm.

Extracellular Matrix

Since the studies of Pischinger (University of Vienna) and Heine (University of Witten-Herdecke), it has been known that the cellsthemselves are not usually the starting pointfor disease as had been postulated up to thattime by leading physicians (Virchow’s CellularPathology). Rather, it is frequently theextracellular matrix (extracellular space andinterstitial connective tissue) which is initiallyaffected. This is where all the interactions ofthe human organism take place between celland milieu.

Connective tissue forms the basic system ofthe body and is its largest organ. Its intercellularportion makes up approx. 70 percent of thewhole volume of the body and the cell tissueapproximately 30 percent.

Its most important tasks include supplying allthe cells of the body with nutrients anddisposing body cells from degradationproducts and metabolic end products.

Other functions include filling the spacesbetween the cells (interstitium) and protectingand encasing different organs and structures.Connective tissue acts as the main structurefor the conduction of nerve impulses (neurons)and functions as a sliding and moving layer.

At the same time the intercellular space is theprimary location of all inflammatory andimmune processes and therefore of all vitalprocesses. Accordingly it represents anessential control variable which, if allowed toget out of control, frequently leads to diseaseof the entire organism.

Connective tissue is a three-dimensionalnetwork in structure consisting of connectivetissue cells and an intercellular substancewhich is composed of connective tissue fibrils,capillaries, nerve endings and open lymphatics.

The fibrils consist of highly-complexcarbohydrate protein structures of which theproteoglycans carry a negative charge and aretherefore capable of bonding with water. Theextracellular fluid performs transportation,nutrition and storage tasks.

The majority of connective tissue cells are madeup of fibrocytes, which produce collagen fibrils.In addition we find macrophages, which breakdown fibrils. Both cell types are capable ofbuilding up or breaking down the appropriateenzymes when certain stimuli are activated.

The basic system (extracellular matrix,intercellular space) fulfils many tasks:

• Nutrition of cells (diffusion from the vesselsinto the cells through the basic system)

• Disposal of cells

• Filtering of metabolic end products

• Storage of metabolic end products

• Capturing contaminants and toxins

• Immune defence

• Conveyance of information

• Storage of information

• Regulation of the acid-base balance

• Repair mechanism

The intercellular space is the body’s quasi"marketplace". It is here predominantly that theexchange, production and storage of "goods"take place.

In particular, the protein carbohydratecomplexes produced from the fibrocytes filtermetabolic products are able if need be to bondthese on account of their negative charge. Thecapture of harmful substances leads in the longrun to the formation of "dumps" and "slagging"of basic tissue. The diffusion capacity

decreases both during transportation to andfrom with consequences of under-supply of thesubstrates necessary for life, accumulation ofmetabolic end products, tissue acidosis andROS increase. This causes functionaldisturbances, illnesses, poor health andpremature biological aging.

Externally these processes are particularlynoticeable in the skin and the skin adnexae.Many people are able to see the effects forthemselves without understanding or beingable to halt the underlying causes.

The Effect of Energised Inhaled AirThe important aim of all therapeuticinterventions is considered to be the ability tobreak this "vicious circle".

A better supply to and removal of the groundsubstance should be achieved by its purificationand harmonisation, especially through therestoration of regulating mechanisms andopening up of self-cleaning and self-healingmechanisms.

The metabolic slags should be released fromthe basic tissue and removed from the bodyby improved venous and lymph drainage.

Naturopathic treatments in particular seem tooffer a suitable way of doing this. There areseveral approaches on offer such as stomachand bowel cleansing, a change in diet awayfrom what is considered to be the civilised dietto a wholefood diet rich in vital substances,moderate (aerobic) and regular physicaltraining, pulsed magnetic field therapy and –something which has been on the increase forsome years now – Spirovital therapy (inhalationof energised air Airnergy®).

This involves a short-term increase in ambientoxygen (ground state) to a higher energy level

Fig. 5: Airnergy device

Anti Aging Report

6 03/09

• The morning line of pills threatened to takeon huge proportions: "... and furthermorethere are other detectable and purelypositive long-term effects… My skin, hair andnails are giving me virtually no problems(especially in winter)…"

• A freelance medical journalist and doctor:"There are dramatic improvements in the appearance of my skin and theneurodermatitis which previously affectedlarge areas of my armpits and neck andshoulder regions, regressed completelywithin a few weeks…even my hair becameprettier, more shiny and curlier, somethingwhich my hairdresser also noticed withoutmy having to draw her attention to it…"

• Racing driver with the beginnings of burnoutsyndrome: "... My skin has improved sinceI have been using the device….In winter Ihave a tendency to develop red areas aroundmy nose and these are now much lessnoticeable and without any stress have evendisappeared completely…"

• Healthy and inquisitive medical technician:"I can tell you that I’m pleasantly surprisedby the results….after three weeks the areasof pigmentation which I got when I took thepill about 30 years ago and which remainedeven after stopping taking the pill, havefaded…also I noticed that the appearanceof my skin has improved, fine lines havebecome invisible and wrinkles greatlyreduced, spider veins have become palerand even disappeared completely and myhusband who is bald found a few new hairsappearing and now he has a growth of finehair across his whole scalp..."

• A married couple who work as dentists: "Wealso noticed that the whole appearance ofour skin has changed, which I put down toimproved circulation…"

• Status post three myocardial infarctions andfive stent implants: "Another very positiveeffect is the improvement in the appearanceof my skin. Fine lines have simply ‘gone’ andmy skin looks smoother with bettercirculation. Spots of pigmentation causedby regularly taking medication have becomemuch paler…"

• Psoriasis: "I noticed that the appearance ofmy skin improved without using creams and

all signs of the psoriasis disappeared frommy hands, elbows and knees....after thesecond week I had no further deterioration.

• I suffer from various problems including badskin. The areas of psoriasis on my facehave disappeared completely…"

• Emphysema: "My grey hair shone. I hadbetter circulation in the skin on my face, armsand hands and they looked pink. Previouslymy skin looked grey..."

• Chronic fatigue syndrome for more than 20 years: "The very first improvement I noticed was my hair stopped falling out. I was very worried because I thought that I would soon be bald. My hairdresser also noticed the change and asked me what I had done to bring about theimprovement…"

L i t e r a t u r eVollmer, H., H. Riebensahm: Das große Buchder Wellness. Gut drauf sein – ein Leben lang.Kilian, Marburg 2000Jacobi, G., H. K. Biesalski, U. Gola, J. Huber,F. Sommer (Hrsg.): Kursbuch Anti- Aging.Thieme, Stuttgart 2005Tittel, K.: Beschreibende und funktionelleAnatomie des Menschen. Urban & Fischer,München 2000Schmiedel, V., M. Augustin (Hrsg.): LeitfadenNaturheilkunde. Urban & Fischer, München2008Klinke, R., S. Silbernagl (Hrsg.): Lehrbuch derPhysiologie. Thieme, Stuttgart 2000Spirduso, W. W., K. L. Francio, P. G. MacRae(Hrsg.): Physical dimensions of aging. HumanKinetics, Leeds 2005Siegenthaler, W., H. E. Blum (Hrsg.): KlinischePathophysiologie. Thieme, Stuttgart 2006www.pressetreff.dewww.praxisbenner.dewww.vetmed.fu-berlin.dewww.flexikon.doccheck.comwww.zentrum-der-gesundheit.dewww.plasticsurgery.orgwww. wikipedia.org/wiki/Sch%C3%B6nheitwww.Int.1-Hochbetagte.doc

(singlet state) based on the action of light of a specific wavelength and a specialphotosensitiser.

This higher oxygen energy level "only" remainsfor fractions of a second before the energyreleased during the return to the ground stateis transmitted to the surrounding water, whichtogether with "normal" atmospheric oxygen inthe ambient air is inhaled.

The other stages involved in spirovitalisationhave yet to be fully researched. Yet given thenumerous individual accounts (of those treated)and case descriptions (from therapists), itdoes appear certain,

that particularly in mitochondria(the aerobic power stations ofcells) and in basic tissue, vital

processes take place, which leadto better utilisation of oxygen andto a "purification" of basic tissue

(improved diffusion).

Other detailed studies are planned or soon tobe implemented and these should reveal theexact modes of action. The effect is in itselfproven, as the case studies below clearlydemonstrate.

Case studies

• A doctor and scientific journalist: "Even aftera short time of inhalation (a few weeks) myskin has clearly taken on a glamorousappearance, which has continued. My skinis smoother, tighter and firmer. Especiallythe fine lines around my neck which you getat my age have clearly reduced and becomesmoother. The effect is better than anyanti-wrinkle skin cream which I have tried upto now…"

• A business woman: "What pleases me as awoman is that the skin on my face and alsoon my body has improved..."

• Status following an accident during thetriathlon competition (fall from a racingbicycle) "I’d like to list the changes which aremost likely to do with Airnergy: My hair andfinger nails are growing better and arestronger....my skin looks clearer…"