anti-cancer diets_ what’s the deal with dairy_ _ eat and beat cancer
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Anti Cancer DietTRANSCRIPT
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11/20/2015 AntiCancerDiets:WhatstheDealwithDairy?| EatandBeatCancer
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AntiCancerDiets:WhatstheDealwithDairy?PostedonJuly23,2014
Ivebeenreservingjudgmentondairyproductsfor55yearsnowsinceGrade1,whenmymomliedtotheschoolauthoritiesandtoldthemIwasallergictomilk.Truthwas:itmademegag.
ButnowthatDr.WalterWillett,chairmanoftheDepartmentofNutrition,HarvardsSchoolofPublicHealth,andanesteemedpanelofscientistshaveopinedonthesubjectandwevehadtimetoreflect,Icansaythiswithcertaintyaboutwhetherornotdairyproductshaveanyplaceinananticancerdiet:
Gotmilk?Gotprostatecancer?
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TheUSandCanadianguidelinessuggestingatleast3servingsadayofdairyproducts,especiallyloworfatfreeones,areclearlywrong.Atthatlevel,dairyproductsmaybedrivingcancersofthereproductiveorgans,nomatterwhatthefatcontent.Andthisisthenumber1puzzlethatnutritionalscientistsneedtosolvenow!
Yes,somedairyproducts(milk,notcheese)mayprotectagainstcolorectalcancer,saystheWorldCancerResearchFoundationandAmericanInstituteofCancerResearch(WCRF/AICR),whoseinternationalteamofscientistshavebeenevaluatingthestudiesondietandcancersincethe1990s.Butwhatsthepointineatingfoodsthatmaypromotecancerinotherorgans?
DairyandProstateCancer
Formen,thestudiesinhumanpopulationsarequiteclear.Highcalciummorethan1500mgadayisprobablyassociatedwithprostatecancer,saysWCRF/AICR.(Somestudieshavealsofoundanassociationwithtesticularcancer.)
(T)heevidencethatmilkconsumptionisrelatedtoprostatecancerriskisactuallyverystrong,specificallyforaggressiveandfatalprostatecancers,Willettsaidin2006duringasymposiumatMcGillUniversity.
Havescientistslearnedanythingsincethattimethatwouldchangehisview?(W)edonthaveanysubstantialnewdataonthistopic,hesaid.
DairyandFemaleCancers
Forwomen,whilethestudiesinbreastcanceraremixed,whatsparticularlytroublesomearestudieslinkingdairytoovariancancer,specificallythreelargestudiesshowinganassociationwithevensmallamounts.
InSweden,wheredairyproductconsumptionandovariancancerratesarehigh,researchersfollowedmorethan60,000womenoveranaverage131/2yearsandfoundthatcomparedtowomenwhoneverorseldomdrankmilk,womenwhoconsumedmorethan1glassofmilkadayhaddoubletheriskofaverycommonandaggressivetypeofovariancancertypicallynotfounduntillatestage.
Thoseresultswereconsistentwithtwoearlierstudies.
HarvardsNursesHealthStudy,anongoinglookatvariousissuesinwomenshealththatWilletthasbeenspearheading,foundthatwomenwhoconsumedoneglassormoreadayofskimorlowfatmilkhada69percentincreaseinthatsamedeadlyovariancancercomparedtowomenwhoalmostneverdrankmilk.Andcomparedtowomenwhoalmostneverateyogurt,womenwhoconsumedfiveormoreservingsaweekweremorethantwiceaslikelytodevelopthatcancer.
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11/20/2015 AntiCancerDiets:WhatstheDealwithDairy?| EatandBeatCancer
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AndtheIowaWomensHealthStudyofpostmenopausalwomenfoundthatthosewhodrankmorethan1glassofskimmilkadayhada73%greaterriskofovariancancerthanthosewhodranklessornoneofit.
Whiletheevidenceisnotasfirmorasrobustasitisforprostatecancerrisk,Willettsaidatthatsymposium,ithastomakeoneworriedaboutrecommendingthreeservingsofmilkaday,especiallysinceovariancancerissodeadly.
Isitthecalcium?
Scientistsarenttotallysurewhatmechanismsareatplay.
HighcalciumintakecandisturbyourproductionofVitaminD,thesunshinevitamin,which,inanimalandcellstudies,keepscancercellsfromproliferatingandhelpsthemreverttotheirnoncancerousstates.ThecurrentUSrecommendationsfordietarycalciummaybetoohigh,Willettsuggested.
Butcalciummightnotbetheortheonlyculprit.
TheSwedishandHarvardstudiesinwomenbothfoundanassociationwithlactose,ormilksugar.Foreach1011gramsoflactoseaday(equivalenttoaglassofmilk),therewasa20percentgreaterrisk.Onecomponentofthatsugar,moleculesofgalactose,maybeparticularlyharmfultoovaries.
Orisittheproteinssendingsignals?
AGermandermatologistwhohasfoundthatdairyproductsarelinkedtobothacneandprostatecancersaysthattheproblemismilksaminoacids.Milkproteinstriggeracascadeofsignalsthattellallcellstogrow.
Sustainedproliferationisthemostcriticalhallmarkofcancer.Thatiswhatmilkisdoing,aprogramofmammalianevolutionintendedtobeoperativeonlyinthepostnatalnursingperiodandnotforlifelongabuse!saidDr.BodoMelnik.
Everwonderwhybodybuildersflocktowheyproteinsupplementsafterworkouts?
Dairyproductscontaintwotypesofprotein:casein,abundantintheaminoacidmethionine,andwhey,richintheaminoacidleucine.
Leucinetriggersmusclegrowth.Ithelpsbuildmusclebydirectlyactivatingacompoundinmusclecalledthemammaliantargetofrapamycin(mTOR).Inconjunctionwithothercompounds,mTORfunctionsasamolecularswitch,ahubforcoordinatingthecomplexsignalingsysteminvolvedinsendingmessageswithincells.Leucineflipstheswitch,turningonthemachinerythattellsyourcells
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tomanufacturemuscleproteins.
Theproblemis:CancercellsalsotakeadvantageofthiscontinuallyopenswitchconstantmTORsignallinginordertokeepproliferating.
Casein,accordingtoT.ColinCampbellsdecadesofresearch(TheChinaStudy),hasdemonstratedaremarkableabilitytopromotecancergrowthintestanimalswhenconsumedinexcessofproteinneeds,andinanimalandcellstudies,dietaryrestrictionofmethionineinhibitsandreversestumorgrowth.
Bothproteins,Melniksays,stimulatetheproductionofhormonesthatindirectlyactivatemoremTORsignalinginsulinandInsulinGrowthFactor1(IGF1).Thesehormonesalsosendmessagesthatsignalcells,includingcancerousones,togrowandthatleadtoreductionsinyourSexHormoneBindingGlobulin,leavingestrogenandtestosteronetocirculateinyourblood.
HighlevelsofIGF1havebeenassociatedwithmanycancers,includingprostateandestrogenpositivebreastcancer.Cancersdrivenbyandrogens(yes,malehormonesbuttheyvebeenimplicatedinbreastandovariancancer)maybeparticularlysusceptibletodairy,Melniksuggests,becauseIGF1stimulatesaverypotentformoftestosteronethatactivatesmTORsignaling,andinwhatscientistscallcrosstalk,overactivemTORsignalingmaythendriveproductionofevenmoretestosterone.
Thefemalehormonesinmilkfrompregnantcowsmayalsoplayapart,hesays.
Hesparticularlyconcernedaboutdairyproductsduringpuberty.Duringthissensitivetimeperiod,thepituitaryglandisalreadysecretinglargeamountsofgrowthhormone,whichstimulatesthelivertoproduceIGF1.Inonestudy,dailymilkconsumptionduringadolescencemorethantripledtheriskofaggressiveprostatecancerlaterinlife.
(Leucinealsostimulatestheoilproducingglands,anddairyproductsduringpubertyhavealsobeenlinkedtoteenageacne.Anotherstudyfoundanassociationbetweenseverelonglastingacneandincreasedriskofprostatecancerlaterinlife.)
ToreadmoreaboutMelniksworkondairyandprostatecancer,seethisreviewandthisone.Forhisdietandacnework,seethisarticleandthisone.ForadiscussionofinsulinandIGF1,seethis.
Whataboutyourbones?
Dontweneedmilkforstrongbones?
Thatsamyth,Willettsaid.Everylargestudythathaslookedatthisissuehas
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foundthatthereisnoreductioninfractureriskwithhigherdairyconsumption,veryconsistentfindings,allthewayuptoover4glassesofmilkaday,hetoldthesymposium.Hesjustpublishedastudyshowingthatmilkconsumptioninadolescencemayactuallyincreasefracturerisk.
Arealldairyproductscreatedequal?
TheUSgovernmenthasbeenurgingconsumerstoswitchfromfulltolowornonfatdairy,butifthecalciumorsugars/lactoseorproteins/aminoacidsaredrivingcancer,thenlowfatproductsarenotanybetterandperhapsevenworse.
Thefatcontentofmilkdoesntalteritslactosecontent.Infact,twopercent,lowandnonfatcowsmilkactuallyhavemoreleucineandmorecalciumthanwhole.Andsheepsmilkhasaroundtwiceasmuchleucineasbovinesecretions.
Sowhatsthedairyproductthatslowestinproteins?Butter.Itsvirtuallyallfat.(Buthighintakesofsaturatedanimalfatsmaybeassociatedwithsomecancers,sotreatitlikeBrylcreemalittledablldoya.)
Howmuchistoomuch?
Thatshardtosay,Willetttoldthesymposium.Withadults,probablyoneservingadayisthelevelwherewedontreallyseemuchevidenceofharm,hesaid.(W)estarttogetconcernedabouttwoorthreeservingsadaybecauseitlookslikethereissomestrongpotentialforharm,particularlyformenandmaybeforwomen.Forchildren,ofcourse,everythingismuchmorecomplicated,andwealsohavemuchlessdata..
Afterdiagnosis?
Talkaboutcomplicated!
Thefewstudiesondairyconsumptionaftercancerdiagnosissuggestthatwholebutnotlowfatproductsmaydriveprogression,althoughitsnotentirelyclear:
breastcancer:Highbutnotlowfatdairyrelatedtohigherriskofdying.breastcancer:Lowerintakeofsaturatedandtransfatslinkedtosurvival.prostatecancer:Wholemilklinkedtolethaldiseasebutlowfatdairyintakemaybeprotectiveintheauthorswords,asurprisingfindingthatshouldbeinterpretedwithcaution.
Itsoundslikethisproblemofwhattodoaboutdairyis(likethecurrentoceantestingpostFukushimaproject)justperfectforcrowdsourcingfunds.Shallwepoolourpennies?
Thebottomline,forusadults,fornow
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Thankgoodnessforplantmilks!
WhenitcomestoIGF1,ofallfoodsdairyproductsappeartobethelargestcontributormoresothananimalmuscle.Incontrast,thehormoneissubstantiallylowerinpeopleonplantbaseddiets.PlantscontainlargeamountsofIGF1bindingproteins,andaccordingtoMelnik,manyhavecomponentsthatcannaturallyinhibitmTORsignaling
greenteacrucifersturmericwholesoyresveratrolandgetthiscaffeine.
(Metformin,adrugcommonlyusedtocontrolinsulinlevelsintype2diabetics,alsolowersmTORsignaling,hesays,butIllsavethatsuccessstoryforanotherday.)
Itlookslikemygutwasrightinrejectingcowsmilkwaybackwhen.Untilthesciencebecomesmorecertain,Illbepracticingtheprecautionaryprincipleofanticancerdietsandsippinganalmondmilklatteinthesunshine.Thanks,mom.Iwonttellanyoneelseaboutyourlittlemilkylie.
2014HarrietSugarMiller
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17THOUGHTSONANTICANCERDIETS:WHATSTHEDEALWITHDAIRY?
ThisentrywaspostedinDairyproducts,Drinks,FatsGoodandBadandtaggedanticancer,anticancerdiet,anticancerfoods,anticancerresources,cancer,canceranddiet,cancerandfood,cancerandnutrition,cancerdiet,cancerprevention,dairy,dairyproductsamdcancer,health,milkbyhsugarmill.Bookmarkthepermalink[http://eatandbeatcancer.com/2014/07/23/anticancerdietswhatsthedealwithdairy/].
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coacervateonJuly24,2014at4:01pmsaid:
Brilliant,thanks!
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hsugarmillonJuly25,2014at6:23amsaid:
Melnikresponds:TherearenewconvincingdatafromaGermaneconometricstudy(UniversityofFrankfurt)showingtherelationshipbetweenmilk/dairyconsumptionandmortalityratesofprostateandovariancancerin50countries.
Thearticle,inGerman,isathttp://www.econstor.eu/bitstream/10419/97324/1/786965215.pdf.Theabstract,inEnglish,isathttp://www.econstor.eu/handle/10419/97324.
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alThomasononJuly29,2014at12:38pmsaid:
Veryclearconclusionsforthelast30plusyearsbutwhataboutdairyinthefirstpartofthe20thcenturywithoutall
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thepesticidesetcbeingputintothefoodchain?Noneofmyrelativesthatlivedonthedairyoperationsofthe1920s,30s40or50sdiedduetocancersandeventheonesthatmovedawaytotownastheybecameadultshadthatcausemostlyoldage,asthebodyfinallytiredoutinlate80sand90s.HM.
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AnonymousonNovember21,2014at3:03amsaid:
TheGermanstudylooksinteresting,itsashameitisnotavailableinEnglish.Youdoagoodjobofthissummaryondairythanks.
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hsugarmillonNovember21,2014at7:46amsaid:
TheGermanstudiesareavailableinEnglish.Iidentifiedtheminthisparagraph.Justgototheparagraphinthearticleandclickonthelinks:
ToreadmoreaboutMelniksworkondairyandprostatecancer,seethisreviewandthisone.Forhisdietandacnework,seethisarticleandthisone.ForadiscussionofinsulinandIGF1,seethis.
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AnonymousonJuly26,2014at11:58amsaid:
Shockingcancerwithmilk
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AnonymousonJuly26,2014at1:10pmsaid:
Ifdairyproductscausedcancerorincreasetheriskofcancer,onewouldthinkpowerlifters,bodybuilders,professionalandamateurathleteswoulddisplayahigherincidentrateofcancerthanthegeneralpopulation.ImnottosureImthesciencebehindthisresearch.
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hsugarmillonJuly26,2014at1:17pmsaid:
Youraiseanimportantquestion.Arethosewheysupplementsincreasingcancerrisk?Isthereanygooddataonthat?Andhowdostudiescontrolfortheprotectiveeffectsofexercise?
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rdfeinmanonJuly26,2014at2:06pmsaid:
Myseriousanswertothisissimplyonecannotacceptanyconclusionsofthistypefromtheseresearcherswithoutaverycarefulanalysisoftheprimarydata.(Sometimesscientists)donotdistinguishbetweenstatisticallysignificantandclinicallyimportant,thatis,havingameaningful
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effectsize.Frequently,theydonotdistinguishbetweenstatisticallysignificantandsimplecommonsense.IusuallycommentwithsomeironybecauseIfinditgenuinelydistressingtoseethiskindofcorruptionofscience.Areallthesestudieswrong?Nowaytotellwithoutgoingbacktotheoriginalreportandanalyzingcarefully.
commentedited
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hsugarmillonJuly26,2014at2:31pmsaid:
Thisquestionwhattodoaboutdairyneedsanswersnow.Untilthescienceissettled,Illbeadoptingtheprecautionaryprinciple,weighingtherisks(notjustthelikelihood,butthegravitytoo)andproceedingcautiously.Thepotentialconsequencesaregrave.
Thankyou,Dr.RichardFeinman,forcontributingtothediscussionandforyourenlighteningblog.http://feinmantheother.com/
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rdfeinmanonJuly27,2014at10:53amsaid:
Ididnotmeantobeoverlynegative.Itisveryimportantthatweexaminetheeffectofdietoncancerbutifwedoitinanonrigorousway,takingeverythingofftheshelf(ratherthanstartingfromfundamentalprinciples)andtestitandbesatisfiedwithanyrisknomatterhowsmall,wewillwindupwithmoreblindalleys
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thanresults.Whatweknowisthatreducingcaloriesand/orreducingcarbohydrateisthemostreasonableapproachtocancertherapyrightnow.
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AnonymousonAugust3,2014at11:03pmsaid:
ThisisaloadofbullIhavedrankmilkfor53yearsanddonthaveanycancer.Itrytogownallmyownfood.Milkfromafarmisalotbetterthenfromthestores.Havetheyeverdidtestbetweenmilkfromafarmandstoremilk?
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AndyFarrellonJune11,2015at6:39pmsaid:
Ifthesestudiesofscoresofpeoplearebull,howisityourstudyof1personismorereliable?
IfyoumetsomeonewhosurvivedaplanecrashandarguedplanecrashesareperfectlysurvivablethereforesafebecauseIsurvived,youwouldlaugh.
Ourpersonalexperiencesarecertainlyinterestingbuttheyarenotverygoodindicatorsastowhatriskswemayhavedodgedorwhatbadbehaviourswevesimplybeenluckytonotexperiencetheconsequencesof.
Thewholepointofastudyistotryandeliminatesubjectivenessandfocusonwhathappenstomostofthepeoplemostofthetime.
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AdrienonAugust24,2014at4:01amsaid:
Hi,Couldyouprovidethesources(citations)forthelistoffoodsthatreduceIGF1byalteringmTorsignaling?Thanks.
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hsugarmillonAugust24,2014at7:17amsaid:
ThesourceisDr.Melniksarticlepublishedin2012inNutritionandMetabolism:http://www.nutritionandmetabolism.com/content/9/1/74%20
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