anti estrogen
DESCRIPTION
Anti EstrogenTRANSCRIPT
Look Up>Drugs>Clomiphene
Clomiphene
Pronunciation
U.S. Brand Names
Generic Available
Synonyms
Pharmacological Index
Use
Pregnancy Risk Factor
Contraindications
Warnings/Precautions
Adverse Reactions
Drug Interactions
Stability
Mechanism of Action
Pharmacodynamics/Kinetics
Usual Dosage
Reference Range
Test Interactions
Mental Health: Effects on Mental Status
Mental Health: Effects on Psychiatric Treatment
Dental Health: Local Anesthetic/Vasoconstrictor Precautions
Dental Health: Effects on Dental Treatment
Patient Information
Nursing Implications
Dosage Forms
References
Pronunciation
(KLOE mi feen)
U.S. Brand Names
Clomid; Milophene; Serophene
Generic Available
No
Synonyms
Clomiphene Citrate
Pharmacological Index
Ovulation Stimulator
Use
Treatment of ovulatory failure in patients desiring pregnancy
Pregnancy Risk Factor
X
Contraindications
Hypersensitivity or allergy to clomiphene citrate or any of its components; liver disease, abnormal uterine bleeding, suspected pregnancy, enlargement or development of ovarian cyst, uncontrolled thyroid or adrenal dysfunction in the presence of an organic intracranial lesion such as pituitary tumor
Warnings/Precautions
Patients unusually sensitive to pituitary gonadotropins (eg, polycystic ovary disease); multiple pregnancies, blurring or other visual symptoms can occur, ovarian hyperstimulation syndrome, and abdominal pain
Adverse Reactions
>10%: Endocrine & metabolic: Hot flashes, ovarian enlargement 1% to 10%: Cardiovascular: Thromboembolism Central nervous system: Mental depression, headache Endocrine & metabolic: Breast enlargement (males), breast discomfort (females), abnormal menstrual flow Gastrointestinal: Distention, bloating, nausea, vomiting, hepatotoxicity Ocular: Blurring of vision, diplopia, floaters, after-images, phosphenes, photophobia 95% to albumin and -glycoprotein Metabolism: Extensive first pass metabolism Bioavailability: ~2% Half-life: 27.7-32.5 hours Elimination: Primarily in the feces and 0.2% renal
Usual Dosage
Adults: Female: Oral: 60 mg/day which may be administered any time of the day without regard to meals
Monitoring Parameters
Radiologic evaluation of bone mineral density (BMD) is the best measure of the treatment of osteoporosis; to monitor for the potential toxicities of raloxifene, complete blood counts should be evaluated periodically.
Mental Health: Effects on Mental Status
May cause insomnia or depression
Mental Health: Effects on Psychiatric Treatment
None reported
Dental Health: Local Anesthetic/Vasoconstrictor Precautions
No information available to require special precautions
Dental Health: Effects on Dental Treatment
No effects or complications reported
Patient Information
May be taken at any time of day without regard to meals. This medication is given to reduce incidence of osteoporosis; it will not reduce hot flashes or flushing. You may experience flu-like symptoms at beginning of therapy (these may resolve with use). Mild analgesics may reduce joint pain. Rest and cool environment may reduce hot flashes. Report fever; acute migraine; insomnia or emotional depression; unusual weight gain; unresolved gastric distress; urinary infection or vaginal burning or itching; chest pain; or swelling, warmth, or pain in calves. Pregnancy/breast-feeding precautions: Inform prescriber if you are pregnant. Do not breast-feed.
Dosage Forms
Tablet, as hydrochloride: 60 mg
Danazol
Pronunciation
U.S. Brand Names
Generic Available
Canadian Brand Names
Pharmacological Index
Use
Pregnancy Risk Factor
Contraindications
Warnings/Precautions
Adverse Reactions
Drug Interactions
Mechanism of Action
Pharmacodynamics/Kinetics
Usual Dosage
Mental Health: Effects on Mental Status
Mental Health: Effects on Psychiatric Treatment
Dental Health: Local Anesthetic/Vasoconstrictor Precautions
Dental Health: Effects on Dental Treatment
Patient Information
Nursing Implications
Dosage Forms
References
Pronunciation
(DA na zole)
U.S. Brand Names
Danocrine
Generic Available
No
Canadian Brand Names
Cyclomen
Pharmacological Index
Androgen
Use
Treatment of endometriosis, fibrocystic breast disease, and hereditary angioedema
Pregnancy Risk Factor
X
Contraindications
Undiagnosed genital bleeding, hypersensitivity to danazol or any component; pregnancy
Warnings/Precautions
Use with caution in patients with seizure disorders, migraine, or conditions influenced by edema; impaired hepatic, renal, or cardiac disease, pregnancy, lactation
Adverse Reactions
>10%: Cardiovascular: Edema Dermatologic: Oily skin, acne, hirsutism Endocrine & metabolic: Fluid retention, breakthrough bleeding, irregular menstrual periods, decreased breast size Gastrointestinal: Weight gain Hepatic: Hepatic impairment Miscellaneous: Voice deepening 1% to 10%: Endocrine & metabolic: Virilization, androgenic effects, amenorrhea, hypoestrogenism Neuromuscular & skeletal: Weakness