anti-diabetic drugsqu.edu.iq/ph/wp-content/uploads/2016/03/anti-diabetic-drugs1.pdf ·...
TRANSCRIPT
![Page 1: Anti-Diabetic Drugsqu.edu.iq/ph/wp-content/uploads/2016/03/Anti-Diabetic-Drugs1.pdf · Anti-Diabetic Drugs Bassim I Mohammad Specialist Physician-Assistant Professor College of Pharmacy](https://reader033.vdocument.in/reader033/viewer/2022060606/605c576967836d08ae557158/html5/thumbnails/1.jpg)
Anti-Diabetic Drugs
Bassim I Mohammad
Specialist Physician-Assistant Professor
College of Pharmacy/ Al Qadisiyah University
Iraq
![Page 2: Anti-Diabetic Drugsqu.edu.iq/ph/wp-content/uploads/2016/03/Anti-Diabetic-Drugs1.pdf · Anti-Diabetic Drugs Bassim I Mohammad Specialist Physician-Assistant Professor College of Pharmacy](https://reader033.vdocument.in/reader033/viewer/2022060606/605c576967836d08ae557158/html5/thumbnails/2.jpg)
DM is an elevated blood glucose level associated with absent ,
or inadequate pancreatic insulin secretion, with or without
concurrent impairment insulin action
Diabetes Mellitus (Definition)
![Page 3: Anti-Diabetic Drugsqu.edu.iq/ph/wp-content/uploads/2016/03/Anti-Diabetic-Drugs1.pdf · Anti-Diabetic Drugs Bassim I Mohammad Specialist Physician-Assistant Professor College of Pharmacy](https://reader033.vdocument.in/reader033/viewer/2022060606/605c576967836d08ae557158/html5/thumbnails/3.jpg)
TYPE 1: characterized by beta cell destruction and severe or
absolute insulin deficiency (immune form)
TYPE 2: characterized by tissue resistance to the action of insulin
combined with a relative deficiency in insulin secretion
TYPE 3: refers to multiple other specific causes of an elevated
blood glucose: pancreatectomy, pancreatitis, drug therapy…etc)
TYPE 4:Gestational diabetes is defined as any abnormality in
glucose levels noted for the first time during pregnancy
Diabetes Mellitus (Classification)
![Page 4: Anti-Diabetic Drugsqu.edu.iq/ph/wp-content/uploads/2016/03/Anti-Diabetic-Drugs1.pdf · Anti-Diabetic Drugs Bassim I Mohammad Specialist Physician-Assistant Professor College of Pharmacy](https://reader033.vdocument.in/reader033/viewer/2022060606/605c576967836d08ae557158/html5/thumbnails/4.jpg)
Diabetes Mellitus (Clinical Features)
Polyuria
Polydipsia
Polyphagia
Weight loss
![Page 5: Anti-Diabetic Drugsqu.edu.iq/ph/wp-content/uploads/2016/03/Anti-Diabetic-Drugs1.pdf · Anti-Diabetic Drugs Bassim I Mohammad Specialist Physician-Assistant Professor College of Pharmacy](https://reader033.vdocument.in/reader033/viewer/2022060606/605c576967836d08ae557158/html5/thumbnails/5.jpg)
Criteria for the Diagnosis of Diabetes
A1C ≥6.5%
OR
Fasting plasma glucose (FPG) ≥126 mg/dL (7.0 mmol/L)
OR
2-h plasma glucose ≥200 mg/dL (11.1 mmol/L) during an OGTT
OR
A random plasma glucose ≥200 mg/dL (11.1 mmol/L)
ADA. 2. Classification and Diagnosis. Diabetes Care 2015;38(suppl 1):S9; Table 2.1
![Page 6: Anti-Diabetic Drugsqu.edu.iq/ph/wp-content/uploads/2016/03/Anti-Diabetic-Drugs1.pdf · Anti-Diabetic Drugs Bassim I Mohammad Specialist Physician-Assistant Professor College of Pharmacy](https://reader033.vdocument.in/reader033/viewer/2022060606/605c576967836d08ae557158/html5/thumbnails/6.jpg)
FPG 100–125 mg/dL (5.6–6.9 mmol/L): IFG
OR
2-h plasma glucose in the 75-g OGTT 140–199 mg/dL (7.8–11.0 mmol/L): IGT
OR
A1C 5.7–6.4%
*For all three tests, risk is continuous, extending below the lower limit of a range and becoming disproportionately greater at higher ends of the range.
ADA. 2. Classification and Diagnosis. Diabetes Care 2015;38(suppl 1):S10; Table 2.3
Categories of Increased Risk for Diabetes (Prediabetes)*
![Page 7: Anti-Diabetic Drugsqu.edu.iq/ph/wp-content/uploads/2016/03/Anti-Diabetic-Drugs1.pdf · Anti-Diabetic Drugs Bassim I Mohammad Specialist Physician-Assistant Professor College of Pharmacy](https://reader033.vdocument.in/reader033/viewer/2022060606/605c576967836d08ae557158/html5/thumbnails/7.jpg)
DM (Complications)
1) Acute Complications:
Diabetic ketoacidosis
Nonketotic hyperosmolar coma
2) Chronic Complications:
(micro/macrovascular)
![Page 8: Anti-Diabetic Drugsqu.edu.iq/ph/wp-content/uploads/2016/03/Anti-Diabetic-Drugs1.pdf · Anti-Diabetic Drugs Bassim I Mohammad Specialist Physician-Assistant Professor College of Pharmacy](https://reader033.vdocument.in/reader033/viewer/2022060606/605c576967836d08ae557158/html5/thumbnails/8.jpg)
Type 1: Insulin is a must, education and nutrition control
Type 2: education, Food control, exercise, OAD
(1) Increase insulin secretion;
(2) Increase the sensitivity of target organs to insulin;
(3) Decrease glucose absorption
(4) Insulin needed serious complications or an emergency
Gestational Diabetes (Insulin)
Diabetes Mellitus (Treatment Strategies)
![Page 9: Anti-Diabetic Drugsqu.edu.iq/ph/wp-content/uploads/2016/03/Anti-Diabetic-Drugs1.pdf · Anti-Diabetic Drugs Bassim I Mohammad Specialist Physician-Assistant Professor College of Pharmacy](https://reader033.vdocument.in/reader033/viewer/2022060606/605c576967836d08ae557158/html5/thumbnails/9.jpg)
Insulin
Oral Anti-Diabetic Agents
Diabetes Mellitus (Treatment)
![Page 10: Anti-Diabetic Drugsqu.edu.iq/ph/wp-content/uploads/2016/03/Anti-Diabetic-Drugs1.pdf · Anti-Diabetic Drugs Bassim I Mohammad Specialist Physician-Assistant Professor College of Pharmacy](https://reader033.vdocument.in/reader033/viewer/2022060606/605c576967836d08ae557158/html5/thumbnails/10.jpg)
Chemistry , Physiology
Pharmacological Effect
Mechanism of action
Clinical Uses
Types and Preparations and mixtures
Delivery systems
Complications
Insulin
![Page 11: Anti-Diabetic Drugsqu.edu.iq/ph/wp-content/uploads/2016/03/Anti-Diabetic-Drugs1.pdf · Anti-Diabetic Drugs Bassim I Mohammad Specialist Physician-Assistant Professor College of Pharmacy](https://reader033.vdocument.in/reader033/viewer/2022060606/605c576967836d08ae557158/html5/thumbnails/11.jpg)
Insulin is a small protein contains 51 amino acids arranged in
two chains (A and B) linked by disulfide bridges.
Proinsulin in the Golgi apparatus of beta cells, packaged into
granules, and hydrolyzed into insulin and C-peptide by removal
of four amino acids
Insulin and C-peptide (has no physiological action) are secreted
in equimolar amounts in response to all insulin secretagogues.
Insulin (Chemistry and Physiology)
![Page 12: Anti-Diabetic Drugsqu.edu.iq/ph/wp-content/uploads/2016/03/Anti-Diabetic-Drugs1.pdf · Anti-Diabetic Drugs Bassim I Mohammad Specialist Physician-Assistant Professor College of Pharmacy](https://reader033.vdocument.in/reader033/viewer/2022060606/605c576967836d08ae557158/html5/thumbnails/12.jpg)
Insulin is released from pancreatic beta cells at a low basal
rate and at a much higher stimulated rate in response to a
variety of stimuli, especially glucose.
Oral glucose elicits more insulin secretion than dose IV
glucose; because oral administration of glucose elicits gut
hormones which augment the insulin response
Insulin (Chemistry and Physiology)
![Page 13: Anti-Diabetic Drugsqu.edu.iq/ph/wp-content/uploads/2016/03/Anti-Diabetic-Drugs1.pdf · Anti-Diabetic Drugs Bassim I Mohammad Specialist Physician-Assistant Professor College of Pharmacy](https://reader033.vdocument.in/reader033/viewer/2022060606/605c576967836d08ae557158/html5/thumbnails/13.jpg)
Insulin release Stimulators/ Inhibitors
Stimulators Inhibitors
Glucose (most important) α-Adrenergic stimulation inhibits release
(most important)
β-Adrenergic stimulation Glucagon
Amino acid Somatostation
Cholecystokinin Leptin
Elevated intracellular Ca2+ Hypoxia
Drugs (eg sulfonylureas) Drugs ( eg e diazoxide, colchicine)
![Page 14: Anti-Diabetic Drugsqu.edu.iq/ph/wp-content/uploads/2016/03/Anti-Diabetic-Drugs1.pdf · Anti-Diabetic Drugs Bassim I Mohammad Specialist Physician-Assistant Professor College of Pharmacy](https://reader033.vdocument.in/reader033/viewer/2022060606/605c576967836d08ae557158/html5/thumbnails/14.jpg)
The liver and kidney are the two main organs that remove
insulin from the circulation
Endogenous insulin: 60% liver, 40% kidney
Exogenous insulin: 60% kidney,40% liver
The half-life of circulating insulin (endogenous) is 3–5
minutes
Is not teratogenic
Insulin (Degradation)
![Page 15: Anti-Diabetic Drugsqu.edu.iq/ph/wp-content/uploads/2016/03/Anti-Diabetic-Drugs1.pdf · Anti-Diabetic Drugs Bassim I Mohammad Specialist Physician-Assistant Professor College of Pharmacy](https://reader033.vdocument.in/reader033/viewer/2022060606/605c576967836d08ae557158/html5/thumbnails/15.jpg)
Carbohydrate metabolism: reducing blood glucose levels by
glycogenolysis ↓, glycogen synthesis ↑, gluconeogenesis ↓
(ketone badies )
Lipid metabolism: fat synthesis ↑, lipolysis↓ , plasma FFA ↓
Protein metabolism: active transport of aa ↑, incorporation of
amino acids into protein ↑, protein catabolism ↓
HR↑ , myocardial contractility, renal blood flow ↓
Potassium: k+ uptake into cells ↑
Insulin (Pharmacological effects)
![Page 16: Anti-Diabetic Drugsqu.edu.iq/ph/wp-content/uploads/2016/03/Anti-Diabetic-Drugs1.pdf · Anti-Diabetic Drugs Bassim I Mohammad Specialist Physician-Assistant Professor College of Pharmacy](https://reader033.vdocument.in/reader033/viewer/2022060606/605c576967836d08ae557158/html5/thumbnails/16.jpg)
Action of Insulin on Various Tissues
Liver Muscle Adipose
↓ glucose production ↑ Glucose transport ↑ glucose transport
↑ glycolysis ↑ glycolysis ↑ lipogenesis&
lipoprotein lipase
activity
↑ TG synthesis ↑ glycogen deposition ↓ intracellular
lipolysis
↑ Protein synthesis ↑ protein synthesis
![Page 17: Anti-Diabetic Drugsqu.edu.iq/ph/wp-content/uploads/2016/03/Anti-Diabetic-Drugs1.pdf · Anti-Diabetic Drugs Bassim I Mohammad Specialist Physician-Assistant Professor College of Pharmacy](https://reader033.vdocument.in/reader033/viewer/2022060606/605c576967836d08ae557158/html5/thumbnails/17.jpg)
Insulin binds to specialized receptors (found on the
membranes of most tissues particularly target tissues, ie, liver,
muscle, and adipose tissue) with high specificity and affinity.
Insulin receptor consists of two subnits. An α subunit, which
constitutes the recognition site and β subunits, which contains
a tyrosine kinase.
Insulin (Mechanism of action)
![Page 18: Anti-Diabetic Drugsqu.edu.iq/ph/wp-content/uploads/2016/03/Anti-Diabetic-Drugs1.pdf · Anti-Diabetic Drugs Bassim I Mohammad Specialist Physician-Assistant Professor College of Pharmacy](https://reader033.vdocument.in/reader033/viewer/2022060606/605c576967836d08ae557158/html5/thumbnails/18.jpg)
The binding of an insulin molecule to the α subunits activates
the receptor and through a conformational change, facilitates
mutual phosphorylation of tyrosine residues on the β subunits
and tyrosine kinase activity.
These process results in multiple effects, including increase in
glucose uptake (translocation of GLUT 4), increased glycogen
synthase activity and increased glycogen formation; multiple
effects on protein synthesis, lipolysis, and lipogenesis ..etc
Insulin (Mechanism of action)
![Page 19: Anti-Diabetic Drugsqu.edu.iq/ph/wp-content/uploads/2016/03/Anti-Diabetic-Drugs1.pdf · Anti-Diabetic Drugs Bassim I Mohammad Specialist Physician-Assistant Professor College of Pharmacy](https://reader033.vdocument.in/reader033/viewer/2022060606/605c576967836d08ae557158/html5/thumbnails/19.jpg)
19
Effect of insulin on glucose uptake and metabolism. Insulin binds to its
receptor (1) which in turn starts many protein activation cascades (2). These
include: translocation of Glut-4 transporter to the plasma membrane and influx
of glucose (3), glycogen synthesis (4), glycolysis (5) and fatty acid synthesis (6).
![Page 20: Anti-Diabetic Drugsqu.edu.iq/ph/wp-content/uploads/2016/03/Anti-Diabetic-Drugs1.pdf · Anti-Diabetic Drugs Bassim I Mohammad Specialist Physician-Assistant Professor College of Pharmacy](https://reader033.vdocument.in/reader033/viewer/2022060606/605c576967836d08ae557158/html5/thumbnails/20.jpg)
Insulin-dependent patients with diabetes mellitus (type 1 diabetes mellitus)
Insulin-independent patients: failure to other drugs
Diabetic complications: diabetic, hyperosmotic nonketotic coma
Critical (stress) situations of diabetic patients: fever, severe infection,
pregnancy, trauma, operation
Others: promotion of K+ uptake into the cells, pshychiatric disorders
Insulin (Clinical uses)
![Page 21: Anti-Diabetic Drugsqu.edu.iq/ph/wp-content/uploads/2016/03/Anti-Diabetic-Drugs1.pdf · Anti-Diabetic Drugs Bassim I Mohammad Specialist Physician-Assistant Professor College of Pharmacy](https://reader033.vdocument.in/reader033/viewer/2022060606/605c576967836d08ae557158/html5/thumbnails/21.jpg)
Commercial insulin preparations differ in a number of ways,
recombinant DNA production techniques, amino acid
sequence, concentration, solubility, and the time of onset and
duration of their biologic action
Insulin (Available Preparations)
![Page 22: Anti-Diabetic Drugsqu.edu.iq/ph/wp-content/uploads/2016/03/Anti-Diabetic-Drugs1.pdf · Anti-Diabetic Drugs Bassim I Mohammad Specialist Physician-Assistant Professor College of Pharmacy](https://reader033.vdocument.in/reader033/viewer/2022060606/605c576967836d08ae557158/html5/thumbnails/22.jpg)
Insulin (4 Injectable Available Preparations)
1. Rapid (Ultra-short) acting (very fast onset and short duration)
2. Short-acting (Regular) (rapid onset of action)
3. Intermediate-acting
4. Long-acting (slow onset of action)
![Page 23: Anti-Diabetic Drugsqu.edu.iq/ph/wp-content/uploads/2016/03/Anti-Diabetic-Drugs1.pdf · Anti-Diabetic Drugs Bassim I Mohammad Specialist Physician-Assistant Professor College of Pharmacy](https://reader033.vdocument.in/reader033/viewer/2022060606/605c576967836d08ae557158/html5/thumbnails/23.jpg)
Rapid acting and short-acting insulins are dispensed as clear solutions at
neutral pH and contain small amounts of zinc to improve their stability
and shelf life
Intermediate-acting NPH insulin have been modified to provide
prolonged action and are dispensed as a turbid suspension at neutral pH
with protamine in phosphate buffer (neutral protamine Hagedorn [NPH]
insulin)
Insulin glargine and insulin detemir are clear, soluble long-acting insulins
Insulin (Available Preparations)
![Page 24: Anti-Diabetic Drugsqu.edu.iq/ph/wp-content/uploads/2016/03/Anti-Diabetic-Drugs1.pdf · Anti-Diabetic Drugs Bassim I Mohammad Specialist Physician-Assistant Professor College of Pharmacy](https://reader033.vdocument.in/reader033/viewer/2022060606/605c576967836d08ae557158/html5/thumbnails/24.jpg)
Three rapid-acting Insulin analogs Are Commercially Available (Insulin
lispro, Insulin aspart, Insulin glulisine)
Permit more physiologic prandial insulin replacement because their rapid
onset and early peak action more
Their duration of action is 4–5 hours, which decreases the risk of late
postmeal hypoglycemia
Have the lowest variability of absorption (approximately 5%) of all
available commercial insulins
Rapid-acting Insulin
![Page 25: Anti-Diabetic Drugsqu.edu.iq/ph/wp-content/uploads/2016/03/Anti-Diabetic-Drugs1.pdf · Anti-Diabetic Drugs Bassim I Mohammad Specialist Physician-Assistant Professor College of Pharmacy](https://reader033.vdocument.in/reader033/viewer/2022060606/605c576967836d08ae557158/html5/thumbnails/25.jpg)
Its effect appears within 30 minutes, peaks between 2-3 hours after
subcutaneous injection, and generally lasts 5–8 hours
The hexameric nature of regular insulin causes a delayed onset and
prolongs the time to peak action
After S/C injection, the insulin hexamersare too large and bulky to be
transported across the vascular endothelium into the bloodstream. As the
hexamers break down into dimers and finally monomers. This results in
three rates of absorption of the injected insulin, with the final monomeric
phase having the fastest uptake out of the injection
Short-acting (Regular) Insulin
![Page 26: Anti-Diabetic Drugsqu.edu.iq/ph/wp-content/uploads/2016/03/Anti-Diabetic-Drugs1.pdf · Anti-Diabetic Drugs Bassim I Mohammad Specialist Physician-Assistant Professor College of Pharmacy](https://reader033.vdocument.in/reader033/viewer/2022060606/605c576967836d08ae557158/html5/thumbnails/26.jpg)
Clinically, when regular insulin is administered at mealtime, the blood
glucose rises faster than the insulin with resultant early postprandial
hyperglycemia and an increased risk of late postprandial hypoglycemia.
Therefore, regular insulin should be injected 30–45 or more minutes
before the meal to minimize the mismatching
Short-acting (Regular) Insulin
![Page 27: Anti-Diabetic Drugsqu.edu.iq/ph/wp-content/uploads/2016/03/Anti-Diabetic-Drugs1.pdf · Anti-Diabetic Drugs Bassim I Mohammad Specialist Physician-Assistant Professor College of Pharmacy](https://reader033.vdocument.in/reader033/viewer/2022060606/605c576967836d08ae557158/html5/thumbnails/27.jpg)
The delayed absorption, dose-dependent duration of action, and variability
of absorption (∼ 25%) of regular human insulin frequently results in a
mismatching of insulin availability with need, and its use is declining
It is particularly useful for IV therapy in the management of DKA and
when the insulin requirement is changing rapidly, such as after surgery or
during acute infections.
Limitations of regular insulin, namely, highly dose dependent PKs and
PDs profiles, and variability in absorption
Short-acting (Regular) Insulin
![Page 28: Anti-Diabetic Drugsqu.edu.iq/ph/wp-content/uploads/2016/03/Anti-Diabetic-Drugs1.pdf · Anti-Diabetic Drugs Bassim I Mohammad Specialist Physician-Assistant Professor College of Pharmacy](https://reader033.vdocument.in/reader033/viewer/2022060606/605c576967836d08ae557158/html5/thumbnails/28.jpg)
NPH insulin is an intermediate-acting insulin is a suspension of
crystalline zinc insulin combined with protamine (a polypeptide).
The conjugation with protamine delays its onset of action and prolongs it
effectiveness.
Has an onset of approximately 2–5 hours and duration of 4–12 hours and
is usually mixed with regular, lispro, aspart, or glulisine insulin
The action of NPH is highly unpredictable, and its variability of
absorption is over 50%
Intermediate-acting NPH (neutral protamine Hagedorn, or
isophane) Insulin
![Page 29: Anti-Diabetic Drugsqu.edu.iq/ph/wp-content/uploads/2016/03/Anti-Diabetic-Drugs1.pdf · Anti-Diabetic Drugs Bassim I Mohammad Specialist Physician-Assistant Professor College of Pharmacy](https://reader033.vdocument.in/reader033/viewer/2022060606/605c576967836d08ae557158/html5/thumbnails/29.jpg)
Insulin glargine is a soluble, “peakless” (ie, having a broad plasma
concentration plateau), long-acting insulin analog
Achieves a maximum effect after 4–6 hours. This maximum activity is
maintained for 11–24 hours or longer. Glargine is usually given once daily
Should not be mixed with other insulins (separate syringes must be used)
Long-acting Insulin (Glargine)
![Page 30: Anti-Diabetic Drugsqu.edu.iq/ph/wp-content/uploads/2016/03/Anti-Diabetic-Drugs1.pdf · Anti-Diabetic Drugs Bassim I Mohammad Specialist Physician-Assistant Professor College of Pharmacy](https://reader033.vdocument.in/reader033/viewer/2022060606/605c576967836d08ae557158/html5/thumbnails/30.jpg)
30
Profile of Insulin Glargine vs NPH
Glargine
NPH
![Page 31: Anti-Diabetic Drugsqu.edu.iq/ph/wp-content/uploads/2016/03/Anti-Diabetic-Drugs1.pdf · Anti-Diabetic Drugs Bassim I Mohammad Specialist Physician-Assistant Professor College of Pharmacy](https://reader033.vdocument.in/reader033/viewer/2022060606/605c576967836d08ae557158/html5/thumbnails/31.jpg)
This insulin is the most recently developed long-acting insulin analog
Has the most reproducible effect of the intermediate- and long-acting
insulins, and its use is associated with less hypoglycemia than NPH
insulin
Has a dose-dependent onset of action of 1–2 hours and duration of action
of more than 12 hours.
It is given twice daily to obtain a smooth background insulin level.
Long-acting Insulin (Insulin detemir)
![Page 32: Anti-Diabetic Drugsqu.edu.iq/ph/wp-content/uploads/2016/03/Anti-Diabetic-Drugs1.pdf · Anti-Diabetic Drugs Bassim I Mohammad Specialist Physician-Assistant Professor College of Pharmacy](https://reader033.vdocument.in/reader033/viewer/2022060606/605c576967836d08ae557158/html5/thumbnails/32.jpg)
Because NPH insulins require several hours to reach adequate therapeutic
levels, their use in diabetic patients usually requires supplements of rapid- or
short-acting insulin before meals.
These are often mixed together in the same syringe before injection. Insulin
lispro, aspart, and glulisine can be acutely mixed (ie, just before injection)
with NPH insulin without affecting their rapid absorption.
Premixed formulations of 70%/30% NPH/regular continue to be available.
These preparations have all the limitations of regular insulin, namely, highly
dose dependent PKs and PDs profiles, and variability in absorption
Mixtures (combinations) Of Insulins
![Page 33: Anti-Diabetic Drugsqu.edu.iq/ph/wp-content/uploads/2016/03/Anti-Diabetic-Drugs1.pdf · Anti-Diabetic Drugs Bassim I Mohammad Specialist Physician-Assistant Professor College of Pharmacy](https://reader033.vdocument.in/reader033/viewer/2022060606/605c576967836d08ae557158/html5/thumbnails/33.jpg)
Standard Delivery (conventional disposable syringes)
Portable Pen Injectors
Continuous Subcutaneous Insulin Infusion Devices ( Insulin Pumps)
Inhaled Insulin (dry powder formulation) used in adult, peak level reached
15 minutes and last for 3 hours (faster onset and shorter duratio than SC )
Insulin Delivery Systems
![Page 34: Anti-Diabetic Drugsqu.edu.iq/ph/wp-content/uploads/2016/03/Anti-Diabetic-Drugs1.pdf · Anti-Diabetic Drugs Bassim I Mohammad Specialist Physician-Assistant Professor College of Pharmacy](https://reader033.vdocument.in/reader033/viewer/2022060606/605c576967836d08ae557158/html5/thumbnails/34.jpg)
Insulin Delivery Systems
![Page 35: Anti-Diabetic Drugsqu.edu.iq/ph/wp-content/uploads/2016/03/Anti-Diabetic-Drugs1.pdf · Anti-Diabetic Drugs Bassim I Mohammad Specialist Physician-Assistant Professor College of Pharmacy](https://reader033.vdocument.in/reader033/viewer/2022060606/605c576967836d08ae557158/html5/thumbnails/35.jpg)
1) Hypoglycemia:
is the most common complication of insulin therapy. They usually result from
(Overdose of insulin, Excessive (unusual) physical exercise, meal is missed)
Mild Hypoglycemia and conscious patient treated by dextrose tab, glucose
gel or any sugar containing food or beverages
Severe hypoglycemia and disoriented or unconscious patient best treated by
IV 20-50 ml of 50% glucose over 2-3 minutes. Alternatively SC or IM 1mg
of glucagon. If patient still stuporus or glucagon not available, small amount
of honey or syrup can be inserted into buccal pouch.
Complications of Insulin Therapy
![Page 36: Anti-Diabetic Drugsqu.edu.iq/ph/wp-content/uploads/2016/03/Anti-Diabetic-Drugs1.pdf · Anti-Diabetic Drugs Bassim I Mohammad Specialist Physician-Assistant Professor College of Pharmacy](https://reader033.vdocument.in/reader033/viewer/2022060606/605c576967836d08ae557158/html5/thumbnails/36.jpg)
2) Immunopathology of Insulin Therapy:
Local or systemic allergic reactions
Immune insulin resistance, A low titer of circulating IgG anti-insulin
antibodies that neutralize the action of insulin to a negligible extent develops
in most insulin-treated patients.
3) Lipodystrophy at Injection Sites (with new prparation, atrophy less,
hypertrophy more)
4) Weight gain
Complications of Insulin Therapy
![Page 37: Anti-Diabetic Drugsqu.edu.iq/ph/wp-content/uploads/2016/03/Anti-Diabetic-Drugs1.pdf · Anti-Diabetic Drugs Bassim I Mohammad Specialist Physician-Assistant Professor College of Pharmacy](https://reader033.vdocument.in/reader033/viewer/2022060606/605c576967836d08ae557158/html5/thumbnails/37.jpg)
Promising
![Page 38: Anti-Diabetic Drugsqu.edu.iq/ph/wp-content/uploads/2016/03/Anti-Diabetic-Drugs1.pdf · Anti-Diabetic Drugs Bassim I Mohammad Specialist Physician-Assistant Professor College of Pharmacy](https://reader033.vdocument.in/reader033/viewer/2022060606/605c576967836d08ae557158/html5/thumbnails/38.jpg)
Thank You