7/21/2019 Anti Manic

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NOTES INDICATIONADMINISTRATION & DOSAGE

OAADVERSE EFFECTS

DRUG-

LITHIUM CLINICAL RESPONSEPatients presentingwith mania generally showa leas !ar"al res!onse ol"h"#$ w"h"n he %rs wee's o( hera!y

For patients presentingwith depression) he"$e(ra$e "s *ons"+era,lylonger I wo#l+ ,e .-/ wee'so see he res!onse

Dr#g o( *ho"*e (or herea$en an+ !re0en"on o(,"!olar +"sor+erL"h"#$ *ar,onae an+*"rae are he wo *l"n"*allyrele0an sal (or$s1L"h"#$ *ar,onae1L"h"#$ *"rae "s a0a"la,leas l"2#"+ an+ hel!(#l "n!a"ens who arenon*o$!l"an w"h a,les or*a!s#les

In+"*a"ons3As prophylaxis "n!re0en"ng ,oh $an"a an++e!ress"on

Adjunct to TCAs !!"Is"n !a"ens who +o nores!on+ (#lly oan"+e!ressans alone

!chi#oa$ecti%e disorders1S*h"4o!hren"* sy$!o$s!l#s alere+ e5e*s "n he(or$ o( +e!ress"on an+e6*"e$en1sho#l+ ,e "n *o$,"na"onw"h an"!sy*ho"*s1L"h"#$ alone "s rarelys#**ess(#l "n rea"ngs*h"4o!hren"a

&ipolar 'isorder(1Mild Mania(L"h"#$ alone "s e5e*"0eCar,a$a4e!"ne "s #se(#lwhen $an"* e!"so+es are no*onrolle+ ,y l"h"#$ alone1 !e%ere maniaAlways a++ *lona4e!a$ 7lora4e!a$ an+ o(en g"0e oneo( he an"-!sy*ho"* +r#gs1'epressionRe2#"res *on*#rren #se o(an"+e!ressans

Da"ly +ose3 /88-9/88$ga$ong +"5eren "n+"0"+#alsMa:or"y re2#"res3 ;<88-;=88 $g7+Al$os always ne*essary og"0e L"h"#$ "n +"0"+e+ +oseso a0o"+ gasr"* +"sress when"n""a"ng rea$enMe+"*a"on "s ,es a'enw"h or shorly a(er $ealsMaintenance Therapy(Pa"ens who ha0e one or$ore e!"so+es o( "llness !eryear are *an+"+aes (or$a"nenan*e rea$en

)* +$ects onneurotransmittersInh"," NE release an+a**elerae "s $ea,ol"s$May "n*rease !resyna!"*re-#!a'e o( NE an+ <->T

,* +$ect on secondmessengers and -proteins(Inh","s *on0ers"on o( IP o"nos"ollea+s o +e!le"on o( PIPPIP IP9 an+ DAGFor ,oh a-a+renerg"* an+$#s*ar"n"* rans$"ss"on

+$ect on -.proteins"n0ol0e+ "n re*e!or+esens""4a"on) "n$o+#la"ng $e$,ranesr#*#re e0ens) "nreg#la"ng rans*r"!"on) "n$e+"a"ng "$$#neres!onses) "n reg#la"ng *ellgrowh) an+ "n learn"ng)$oo+ an+ $e$ory

Ne#rolog"* an+ Psy*h"ar"*1Tre$or1Choreoaheos"s) aa6"a)+ysarhr"a) $oorhy!era*"0"y) a!has"a1Psy*h"ar"* +"s#r,an*es?*on(#s"on@ Thyro"+ (#n*"on1De*rease+ hyro"+ a*"0"y?hy!ohyro"+"s$@

Renal1Poly#r"a) !oly+"!s"a re0ers",le1L"h"#$-"n+#*e+ +"a,ees"ns"!"+#s

 Trea$en3 a$"lor"+e1Long er$ renal +ys(#n*"on3Chron"* "ners""al ne!hr""sM"n"$al *hangeglo$er#lo!ahy

Pregnan*y1L"h"#$ "s rans(erre+ on#rs"ng "n(ans hro#gh,reas$"l'1L"h"#$ o6"*"y "n new,orn3lehargy) *yanos"s) !oor s#*')he!ao$egaly1In*rease "n (re2#en*y o(*ar+"a* ano$al"es ?E,se"nBsano$aly@

M"s*ellaneo#s31A*ne"(or$ er#!"ons1Foll"*#l""s1Le#'o*yos"s

OVERDOSE Thera!e#"* o0er+ose "s$ore *o$$on hana**"+enal "nges"on +#e oa**#$#la"on o( l"h"#$ ?eg#se o( +"#re"*s ) NSAIDs@Any 0al#e o0er $E27L$#s ,e *ons"+ere+ as"n+"*a"ng !oen"al o6"*"yNor$al L"h"#$ ser#$

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