anticholinergics by: angela tipton. how do you define anticholinergic ( an-ti-koh-luh-nur-jik):1. of...
TRANSCRIPT
AnticholinergicsBy: Angela
Tipton
How do you define Anticholinergic ( an-ti-koh-luh-
nur-jik):1. Of or pertaining to a substance that
opposes the effects of acetylcholine; interfering
with the passage of parasympathetic nerve
impulses. 2. A drug or agent that blocks these
nerve impulses, used to control intestinal spasm,
increase the heart rate, dilate the pupils for
examination of the eyes, dry secretions in
anesthesia, and in some forms to treat
Alzheimer’s disease.
Anticholinergics originated between the 1940’s
and the 1945’s.
Anticholinergics are
a type of
bronchodilators
they affect the
muscles around the
bronchi.
Anticholinergics
work by stopping
the muscles from
tightening.
There are different types of Anticholinergic’s there are short acting and long acting some of the short acting anticholinergics are: GENERIC NAME TRADE NAME
Ipratropium bromide AtroventOxitropium bromide Oxiven
These types tend to work within 15 minutes and last for about 6-8 hours. There is currently only one long lasting anticholinergic drug called: tiotropium (Spiriva) which takes about 20 minutes to work and will usually last for 24 hours.
Possible Side Effects of Anticholinergic’s
Some possible side effects that you many experience from using anticholinergic drugs can be: Dry mouth, Blurred Vision (if eyes come in contact with spray.), worsening glaucoma and dry cough. Men who have prostate problems may have more difficulty urinating.
Anticholinergics are associated with Beta-
agonists which affect the bronchioles. There are
also two types of beta-agonists which are short
acting and long acting. Some short acting beta-
agonists last for about 4-5 hours some examples
of these are :Airolin, Inspiryl, Salbulin, albuterol,
bambuterol, bambes, alupent, metaprel, prometa,
brethine, bitolerol just to name a few.
Long lasting beta-agonists last for about 12
hours. Some examples of these types are:
Foradil, Oxis, Serevent.
Foradil - is a long-acting bronchodilator that
relaxes muscles in the airways to improve
breathing. It is used to prevent bronchospasm
in people with reversible obstructive airways
disease, including symptoms of night-time
asthma.
Side effects of Beta-Agonists
Some side effects that you may
experience from using beta-agonists
drugs can be: a fast heart beat, shakiness
and cramping of hands, legs and feet.
Anticholinergic Drugs and Drugs with Anticholinergic side effects used in the Elderly
Anticholinergics
Antiemetics/antivertigo
Anti-Parkinson’s
Antispasmodics(GI)
Antispasmodics(URO)
Antimigraine
Bronchodilators
Preanesthetics
Mydriatcs
Drugs with anticholinergic side
effects
Antiarrythmics
Antidiarrheals
Antihistamines
Skeletal muscle relaxants
Antiulcer drugs
Antidepressants
Antipsychotics
Herbals
Anticholinergic drugs are used to treat a variety of
disorders like gastrointestinal cramps, Urinary
bladder spasms, motion sickness, muscular
spasms. It can also be used as an aid to
anesthesia.
Anticholinergic drugs help to balance out the
production of Dopamine and Acetylcholine. They
can cause drowsiness and are also well known for
causing acute cognitive impairment in individuals
with dementia.
Just some more definitionsCholinergic – an agent that stimulates sites where acetylcholine is the neurotransmitter. Anticholinergic – an agent which blocks sites where acetylcholine is the neurotransmitter. Adrenergic- Stimulates sites where norepinephrine or epinephrine is the neurotransmitter. Antiadrengeric- Blocks sites where norepinephrine or epinephrine is the neurotransmitter. Beta-agonists – mainly affect the muscles around the airways.
Autonomic Nervous SystemThere are two
divisions to the ANS
there is the
sympathetic division
and the
parasympathetic
division. There is also
autonomic
neurotransmitters.
Sympathetic DivisionA. Location of Preganglionic neurons: T1 - L2 in the lateral horns of the gray matter of the spinal cord.
B. Preganglionic neurons send fibers out the ventral root. They leave the spinal nerves through the white rami (myelin) and enter the sympathetic trunk.
C. Ganglionic neurons are located within the sympathetic chain ganglia or in collateral ganglia outside of the sympathetic trunk.
D. Postganglionic fibers leave the sympathetic trunk through the gray rami and pass through the spinal nerve again before terminating on the effector organ.
E. Preganglionic fibers are short and myelinated.
F. Postganglionic fibers are long and unmyelinated.
H. Preganglionic fibers may:
Continued….1. Synapse with one or more neurons in the sympathetic trunk directly across from them;
2. Ascend or descend in the trunk before synapsing;
3. Pass through the sympathetic trunk and synapse with a collateral ganglion outside the sympathetic trunk; or
4. Directly stimulate the release of epinephrine and norepinephrine from the adrenal medulla.
I. The sympathetic division is responsible for vasomotor (sympathetic) tone:
Parasympathetic DivisionA. Location of preganglionic neurons: Brain stem and S2, S3, and S4.
B. Preganglionic fibers travel through cranial nerves III, VII, IX, and X, and spinal nerves S2-S4, and synapse with peripheral ganglia located very near or directly on the effector organ.
C. Ganglionic neurons are located within peripheral ganglia.
D. Preganglionic fibers are long and myelinated.
E. Postganglionic fibers are short and not myelinated.
F. Parasympathetic fibers do not control the diameter of the systemic arterioles but ARE responsible for peristalsis.
Autonomic NeurotransmittersA. Cholinergic fibers - release ACh
All preganglionic fibers release ACh (both parasympathetic & sympathetic)
Parasympathetic postganglionic fibers also release ACh
B. Adrenergic fibers - release NE
Sympathetic postganglionic fibers release NE except those that innervate sweat glands and some blood vessels in the skin and skeletal muscles (which cause vasodilation rather than vasoconstriction)
C. Actions of Autonomic NT's
D. Receptors of Effectors
Continued….1. Types of Cholinergic Receptors (bind Ach):
2. Types of Adrenergic Receptors (bind NE):
a. Alpha
B. Beta
Beta-blockers for heart patients
Adrenergic Drugs
Adrenergic drugs -are drugs that stimulate the sympathetic
nervous system. They are used to increase the output of the
heart, to raise blood pressure, and to increase urine flow as
part of the treatment of shock. Adrenergic’s are also used as
heart stimulants. They may be given to a patient to reverse
the drop in blood pressure that is sometimes caused by
general anesthesia.